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Amelanotic melanoma

MedGen UID:
64644
•Concept ID:
C0206735
•
Neoplastic Process
Synonyms: Amelanotic Melanoma; Amelanotic Melanomas; Melanoma, Amelanotic; Melanomas, Amelanotic
SNOMED CT: Amelanotic melanoma (70594002)
 
Monarch Initiative: MONDO:0002971

Definition

A melanoma characterized by the complete absence of melanin pigment in the melanoma cells. It occurs more frequently on the face and it is often associated with desmoplastic reaction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmelanotic melanoma

Professional guidelines

PubMed

Circumscribed choroidal hemangioma: An overview of clinical manifestation, diagnosis and management.
Sen M, Honavar SG
Indian J Ophthalmol 2019 Dec;67(12):1965-1973. doi: 10.4103/ijo.IJO_2036_19. PMID: 31755430Free PMC Article
Genital melanoma: prognosis factors and treatment modality.
Ferraioli D, Lamblin G, Mathevet P, Hetu J, Berakdar I, Beurrier F, Chopin N
Arch Gynecol Obstet 2016 Nov;294(5):1037-1045. Epub 2016 Jun 30 doi: 10.1007/s00404-016-4144-4. PMID: 27365105
Surgical management of primary anorectal melanoma.
Pessaux P, Pocard M, Elias D, Duvillard P, Avril MF, Zimmerman P, Lasser P
Br J Surg 2004 Sep;91(9):1183-7. doi: 10.1002/bjs.4592. PMID: 15449271

Recent clinical studies

Etiology

Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study.
Paolino G, Bearzi P, Pampena R, Longo C, Frascione P, Rizzo N, Raucci M, Carbone A, Cantisani C, Ricci F, Didona D, Frattini F, Bulotta A, Gregorc V, Mercuri SR
Int J Dermatol 2020 Nov;59(11):1371-1380. Epub 2020 Jul 29 doi: 10.1111/ijd.15064. PMID: 32726478
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Clinically amelanotic or hypomelanotic melanoma: Anatomic distribution, risk factors, and survival.
Wee E, Wolfe R, Mclean C, Kelly JW, Pan Y
J Am Acad Dermatol 2018 Oct;79(4):645-651.e4. doi: 10.1016/j.jaad.2018.04.045. PMID: 30241625
The limitations of dermoscopy: false-positive and false-negative tumours.
Papageorgiou V, Apalla Z, Sotiriou E, Papageorgiou C, Lazaridou E, Vakirlis S, Ioannides D, Lallas A
J Eur Acad Dermatol Venereol 2018 Jun;32(6):879-888. Epub 2018 Jan 24 doi: 10.1111/jdv.14782. PMID: 29314288

Diagnosis

Acral Amelanotic Melanoma.
Bouceiro-Mendes R, Soares-de-Almeida L
Acta Med Port 2021 Jun 1;34(6):468. Epub 2021 Apr 13 doi: 10.20344/amp.13044. PMID: 33861192
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Amelanotic melanoma.
Muinonen-Martin AJ, O'Shea SJ, Newton-Bishop J
BMJ 2018 Mar 15;360:k826. doi: 10.1136/bmj.k826. PMID: 29545447
Amelanotic malignant melanoma.
Adler MJ, White CR Jr
Semin Cutan Med Surg 1997 Jun;16(2):122-30. doi: 10.1016/s1085-5629(97)80006-5. PMID: 9220551

Therapy

Pterostilbene-Mediated Inhibition of Cell Proliferation and Cell Death Induction in Amelanotic and Melanotic Melanoma.
Wawszczyk J, Jesse K, Kapral M
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021115. PMID: 36674631Free PMC Article
Oral Amelanotic Melanomas: Clinicopathologic Features of 8 Cases and Review of the Literature.
Soares CD, Carlos R, Andrade BAB, Cunha JLS, Agostini M, Romañach MJ, Hernandez-Guerrero JC, Mosqueda-Taylor A, Almeida OP, Jorge J
Int J Surg Pathol 2021 May;29(3):263-272. Epub 2020 Jul 31 doi: 10.1177/1066896920946435. PMID: 32734791
The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA.
O'Day RF, Pejnovic TM, Isaacs T, Muecke JS, Glasson WJ, Campbell WG
Retina 2020 May;40(5):972-976. doi: 10.1097/IAE.0000000000002520. PMID: 30908472
Amelanotic and Pigmented Uveal Melanoma.
Silva AMM, Fonseca MCF, Proença RD
JAMA Ophthalmol 2018 Jul 12;136(7):e181114. doi: 10.1001/jamaophthalmol.2018.1114. PMID: 30003241

Prognosis

Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck.
Guo W, Yin G, Liu H, Duan H, Huang Z, Chen X
Acta Otolaryngol 2020 Sep;140(9):785-788. Epub 2020 May 23 doi: 10.1080/00016489.2020.1763456. PMID: 32449432
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Genital melanoma: prognosis factors and treatment modality.
Ferraioli D, Lamblin G, Mathevet P, Hetu J, Berakdar I, Beurrier F, Chopin N
Arch Gynecol Obstet 2016 Nov;294(5):1037-1045. Epub 2016 Jun 30 doi: 10.1007/s00404-016-4144-4. PMID: 27365105
Amelanotic malignant melanoma.
Adler MJ, White CR Jr
Semin Cutan Med Surg 1997 Jun;16(2):122-30. doi: 10.1016/s1085-5629(97)80006-5. PMID: 9220551

Clinical prediction guides

Analysis and prediction of 5-year survival in patients with cutaneous melanoma: a model-based period analysis.
Zheng S, Yu H, Zheng X, Wu UT, Ming WK, Huang H, Song J, Zhang X, Lyu J, Deng L
Front Endocrinol (Lausanne) 2023;14:1238086. Epub 2023 Dec 6 doi: 10.3389/fendo.2023.1238086. PMID: 38125787Free PMC Article
The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells.
Miliński M, Staś M, Rok J, Beberok A, Wrześniok D
Pharmacol Rep 2023 Aug;75(4):995-1004. Epub 2023 May 17 doi: 10.1007/s43440-023-00493-1. PMID: 37195561Free PMC Article
Oral Amelanotic Melanomas: Clinicopathologic Features of 8 Cases and Review of the Literature.
Soares CD, Carlos R, Andrade BAB, Cunha JLS, Agostini M, Romañach MJ, Hernandez-Guerrero JC, Mosqueda-Taylor A, Almeida OP, Jorge J
Int J Surg Pathol 2021 May;29(3):263-272. Epub 2020 Jul 31 doi: 10.1177/1066896920946435. PMID: 32734791
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Hereditary sensory neuropathy type I.
Auer-Grumbach M
Orphanet J Rare Dis 2008 Mar 18;3:7. doi: 10.1186/1750-1172-3-7. PMID: 18348718Free PMC Article

Recent systematic reviews

Oral Amelanotic Melanoma: A Systematic Review of Case Reports and Case Series.
Bansal SP, Dhanawade SS, Arvandekar AS, Mehta V, Desai RS
Head Neck Pathol 2022 Jun;16(2):513-524. Epub 2021 Jul 26 doi: 10.1007/s12105-021-01366-w. PMID: 34309791Free PMC Article
The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045
Amelanotic Meningeal Melanoma with Leptomeningeal Dissemination: A Case Report and Systematic Literature Review.
Zhang S, Wang W, Su X, Tan Q, Sun H, Liu Z, Chen N, Gong Q, Yue Q
World Neurosurg 2019 Feb;122:229-239. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.199. PMID: 30404049

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