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Chronic idiopathic urticaria

MedGen UID:
662267
•Concept ID:
C0578870
•
Disease or Syndrome
Synonyms: Chronic Idiopathic Urticaria; Chronic Idiopathic Urticarias; Chronic Spontaneous Urticaria; Chronic Spontaneous Urticarias; Chronic Urticaria, Idiopathic; Idiopathic Chronic Urticaria; Idiopathic Chronic Urticarias; Idiopathic Urticaria, Chronic; Spontaneous Urticaria, Chronic; Urticaria, Chronic Idiopathic; Urticaria, Chronic Spontaneous; Urticaria, Idiopathic Chronic
SNOMED CT: Chronic spontaneous urticaria (302162004); CSU - chronic spontaneous urticaria (302162004); Chronic idiopathic urticaria (302162004)
 
HPO: HP:0410133
Monarch Initiative: MONDO:0044212

Definition

Urticaria characterized by spontaneously recurring hives for 6 weeks or longer. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic idiopathic urticaria

Professional guidelines

PubMed

Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review.
Greiner B, Nicks S, Adame M, McCracken J
Clin Rev Allergy Immunol 2022 Dec;63(3):381-389. Epub 2022 Sep 1 doi: 10.1007/s12016-022-08952-y. PMID: 36048326
Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic (Spontaneous) Urticaria: A Meta-analysis of "Real-world" Evidence.
Tharp MD, Bernstein JA, Kavati A, Ortiz B, MacDonald K, Denhaerynck K, Abraham I, Lee CS
JAMA Dermatol 2019 Jan 1;155(1):29-38. doi: 10.1001/jamadermatol.2018.3447. PMID: 30427977Free PMC Article
Chronic urticaria--assessment and treatment.
Fernando S, Broadfoot A
Aust Fam Physician 2010 Mar;39(3):135-8. PMID: 20369115

Recent clinical studies

Etiology

Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on H1 antihistamines: a randomized, placebo-controlled study.
Saini SS, Bindslev-Jensen C, Maurer M, Grob JJ, Bülbül Baskan E, Bradley MS, Canvin J, Rahmaoui A, Georgiou P, Alpan O, Spector S, Rosén K
J Invest Dermatol 2015 Jan;135(1):67-75. Epub 2014 Jul 21 doi: 10.1038/jid.2014.306. PMID: 25046337Free PMC Article
Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria.
Maurer M, Rosén K, Hsieh HJ, Saini S, Grattan C, Gimenéz-Arnau A, Agarwal S, Doyle R, Canvin J, Kaplan A, Casale T
N Engl J Med 2013 Mar 7;368(10):924-35. Epub 2013 Feb 24 doi: 10.1056/NEJMoa1215372. PMID: 23432142
Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.
Maurer M, Weller K, Bindslev-Jensen C, Giménez-Arnau A, Bousquet PJ, Bousquet J, Canonica GW, Church MK, Godse KV, Grattan CE, Greaves MW, Hide M, Kalogeromitros D, Kaplan AP, Saini SS, Zhu XJ, Zuberbier T
Allergy 2011 Mar;66(3):317-30. Epub 2010 Nov 17 doi: 10.1111/j.1398-9995.2010.02496.x. PMID: 21083565
Analgesics.
Szczeklik A
Chem Immunol Allergy 2010;95:170-179. Epub 2010 Jun 1 doi: 10.1159/000315950. PMID: 20519889
Unusual urticarias.
Black AK
J Dermatol 2001 Nov;28(11):632-4. doi: 10.1111/j.1346-8138.2001.tb00050.x. PMID: 11770721

Diagnosis

Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review.
Greiner B, Nicks S, Adame M, McCracken J
Clin Rev Allergy Immunol 2022 Dec;63(3):381-389. Epub 2022 Sep 1 doi: 10.1007/s12016-022-08952-y. PMID: 36048326
Allergy to food additives.
Valluzzi RL, Fierro V, Arasi S, Mennini M, Pecora V, Fiocchi A
Curr Opin Allergy Clin Immunol 2019 Jun;19(3):256-262. doi: 10.1097/ACI.0000000000000528. PMID: 30883393
Chronic Spontaneous Urticaria: The Devil's Itch.
Saini SS, Kaplan AP
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1097-1106. doi: 10.1016/j.jaip.2018.04.013. PMID: 30033911Free PMC Article
Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report.
Maurer M, Weller K, Bindslev-Jensen C, Giménez-Arnau A, Bousquet PJ, Bousquet J, Canonica GW, Church MK, Godse KV, Grattan CE, Greaves MW, Hide M, Kalogeromitros D, Kaplan AP, Saini SS, Zhu XJ, Zuberbier T
Allergy 2011 Mar;66(3):317-30. Epub 2010 Nov 17 doi: 10.1111/j.1398-9995.2010.02496.x. PMID: 21083565
Choosing topical corticosteroids.
Ference JD, Last AR
Am Fam Physician 2009 Jan 15;79(2):135-40. PMID: 19178066

Therapy

Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review.
Greiner B, Nicks S, Adame M, McCracken J
Clin Rev Allergy Immunol 2022 Dec;63(3):381-389. Epub 2022 Sep 1 doi: 10.1007/s12016-022-08952-y. PMID: 36048326
Omalizumab Updosing in Chronic Spontaneous Urticaria: an Overview of Real-World Evidence.
Metz M, Vadasz Z, Kocatürk E, Giménez-Arnau AM
Clin Rev Allergy Immunol 2020 Aug;59(1):38-45. doi: 10.1007/s12016-020-08794-6. PMID: 32418171Free PMC Article
Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic (Spontaneous) Urticaria: A Meta-analysis of "Real-world" Evidence.
Tharp MD, Bernstein JA, Kavati A, Ortiz B, MacDonald K, Denhaerynck K, Abraham I, Lee CS
JAMA Dermatol 2019 Jan 1;155(1):29-38. doi: 10.1001/jamadermatol.2018.3447. PMID: 30427977Free PMC Article
Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria.
Maurer M, Rosén K, Hsieh HJ, Saini S, Grattan C, Gimenéz-Arnau A, Agarwal S, Doyle R, Canvin J, Kaplan A, Casale T
N Engl J Med 2013 Mar 7;368(10):924-35. Epub 2013 Feb 24 doi: 10.1056/NEJMoa1215372. PMID: 23432142
Choosing topical corticosteroids.
Ference JD, Last AR
Am Fam Physician 2009 Jan 15;79(2):135-40. PMID: 19178066

Prognosis

Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review.
Greiner B, Nicks S, Adame M, McCracken J
Clin Rev Allergy Immunol 2022 Dec;63(3):381-389. Epub 2022 Sep 1 doi: 10.1007/s12016-022-08952-y. PMID: 36048326
Recurrence of Chronic Urticaria: Incidence and Associated Factors.
Kim JK, Har D, Brown LS, Khan DA
J Allergy Clin Immunol Pract 2018 Mar-Apr;6(2):582-585. Epub 2017 Sep 6 doi: 10.1016/j.jaip.2017.07.012. PMID: 28888844
Questions and answers in chronic urticaria: where do we stand and where do we go?
Maurer M, Church MK, Marsland AM, Sussman G, Siebenhaar F, Vestergaard C, Broom B
J Eur Acad Dermatol Venereol 2016 Jul;30 Suppl 5:7-15. doi: 10.1111/jdv.13695. PMID: 27286498
Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on H1 antihistamines: a randomized, placebo-controlled study.
Saini SS, Bindslev-Jensen C, Maurer M, Grob JJ, Bülbül Baskan E, Bradley MS, Canvin J, Rahmaoui A, Georgiou P, Alpan O, Spector S, Rosén K
J Invest Dermatol 2015 Jan;135(1):67-75. Epub 2014 Jul 21 doi: 10.1038/jid.2014.306. PMID: 25046337Free PMC Article
Unusual urticarias.
Black AK
J Dermatol 2001 Nov;28(11):632-4. doi: 10.1111/j.1346-8138.2001.tb00050.x. PMID: 11770721

Clinical prediction guides

Comparative Efficacy and Acceptability of Licensed Dose Second-Generation Antihistamines in Chronic Spontaneous Urticaria: A Network Meta-Analysis.
Phinyo P, Koompawichit P, Nochaiwong S, Tovanabutra N, Chiewchanvit S, Chuamanochan M
J Allergy Clin Immunol Pract 2021 Feb;9(2):956-970.e57. Epub 2020 Sep 8 doi: 10.1016/j.jaip.2020.08.055. PMID: 32916325
Omalizumab Updosing in Chronic Spontaneous Urticaria: an Overview of Real-World Evidence.
Metz M, Vadasz Z, Kocatürk E, Giménez-Arnau AM
Clin Rev Allergy Immunol 2020 Aug;59(1):38-45. doi: 10.1007/s12016-020-08794-6. PMID: 32418171Free PMC Article
Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic (Spontaneous) Urticaria: A Meta-analysis of "Real-world" Evidence.
Tharp MD, Bernstein JA, Kavati A, Ortiz B, MacDonald K, Denhaerynck K, Abraham I, Lee CS
JAMA Dermatol 2019 Jan 1;155(1):29-38. doi: 10.1001/jamadermatol.2018.3447. PMID: 30427977Free PMC Article
Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria.
Maurer M, Rosén K, Hsieh HJ, Saini S, Grattan C, Gimenéz-Arnau A, Agarwal S, Doyle R, Canvin J, Kaplan A, Casale T
N Engl J Med 2013 Mar 7;368(10):924-35. Epub 2013 Feb 24 doi: 10.1056/NEJMoa1215372. PMID: 23432142
Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.
Devillier P, Roche N, Faisy C
Clin Pharmacokinet 2008;47(4):217-30. doi: 10.2165/00003088-200847040-00001. PMID: 18336052

Recent systematic reviews

Systematic Literature Review of the Use of Productivity Losses/Gains in Cost-Effectiveness Analyses of Immune-Mediated Disorders.
Yuasa A, Yonemoto N, Kamei K, Murofushi T, LoPresti M, Taneja A, Horgan J, Ikeda S
Adv Ther 2022 Dec;39(12):5327-5350. Epub 2022 Oct 7 doi: 10.1007/s12325-022-02321-z. PMID: 36205907Free PMC Article
Alexithymia and Cutaneous Disease Morbidity: A Systematic Review.
Holmes A, Marella P, Rodriguez C, Glass Ii D, Goerlich KS
Dermatology 2022;238(6):1120-1129. Epub 2022 May 30 doi: 10.1159/000524736. PMID: 35636409
Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria: A systematic review for the EAACI Biologicals Guidelines.
Agache I, Rocha C, Pereira A, Song Y, Alonso-Coello P, Solà I, Beltran J, Posso M, Akdis CA, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong P, O'Mahony L, Schwarze J, Werfel T, Canelo-Aybar C, Palomares O, Jutel M
Allergy 2021 Jan;76(1):59-70. Epub 2020 Sep 7 doi: 10.1111/all.14547. PMID: 32767573
Influence of prolonged treatment with omalizumab on the development of solid epithelial cancer in patients with atopic asthma and chronic idiopathic urticaria: A systematic review and meta-analysis.
Johnston A, Smith C, Zheng C, Aaron SD, Kelly SE, Skidmore B, Wells GA
Clin Exp Allergy 2019 Oct;49(10):1291-1305. Epub 2019 Aug 6 doi: 10.1111/cea.13457. PMID: 31295369
Omalizumab for the Treatment of Chronic Idiopathic Urticaria: Systematic Review of the Literature.
Tonacci A, Billeci L, Pioggia G, Navarra M, Gangemi S
Pharmacotherapy 2017 Apr;37(4):464-480. Epub 2017 Mar 23 doi: 10.1002/phar.1915. PMID: 28226418

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