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Neoplasms, Complex and Mixed

MedGen UID:
60223
•Concept ID:
C0206764
•
Neoplastic Process
Synonym: Complex and Mixed Neoplasms

Definition

Neoplasms composed of more than one type of neoplastic tissue. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Complex and Mixed

Professional guidelines

PubMed

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations.
Holloway RW, Abu-Rustum NR, Backes FJ, Boggess JF, Gotlieb WH, Jeffrey Lowery W, Rossi EC, Tanner EJ, Wolsky RJ
Gynecol Oncol 2017 Aug;146(2):405-415. Epub 2017 May 28 doi: 10.1016/j.ygyno.2017.05.027. PMID: 28566221Free PMC Article
Biology and Treatment of Rhabdoid Tumor.
Geller JI, Roth JJ, Biegel JA
Crit Rev Oncog 2015;20(3-4):199-216. doi: 10.1615/critrevoncog.2015013566. PMID: 26349416Free PMC Article
Wilms' tumor- roadmaps of management.
Sarin YK, Bhatnagar SN
Indian J Pediatr 2012 Jun;79(6):776-86. Epub 2012 May 4 doi: 10.1007/s12098-012-0747-3. PMID: 22555907

Recent clinical studies

Etiology

Clinical and pathological analysis of cutaneous mixed tumors.
Shi J, Yuan MX, Chen S, Chen HX, Zhang JY, Cheng JW, Zhang Q, Miao X
Arch Dermatol Res 2024 Oct 14;316(10):680. doi: 10.1007/s00403-024-03429-8. PMID: 39400754
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Recurrent differentiated thyroid cancer.
Shaha AR
Endocr Pract 2012 Jul-Aug;18(4):600-3. doi: 10.4158/EP12047.CO. PMID: 22849875
The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children.
Kaderali Z, Lamberti-Pasculli M, Rutka JT
Childs Nerv Syst 2009 Jul;25(7):787-93. Epub 2008 Dec 11 doi: 10.1007/s00381-008-0771-9. PMID: 19082611
Pulmonary metastasectomy in pediatric patients.
Kayton ML
Thorac Surg Clin 2006 May;16(2):167-83, vi. doi: 10.1016/j.thorsurg.2006.01.001. PMID: 16805206

Diagnosis

Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma.
Sciarra A, Park YN, Sempoux C
Hum Pathol 2020 Feb;96:48-55. Epub 2020 Jan 10 doi: 10.1016/j.humpath.2019.11.001. PMID: 31931021
Luteinized Fibrothecoma.
Haghayeghi K, Hansen K, Quddus MR
Int J Surg Pathol 2019 Sep;27(6):654-655. Epub 2018 Dec 6 doi: 10.1177/1066896918817372. PMID: 30520326
Nonuterine Lipoleiomyoma.
Bommakanti K, Valasek MA, Sicklick JK
Am Surg 2017 Dec 1;83(12):e474-475. PMID: 29336739Free PMC Article
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Recurrent differentiated thyroid cancer.
Shaha AR
Endocr Pract 2012 Jul-Aug;18(4):600-3. doi: 10.4158/EP12047.CO. PMID: 22849875

Therapy

Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Mixed acinar and macrocystic ductal prostatic adenocarcinoma.
Giganti F, Allen C, Sridhar A, Tandogdu Z, Ramachandran N, Dickinson L, Haider A, Freeman A, Ball R, Moore CM
Lancet Oncol 2021 Jan;22(1):e37. doi: 10.1016/S1470-2045(20)30435-6. PMID: 33387504
The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures.
Chen L, Oke T, Siegel N, Cojocaru G, Tam AJ, Blosser RL, Swailes J, Ligon JA, Lebid A, Morris C, Levin A, Rhee DS, Johnston FM, Greer JB, Meyer CF, Ladle BH, Thompson ED, Montgomery EA, Choi W, McConkey DJ, Anders RA, Pardoll DM, Llosa NJ
Clin Cancer Res 2020 Aug 1;26(15):4018-4030. Epub 2020 Apr 24 doi: 10.1158/1078-0432.CCR-19-3416. PMID: 32332015Free PMC Article
Tumors with intrahepatic bile duct differentiation in cirrhosis: implications on outcomes after liver transplantation.
Facciuto ME, Singh MK, Lubezky N, Selim MA, Robinson D, Kim-Schluger L, Florman S, Ward SC, Thung SN, Fiel M, Schiano TD
Transplantation 2015 Jan;99(1):151-7. doi: 10.1097/TP.0000000000000286. PMID: 25029385
Composite hemangioendothelioma and its classification as a low-grade malignancy.
McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827

Prognosis

Goblet Cell Carcinoid/Carcinoma: An Update.
Zhang K, Meyerson C, Kassardjian A, Westbrook LM, Zheng W, Wang HL
Adv Anat Pathol 2019 Mar;26(2):75-83. doi: 10.1097/PAP.0000000000000222. PMID: 30601149
Combined hepatocellular cholangiocarcinoma: Controversies to be addressed.
Wang AQ, Zheng YC, Du J, Zhu CP, Huang HC, Wang SS, Wu LC, Wan XS, Zhang HH, Miao RY, Sang XT, Zhao HT
World J Gastroenterol 2016 May 14;22(18):4459-65. doi: 10.3748/wjg.v22.i18.4459. PMID: 27182157Free PMC Article
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Recurrent differentiated thyroid cancer.
Shaha AR
Endocr Pract 2012 Jul-Aug;18(4):600-3. doi: 10.4158/EP12047.CO. PMID: 22849875
Adrenocorticotropin-secreting pancreatoblastoma.
Kletter GB, Sweetser DA, Wallace SF, Sawin RS, Rutledge JC, Geyer JR
J Pediatr Endocrinol Metab 2007 May;20(5):639-42. doi: 10.1515/jpem.2007.20.5.639. PMID: 17642425

Clinical prediction guides

Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma.
Sciarra A, Park YN, Sempoux C
Hum Pathol 2020 Feb;96:48-55. Epub 2020 Jan 10 doi: 10.1016/j.humpath.2019.11.001. PMID: 31931021
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.
Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N
Cancer Cell 2019 Jun 10;35(6):932-947.e8. Epub 2019 May 23 doi: 10.1016/j.ccell.2019.04.007. PMID: 31130341Free PMC Article
Histopathology of hepatocellular carcinoma.
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Composite hemangioendothelioma and its classification as a low-grade malignancy.
McNab PM, Quigley BC, Glass LF, Jukic DM
Am J Dermatopathol 2013 Jun;35(4):517-22. doi: 10.1097/DAD.0b013e31827a0d37. PMID: 23694827
Pathology of combined hepatocellular-cholangiocarcinoma.
Yeh MM
J Gastroenterol Hepatol 2010 Sep;25(9):1485-92. doi: 10.1111/j.1440-1746.2010.06430.x. PMID: 20796144

Recent systematic reviews

Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Endoscopic Submucosal Dissection of Early Gastric Cancer with Mixed-Type Histology: A Systematic Review.
Bang CS, Yang YJ, Lee JJ, Baik GH
Dig Dis Sci 2020 Jan;65(1):276-291. Epub 2019 Jul 31 doi: 10.1007/s10620-019-05761-w. PMID: 31367880
Long-term outcomes of combined hepatocellular-cholangiocarcinoma after hepatectomy or liver transplantation: A systematic review and meta-analysis.
Li DB, Si XY, Wang SJ, Zhou YM
Hepatobiliary Pancreat Dis Int 2019 Feb;18(1):12-18. Epub 2018 Oct 25 doi: 10.1016/j.hbpd.2018.10.001. PMID: 30442549

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