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Unresectable Gallbladder Carcinoma

MedGen UID:
75874
•Concept ID:
C0278807
•
Neoplastic Process
Synonyms: Gallbladder Cancer Unresectable; Gallbladder Carcinoma Unresectable; Unresectable Cancer of Gallbladder; Unresectable Cancer of the Gallbladder; Unresectable Gallbladder Cancer

Definition

A carcinoma that arises from the gallbladder and it is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Gallbladder Carcinoma

Professional guidelines

PubMed

A Practical Guide for the Systemic Treatment of Biliary Tract Cancer in Canada.
Ramjeesingh R, Chaudhury P, Tam VC, Roberge D, Lim HJ, Knox JJ, Asselah J, Doucette S, Chhiber N, Goodwin R
Curr Oncol 2023 Jul 25;30(8):7132-7150. doi: 10.3390/curroncol30080517. PMID: 37622998Free PMC Article
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131
Multimodality Management of Localized Biliary Cancer.
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050

Recent clinical studies

Etiology

Comparison of Chemotherapy Combined with Percutaneous Electroporation and Chemotherapy Alone in the Management of Locally Advanced Gallbladder Carcinoma (GBC): A Study Protocol.
Kalra N, Bhujade H, Baloji A, Khosla D, Samra S, Srinivasan R, Gupta P, Singh H, Gupta V, Kapoor R, Dahiya D, Gupta R, Kishore K, Sandhu M
Cardiovasc Intervent Radiol 2024 Nov;47(11):1532-1539. Epub 2024 Sep 27 doi: 10.1007/s00270-024-03856-0. PMID: 39333372
Is external palliative radiotherapy for gallbladder carcinoma effective?
Eleftheriadis N, Pistevou-Gombaki K, Plataniotis G, Sofroniadis I, Kouloulias V
Onkologie 2001 Dec;24(6):581-4. doi: 10.1159/000055147. PMID: 11799314
Palliative treatment with metallic stents for unresectable gallbladder carcinoma involving the portal vein and bile duct.
Tanaka Ji, Andoh H, Yoshioka M, Furuya T, Asanuma Y, Koyama K
J Hepatobiliary Pancreat Surg 2000;7(3):331-5. doi: 10.1007/s005340070058. PMID: 10982636

Diagnosis

Is external palliative radiotherapy for gallbladder carcinoma effective?
Eleftheriadis N, Pistevou-Gombaki K, Plataniotis G, Sofroniadis I, Kouloulias V
Onkologie 2001 Dec;24(6):581-4. doi: 10.1159/000055147. PMID: 11799314
Palliative treatment with metallic stents for unresectable gallbladder carcinoma involving the portal vein and bile duct.
Tanaka Ji, Andoh H, Yoshioka M, Furuya T, Asanuma Y, Koyama K
J Hepatobiliary Pancreat Surg 2000;7(3):331-5. doi: 10.1007/s005340070058. PMID: 10982636

Therapy

Comparison of Chemotherapy Combined with Percutaneous Electroporation and Chemotherapy Alone in the Management of Locally Advanced Gallbladder Carcinoma (GBC): A Study Protocol.
Kalra N, Bhujade H, Baloji A, Khosla D, Samra S, Srinivasan R, Gupta P, Singh H, Gupta V, Kapoor R, Dahiya D, Gupta R, Kishore K, Sandhu M
Cardiovasc Intervent Radiol 2024 Nov;47(11):1532-1539. Epub 2024 Sep 27 doi: 10.1007/s00270-024-03856-0. PMID: 39333372
Is external palliative radiotherapy for gallbladder carcinoma effective?
Eleftheriadis N, Pistevou-Gombaki K, Plataniotis G, Sofroniadis I, Kouloulias V
Onkologie 2001 Dec;24(6):581-4. doi: 10.1159/000055147. PMID: 11799314
A phase II study of gemcitabine in gallbladder carcinoma.
Gallardo JO, Rubio B, Fodor M, Orlandi L, Yáñez M, Gamargo C, Ahumada M
Ann Oncol 2001 Oct;12(10):1403-6. doi: 10.1023/a:1012543223020. PMID: 11762811

Prognosis

Is external palliative radiotherapy for gallbladder carcinoma effective?
Eleftheriadis N, Pistevou-Gombaki K, Plataniotis G, Sofroniadis I, Kouloulias V
Onkologie 2001 Dec;24(6):581-4. doi: 10.1159/000055147. PMID: 11799314
Palliative treatment with metallic stents for unresectable gallbladder carcinoma involving the portal vein and bile duct.
Tanaka Ji, Andoh H, Yoshioka M, Furuya T, Asanuma Y, Koyama K
J Hepatobiliary Pancreat Surg 2000;7(3):331-5. doi: 10.1007/s005340070058. PMID: 10982636

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