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Dyslipidemia

MedGen UID:
66067
•Concept ID:
C0242339
•
Disease or Syndrome
Synonym: Dyslipidemias
SNOMED CT: Dyslipidemia (370992007); High blood cholesterol/triglycerides (370992007)

Definition

A lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides. [from NCI]

Professional guidelines

PubMed

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021.
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI
Int J Mol Sci 2022 Jan 12;23(2) doi: 10.3390/ijms23020786. PMID: 35054972Free PMC Article
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B
Circulation 2019 Sep 10;140(11):e596-e646. Epub 2019 Mar 17 doi: 10.1161/CIR.0000000000000678. PMID: 30879355Free PMC Article

Recent clinical studies

Etiology

Dyslipidemia.
Arvanitis M, Lowenstein CJ
Ann Intern Med 2023 Jun;176(6):ITC81-ITC96. Epub 2023 Jun 13 doi: 10.7326/AITC202306200. PMID: 37307585
Mechanisms and Treatment of Dyslipidemia in Diabetes.
Bahiru E, Hsiao R, Phillipson D, Watson KE
Curr Cardiol Rep 2021 Mar 2;23(4):26. doi: 10.1007/s11886-021-01455-w. PMID: 33655372
Obesity and dyslipidemia.
Vekic J, Zeljkovic A, Stefanovic A, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V
Metabolism 2019 Mar;92:71-81. Epub 2018 Nov 14 doi: 10.1016/j.metabol.2018.11.005. PMID: 30447223
Diabetes and lipid metabolism.
Athyros VG, Doumas M, Imprialos KP, Stavropoulos K, Georgianou E, Katsimardou A, Karagiannis A
Hormones (Athens) 2018 Mar;17(1):61-67. Epub 2018 Apr 16 doi: 10.1007/s42000-018-0014-8. PMID: 29858856
Diabetic dyslipidemia.
Wu L, Parhofer KG
Metabolism 2014 Dec;63(12):1469-79. Epub 2014 Aug 29 doi: 10.1016/j.metabol.2014.08.010. PMID: 25242435

Diagnosis

Hypertension and Dyslipidemia Combined Therapeutic Approaches.
Borghi C, Fogacci F, Agnoletti D, Cicero AFG
High Blood Press Cardiovasc Prev 2022 May;29(3):221-230. Epub 2022 Mar 25 doi: 10.1007/s40292-022-00507-8. PMID: 35334087Free PMC Article
A Modern Approach to Dyslipidemia.
Berberich AJ, Hegele RA
Endocr Rev 2022 Jul 13;43(4):611-653. doi: 10.1210/endrev/bnab037. PMID: 34676866Free PMC Article
Dyslipidemia Management in 2020: An Update on Diagnosis and Therapeutic Perspectives.
Karantas ID, Okur ME, Okur NÜ, Siafaka PI
Endocr Metab Immune Disord Drug Targets 2021;21(5):815-834. doi: 10.2174/1871530320666200810144004. PMID: 32778041
Dyslipidemia.
Kopin L, Lowenstein C
Ann Intern Med 2017 Dec 5;167(11):ITC81-ITC96. doi: 10.7326/AITC201712050. PMID: 29204622
Diabetic dyslipidemia.
Wu L, Parhofer KG
Metabolism 2014 Dec;63(12):1469-79. Epub 2014 Aug 29 doi: 10.1016/j.metabol.2014.08.010. PMID: 25242435

Therapy

Study protocol and baseline characteristics of Randomized trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid: RESPECT-EPA, the combination of a randomized control trial and an observational biomarker study.
Nishizaki Y, Miyauchi K, Iwata H, Inoue T, Hirayama A, Kimura K, Ozaki Y, Murohara T, Ueshima K, Kuwabara Y, Tanaka-Mizuno S, Yanagisawa N, Sato T, Daida H
Am Heart J 2023 Mar;257:1-8. Epub 2022 Nov 11 doi: 10.1016/j.ahj.2022.11.008. PMID: 36372250
Reducing residual cardiovascular risk in Europe: Therapeutic implications of European medicines agency approval of icosapent ethyl/eicosapentaenoic acid.
Chapman MJ, Zamorano JL, Parhofer KG
Pharmacol Ther 2022 Sep;237:108172. Epub 2022 Mar 15 doi: 10.1016/j.pharmthera.2022.108172. PMID: 35304222
Leptin in Leanness and Obesity: JACC State-of-the-Art Review.
Perakakis N, Farr OM, Mantzoros CS
J Am Coll Cardiol 2021 Feb 16;77(6):745-760. doi: 10.1016/j.jacc.2020.11.069. PMID: 33573745Free PMC Article
Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved.
Watanabe Y, Tatsuno I
J Atheroscler Thromb 2020 Mar 1;27(3):183-198. Epub 2019 Oct 3 doi: 10.5551/jat.50658. PMID: 31582621Free PMC Article
Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.
Cheng HS, Tan WR, Low ZS, Marvalim C, Lee JYH, Tan NS
Int J Mol Sci 2019 Oct 11;20(20) doi: 10.3390/ijms20205055. PMID: 31614690Free PMC Article

Prognosis

The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old.
Wu Y, Yang Y, Zhang J, Liu S, Zhuang W
Cardiovasc Diabetol 2023 Jun 9;22(1):132. doi: 10.1186/s12933-023-01870-z. PMID: 37296457Free PMC Article
Fontan-Associated Dyslipidemia.
Lubert AM, Alsaied T, Palermo JJ, Anwar N, Urbina EM, Brown NM, Alexander C, Almeneisi H, Wu F, Leventhal AR, Aldweib N, Mendelson M, Opotowsky AR
J Am Heart Assoc 2021 Apr 6;10(7):e019578. Epub 2021 Mar 31 doi: 10.1161/JAHA.120.019578. PMID: 33787283Free PMC Article
Pediatric Dyslipidemia-Beyond Familial Hypercholesterolemia.
Lazarte J, Hegele RA
Can J Cardiol 2020 Sep;36(9):1362-1371. Epub 2020 Mar 23 doi: 10.1016/j.cjca.2020.03.020. PMID: 32640212
Triglyceride-Rich Lipoprotein Cholesterol, Small Dense LDL Cholesterol, and Incident Cardiovascular Disease.
Duran EK, Aday AW, Cook NR, Buring JE, Ridker PM, Pradhan AD
J Am Coll Cardiol 2020 May 5;75(17):2122-2135. doi: 10.1016/j.jacc.2020.02.059. PMID: 32354380Free PMC Article
Alzheimer's disease: risk factors and potentially protective measures.
Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG
J Biomed Sci 2019 May 9;26(1):33. doi: 10.1186/s12929-019-0524-y. PMID: 31072403Free PMC Article

Clinical prediction guides

Major Global Coronary Artery Calcium Guidelines.
Golub IS, Termeie OG, Kristo S, Schroeder LP, Lakshmanan S, Shafter AM, Hussein L, Verghese D, Aldana-Bitar J, Manubolu VS, Budoff MJ
JACC Cardiovasc Imaging 2023 Jan;16(1):98-117. Epub 2022 Sep 14 doi: 10.1016/j.jcmg.2022.06.018. PMID: 36599573
Metabolic syndrome: pathophysiology, management, and modulation by natural compounds.
Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL
Ther Adv Cardiovasc Dis 2017 Aug;11(8):215-225. Epub 2017 Jun 22 doi: 10.1177/1753944717711379. PMID: 28639538Free PMC Article
Secondary stroke prevention: challenges and solutions.
Esenwa C, Gutierrez J
Vasc Health Risk Manag 2015;11:437-50. Epub 2015 Aug 7 doi: 10.2147/VHRM.S63791. PMID: 26300647Free PMC Article
Triglycerides: how much credit do they deserve?
Kohli P, Cannon CP
Med Clin North Am 2012 Jan;96(1):39-55. doi: 10.1016/j.mcna.2011.11.006. PMID: 22391250
Biochemistry and biomarkers of inflamed patients: why look, what to assess.
Kaysen GA
Clin J Am Soc Nephrol 2009 Dec;4 Suppl 1:S56-63. doi: 10.2215/CJN.03090509. PMID: 19996007

Recent systematic reviews

Ultra-processed foods increase noncommunicable chronic disease risk.
Jardim MZ, Costa BVL, Pessoa MC, Duarte CK
Nutr Res 2021 Nov;95:19-34. Epub 2021 Sep 11 doi: 10.1016/j.nutres.2021.08.006. PMID: 34798466
Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review.
Alloubani A, Nimer R, Samara R
Curr Cardiol Rev 2021;17(6):e051121189015. doi: 10.2174/1573403X16999201210200342. PMID: 33305711Free PMC Article
Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.
Riaz H, Khan MS, Siddiqi TJ, Usman MS, Shah N, Goyal A, Khan SS, Mookadam F, Krasuski RA, Ahmed H
JAMA Netw Open 2018 Nov 2;1(7):e183788. doi: 10.1001/jamanetworkopen.2018.3788. PMID: 30646365Free PMC Article
Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression.
Jike M, Itani O, Watanabe N, Buysse DJ, Kaneita Y
Sleep Med Rev 2018 Jun;39:25-36. Epub 2017 Jul 5 doi: 10.1016/j.smrv.2017.06.011. PMID: 28890167
Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression.
Itani O, Jike M, Watanabe N, Kaneita Y
Sleep Med 2017 Apr;32:246-256. Epub 2016 Aug 26 doi: 10.1016/j.sleep.2016.08.006. PMID: 27743803

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