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Meningococcal infection

MedGen UID:
7537
•Concept ID:
C0025303
•
Disease or Syndrome
Synonyms: Infection, Meningococcal; Infections, Meningococcal; Meningococcal Disease; Meningococcal Diseases; Meningococcal Infection; Meningococcal Infections
SNOMED CT: Meningococcal disease (23511006); Meningococcal infectious disease (23511006); Infection due to Neisseria meningitidis (23511006); Meningococcal infection (23511006)
 
Monarch Initiative: MONDO:0005373

Definition

Infections with bacteria of the species neisseria meningitidis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningococcal infection

Professional guidelines

PubMed

An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Severe meningococcal infection: a review of epidemiology, diagnosis, and management.
Campsall PA, Laupland KB, Niven DJ
Crit Care Clin 2013 Jul;29(3):393-409. doi: 10.1016/j.ccc.2013.03.001. PMID: 23830646
Management of meningococcal infections.
Klein NJ, Heyderman RS, Levin M
Br J Hosp Med 1993 Jun 16-Jul 13;50(1):42-9. PMID: 8364705

Recent clinical studies

Etiology

Complement-driven hemolytic uremic syndrome.
Leon J, LeStang MB, Sberro-Soussan R, Servais A, Anglicheau D, Frémeaux-Bacchi V, Zuber J
Am J Hematol 2023 May;98 Suppl 4:S44-S56. doi: 10.1002/ajh.26854. PMID: 36683290
Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis.
Socié G, Caby-Tosi MP, Marantz JL, Cole A, Bedrosian CL, Gasteyger C, Mujeebuddin A, Hillmen P, Vande Walle J, Haller H
Br J Haematol 2019 Apr;185(2):297-310. Epub 2019 Feb 15 doi: 10.1111/bjh.15790. PMID: 30768680Free PMC Article
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study.
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Neisseria meningitidis: biology, microbiology, and epidemiology.
Rouphael NG, Stephens DS
Methods Mol Biol 2012;799:1-20. doi: 10.1007/978-1-61779-346-2_1. PMID: 21993636Free PMC Article

Diagnosis

Recognizing Vaccine-Preventable Diseases and Managing Outbreaks.
Hamilton JL
Prim Care 2020 Sep;47(3):467-481. Epub 2020 May 22 doi: 10.1016/j.pop.2020.05.003. PMID: 32718444
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study.
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Severe meningococcal infection: a review of epidemiology, diagnosis, and management.
Campsall PA, Laupland KB, Niven DJ
Crit Care Clin 2013 Jul;29(3):393-409. doi: 10.1016/j.ccc.2013.03.001. PMID: 23830646
Meningococcemia.
Salzman MB, Rubin LG
Infect Dis Clin North Am 1996 Dec;10(4):709-25. doi: 10.1016/s0891-5520(05)70323-8. PMID: 8958165

Therapy

Long-Term Safety and Efficacy of Eculizumab in Aquaporin-4 IgG-Positive NMOSD.
Wingerchuk DM, Fujihara K, Palace J, Berthele A, Levy M, Kim HJ, Nakashima I, Oreja-Guevara C, Wang KC, Miller L, Shang S, Sabatella G, Yountz M, Pittock SJ; PREVENT Study Group
Ann Neurol 2021 Jun;89(6):1088-1098. Epub 2021 Feb 27 doi: 10.1002/ana.26049. PMID: 33586143Free PMC Article
Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis.
Socié G, Caby-Tosi MP, Marantz JL, Cole A, Bedrosian CL, Gasteyger C, Mujeebuddin A, Hillmen P, Vande Walle J, Haller H
Br J Haematol 2019 Apr;185(2):297-310. Epub 2019 Feb 15 doi: 10.1111/bjh.15790. PMID: 30768680Free PMC Article
Long-term safety and efficacy of eculizumab in generalized myasthenia gravis.
Muppidi S, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Nowak RJ, Andersen H, Casasnovas C, de Bleecker JL, Vu TH, Mantegazza R, O'Brien FL, Wang JJ, Fujita KP, Howard JF Jr; Regain Study Group
Muscle Nerve 2019 Jul;60(1):14-24. Epub 2019 Mar 8 doi: 10.1002/mus.26447. PMID: 30767274Free PMC Article
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study.
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752

Prognosis

Complement-driven hemolytic uremic syndrome.
Leon J, LeStang MB, Sberro-Soussan R, Servais A, Anglicheau D, Frémeaux-Bacchi V, Zuber J
Am J Hematol 2023 May;98 Suppl 4:S44-S56. doi: 10.1002/ajh.26854. PMID: 36683290
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Severe meningococcal infection: a review of epidemiology, diagnosis, and management.
Campsall PA, Laupland KB, Niven DJ
Crit Care Clin 2013 Jul;29(3):393-409. doi: 10.1016/j.ccc.2013.03.001. PMID: 23830646
Meningococcal infection.
Boyne L
Nurs Stand 2001 Oct 31-Nov 6;16(7):47-53; quiz 54-5. doi: 10.7748/ns2001.10.16.7.47.c3110. PMID: 11974830
Meningococcemia.
Salzman MB, Rubin LG
Infect Dis Clin North Am 1996 Dec;10(4):709-25. doi: 10.1016/s0891-5520(05)70323-8. PMID: 8958165

Clinical prediction guides

Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study.
Brocklebank V, Walsh PR, Smith-Jackson K, Hallam TM, Marchbank KJ, Wilson V, Bigirumurame T, Dutt T, Montgomery EK, Malina M, Wong EKS, Johnson S, Sheerin NS, Kavanagh D
Blood 2023 Oct 19;142(16):1371-1386. doi: 10.1182/blood.2022018833. PMID: 37369098Free PMC Article
Interventions for atypical haemolytic uraemic syndrome.
Pugh D, O'Sullivan ED, Duthie FA, Masson P, Kavanagh D
Cochrane Database Syst Rev 2021 Mar 23;3(3):CD012862. doi: 10.1002/14651858.CD012862.pub2. PMID: 33783815Free PMC Article
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study.
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Pathogenesis of meningococcemia.
Coureuil M, Join-Lambert O, Lécuyer H, Bourdoulous S, Marullo S, Nassif X
Cold Spring Harb Perspect Med 2013 Jun 1;3(6) doi: 10.1101/cshperspect.a012393. PMID: 23732856Free PMC Article

Recent systematic reviews

Interventions for atypical haemolytic uraemic syndrome.
Pugh D, O'Sullivan ED, Duthie FA, Masson P, Kavanagh D
Cochrane Database Syst Rev 2021 Mar 23;3(3):CD012862. doi: 10.1002/14651858.CD012862.pub2. PMID: 33783815Free PMC Article
Pre-admission antibiotics for suspected cases of meningococcal disease.
Sudarsanam TD, Rupali P, Tharyan P, Abraham OC, Thomas K
Cochrane Database Syst Rev 2017 Jun 14;6(6):CD005437. doi: 10.1002/14651858.CD005437.pub4. PMID: 28613408Free PMC Article
Antibiotics for preventing meningococcal infections.
Zalmanovici Trestioreanu A, Fraser A, Gafter-Gvili A, Paul M, Leibovici L
Cochrane Database Syst Rev 2013 Oct 25;2013(10):CD004785. doi: 10.1002/14651858.CD004785.pub5. PMID: 24163051Free PMC Article
Antibiotics for preventing meningococcal infections.
Zalmanovici Trestioreanu A, Fraser A, Gafter-Gvili A, Paul M, Leibovici L
Cochrane Database Syst Rev 2011 Aug 10;(8):CD004785. doi: 10.1002/14651858.CD004785.pub4. PMID: 21833949
Meningococcal carriage by age: a systematic review and meta-analysis.
Christensen H, May M, Bowen L, Hickman M, Trotter CL
Lancet Infect Dis 2010 Dec;10(12):853-61. Epub 2010 Nov 11 doi: 10.1016/S1473-3099(10)70251-6. PMID: 21075057

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