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Ocular melanoma with extraocular extension

MedGen UID:
75884
•Concept ID:
C0278869
•
Neoplastic Process
Synonyms: Extraocular Extension Melanoma; extraocular extension melanoma; Extraocular Extension of Melanoma; extraocular extension of melanoma; Ocular Melanoma with Extraocular Extension; ocular melanoma with extraocular extension
 
Monarch Initiative: MONDO:0006326

Definition

A melanoma arising from and extending beyond the structures of the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular melanoma with extraocular extension

Professional guidelines

PubMed

Current management of posterior uveal melanoma.
Shields JA, Shields CL
Mayo Clin Proc 1993 Dec;68(12):1196-200. doi: 10.1016/s0025-6196(12)60072-x. PMID: 8246622
Diagnosis and differential diagnosis of malignant melanomas of the choroid.
De Laey JJ
Bull Soc Belge Ophtalmol 1993;248:6-10. PMID: 8044333

Recent clinical studies

Etiology

Adjuvant External Beam Radiotherapy Following Enucleation of Eyes With Extraocular Extension From Uveal Melanoma.
Roelofs KA, Cohen VML, Sagoo MS, Plowman PN, Negretti GS, O'Day R, Hay G, Arora AK, Damato B
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S48-S53. doi: 10.1097/IOP.0000000000001800. PMID: 33009323
Prognosis of uveal melanoma based on race in 8100 patients: The 2015 Doyne Lecture.
Shields CL, Kaliki S, Cohen MN, Shields PW, Furuta M, Shields JA
Eye (Lond) 2015 Aug;29(8):1027-35. Epub 2015 Aug 7 doi: 10.1038/eye.2015.51. PMID: 26248525Free PMC Article
Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: what can we learn from the eye?
Hos D, Schlereth SL, Bock F, Heindl LM, Cursiefen C
Semin Cell Dev Biol 2015 Feb;38:117-30. Epub 2014 Nov 20 doi: 10.1016/j.semcdb.2014.11.003. PMID: 25460541
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659

Diagnosis

Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659
Prevalence of ocular and oculodermal melanocytosis in Spanish population with uveal melanoma.
Carreño E, Saornil MA, Garcia-Alvarez C, Lopez-Lara F, De Frutos-Baraja JM, Almaraz A
Eye (Lond) 2012 Jan;26(1):159-62. Epub 2011 Oct 21 doi: 10.1038/eye.2011.257. PMID: 22020174Free PMC Article
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628

Therapy

Primary transpupillary thermotherapy for choroidal melanoma in 391 cases: importance of risk factors in tumor control.
Mashayekhi A, Shields CL, Rishi P, Atalay HT, Pellegrini M, McLaughlin JP, Patrick KA, Morton SJ, Remmer MH, Parendo A, Schlitt MA, Shields JA
Ophthalmology 2015 Mar;122(3):600-9. Epub 2014 Nov 13 doi: 10.1016/j.ophtha.2014.09.029. PMID: 25439431
Staging of ciliary body and choroidal melanomas based on anatomic extent.
Kujala E, Damato B, Coupland SE, Desjardins L, Bechrakis NE, Grange JD, Kivelä T
J Clin Oncol 2013 Aug 1;31(22):2825-31. Epub 2013 Jul 1 doi: 10.1200/JCO.2012.45.2771. PMID: 23816968
Episcleral brachytherapy for uveal melanoma: analysis of 136 cases.
García-Álvarez C, Saornil MA, López-Lara F, Almaraz A, Muñoz MF, Frutos-Baraja J, Muiños Y
Clin Transl Oncol 2012 May;14(5):350-5. doi: 10.1007/s12094-012-0807-1. PMID: 22551540
Visual acuity after Ruthenium(106) brachytherapy of choroidal melanomas.
Damato B, Patel I, Campbell IR, Mayles HM, Errington RD
Int J Radiat Oncol Biol Phys 2005 Oct 1;63(2):392-400. doi: 10.1016/j.ijrobp.2005.02.059. PMID: 15990248
Current management of posterior uveal melanoma.
Shields JA, Shields CL
Mayo Clin Proc 1993 Dec;68(12):1196-200. doi: 10.1016/s0025-6196(12)60072-x. PMID: 8246622

Prognosis

CHOROIDAL TUMOR BIOPSY: A Review of the Current State and a Glance Into Future Techniques.
Finn AP, Materin MA, Mruthyunjaya P
Retina 2018 Sep;38 Suppl 1:S79-S87. doi: 10.1097/IAE.0000000000001997. PMID: 29280938
Prognosis of uveal melanoma based on race in 8100 patients: The 2015 Doyne Lecture.
Shields CL, Kaliki S, Cohen MN, Shields PW, Furuta M, Shields JA
Eye (Lond) 2015 Aug;29(8):1027-35. Epub 2015 Aug 7 doi: 10.1038/eye.2015.51. PMID: 26248525Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659

Clinical prediction guides

Adjuvant External Beam Radiotherapy Following Enucleation of Eyes With Extraocular Extension From Uveal Melanoma.
Roelofs KA, Cohen VML, Sagoo MS, Plowman PN, Negretti GS, O'Day R, Hay G, Arora AK, Damato B
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S48-S53. doi: 10.1097/IOP.0000000000001800. PMID: 33009323
Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
The lymphangiogenic and hemangiogenic privilege of the human sclera.
Atta G, Tempfer H, Kaser-Eichberger A, Guo Y, Schroedl F, Traweger A, Heindl LM
Ann Anat 2020 Jul;230:151485. Epub 2020 Feb 28 doi: 10.1016/j.aanat.2020.151485. PMID: 32120002
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Iris melanoma: features and prognosis in 317 children and adults.
Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA
J AAPOS 2012 Feb;16(1):10-6. doi: 10.1016/j.jaapos.2011.10.012. PMID: 22370659

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