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Angiomyolipoma

MedGen UID:
64622
Concept ID:
C0206633
Neoplastic Process
Synonym: Angiomyolipomas
SNOMED CT: Angiomyolipoma (19929002); Angiomyolipoma (1293131004)
 
Monarch Initiative: MONDO:0002603

Definition

A neoplasm with perivascular epithelioid cell differentiation often associated with tuberous sclerosis. It is characterized by a mixture of epithelioid cells, smooth muscle, vessels, and mature adipose tissue. The kidney is the most common site of involvement. Other sites of involvement include the liver, lung, lymph nodes, and retroperitoneum. The vast majority of cases follow a benign clinical course. However, cases of metastatic angiomyolipomas with sarcomatoid features have been described. [from NCI]

Professional guidelines

PubMed

Gupta N, McCarthy C
Respir Med Res 2023 Jun;83:101016. Epub 2023 Apr 21 doi: 10.1016/j.resmer.2023.101016. PMID: 37087907
Cottin V, Blanchard E, Kerjouan M, Lazor R, Reynaud-Gaubert M, Taille C, Uzunhan Y, Wemeau L, Andrejak C, Baud D, Bonniaud P, Brillet PY, Calender A, Chalabreysse L, Court-Fortune I, Desbaillets NP, Ferretti G, Guillemot A, Hardelin L, Kambouchner M, Leclerc V, Lederlin M, Malinge MC, Mancel A, Marchand-Adam S, Maury JM, Naccache JM, Nasser M, Nunes H, Pagnoux G, Prévot G, Rousset-Jablonski C, Rouviere O, Si-Mohamed S, Touraine R, Traclet J, Turquier S, Vagnarelli S, Ahmad K; OrphaLung network
Respir Med Res 2023 Jun;83:101010. Epub 2023 Mar 24 doi: 10.1016/j.resmer.2023.101010. PMID: 37087906
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Hammer PM, Tan SY
Surg Pathol Clin 2024 Mar;17(1):105-118. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.002. PMID: 38278600
Almazedi B, Stubbs C
Clin Radiol 2024 Jan;79(1):25-32. Epub 2023 Oct 14 doi: 10.1016/j.crad.2023.09.028. PMID: 37925365
Çalışkan S, Gümrükçü G, Özsoy E, Topaktas R, Öztürk Mİ
Rev Assoc Med Bras (1992) 2019 Aug 5;65(7):977-981. doi: 10.1590/1806-9282.65.7.977. PMID: 31389508
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Lemaitre L, Claudon M, Dubrulle F, Mazeman E
Semin Ultrasound CT MR 1997 Apr;18(2):100-14. doi: 10.1016/s0887-2171(97)90054-8. PMID: 9163829

Diagnosis

Çalışkan S, Gümrükçü G, Özsoy E, Topaktas R, Öztürk Mİ
Rev Assoc Med Bras (1992) 2019 Aug 5;65(7):977-981. doi: 10.1590/1806-9282.65.7.977. PMID: 31389508
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Lienert AR, Nicol D
BJU Int 2012 Dec;110 Suppl 4:25-7. doi: 10.1111/j.1464-410X.2012.11618.x. PMID: 23194120
Petrolla AA, Xin W
Arch Pathol Lab Med 2008 Oct;132(10):1679-82. doi: 10.5858/2008-132-1679-HA. PMID: 18834230
Eble JN
Semin Diagn Pathol 1998 Feb;15(1):21-40. PMID: 9503504

Therapy

Cockerell I, Christensen J, Hoei-Hansen CE, Holst L, Grenaa Frederiksen M, Issa-Epe AI, Nedregaard B, Solhoff R, Heimdal K, Johannessen Landmark C, Lund C, Nærland T
Orphanet J Rare Dis 2023 Dec 2;18(1):377. doi: 10.1186/s13023-023-02982-1. PMID: 38042867Free PMC Article
Warrior K, Dilling DF
J Heart Lung Transplant 2023 Jan;42(1):40-52. Epub 2022 Oct 8 doi: 10.1016/j.healun.2022.09.021. PMID: 36334961
Johnson SR, Taveira-DaSilva AM, Moss J
Clin Chest Med 2016 Sep;37(3):389-403. doi: 10.1016/j.ccm.2016.04.002. PMID: 27514586
Henske EP, Jóźwiak S, Kingswood JC, Sampson JR, Thiele EA
Nat Rev Dis Primers 2016 May 26;2:16035. doi: 10.1038/nrdp.2016.35. PMID: 27226234
Grenier N, Petitpierre F, Le Bras Y, Lasserre AS, Cornelis F
Nephrol Ther 2016 Apr;12 Suppl 1:S139-43. Epub 2016 Mar 8 doi: 10.1016/j.nephro.2016.01.009. PMID: 26968474

Prognosis

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
LeRoy MA, Rao P
Arch Pathol Lab Med 2016 Jun;140(6):594-7. doi: 10.5858/arpa.2015-0170-RS. PMID: 27232352
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428
Kelly J, Moss J
Am J Med Sci 2001 Jan;321(1):17-25. doi: 10.1097/00000441-200101000-00004. PMID: 11202475
Eble JN
Semin Diagn Pathol 1998 Feb;15(1):21-40. PMID: 9503504

Clinical prediction guides

Chung A, Raman SS
Urol Clin North Am 2023 May;50(2):161-180. doi: 10.1016/j.ucl.2023.01.006. PMID: 36948664
Salles DC, Asrani K, Woo J, Vidotto T, Liu HB, Vidal I, Matoso A, Netto GJ, Argani P, Lotan TL
J Pathol 2022 Jun;257(2):158-171. Epub 2022 Mar 29 doi: 10.1002/path.5875. PMID: 35072947Free PMC Article
Doubková M, Štefániková M, Čan V, Merta Z, Svoboda M
Klin Onkol 2019 Fall;32(5):367-374. doi: 10.14735/amko2019367. PMID: 31610670
Ma MKM, Yung S, Chan TM
Transplantation 2018 Feb;102(2S Suppl 1):S32-S40. doi: 10.1097/TP.0000000000001729. PMID: 29369972
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW
Am J Surg Pathol 2005 Dec;29(12):1558-75. doi: 10.1097/01.pas.0000173232.22117.37. PMID: 16327428

Recent systematic reviews

Dehghani Firouzabadi F, Gopal N, Hasani A, Homayounieh F, Li X, Jones EC, Yazdian Anari P, Turkbey E, Malayeri AA
PLoS One 2023;18(7):e0287299. Epub 2023 Jul 27 doi: 10.1371/journal.pone.0287299. PMID: 37498830Free PMC Article
Sasongko TH, Kademane K, Chai Soon Hou S, Jocelyn TXY, Zabidi-Hussin Z
Cochrane Database Syst Rev 2023 Jul 11;7(7):CD011272. doi: 10.1002/14651858.CD011272.pub3. PMID: 37432030Free PMC Article
Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188
Murray TE, Doyle F, Lee M
J Urol 2015 Sep;194(3):635-9. Epub 2015 Apr 25 doi: 10.1016/j.juro.2015.04.081. PMID: 25916674
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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