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Amelanotic melanoma

MedGen UID:
64644
Concept ID:
C0206735
Neoplastic Process
Synonyms: Amelanotic Melanoma; Amelanotic Melanomas; Melanoma, Amelanotic; Melanomas, Amelanotic
SNOMED CT: Amelanotic melanoma (70594002)
 
Monarch Initiative: MONDO:0002971

Definition

A melanoma characterized by the complete absence of melanin pigment in the melanoma cells. It occurs more frequently on the face and it is often associated with desmoplastic reaction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmelanotic melanoma

Professional guidelines

PubMed

Sen M, Honavar SG
Indian J Ophthalmol 2019 Dec;67(12):1965-1973. doi: 10.4103/ijo.IJO_2036_19. PMID: 31755430Free PMC Article
Ferraioli D, Lamblin G, Mathevet P, Hetu J, Berakdar I, Beurrier F, Chopin N
Arch Gynecol Obstet 2016 Nov;294(5):1037-1045. Epub 2016 Jun 30 doi: 10.1007/s00404-016-4144-4. PMID: 27365105
Pessaux P, Pocard M, Elias D, Duvillard P, Avril MF, Zimmerman P, Lasser P
Br J Surg 2004 Sep;91(9):1183-7. doi: 10.1002/bjs.4592. PMID: 15449271

Recent clinical studies

Etiology

Paolino G, Bearzi P, Pampena R, Longo C, Frascione P, Rizzo N, Raucci M, Carbone A, Cantisani C, Ricci F, Didona D, Frattini F, Bulotta A, Gregorc V, Mercuri SR
Int J Dermatol 2020 Nov;59(11):1371-1380. Epub 2020 Jul 29 doi: 10.1111/ijd.15064. PMID: 32726478
Greco V, Cappello M, Megna M, Costa C, Villani A, Fabbrocini G, Marino V, Scalvenzi M
Australas J Dermatol 2020 Nov;61(4):337-341. Epub 2020 Jul 27 doi: 10.1111/ajd.13366. PMID: 32715462
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Vernali S, Waxweiler WT, Dillon PM, Kanetsky PA, Orlow I, Luo L, Busam KJ, Kricker A, Armstrong BK, Anton-Culver H, Gruber SB, Gallagher RP, Zanetti R, Rosso S, Sacchetto L, Dwyer T, Cust AE, Ollila DW, Begg CB, Berwick M, Thomas NE; GEM Study Group
JAMA Dermatol 2017 Oct 1;153(10):1026-1031. doi: 10.1001/jamadermatol.2017.2444. PMID: 28746718Free PMC Article

Diagnosis

Bouceiro-Mendes R, Soares-de-Almeida L
Acta Med Port 2021 Jun 1;34(6):468. Epub 2021 Apr 13 doi: 10.20344/amp.13044. PMID: 33861192
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Muinonen-Martin AJ, O'Shea SJ, Newton-Bishop J
BMJ 2018 Mar 15;360:k826. doi: 10.1136/bmj.k826. PMID: 29545447
Hosseini H, Eghtedari M, Roozitalab M, Ashraf M, Shahrzad S
BMJ Case Rep 2011 Mar 3;2011 doi: 10.1136/bcr.07.2010.3158. PMID: 22707621Free PMC Article

Therapy

Wawszczyk J, Jesse K, Kapral M
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021115. PMID: 36674631Free PMC Article
Soares CD, Carlos R, Andrade BAB, Cunha JLS, Agostini M, Romañach MJ, Hernandez-Guerrero JC, Mosqueda-Taylor A, Almeida OP, Jorge J
Int J Surg Pathol 2021 May;29(3):263-272. Epub 2020 Jul 31 doi: 10.1177/1066896920946435. PMID: 32734791
Curman P, Lapins J, Radros N, Krynitz B, Wikström JD
Acta Derm Venereol 2020 Mar 12;100(6):adv00082. doi: 10.2340/00015555-3397. PMID: 31930427Free PMC Article
O'Day RF, Pejnovic TM, Isaacs T, Muecke JS, Glasson WJ, Campbell WG
Retina 2020 May;40(5):972-976. doi: 10.1097/IAE.0000000000002520. PMID: 30908472
Silva AMM, Fonseca MCF, Proença RD
JAMA Ophthalmol 2018 Jul 12;136(7):e181114. doi: 10.1001/jamaophthalmol.2018.1114. PMID: 30003241

Prognosis

Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Barnhill RL, Gupta K
Clin Dermatol 2009 Nov-Dec;27(6):564-87. doi: 10.1016/j.clindermatol.2008.09.015. PMID: 19880044
Samaila MO, Mbibu HN, Oluwole OP
Surg Infect (Larchmt) 2007 Oct;8(5):519-22. doi: 10.1089/sur.2006.052. PMID: 17999585
Adler MJ, White CR Jr
Semin Cutan Med Surg 1997 Jun;16(2):122-30. doi: 10.1016/s1085-5629(97)80006-5. PMID: 9220551

Clinical prediction guides

Soares CD, Carlos R, Andrade BAB, Cunha JLS, Agostini M, Romañach MJ, Hernandez-Guerrero JC, Mosqueda-Taylor A, Almeida OP, Jorge J
Int J Surg Pathol 2021 May;29(3):263-272. Epub 2020 Jul 31 doi: 10.1177/1066896920946435. PMID: 32734791
Greco V, Cappello M, Megna M, Costa C, Villani A, Fabbrocini G, Marino V, Scalvenzi M
Australas J Dermatol 2020 Nov;61(4):337-341. Epub 2020 Jul 27 doi: 10.1111/ajd.13366. PMID: 32715462
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Detrixhe A, Libon F, Mansuy M, Nikkels-Tassoudji N, Rorive A, Arrese JE, Quatresooz P, Reginster MA, Nikkels AF
Melanoma Res 2016 Dec;26(6):631-634. doi: 10.1097/CMR.0000000000000294. PMID: 27537773
Auer-Grumbach M
Orphanet J Rare Dis 2008 Mar 18;3:7. doi: 10.1186/1750-1172-3-7. PMID: 18348718Free PMC Article

Recent systematic reviews

Bansal SP, Dhanawade SS, Arvandekar AS, Mehta V, Desai RS
Head Neck Pathol 2022 Jun;16(2):513-524. Epub 2021 Jul 26 doi: 10.1007/s12105-021-01366-w. PMID: 34309791Free PMC Article
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045
Zhang S, Wang W, Su X, Tan Q, Sun H, Liu Z, Chen N, Gong Q, Yue Q
World Neurosurg 2019 Feb;122:229-239. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.199. PMID: 30404049

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