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Neoplasms, Complex and Mixed

MedGen UID:
60223
•Concept ID:
C0206764
•
Neoplastic Process
Synonym: Complex and Mixed Neoplasms

Definition

Neoplasms composed of more than one type of neoplastic tissue. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Complex and Mixed

Professional guidelines

PubMed

Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) with Non-Pharmacological Interventions: Clinical Recommendations from a Systematic Scoping Review and an Expert Consensus Process.
Klafke N, Bossert J, Kröger B, Neuberger P, Heyder U, Layer M, Winkler M, Idler C, Kaschdailewitsch E, Heine R, John H, Zielke T, Schmeling B, Joy S, Mertens I, Babadag-Savas B, Kohler S, Mahler C, Witt CM, Steinmann D, Voiss P, Stolz R
Med Sci (Basel) 2023 Jan 30;11(1) doi: 10.3390/medsci11010015. PMID: 36810482Free PMC Article
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations.
Holloway RW, Abu-Rustum NR, Backes FJ, Boggess JF, Gotlieb WH, Jeffrey Lowery W, Rossi EC, Tanner EJ, Wolsky RJ
Gynecol Oncol 2017 Aug;146(2):405-415. Epub 2017 May 28 doi: 10.1016/j.ygyno.2017.05.027. PMID: 28566221Free PMC Article

Recent clinical studies

Etiology

Presentation and outcome of mixed neuroendocrine non-neuroendocrine neoplasms of the pancreas.
Nießen A, Schimmack S, Weber TF, Mayer P, Bergmann F, Hinz U, Büchler MW, Strobel O
Pancreatology 2021 Jan;21(1):224-235. Epub 2020 Dec 3 doi: 10.1016/j.pan.2020.11.020. PMID: 33309225
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Pulmonary Sarcomatoid Carcinomas: A Review.
Weissferdt A
Adv Anat Pathol 2018 Sep;25(5):304-313. doi: 10.1097/PAP.0000000000000202. PMID: 29912718
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.
La Rosa S, Sessa F, Uccella S
Endocr Pathol 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9. PMID: 27169712
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Diagnosis

Looking into digestive mixed neuroendocrine - nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors.
Uccella S, La Rosa S
Histopathology 2020 Nov;77(5):700-717. Epub 2020 Sep 12 doi: 10.1111/his.14178. PMID: 32538468
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N
Cancer Cell 2019 Jun 10;35(6):932-947.e8. Epub 2019 May 23 doi: 10.1016/j.ccell.2019.04.007. PMID: 31130341Free PMC Article
Pulmonary Sarcomatoid Carcinomas: A Review.
Weissferdt A
Adv Anat Pathol 2018 Sep;25(5):304-313. doi: 10.1097/PAP.0000000000000202. PMID: 29912718
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.
La Rosa S, Sessa F, Uccella S
Endocr Pathol 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9. PMID: 27169712
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Therapy

Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Appendiceal tumors with glandular and neuroendocrine features exhibiting peritoneal metastases - Critical evaluation of outcome following cytoreductive surgery with perioperative chemotherapy.
Barrak D, Desale S, Yoon JJ, Dugan MM, Kodavanti PP, Sampah ME, Sugarbaker PH
Eur J Surg Oncol 2021 Jun;47(6):1278-1285. Epub 2021 Jan 21 doi: 10.1016/j.ejso.2021.01.010. PMID: 33500181
Pancreatic adenocarcinosarcoma of monoclonal origin: a case report.
Kim HS, Kim JI, Jeong M, Seo JH, Kim IK, Cheung DY, Kim TJ, Kang CS
World J Gastroenterol 2014 Sep 21;20(35):12682-6. doi: 10.3748/wjg.v20.i35.12682. PMID: 25253976Free PMC Article
Composite hemangioendothelioma and its classification as a low-grade malignancy.
McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827
Mixed squamous cell and glandular papilloma of the lung: a case study and literature review.
Inamura K, Kumasaka T, Furuta R, Shimada K, Hiyama N, Furuhata Y, Tanaka I, Takemura T
Pathol Int 2011 Apr;61(4):252-8. Epub 2011 Mar 8 doi: 10.1111/j.1440-1827.2011.02659.x. PMID: 21418399

Prognosis

Clinicopathological Features of Gastroesophageal Neuroendocrine Neoplasms.
Liu M, Popa EC, Finnerty BM, Fahey TJ 3rd, Zarnegar R
Curr Gastroenterol Rep 2020 Aug 14;22(10):50. doi: 10.1007/s11894-020-00788-w. PMID: 32797314
Looking into digestive mixed neuroendocrine - nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors.
Uccella S, La Rosa S
Histopathology 2020 Nov;77(5):700-717. Epub 2020 Sep 12 doi: 10.1111/his.14178. PMID: 32538468
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N
Cancer Cell 2019 Jun 10;35(6):932-947.e8. Epub 2019 May 23 doi: 10.1016/j.ccell.2019.04.007. PMID: 31130341Free PMC Article
Pulmonary Sarcomatoid Carcinomas: A Review.
Weissferdt A
Adv Anat Pathol 2018 Sep;25(5):304-313. doi: 10.1097/PAP.0000000000000202. PMID: 29912718

Clinical prediction guides

Looking into digestive mixed neuroendocrine - nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors.
Uccella S, La Rosa S
Histopathology 2020 Nov;77(5):700-717. Epub 2020 Sep 12 doi: 10.1111/his.14178. PMID: 32538468
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N
Cancer Cell 2019 Jun 10;35(6):932-947.e8. Epub 2019 May 23 doi: 10.1016/j.ccell.2019.04.007. PMID: 31130341Free PMC Article
Pulmonary Sarcomatoid Carcinomas: A Review.
Weissferdt A
Adv Anat Pathol 2018 Sep;25(5):304-313. doi: 10.1097/PAP.0000000000000202. PMID: 29912718
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.
La Rosa S, Sessa F, Uccella S
Endocr Pathol 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9. PMID: 27169712

Recent systematic reviews

Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Endoscopic Submucosal Dissection of Early Gastric Cancer with Mixed-Type Histology: A Systematic Review.
Bang CS, Yang YJ, Lee JJ, Baik GH
Dig Dis Sci 2020 Jan;65(1):276-291. Epub 2019 Jul 31 doi: 10.1007/s10620-019-05761-w. PMID: 31367880
Long-term outcomes of combined hepatocellular-cholangiocarcinoma after hepatectomy or liver transplantation: A systematic review and meta-analysis.
Li DB, Si XY, Wang SJ, Zhou YM
Hepatobiliary Pancreat Dis Int 2019 Feb;18(1):12-18. Epub 2018 Oct 25 doi: 10.1016/j.hbpd.2018.10.001. PMID: 30442549

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