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Recurrent Malignant Testicular Germ Cell Tumor

MedGen UID:
75879
•Concept ID:
C0278841
•
Neoplastic Process
Synonyms: Recurrent Cancer of Testis; Recurrent Cancer of the Testis; Recurrent Testicular Cancer; Relapsed Cancer of Testis; Relapsed Cancer of the Testis; Relapsed Testicular Cancer

Definition

Malignant testicular germ cell tumor reemerging after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Testicular Germ Cell Tumor

Professional guidelines

PubMed

Genetics of testicular cancer: a review.
Martin FC, Conduit C, Loveland KL, Thomas B, Lewin J, Tran B
Curr Opin Urol 2022 Sep 1;32(5):481-487. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001017. PMID: 35855571
Salvage management of patients with relapsing testicular germ cell tumors.
Heidenreich A, Pfister D, Paffenholz P
Curr Opin Urol 2021 May 1;31(3):206-213. doi: 10.1097/MOU.0000000000000875. PMID: 33742980
Pharmacotherapeutic treatment of germ cell tumors: standard of care and recent developments.
Oing C, Seidel C, von Amsberg G, Oechsle K, Bokemeyer C
Expert Opin Pharmacother 2016;17(4):545-60. Epub 2015 Dec 31 doi: 10.1517/14656566.2016.1127357. PMID: 26630452

Recent clinical studies

Etiology

Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors.
Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective.
García Rojo E, Giannarini G, García Gómez B, Feltes Ochoa JA, Guerrero Ramos F, Alonso Isa M, Brime Menendez R, Saenz Calzada DM, Justo Quintas J, Fraile A, Manfredi C, Romero Otero J
Medicina (Kaunas) 2023 Jul 5;59(7) doi: 10.3390/medicina59071249. PMID: 37512061Free PMC Article
Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Testicular germ cell tumor: a comprehensive review.
Batool A, Karimi N, Wu XN, Chen SR, Liu YX
Cell Mol Life Sci 2019 May;76(9):1713-1727. Epub 2019 Jan 22 doi: 10.1007/s00018-019-03022-7. PMID: 30671589Free PMC Article

Diagnosis

Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors.
Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Genetics of testicular cancer: a review.
Martin FC, Conduit C, Loveland KL, Thomas B, Lewin J, Tran B
Curr Opin Urol 2022 Sep 1;32(5):481-487. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001017. PMID: 35855571
Further insights into testicular germ cell tumor oncogenesis: potential therapeutic targets.
Chieffi P, De Martino M, Esposito F
Expert Rev Anticancer Ther 2020 Mar;20(3):189-195. Epub 2020 Mar 12 doi: 10.1080/14737140.2020.1736566. PMID: 32164473
Testicular germ cell tumor: a comprehensive review.
Batool A, Karimi N, Wu XN, Chen SR, Liu YX
Cell Mol Life Sci 2019 May;76(9):1713-1727. Epub 2019 Jan 22 doi: 10.1007/s00018-019-03022-7. PMID: 30671589Free PMC Article

Therapy

Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors.
Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Further insights into testicular germ cell tumor oncogenesis: potential therapeutic targets.
Chieffi P, De Martino M, Esposito F
Expert Rev Anticancer Ther 2020 Mar;20(3):189-195. Epub 2020 Mar 12 doi: 10.1080/14737140.2020.1736566. PMID: 32164473
Testicular cancer--discoveries and updates.
Hanna NH, Einhorn LH
N Engl J Med 2014 Nov 20;371(21):2005-16. doi: 10.1056/NEJMra1407550. PMID: 25409373

Prognosis

Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors.
Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Biomarkers of disease recurrence in stage I testicular germ cell tumours.
Lesko P, Chovanec M, Mego M
Nat Rev Urol 2022 Nov;19(11):637-658. Epub 2022 Aug 26 doi: 10.1038/s41585-022-00624-y. PMID: 36028719
Promising novel therapies for relapsed and refractory testicular germ cell tumors.
Kozakova K, Mego M, Cheng L, Chovanec M
Expert Rev Anticancer Ther 2021 Jan;21(1):53-69. Epub 2020 Nov 2 doi: 10.1080/14737140.2021.1838279. PMID: 33138660
Current pharmacotherapy for testicular germ cell cancer.
Alsdorf W, Seidel C, Bokemeyer C, Oing C
Expert Opin Pharmacother 2019 May;20(7):837-850. Epub 2019 Mar 8 doi: 10.1080/14656566.2019.1583745. PMID: 30849243
Late Relapse of Testicular Germ Cell Tumors.
O'Shaughnessy MJ, Feldman DR, Carver BS, Sheinfeld J
Urol Clin North Am 2015 Aug;42(3):359-68. Epub 2015 Jun 16 doi: 10.1016/j.ucl.2015.04.010. PMID: 26216823

Clinical prediction guides

Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors.
Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
Promising novel therapies for relapsed and refractory testicular germ cell tumors.
Kozakova K, Mego M, Cheng L, Chovanec M
Expert Rev Anticancer Ther 2021 Jan;21(1):53-69. Epub 2020 Nov 2 doi: 10.1080/14737140.2021.1838279. PMID: 33138660
Late Relapse of Testicular Germ Cell Tumors.
O'Shaughnessy MJ, Feldman DR, Carver BS, Sheinfeld J
Urol Clin North Am 2015 Aug;42(3):359-68. Epub 2015 Jun 16 doi: 10.1016/j.ucl.2015.04.010. PMID: 26216823
Testicular germ cell tumors.
Bridges B, Hussain A
Curr Opin Oncol 2007 May;19(3):222-8. doi: 10.1097/CCO.0b013e3280ad43df. PMID: 17414640

Recent systematic reviews

Primary retroperitoneal lymph node dissection for clinical stage II seminoma: A systematic review and meta-analysis of safety and oncological effectiveness.
Kardoust Parizi M, Margulis V, Bagrodia A, Bekku K, Klemm J, Matsukawa A, Alimohammadi A, Motlagh RS, Mostafaei H, Laukhtina E, Shariat SF
Urol Oncol 2024 Apr;42(4):102-109. Epub 2024 Feb 14 doi: 10.1016/j.urolonc.2024.01.014. PMID: 38360519
A Systematic Review Investigating the Difference between 1 Cycle versus 2 Cycles of Adjuvant Chemotherapy in Stage I Testicular Germ Cell Cancers.
Rohozneanu EF, Deac C, Căinap CI
Medicina (Kaunas) 2023 May 10;59(5) doi: 10.3390/medicina59050916. PMID: 37241148Free PMC Article
The role of robotic retroperitoneal lymph node dissection in testicular cancer: a systematic review and meta-analysis.
Ge S, Zeng Z, Li Y, Gan L, Meng C, Li K, Wang Z, Zheng L
Int J Surg 2023 Sep 1;109(9):2808-2818. doi: 10.1097/JS9.0000000000000520. PMID: 37222676Free PMC Article
Testicular germ cell tumours' clinical stage I: comparison of surveillance with adjuvant treatment strategies regarding recurrence rates and overall survival-a systematic review.
Ruf CG, Schmidt S, Kliesch S, Oing C, Pfister D, Busch J, Heinzelbecker J, Winter C, Zengerling F, Albers P, Oechsle K, Krege S, Lackner J, Dieckmann KP
World J Urol 2022 Dec;40(12):2889-2900. Epub 2022 Sep 15 doi: 10.1007/s00345-022-04145-6. PMID: 36107211Free PMC Article
A comprehensive systematic review of testicular germ cell tumor surveillance.
Groll RJ, Warde P, Jewett MA
Crit Rev Oncol Hematol 2007 Dec;64(3):182-97. Epub 2007 Jul 20 doi: 10.1016/j.critrevonc.2007.04.014. PMID: 17644403

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