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Ototoxicity

MedGen UID:
66719
•Concept ID:
C0235280
•
Pathologic Function
Synonyms: Otological Toxicity; Ototoxicities; Toxicity, Otological
SNOMED CT: Ototoxicity (9062008)

Definition

Damage to the inner ear as a result of exposure to drugs or chemicals. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOtotoxicity

Professional guidelines

PubMed

ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment.
Li PK, Chow KM, Cho Y, Fan S, Figueiredo AE, Harris T, Kanjanabuch T, Kim YL, Madero M, Malyszko J, Mehrotra R, Okpechi IG, Perl J, Piraino B, Runnegar N, Teitelbaum I, Wong JK, Yu X, Johnson DW
Perit Dial Int 2022 Mar;42(2):110-153. doi: 10.1177/08968608221080586. PMID: 35264029
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444

Recent clinical studies

Etiology

Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.
Rizk HG, Lee JA, Liu YF, Endriukaitis L, Isaac JL, Bullington WM
Pharmacotherapy 2020 Dec;40(12):1265-1275. Epub 2020 Nov 18 doi: 10.1002/phar.2478. PMID: 33080070
Aminoglycoside Vestibulotoxicity.
Rutka J
Adv Otorhinolaryngol 2019;82:101-110. Epub 2019 Jan 15 doi: 10.1159/000490277. PMID: 30947191
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254Free PMC Article
Aminoglycoside-induced ototoxicity.
Selimoglu E
Curr Pharm Des 2007;13(1):119-26. doi: 10.2174/138161207779313731. PMID: 17266591
Aminoglycoside toxicity: daily versus thrice-weekly dosing for treatment of mycobacterial diseases.
Peloquin CA, Berning SE, Nitta AT, Simone PM, Goble M, Huitt GA, Iseman MD, Cook JL, Curran-Everett D
Clin Infect Dis 2004 Jun 1;38(11):1538-44. Epub 2004 May 5 doi: 10.1086/420742. PMID: 15156439

Diagnosis

Ototoxicity and Teprotumumab.
Highland J, Gordon S, Reddy D, Patel N
Ann Otol Rhinol Laryngol 2022 Aug;131(8):910-913. Epub 2021 Aug 27 doi: 10.1177/00034894211042740. PMID: 34448414
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Bilateral Vestibular Dysfunction.
Lee SU, Kim HJ, Kim JS
Semin Neurol 2020 Feb;40(1):40-48. Epub 2020 Jan 14 doi: 10.1055/s-0039-3402066. PMID: 31935769
Drug-Induced Ototoxicity: Diagnosis and Monitoring.
Campbell KCM, Le Prell CG
Drug Saf 2018 May;41(5):451-464. doi: 10.1007/s40264-017-0629-8. PMID: 29404977
Bilateral vestibulopathy.
Strupp M, Feil K, Dieterich M, Brandt T
Handb Clin Neurol 2016;137:235-40. doi: 10.1016/B978-0-444-63437-5.00017-0. PMID: 27638075

Therapy

Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions.
Tan WJT, Vlajkovic SM
Int J Mol Sci 2023 Nov 20;24(22) doi: 10.3390/ijms242216545. PMID: 38003734Free PMC Article
Mechanisms of Ototoxicity and Otoprotection.
Steyger PS
Otolaryngol Clin North Am 2021 Dec;54(6):1101-1115. doi: 10.1016/j.otc.2021.08.007. PMID: 34774227Free PMC Article
Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.
Rizk HG, Lee JA, Liu YF, Endriukaitis L, Isaac JL, Bullington WM
Pharmacotherapy 2020 Dec;40(12):1265-1275. Epub 2020 Nov 18 doi: 10.1002/phar.2478. PMID: 33080070
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article

Prognosis

Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article
Monitoring neonates for ototoxicity.
Garinis AC, Kemph A, Tharpe AM, Weitkamp JH, McEvoy C, Steyger PS
Int J Audiol 2018 Sep;57(sup4):S41-S48. Epub 2017 Jun 22 doi: 10.1080/14992027.2017.1339130. PMID: 28949262Free PMC Article
Bilateral vestibulopathy.
Strupp M, Feil K, Dieterich M, Brandt T
Handb Clin Neurol 2016;137:235-40. doi: 10.1016/B978-0-444-63437-5.00017-0. PMID: 27638075
Aminoglycoside-induced ototoxicity.
Selimoglu E
Curr Pharm Des 2007;13(1):119-26. doi: 10.2174/138161207779313731. PMID: 17266591

Clinical prediction guides

Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype.
McDermott JH, Wolf J, Hoshitsuki K, Huddart R, Caudle KE, Whirl-Carrillo M, Steyger PS, Smith RJH, Cody N, Rodriguez-Antona C, Klein TE, Newman WG
Clin Pharmacol Ther 2022 Feb;111(2):366-372. Epub 2021 Jun 20 doi: 10.1002/cpt.2309. PMID: 34032273Free PMC Article
Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.
Rizk HG, Lee JA, Liu YF, Endriukaitis L, Isaac JL, Bullington WM
Pharmacotherapy 2020 Dec;40(12):1265-1275. Epub 2020 Nov 18 doi: 10.1002/phar.2478. PMID: 33080070
Adverse drug reactions in tuberculosis and management.
Prasad R, Singh A, Gupta N
Indian J Tuberc 2019 Oct;66(4):520-532. doi: 10.1016/j.ijtb.2019.11.005. PMID: 31813444
Aminoglycoside Vestibulotoxicity.
Rutka J
Adv Otorhinolaryngol 2019;82:101-110. Epub 2019 Jan 15 doi: 10.1159/000490277. PMID: 30947191
Monitoring neonates for ototoxicity.
Garinis AC, Kemph A, Tharpe AM, Weitkamp JH, McEvoy C, Steyger PS
Int J Audiol 2018 Sep;57(sup4):S41-S48. Epub 2017 Jun 22 doi: 10.1080/14992027.2017.1339130. PMID: 28949262Free PMC Article

Recent systematic reviews

Antibiotic regimens for early-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Topical antibiotics for chronic suppurative otitis media.
Brennan-Jones CG, Head K, Chong LY, Burton MJ, Schilder AG, Bhutta MF
Cochrane Database Syst Rev 2020 Jan 2;1(1):CD013051. doi: 10.1002/14651858.CD013051.pub2. PMID: 31896168Free PMC Article
Systemic Aminoglycosides-Induced Vestibulotoxicity in Humans.
Van Hecke R, Van Rompaey V, Wuyts FL, Leyssens L, Maes L
Ear Hear 2017 Nov/Dec;38(6):653-662. doi: 10.1097/AUD.0000000000000458. PMID: 28650850
Amikacin use and therapeutic drug monitoring in adults: do dose regimens and drug exposures affect either outcome or adverse events? A systematic review.
Jenkins A, Thomson AH, Brown NM, Semple Y, Sluman C, MacGowan A, Lovering AM, Wiffen PJ; (BSAC Working Party on Therapeutic Drug Monitoring)
J Antimicrob Chemother 2016 Oct;71(10):2754-9. Epub 2016 Jul 11 doi: 10.1093/jac/dkw250. PMID: 27494904

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