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Recurrent Adult Soft Tissue Sarcoma

MedGen UID:
75850
•Concept ID:
C0278665
•
Neoplastic Process
Synonyms: Recurrent Adult Sarcoma of Soft Tissue; Recurrent Adult Sarcoma of the Soft Tissue; Relapsed Adult Sarcoma of Soft Tissue; Relapsed Adult Sarcoma of the Soft Tissue; Relapsed Adult Soft Tissue Sarcoma

Definition

A soft tissue sarcoma occurring in adults that has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adult Soft Tissue Sarcoma

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation.
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG
Am J Surg Pathol 1998 Jul;22(7):779-94. doi: 10.1097/00000478-199807000-00001. PMID: 9669341
Management of extremity sarcomas.
Brennan MF
Aust N Z J Surg 1988 Sep;58(9):693-702. doi: 10.1111/j.1445-2197.1988.tb01099.x. PMID: 3074771

Recent clinical studies

Etiology

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline.
Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA
Pract Radiat Oncol 2021 Sep-Oct;11(5):339-351. Epub 2021 Jul 26 doi: 10.1016/j.prro.2021.04.005. PMID: 34326023
MFH and high-grade undifferentiated pleomorphic sarcoma-what's in a name?
Delisca GO, Mesko NW, Alamanda VK, Archer KR, Song Y, Halpern JL, Schwartz HS, Holt GE
J Surg Oncol 2015 Feb;111(2):173-7. Epub 2014 Sep 12 doi: 10.1002/jso.23787. PMID: 25219789
Surveillance in patients with sarcoma of the extremities.
Cool P, Grimer R, Rees R
Eur J Surg Oncol 2005 Nov;31(9):1020-4. Epub 2005 Sep 19 doi: 10.1016/j.ejso.2005.07.015. PMID: 16171968
Metastatic patterns in soft-tissue sarcomas.
Vezeridis MP, Moore R, Karakousis CP
Arch Surg 1983 Aug;118(8):915-8. doi: 10.1001/archsurg.1983.01390080023007. PMID: 6307217

Diagnosis

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
Management of sarcomas in children, adolescents and adults: Interactions in two different age groups under the umbrellas of GSF-GETO and SFCE, with the support of the NETSARC+ network.
Bompas E, Martin V, Meniai F, Toulmonde M, Marec-Berard P, Claude L, Ducimetiere F, Chargari C, Minard-Colin V, Corradini N, Laurence V, Piperno-Neumann S, Defachelles AS, Bernier V, Italiano A, Orbach D, Blay JY, Gaspar N, Berlanga P
Bull Cancer 2021 Feb;108(2):163-176. Epub 2021 Jan 14 doi: 10.1016/j.bulcan.2020.10.009. PMID: 33455736
MFH and high-grade undifferentiated pleomorphic sarcoma-what's in a name?
Delisca GO, Mesko NW, Alamanda VK, Archer KR, Song Y, Halpern JL, Schwartz HS, Holt GE
J Surg Oncol 2015 Feb;111(2):173-7. Epub 2014 Sep 12 doi: 10.1002/jso.23787. PMID: 25219789
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899
Soft tissue sarcomas.
Lawrence W Jr, Neifeld JP
Curr Probl Surg 1989 Nov;26(11):753-827. doi: 10.1016/0011-3840(89)90036-1. PMID: 2686945

Therapy

Experience with second-line trabectedin in daily clinical practice: case studies.
Martín-Broto J, Hindi N, Grignani G, Merlini A, Ibrahim T, Le Cesne A
Future Oncol 2022 Sep;18(30s):23-32. Epub 2022 Oct 6 doi: 10.2217/fon-2022-0519. PMID: 36200932
Management of sarcomas in children, adolescents and adults: Interactions in two different age groups under the umbrellas of GSF-GETO and SFCE, with the support of the NETSARC+ network.
Bompas E, Martin V, Meniai F, Toulmonde M, Marec-Berard P, Claude L, Ducimetiere F, Chargari C, Minard-Colin V, Corradini N, Laurence V, Piperno-Neumann S, Defachelles AS, Bernier V, Italiano A, Orbach D, Blay JY, Gaspar N, Berlanga P
Bull Cancer 2021 Feb;108(2):163-176. Epub 2021 Jan 14 doi: 10.1016/j.bulcan.2020.10.009. PMID: 33455736
Non-rhabdomyosarcoma.
Dasgupta R, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):284-289. Epub 2016 Sep 22 doi: 10.1053/j.sempedsurg.2016.09.012. PMID: 27955731
Soft tissue sarcomas in adults.
Karakousis CP, Perez RP
CA Cancer J Clin 1994 Jul-Aug;44(4):200-10. doi: 10.3322/canjclin.44.4.200. PMID: 8019927
Management of extremity sarcomas.
Brennan MF
Aust N Z J Surg 1988 Sep;58(9):693-702. doi: 10.1111/j.1445-2197.1988.tb01099.x. PMID: 3074771

Prognosis

Intraoperative ultrasonography-guided surgery for malignant soft tissue tumor.
Takeuchi A, Yamamoto N, Hayashi K, Miwa S, Igarashi K, Yonezawa H, Morinaga S, Araki Y, Asano Y, Ikeda H, Tsuchiya H
J Surg Oncol 2020 Dec;122(8):1791-1801. Epub 2020 Aug 19 doi: 10.1002/jso.26181. PMID: 32815149
Neoadjuvant radiation improves margin-negative resection rates in extremity sarcoma but not survival.
Shelby RD, Suarez-Kelly LP, Yu PY, Hughes TM, Ethun CG, Tran TB, Poultsides G, King DM, Bedi M, Mogal H, Clarke C, Tseng J, Roggin KK, Chouliaras K, Votanopoulos K, Krasnick BA, Fields RC, Pollock RE, Howard JH, Cardona K, Grignol V
J Surg Oncol 2020 Jun;121(8):1249-1258. Epub 2020 Mar 30 doi: 10.1002/jso.25905. PMID: 32232871
Optimal surgical margin for infiltrative soft tissue sarcomas: Assessing the efficacy of excising beyond the infiltration.
Iwata S, Araki A, Funatsu H, Yonemoto T, Kamoda H, Itami M, Ishii T
J Surg Oncol 2018 Sep;118(3):525-531. doi: 10.1002/jso.25165. PMID: 30259517
Synovial Sarcoma Recurrence in Children and Young Adults.
Scheer M, Dantonello T, Hallmen E, Blank B, Sparber-Sauer M, Vokuhl C, Leuschner I, Münter MW, von Kalle T, Bielack SS, Klingebiel T, Koscielniak E; Cooperative Weichteilsarkom Studiengruppe [CWS]
Ann Surg Oncol 2016 Dec;23(Suppl 5):618-626. Epub 2016 Sep 8 doi: 10.1245/s10434-016-5535-2. PMID: 27638676
Surveillance in patients with sarcoma of the extremities.
Cool P, Grimer R, Rees R
Eur J Surg Oncol 2005 Nov;31(9):1020-4. Epub 2005 Sep 19 doi: 10.1016/j.ejso.2005.07.015. PMID: 16171968

Clinical prediction guides

Outcomes of non-angiosarcoma radiation-associated soft tissue sarcomas of the chest.
Garayua-Cruz L, Broida SE, Okuno SH, Robinson SI, Siontis BL, Welliver MX, Wilke BK, Goulding KA, Rose PS, Houdek MT
J Surg Oncol 2024 Jul;130(1):56-63. Epub 2024 Jun 12 doi: 10.1002/jso.27686. PMID: 38864186
Popliteal Fossa Sarcomas.
Erdogan O, Çeli K A, Yildirim ANT, Tekçe E, Altun G, Demi Röz S, Güler Y, Ozkan K, Gurkan V
Acta Chir Orthop Traumatol Cech 2023;90(3):181-187. PMID: 37395425
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142Free PMC Article
A technical note to prevent superficial tumor cell dissemination at fungating soft tissue tumor resection.
Musser E, Smolle M, Friesenbichler J, Leithner A, Bergovec M
Orthop Traumatol Surg Res 2019 Oct;105(6):1211-1213. Epub 2019 Jun 14 doi: 10.1016/j.otsr.2019.04.013. PMID: 31208933
Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma.
Li Q, Zhuang R, Zhu J, Lu W, Hou Y, Liu J, Zhang Y, Wang Y, Liu T, Wang Z, Zhou Y
Future Oncol 2015;11(12):1759-66. doi: 10.2217/fon.15.54. PMID: 26075444

Recent systematic reviews

Surgical management of tracheal chondrosarcoma.
Rotolo N, Cattoni M, Nardecchia E, De Maio S, Franzi F, Pettenon F, Imperatori A
Acta Chir Belg 2022 Oct;122(5):361-365. Epub 2020 Dec 25 doi: 10.1080/00015458.2020.1863039. PMID: 33306456
Chondrosarcoma of the Temporomandibular Joint: Systematic Review and Survival Analysis of Cases Reported to Date.
Faro TF, Martins-de-Barros AV, Lima GTWF, Raposo AP, Borges MA, Araújo FADC, Carvalho MV, Nogueira EFC, Laureano Filho JR
Head Neck Pathol 2021 Sep;15(3):923-934. Epub 2021 Mar 22 doi: 10.1007/s12105-021-01313-9. PMID: 33751416Free PMC Article
Use of endobronchial ultrasound to evaluate nonthrombotic endovascular lesions in pulmonary arteries: a systematic review.
Al-Saffar F, Ibrahim S, Seeram V, Bajwa AA, Shujaat A
J Bronchology Interv Pulmonol 2015 Jan;22(1):28-32. doi: 10.1097/LBR.0000000000000133. PMID: 25590480
Multicentric liposarcoma.
Conesa X, Seijas R, Ares O, Huguet P, Perez-Dominguez M
Acta Orthop Belg 2011 Feb;77(1):9-14. PMID: 21473438
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899

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