U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hyperalphalipoproteinemia

MedGen UID:
87465
Concept ID:
C0342883
Disease or Syndrome
Synonym: High blood hdl level
SNOMED CT: Hyperalphalipoproteinemia (238080004)
 
Monarch Initiative: MONDO:0015903
Orphanet: ORPHA181428

Definition

An autosomal dominant genetic condition caused by mutation(s) in the CETP gene, encoding cholesteryl ester transfer protein. Affected individuals may have increased longevity due to decreased risk of coronary heart disease. [from NCI]

Professional guidelines

PubMed

Loaeza-Del Castillo AM, Gaytán-Santillán A, López-Tello A, Merit MV, Milke-García MDP, Flores-Rodríguez J, Alvirde-García U
Ann Hepatol 2019 Nov-Dec;18(6):879-882. Epub 2019 Aug 22 doi: 10.1016/j.aohep.2019.07.006. PMID: 31506216

Recent clinical studies

Etiology

Kaewkrasaesin C, Chatchomchuan W, Muanpetch S, Khovidhunkit W
J Clin Lipidol 2021 Sep-Oct;15(5):752-759. Epub 2021 Sep 1 doi: 10.1016/j.jacl.2021.08.059. PMID: 34535418
Cole J, Blackhurst DM, Solomon GAE, Ratanjee BD, Benjamin R, Marais AD
J Clin Lipidol 2021 Jan-Feb;15(1):142-150.e2. Epub 2020 Dec 24 doi: 10.1016/j.jacl.2020.12.007. PMID: 33414088
Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600
Oates CP, Koenig D, Rhyne J, Bogush N, O'Connell J, Mitchell BD, Miller M
J Clin Lipidol 2018 Jan-Feb;12(1):110-115. Epub 2017 Nov 21 doi: 10.1016/j.jacl.2017.10.021. PMID: 29198934Free PMC Article
van der Steeg WA, Hovingh GK, Klerkx AH, Hutten BA, Nootenboom IC, Levels JH, van Tol A, Dallinga-Thie GM, Zwinderman AH, Kastelein JJ, Kuivenhoven JA
J Lipid Res 2007 Mar;48(3):674-82. Epub 2006 Dec 27 doi: 10.1194/jlr.M600405-JLR200. PMID: 17192423

Diagnosis

Okada T, Sumida M, Ohama T, Katayama Y, Saga A, Inui H, Kanno K, Masuda D, Koseki M, Nishida M, Sakata Y, Yamashita S
J Atheroscler Thromb 2021 Jul 1;28(7):703-715. Epub 2020 Oct 17 doi: 10.5551/jat.56887. PMID: 33028763Free PMC Article
Mcpherson PA
Lab Med 2020 Mar 10;51(2):217-220. doi: 10.1093/labmed/lmz036. PMID: 31414129
Schaefer EJ, Geller AS, Endress G
Curr Opin Lipidol 2019 Apr;30(2):56-62. doi: 10.1097/MOL.0000000000000590. PMID: 30720493
Laurinavicius AG, Santos IS, Santos RD, Bensenor IM, Conceição RD, Lotufo PA
J Clin Lipidol 2016 Jul-Aug;10(4):898-904.e1. Epub 2016 Mar 21 doi: 10.1016/j.jacl.2016.03.007. PMID: 27578121
Plengpanich W, Tongkobpetch S, Shotelersuk V, Le Goff W, Khovidhunkit W
Clin Chim Acta 2013 Feb 1;416:92-5. Epub 2012 Dec 5 doi: 10.1016/j.cca.2012.11.024. PMID: 23219720

Therapy

Okada T, Sumida M, Ohama T, Katayama Y, Saga A, Inui H, Kanno K, Masuda D, Koseki M, Nishida M, Sakata Y, Yamashita S
J Atheroscler Thromb 2021 Jul 1;28(7):703-715. Epub 2020 Oct 17 doi: 10.5551/jat.56887. PMID: 33028763Free PMC Article
Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600
Mcpherson PA
Lab Med 2020 Mar 10;51(2):217-220. doi: 10.1093/labmed/lmz036. PMID: 31414129
Assmann G, von Eckardstein A, Funke H
Circulation 1993 Apr;87(4 Suppl):III28-34. PMID: 8462178
Kuusi T, Ehnholm C, Viikari J, Härkönen R, Vartiainen E, Puska P, Taskinen MR
J Lipid Res 1989 Aug;30(8):1117-26. PMID: 2504859

Prognosis

Schaefer EJ, Geller AS, Endress G
Curr Opin Lipidol 2019 Apr;30(2):56-62. doi: 10.1097/MOL.0000000000000590. PMID: 30720493
Oates CP, Koenig D, Rhyne J, Bogush N, O'Connell J, Mitchell BD, Miller M
J Clin Lipidol 2018 Jan-Feb;12(1):110-115. Epub 2017 Nov 21 doi: 10.1016/j.jacl.2017.10.021. PMID: 29198934Free PMC Article
Hancock-Cerutti W, Lhomme M, Dauteuille C, Lecocq S, Chapman MJ, Rader DJ, Kontush A, Cuchel M
J Clin Lipidol 2017 Sep-Oct;11(5):1192-1200.e3. Epub 2017 Jul 8 doi: 10.1016/j.jacl.2017.06.018. PMID: 28826666Free PMC Article
Plengpanich W, Siriwong S, Khovidhunkit W
Metabolism 2009 Aug;58(8):1178-84. Epub 2009 Jun 18 doi: 10.1016/j.metabol.2009.03.020. PMID: 19428034
Glueck CJ, Fallat RW, Millett F, Steiner PM
Arch Intern Med 1975 Aug;135(8):1025-8. PMID: 168823

Clinical prediction guides

Oates CP, Koenig D, Rhyne J, Bogush N, O'Connell J, Mitchell BD, Miller M
J Clin Lipidol 2018 Jan-Feb;12(1):110-115. Epub 2017 Nov 21 doi: 10.1016/j.jacl.2017.10.021. PMID: 29198934Free PMC Article
Hancock-Cerutti W, Lhomme M, Dauteuille C, Lecocq S, Chapman MJ, Rader DJ, Kontush A, Cuchel M
J Clin Lipidol 2017 Sep-Oct;11(5):1192-1200.e3. Epub 2017 Jul 8 doi: 10.1016/j.jacl.2017.06.018. PMID: 28826666Free PMC Article
Yao Z, Wang Y
Curr Opin Lipidol 2012 Jun;23(3):206-212. doi: 10.1097/MOL.0b013e328352dc70. PMID: 22510806
Enzi G
Medicine (Baltimore) 1984 Jan;63(1):56-64. doi: 10.1097/00005792-198401000-00004. PMID: 6318013
Glueck CJ, Fallat RW, Millett F, Steiner PM
Arch Intern Med 1975 Aug;135(8):1025-8. PMID: 168823

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...