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Dyslipidemia

MedGen UID:
66067
Concept ID:
C0242339
Disease or Syndrome
Synonym: Dyslipidemias
SNOMED CT: Dyslipidemia (370992007); High blood cholesterol/triglycerides (370992007)

Definition

A lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides. [from NCI]

Professional guidelines

PubMed

Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI
Int J Mol Sci 2022 Jan 12;23(2) doi: 10.3390/ijms23020786. PMID: 35054972Free PMC Article
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e596-e646. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000678. PMID: 30879355Free PMC Article

Recent clinical studies

Etiology

Nussbaumerova B, Rosolova H
Curr Atheroscler Rep 2023 Dec;25(12):947-955. Epub 2023 Nov 18 doi: 10.1007/s11883-023-01167-2. PMID: 37979064
Ballard-Hernandez J, Sall J
Nurs Clin North Am 2023 Sep;58(3):295-308. Epub 2023 Jun 15 doi: 10.1016/j.cnur.2023.05.002. PMID: 37536782
Arvanitis M, Lowenstein CJ
Ann Intern Med 2023 Jun;176(6):ITC81-ITC96. Epub 2023 Jun 13 doi: 10.7326/AITC202306200. PMID: 37307585
Vekic J, Zeljkovic A, Stefanovic A, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V
Metabolism 2019 Mar;92:71-81. Epub 2018 Nov 14 doi: 10.1016/j.metabol.2018.11.005. PMID: 30447223
Wu L, Parhofer KG
Metabolism 2014 Dec;63(12):1469-79. Epub 2014 Aug 29 doi: 10.1016/j.metabol.2014.08.010. PMID: 25242435

Diagnosis

Ballard-Hernandez J, Sall J
Nurs Clin North Am 2023 Sep;58(3):295-308. Epub 2023 Jun 15 doi: 10.1016/j.cnur.2023.05.002. PMID: 37536782
Borghi C, Fogacci F, Agnoletti D, Cicero AFG
High Blood Press Cardiovasc Prev 2022 May;29(3):221-230. Epub 2022 Mar 25 doi: 10.1007/s40292-022-00507-8. PMID: 35334087Free PMC Article
Berberich AJ, Hegele RA
Endocr Rev 2022 Jul 13;43(4):611-653. doi: 10.1210/endrev/bnab037. PMID: 34676866Free PMC Article
Katsiki N, Mikhailidis DP, Mantzoros CS
Metabolism 2016 Aug;65(8):1109-23. Epub 2016 May 13 doi: 10.1016/j.metabol.2016.05.003. PMID: 27237577
Wu L, Parhofer KG
Metabolism 2014 Dec;63(12):1469-79. Epub 2014 Aug 29 doi: 10.1016/j.metabol.2014.08.010. PMID: 25242435

Therapy

Nishizaki Y, Miyauchi K, Iwata H, Inoue T, Hirayama A, Kimura K, Ozaki Y, Murohara T, Ueshima K, Kuwabara Y, Tanaka-Mizuno S, Yanagisawa N, Sato T, Daida H
Am Heart J 2023 Mar;257:1-8. Epub 2022 Nov 11 doi: 10.1016/j.ahj.2022.11.008. PMID: 36372250
Chapman MJ, Zamorano JL, Parhofer KG
Pharmacol Ther 2022 Sep;237:108172. Epub 2022 Mar 15 doi: 10.1016/j.pharmthera.2022.108172. PMID: 35304222
Perakakis N, Farr OM, Mantzoros CS
J Am Coll Cardiol 2021 Feb 16;77(6):745-760. doi: 10.1016/j.jacc.2020.11.069. PMID: 33573745Free PMC Article
Watanabe Y, Tatsuno I
J Atheroscler Thromb 2020 Mar 1;27(3):183-198. Epub 2019 Oct 3 doi: 10.5551/jat.50658. PMID: 31582621Free PMC Article
Cheng HS, Tan WR, Low ZS, Marvalim C, Lee JYH, Tan NS
Int J Mol Sci 2019 Oct 11;20(20) doi: 10.3390/ijms20205055. PMID: 31614690Free PMC Article

Prognosis

Wu Y, Yang Y, Zhang J, Liu S, Zhuang W
Cardiovasc Diabetol 2023 Jun 9;22(1):132. doi: 10.1186/s12933-023-01870-z. PMID: 37296457Free PMC Article
Lubert AM, Alsaied T, Palermo JJ, Anwar N, Urbina EM, Brown NM, Alexander C, Almeneisi H, Wu F, Leventhal AR, Aldweib N, Mendelson M, Opotowsky AR
J Am Heart Assoc 2021 Apr 6;10(7):e019578. Epub 2021 Mar 31 doi: 10.1161/JAHA.120.019578. PMID: 33787283Free PMC Article
Lazarte J, Hegele RA
Can J Cardiol 2020 Sep;36(9):1362-1371. Epub 2020 Mar 23 doi: 10.1016/j.cjca.2020.03.020. PMID: 32640212
Duran EK, Aday AW, Cook NR, Buring JE, Ridker PM, Pradhan AD
J Am Coll Cardiol 2020 May 5;75(17):2122-2135. doi: 10.1016/j.jacc.2020.02.059. PMID: 32354380Free PMC Article
Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG
J Biomed Sci 2019 May 9;26(1):33. doi: 10.1186/s12929-019-0524-y. PMID: 31072403Free PMC Article

Clinical prediction guides

El Sherbini A, Rosenson RS, Al Rifai M, Virk HUH, Wang Z, Virani S, Glicksberg BS, Lavie CJ, Krittanawong C
Prog Cardiovasc Dis 2024 May-Jun;84:76-89. Epub 2024 Mar 7 doi: 10.1016/j.pcad.2024.03.002. PMID: 38460897
Golub IS, Termeie OG, Kristo S, Schroeder LP, Lakshmanan S, Shafter AM, Hussein L, Verghese D, Aldana-Bitar J, Manubolu VS, Budoff MJ
JACC Cardiovasc Imaging 2023 Jan;16(1):98-117. Epub 2022 Sep 14 doi: 10.1016/j.jcmg.2022.06.018. PMID: 36599573
Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL
Ther Adv Cardiovasc Dis 2017 Aug;11(8):215-225. Epub 2017 Jun 22 doi: 10.1177/1753944717711379. PMID: 28639538Free PMC Article
Esenwa C, Gutierrez J
Vasc Health Risk Manag 2015;11:437-50. Epub 2015 Aug 7 doi: 10.2147/VHRM.S63791. PMID: 26300647Free PMC Article
Kaysen GA
Clin J Am Soc Nephrol 2009 Dec;4 Suppl 1:S56-63. doi: 10.2215/CJN.03090509. PMID: 19996007

Recent systematic reviews

Mambrini SP, Menichetti F, Ravella S, Pellizzari M, De Amicis R, Foppiani A, Battezzati A, Bertoli S, Leone A
Nutrients 2023 May 31;15(11) doi: 10.3390/nu15112583. PMID: 37299546Free PMC Article
Alloubani A, Nimer R, Samara R
Curr Cardiol Rev 2021;17(6):e051121189015. doi: 10.2174/1573403X16999201210200342. PMID: 33305711Free PMC Article
Nair AR, Pillai AJ, Nair N
Curr Cardiol Rev 2021;17(4):e230421187681. doi: 10.2174/1573403X16666201106141811. PMID: 33155924Free PMC Article
Jike M, Itani O, Watanabe N, Buysse DJ, Kaneita Y
Sleep Med Rev 2018 Jun;39:25-36. Epub 2017 Jul 5 doi: 10.1016/j.smrv.2017.06.011. PMID: 28890167
Itani O, Jike M, Watanabe N, Kaneita Y
Sleep Med 2017 Apr;32:246-256. Epub 2016 Aug 26 doi: 10.1016/j.sleep.2016.08.006. PMID: 27743803

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