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Angiomyolipoma

MedGen UID:
64622
Concept ID:
C0206633
Neoplastic Process
Synonym: Angiomyolipomas
SNOMED CT: Angiomyolipoma (19929002)
 
Monarch Initiative: MONDO:0002603

Definition

A neoplasm with perivascular epithelioid cell differentiation often associated with tuberous sclerosis. It is characterized by a mixture of epithelioid cells, smooth muscle, vessels, and mature adipose tissue. The kidney is the most common site of involvement. Other sites of involvement include the liver, lung, lymph nodes, and retroperitoneum. The vast majority of cases follow a benign clinical course. However, cases of metastatic angiomyolipomas with sarcomatoid features have been described. [from NCI]

Professional guidelines

PubMed

Yang JW, Liang C, Yang L
Kaohsiung J Med Sci 2022 Oct;38(10):925-932. Epub 2022 Sep 3 doi: 10.1002/kjm2.12586. PMID: 36056704
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Halpenny D, Snow A, McNeill G, Torreggiani WC
Clin Radiol 2010 Feb;65(2):99-108. Epub 2009 Dec 3 doi: 10.1016/j.crad.2009.09.014. PMID: 20103431

Recent clinical studies

Etiology

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Çalışkan S, Gümrükçü G, Özsoy E, Topaktas R, Öztürk Mİ
Rev Assoc Med Bras (1992) 2019 Aug 5;65(7):977-981. doi: 10.1590/1806-9282.65.7.977. PMID: 31389508
Bissler JJ, Christopher Kingswood J
Am J Med Genet C Semin Med Genet 2018 Sep;178(3):338-347. Epub 2018 Oct 11 doi: 10.1002/ajmg.c.31654. PMID: 30307110
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319

Diagnosis

Caliò A, Brunelli M, Segala D, Zamboni G, Bonetti F, Pea M, Martignoni G
Pathology 2021 Jan;53(1):129-140. Epub 2020 Oct 31 doi: 10.1016/j.pathol.2020.08.008. PMID: 33131798
Çalışkan S, Gümrükçü G, Özsoy E, Topaktas R, Öztürk Mİ
Rev Assoc Med Bras (1992) 2019 Aug 5;65(7):977-981. doi: 10.1590/1806-9282.65.7.977. PMID: 31389508
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Petrolla AA, Xin W
Arch Pathol Lab Med 2008 Oct;132(10):1679-82. doi: 10.5858/2008-132-1679-HA. PMID: 18834230
Eble JN
Semin Diagn Pathol 1998 Feb;15(1):21-40. PMID: 9503504

Therapy

Warrior K, Dilling DF
J Heart Lung Transplant 2023 Jan;42(1):40-52. Epub 2022 Oct 8 doi: 10.1016/j.healun.2022.09.021. PMID: 36334961
Ma MKM, Yung S, Chan TM
Transplantation 2018 Feb;102(2S Suppl 1):S32-S40. doi: 10.1097/TP.0000000000001729. PMID: 29369972
Johnson SR, Taveira-DaSilva AM, Moss J
Clin Chest Med 2016 Sep;37(3):389-403. doi: 10.1016/j.ccm.2016.04.002. PMID: 27514586
Henske EP, Jóźwiak S, Kingswood JC, Sampson JR, Thiele EA
Nat Rev Dis Primers 2016 May 26;2:16035. doi: 10.1038/nrdp.2016.35. PMID: 27226234
Grenier N, Petitpierre F, Le Bras Y, Lasserre AS, Cornelis F
Nephrol Ther 2016 Apr;12 Suppl 1:S139-43. Epub 2016 Mar 8 doi: 10.1016/j.nephro.2016.01.009. PMID: 26968474

Prognosis

LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, Alexander LF
Radiographics 2020 Nov-Dec;40(7):2098-2116. Epub 2020 Oct 16 doi: 10.1148/rg.2020200047. PMID: 33064623
Doubková M, Štefániková M, Čan V, Merta Z, Svoboda M
Klin Onkol 2019 Fall;32(5):367-374. doi: 10.14735/amko2019367. PMID: 31610670
Mentzel T
Semin Diagn Pathol 2001 Nov;18(4):250-7. PMID: 11757864
Kelly J, Moss J
Am J Med Sci 2001 Jan;321(1):17-25. doi: 10.1097/00000441-200101000-00004. PMID: 11202475
Eble JN
Semin Diagn Pathol 1998 Feb;15(1):21-40. PMID: 9503504

Clinical prediction guides

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Kuusk T, Neves JB, Tran M, Bex A
World J Urol 2021 Aug;39(8):2861-2868. Epub 2021 Jan 26 doi: 10.1007/s00345-021-03602-y. PMID: 33495866
LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, Alexander LF
Radiographics 2020 Nov-Dec;40(7):2098-2116. Epub 2020 Oct 16 doi: 10.1148/rg.2020200047. PMID: 33064623
Doubková M, Štefániková M, Čan V, Merta Z, Svoboda M
Klin Onkol 2019 Fall;32(5):367-374. doi: 10.14735/amko2019367. PMID: 31610670
Ma MKM, Yung S, Chan TM
Transplantation 2018 Feb;102(2S Suppl 1):S32-S40. doi: 10.1097/TP.0000000000001729. PMID: 29369972

Recent systematic reviews

Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188
Sasongko TH, Ismail NF, Zabidi-Hussin Z
Cochrane Database Syst Rev 2016 Jul 13;7(7):CD011272. doi: 10.1002/14651858.CD011272.pub2. PMID: 27409709Free PMC Article
Sasongko TH, Ismail NF, Nik Abdul Malik NM, Zabidi-Hussin ZA
Orphanet J Rare Dis 2015 Aug 12;10:95. doi: 10.1186/s13023-015-0317-7. PMID: 26259610Free PMC Article
Murray TE, Doyle F, Lee M
J Urol 2015 Sep;194(3):635-9. Epub 2015 Apr 25 doi: 10.1016/j.juro.2015.04.081. PMID: 25916674
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319

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