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Ototoxicity

MedGen UID:
66719
•Concept ID:
C0235280
•
Pathologic Function
Synonym: Ototoxicities
SNOMED CT: Ototoxicity (9062008)

Definition

Damage to the inner ear as a result of exposure to drugs or chemicals. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOtotoxicity

Professional guidelines

PubMed

ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment.
Li PK, Chow KM, Cho Y, Fan S, Figueiredo AE, Harris T, Kanjanabuch T, Kim YL, Madero M, Malyszko J, Mehrotra R, Okpechi IG, Perl J, Piraino B, Runnegar N, Teitelbaum I, Wong JK, Yu X, Johnson DW
Perit Dial Int 2022 Mar;42(2):110-153. doi: 10.1177/08968608221080586. PMID: 35264029
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444

Recent clinical studies

Etiology

Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity.
He F, Huang X, Wei G, Lin X, Zhang W, Zhuang W, He W, Zhan T, Hu H, Yang H
Oxid Med Cell Longev 2022;2022:3080263. Epub 2022 Mar 20 doi: 10.1155/2022/3080263. PMID: 35355868Free PMC Article
Noise: Acoustic Trauma and Tinnitus, the US Military Experience.
Theodoroff SM, Konrad-Martin D
Otolaryngol Clin North Am 2020 Aug;53(4):543-553. Epub 2020 Apr 23 doi: 10.1016/j.otc.2020.03.004. PMID: 32334867Free PMC Article
Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents.
Santos NAGD, Ferreira RS, Santos ACD
Food Chem Toxicol 2020 Feb;136:111079. Epub 2019 Dec 28 doi: 10.1016/j.fct.2019.111079. PMID: 31891754
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254Free PMC Article
Aminoglycoside-induced ototoxicity.
Selimoglu E
Curr Pharm Des 2007;13(1):119-26. doi: 10.2174/138161207779313731. PMID: 17266591

Diagnosis

Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity.
He F, Huang X, Wei G, Lin X, Zhang W, Zhuang W, He W, Zhan T, Hu H, Yang H
Oxid Med Cell Longev 2022;2022:3080263. Epub 2022 Mar 20 doi: 10.1155/2022/3080263. PMID: 35355868Free PMC Article
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Bilateral Vestibular Dysfunction.
Lee SU, Kim HJ, Kim JS
Semin Neurol 2020 Feb;40(1):40-48. Epub 2020 Jan 14 doi: 10.1055/s-0039-3402066. PMID: 31935769
Drug-Induced Ototoxicity: Diagnosis and Monitoring.
Campbell KCM, Le Prell CG
Drug Saf 2018 May;41(5):451-464. doi: 10.1007/s40264-017-0629-8. PMID: 29404977
Understanding platinum-induced ototoxicity.
Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O
Trends Pharmacol Sci 2013 Aug;34(8):458-69. Epub 2013 Jun 13 doi: 10.1016/j.tips.2013.05.006. PMID: 23769626

Therapy

Mechanisms of Ototoxicity and Otoprotection.
Steyger PS
Otolaryngol Clin North Am 2021 Dec;54(6):1101-1115. doi: 10.1016/j.otc.2021.08.007. PMID: 34774227Free PMC Article
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents.
Santos NAGD, Ferreira RS, Santos ACD
Food Chem Toxicol 2020 Feb;136:111079. Epub 2019 Dec 28 doi: 10.1016/j.fct.2019.111079. PMID: 31891754
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article

Prognosis

Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Cisplatin-induced ototoxicity: Updates on molecular mechanisms and otoprotective strategies.
Tang Q, Wang X, Jin H, Mi Y, Liu L, Dong M, Chen Y, Zou Z
Eur J Pharm Biopharm 2021 Jun;163:60-71. Epub 2021 Mar 26 doi: 10.1016/j.ejpb.2021.03.008. PMID: 33775853
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article
Understanding platinum-induced ototoxicity.
Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O
Trends Pharmacol Sci 2013 Aug;34(8):458-69. Epub 2013 Jun 13 doi: 10.1016/j.tips.2013.05.006. PMID: 23769626
Aminoglycoside-induced ototoxicity.
Selimoglu E
Curr Pharm Des 2007;13(1):119-26. doi: 10.2174/138161207779313731. PMID: 17266591

Clinical prediction guides

Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity.
He F, Huang X, Wei G, Lin X, Zhang W, Zhuang W, He W, Zhan T, Hu H, Yang H
Oxid Med Cell Longev 2022;2022:3080263. Epub 2022 Mar 20 doi: 10.1155/2022/3080263. PMID: 35355868Free PMC Article
Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects.
Abadi AJ, Mirzaei S, Mahabady MK, Hashemi F, Zabolian A, Hashemi F, Raee P, Aghamiri S, Ashrafizadeh M, Aref AR, Hamblin MR, Hushmandi K, Zarrabi A, Sethi G
Phytother Res 2022 Jan;36(1):189-213. Epub 2021 Oct 25 doi: 10.1002/ptr.7305. PMID: 34697839
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
Aminoglycoside Vestibulotoxicity.
Rutka J
Adv Otorhinolaryngol 2019;82:101-110. Epub 2019 Jan 15 doi: 10.1159/000490277. PMID: 30947191
Understanding platinum-induced ototoxicity.
Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O
Trends Pharmacol Sci 2013 Aug;34(8):458-69. Epub 2013 Jun 13 doi: 10.1016/j.tips.2013.05.006. PMID: 23769626

Recent systematic reviews

Systemic antibiotics for chronic suppurative otitis media.
Chong LY, Head K, Webster KE, Dew J, Richmond P, Snelling T, Bhutta MF, Schilder AG, Burton MJ, Brennan-Jones CG
Cochrane Database Syst Rev 2021 Feb 4;2(2):CD013052. doi: 10.1002/14651858.CD013052.pub2. PMID: 35819801Free PMC Article
SARS-CoV-2 (COVID-19) and audio-vestibular disorders.
Fancello V, Hatzopoulos S, Corazzi V, Bianchini C, Skarżyńska MB, Pelucchi S, Skarżyński PH, Ciorba A
Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211027373. doi: 10.1177/20587384211027373. PMID: 34142589Free PMC Article
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Topical antibiotics for chronic suppurative otitis media.
Brennan-Jones CG, Head K, Chong LY, Burton MJ, Schilder AG, Bhutta MF
Cochrane Database Syst Rev 2020 Jan 2;1(1):CD013051. doi: 10.1002/14651858.CD013051.pub2. PMID: 31896168Free PMC Article

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