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Critical illness myopathy

MedGen UID:
685768
•Concept ID:
C1135188
•
Disease or Syndrome
Synonym: Critical Illness Myopathy
SNOMED CT: Critical illness myopathy (443819006)

Definition

Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCritical illness myopathy

Professional guidelines

PubMed

Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults.
Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, Hopkins RO, Hough CL, Kress JP, Latronico N, Moss M, Needham DM, Rich MM, Stevens RD, Wilson KC, Winkelman C, Zochodne DW, Ali NA; ATS Committee on ICU-acquired Weakness in Adults; American Thoracic Society
Am J Respir Crit Care Med 2014 Dec 15;190(12):1437-46. doi: 10.1164/rccm.201411-2011ST. PMID: 25496103
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review.
Ydemann M, Eddelien HS, Lauritsen AØ
Dan Med J 2012 Oct;59(10):A4511. PMID: 23158890

Recent clinical studies

Etiology

Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Diaphragm Weakness in the Critically Ill: Basic Mechanisms Reveal Therapeutic Opportunities.
Petrof BJ
Chest 2018 Dec;154(6):1395-1403. Epub 2018 Aug 23 doi: 10.1016/j.chest.2018.08.1028. PMID: 30144420
ICU-Acquired Weakness.
Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article
Critical illness neuromyopathy.
Goodman BP, Boon AJ
Phys Med Rehabil Clin N Am 2008 Feb;19(1):97-110, vii. doi: 10.1016/j.pmr.2007.10.012. PMID: 18194752

Diagnosis

Intensive care unit-acquired weakness: unanswered questions and targets for future research.
Piva S, Fagoni N, Latronico N
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.17376.1. PMID: 31069055Free PMC Article
What is in the Myopathy Literature?
Lacomis D
J Clin Neuromuscul Dis 2018 Jun;19(4):217-223. doi: 10.1097/CND.0000000000000203. PMID: 29794577
ICU-Acquired Weakness.
Jolley SE, Bunnell AE, Hough CL
Chest 2016 Nov;150(5):1129-1140. Epub 2016 Apr 7 doi: 10.1016/j.chest.2016.03.045. PMID: 27063347Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article
Critical illness neuromyopathy.
Goodman BP, Boon AJ
Phys Med Rehabil Clin N Am 2008 Feb;19(1):97-110, vii. doi: 10.1016/j.pmr.2007.10.012. PMID: 18194752

Therapy

Diaphragm Weakness in the Critically Ill: Basic Mechanisms Reveal Therapeutic Opportunities.
Petrof BJ
Chest 2018 Dec;154(6):1395-1403. Epub 2018 Aug 23 doi: 10.1016/j.chest.2018.08.1028. PMID: 30144420
What is in the Myopathy Literature?
Lacomis D
J Clin Neuromuscul Dis 2018 Jun;19(4):217-223. doi: 10.1097/CND.0000000000000203. PMID: 29794577
Physical rehabilitation for critical illness myopathy and neuropathy.
Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD010942. doi: 10.1002/14651858.CD010942.pub2. PMID: 25737049Free PMC Article
ICU-acquired weakness.
Schweickert WD, Hall J
Chest 2007 May;131(5):1541-9. doi: 10.1378/chest.06-2065. PMID: 17494803
Critical illness myopathy.
Lacomis D, Zochodne DW, Bird SJ
Muscle Nerve 2000 Dec;23(12):1785-8. doi: 10.1002/1097-4598(200012)23:12<1785::aid-mus1>3.0.co;2-j. PMID: 11102901

Prognosis

Critical illness-associated weakness and related motor disorders.
Younger DS
Handb Clin Neurol 2023;195:707-777. doi: 10.1016/B978-0-323-98818-6.00031-5. PMID: 37562893
Intensive care unit-acquired weakness: Questions the clinician should ask.
Tortuyaux R, Davion JB, Jourdain M
Rev Neurol (Paris) 2022 Jan-Feb;178(1-2):84-92. Epub 2022 Jan 5 doi: 10.1016/j.neurol.2021.12.007. PMID: 34998522
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article
Critical illness myopathy.
Latronico N, Tomelleri G, Filosto M
Curr Opin Rheumatol 2012 Nov;24(6):616-22. doi: 10.1097/BOR.0b013e3283588d2f. PMID: 22918529
Critical illness neuromyopathy.
Goodman BP, Boon AJ
Phys Med Rehabil Clin N Am 2008 Feb;19(1):97-110, vii. doi: 10.1016/j.pmr.2007.10.012. PMID: 18194752

Clinical prediction guides

Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge.
Merlonghi G, Antonini G, Garibaldi M
Autoimmun Rev 2022 Feb;21(2):102993. Epub 2021 Nov 16 doi: 10.1016/j.autrev.2021.102993. PMID: 34798316
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition.
Lad H, Saumur TM, Herridge MS, Dos Santos CC, Mathur S, Batt J, Gilbert PM
Int J Mol Sci 2020 Oct 22;21(21) doi: 10.3390/ijms21217840. PMID: 33105809Free PMC Article
Intensive care unit-acquired weakness: unanswered questions and targets for future research.
Piva S, Fagoni N, Latronico N
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.17376.1. PMID: 31069055Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article

Recent systematic reviews

Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis.
Price DR, Mikkelsen ME, Umscheid CA, Armstrong EJ
Crit Care Med 2016 Nov;44(11):2070-2078. doi: 10.1097/CCM.0000000000001839. PMID: 27513545
Physical rehabilitation for critical illness myopathy and neuropathy.
Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B
Cochrane Database Syst Rev 2015 Mar 4;2015(3):CD010942. doi: 10.1002/14651858.CD010942.pub2. PMID: 25737049Free PMC Article
Interventions for preventing critical illness polyneuropathy and critical illness myopathy.
Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G
Cochrane Database Syst Rev 2014 Jan 30;2014(1):CD006832. doi: 10.1002/14651858.CD006832.pub3. PMID: 24477672Free PMC Article
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review.
Ydemann M, Eddelien HS, Lauritsen AØ
Dan Med J 2012 Oct;59(10):A4511. PMID: 23158890
Interventions for preventing critical illness polyneuropathy and critical illness myopathy.
Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G
Cochrane Database Syst Rev 2009 Jan 21;(1):CD006832. doi: 10.1002/14651858.CD006832.pub2. PMID: 19160304

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