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Benign deep fibrous histiocytoma

MedGen UID:
690110
•Concept ID:
C1266125
•
Neoplastic Process
Synonyms: Benign Deep Fibrous Histiocytoma; benign deep fibrous histiocytoma; Deep benign fibrous histiocytoma; Deep Benign Fibrous Histiocytoma; deep benign fibrous histiocytoma; Deep Fibrous Histiocytoma; Deep histiocytoma
SNOMED CT: Deep histiocytoma (128741006); Deep benign fibrous histiocytoma (128741006); Deep benign fibrous histiocytoma (1293017002)
 
Monarch Initiative: MONDO:0002990

Definition

A rare, well-circumscribed, pseudo-encapsulated benign fibrous histiocytoma that arises entirely within the subcutaneous tissue or deep soft tissue. It usually affects the extremities or the head and neck region. It recurs locally in a minority of cases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign deep fibrous histiocytoma

Professional guidelines

PubMed

Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma.
Gleason BC, Calder KB, Cibull TL, Thomas AB, Billings SD, Morgan MB, Hiatt KM, Smoller BR
J Cutan Pathol 2009 May;36(5):543-7. Epub 2009 Mar 30 doi: 10.1111/j.1600-0560.2008.01099.x. PMID: 19476522
High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors.
Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M
Arch Pathol Lab Med 2006 Jun;130(6):831-4. doi: 10.5858/2006-130-831-HPAEDR. PMID: 16740036
Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity.
Li N, McNiff J, Hui P, Manfioletti G, Tallini G
Am J Dermatopathol 2004 Aug;26(4):267-72. doi: 10.1097/00000372-200408000-00001. PMID: 15249855

Recent clinical studies

Etiology

From Morphea to Dermatofibrosarcoma Protuberans.
Crnarić I, Šitum M, Delaš Aždajić M, Vučić M, Buljan M
Acta Dermatovenerol Croat 2022 Sep;30(2):113-115. PMID: 36254545
Soft tissue masses: distribution of entities and rate of malignancy in small lesions.
Gassert FG, Gassert FT, Specht K, Knebel C, Lenze U, Makowski MR, von Eisenhart-Rothe R, Gersing AS, Woertler K
BMC Cancer 2021 Jan 22;21(1):93. doi: 10.1186/s12885-020-07769-2. PMID: 33482754Free PMC Article
DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma.
Charli-Joseph Y, Saggini A, Doyle LA, Fletcher CD, Weier J, Mirza S, Vemula S, LeBoit PE
J Am Acad Dermatol 2014 Aug;71(2):256-63. Epub 2014 Apr 19 doi: 10.1016/j.jaad.2014.03.015. PMID: 24755122
Deep fibrous histiocytoma with a clonal karyotypic alteration: molecular cytogenetic characterization of a t(16;17)(p13.3;q21.3).
Frau DV, Erdas E, Caria P, Ambu R, Dettori T, Faa G, Fletcher CD, Vanni R
Cancer Genet Cytogenet 2010 Oct 1;202(1):17-21. doi: 10.1016/j.cancergencyto.2010.06.012. PMID: 20804915
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Fibrous histiocytoma/dermatofibroma in children: the same as adults?
Berklite L, Ranganathan S, John I, Picarsic J, Santoro L, Alaggio R
Hum Pathol 2020 May;99:107-115. Epub 2020 Apr 1 doi: 10.1016/j.humpath.2020.03.012. PMID: 32246988
Recently characterized soft tissue tumors that bring biologic insight.
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Myofibroblastic malignancies.
Fisher C
Adv Anat Pathol 2004 Jul;11(4):190-201. doi: 10.1097/01.pap.0000131773.16130.aa. PMID: 15220822
Myofibrosarcoma.
Fisher C
Virchows Arch 2004 Sep;445(3):215-23. Epub 2004 Jun 2 doi: 10.1007/s00428-004-1038-9. PMID: 15173943
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

Angiomatoid metastatic melanoma.
Zelger BG, Zelger B
Dermatol Surg 2004 Feb;30(2 Pt 2):336-40. doi: 10.1111/j.1524-4725.2004.30082.x. PMID: 14871230
Brachytherapy tubes and free tissue transfer after soft tissue sarcoma resection.
Aflatoon K, Manoso MW, Deune EG, Frassica DA, Frassica FJ
Clin Orthop Relat Res 2003 Oct;(415):248-53. doi: 10.1097/01.blo.0000093886.12372.74. PMID: 14612653
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma).
Hui P, Glusac EJ, Sinard JH, Perkins AS
J Cutan Pathol 2002 Aug;29(7):385-9. doi: 10.1034/j.1600-0560.2002.290701.x. PMID: 12139632
Cell-type related and spatial variation in the expression of integrins in cutaneous tumors.
Tuominen H, Junttila T, Karvonen J, Kallioinen M
J Cutan Pathol 1994 Dec;21(6):500-6. doi: 10.1111/j.1600-0560.1994.tb00719.x. PMID: 7699116
Malignant fibrous histiocytoma in childhood.
Cole CH, Magee JF, Gianoulis M, Rogers PC
Cancer 1993 Jun 15;71(12):4077-83. doi: 10.1002/1097-0142(19930615)71:12<4077::aid-cncr2820711245>3.0.co;2-6. PMID: 8389660

Prognosis

From Morphea to Dermatofibrosarcoma Protuberans.
Crnarić I, Šitum M, Delaš Aždajić M, Vučić M, Buljan M
Acta Dermatovenerol Croat 2022 Sep;30(2):113-115. PMID: 36254545
Fibrous histiocytoma/dermatofibroma in children: the same as adults?
Berklite L, Ranganathan S, John I, Picarsic J, Santoro L, Alaggio R
Hum Pathol 2020 May;99:107-115. Epub 2020 Apr 1 doi: 10.1016/j.humpath.2020.03.012. PMID: 32246988
Deep Benign Fibrous Histiocytoma of the Anterior Mediastinum Mimicking Malignancy.
Puopolo A, Newmarch W, Casserly B
Lung 2017 Aug;195(4):503-506. Epub 2017 May 11 doi: 10.1007/s00408-017-0013-6. PMID: 28497381
Recently characterized soft tissue tumors that bring biologic insight.
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

MUC4 Expression in Angiomatoid Fibrous Histiocytoma.
Abrahao-Machado LF, Bacchi LM, Fernandes IL, Costa FD, Bacchi CE
Appl Immunohistochem Mol Morphol 2020 Sep;28(8):641-645. doi: 10.1097/PAI.0000000000000816. PMID: 31652145
Deep Benign Fibrous Histiocytoma of the Anterior Mediastinum Mimicking Malignancy.
Puopolo A, Newmarch W, Casserly B
Lung 2017 Aug;195(4):503-506. Epub 2017 May 11 doi: 10.1007/s00408-017-0013-6. PMID: 28497381
Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.
Płaszczyca A, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Domanski HA, Lilljebjörn H, Fioretos T, Tayebwa J, Mandahl N, Nord KH, Mertens F
Int J Biochem Cell Biol 2014 Aug;53:475-81. Epub 2014 Apr 8 doi: 10.1016/j.biocel.2014.03.027. PMID: 24721208
Recently characterized soft tissue tumors that bring biologic insight.
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Deep fibrous histiocytoma with a clonal karyotypic alteration: molecular cytogenetic characterization of a t(16;17)(p13.3;q21.3).
Frau DV, Erdas E, Caria P, Ambu R, Dettori T, Faa G, Fletcher CD, Vanni R
Cancer Genet Cytogenet 2010 Oct 1;202(1):17-21. doi: 10.1016/j.cancergencyto.2010.06.012. PMID: 20804915

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