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Adult Acute Myelomonocytic Leukemia

MedGen UID:
76003
Concept ID:
C0279627
Neoplastic Process
Synonyms: Adult Acute M4 Leukemia; Adult Acute Myelomonocytic Leukemia (M4); Adult AMMoL; M4 Adult Acute Leukemia; M4 Adult Acute Myelomonocytic Leukemia

Definition

An acute myelomonocytic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myelomonocytic Leukemia

Professional guidelines

PubMed

Zhao L, Yang J, Chen M, Xiang X, Ma H, Niu T, Gong Y, Chen X, Liu J, Wu Y
Ann Hematol 2024 Apr;103(4):1197-1209. Epub 2024 Feb 8 doi: 10.1007/s00277-024-05646-7. PMID: 38329487
McCullough KB, Kuhn AK, Patnaik MM
Curr Hematol Malig Rep 2021 Jun;16(3):256-266. Epub 2021 Mar 16 doi: 10.1007/s11899-021-00622-8. PMID: 33728588
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article

Recent clinical studies

Etiology

Short NJ, Venugopal S, Qiao W, Kadia TM, Ravandi F, Macaron W, Dinardo CD, Daver N, Konopleva M, Borthakur G, Shpall EJ, Popat U, Champlin RE, Mehta R, Al-Atrash G, Oran B, Jabbour E, Garcia-Manero G, Issa GC, Montalban-Bravo G, Yilmaz M, Maiti A, Kantarjian H
J Hematol Oncol 2022 Jan 29;15(1):12. doi: 10.1186/s13045-022-01229-z. PMID: 35093134Free PMC Article
Carluccio P, Mestice A, Pastore D, Delia M, Ricco A, Russo-Rossi A, Casieri P, Liso A, Martelli MP, Albano F, Specchia G
Eur J Haematol 2014 Feb;92(2):121-6. doi: 10.1111/ejh.12217. PMID: 24138595
Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, Van Loo P, Yoon CJ, Ellis P, Wedge DC, Pellagatti A, Shlien A, Groves MJ, Forbes SA, Raine K, Hinton J, Mudie LJ, McLaren S, Hardy C, Latimer C, Della Porta MG, O'Meara S, Ambaglio I, Galli A, Butler AP, Walldin G, Teague JW, Quek L, Sternberg A, Gambacorti-Passerini C, Cross NC, Green AR, Boultwood J, Vyas P, Hellstrom-Lindberg E, Bowen D, Cazzola M, Stratton MR, Campbell PJ; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
Blood 2013 Nov 21;122(22):3616-27; quiz 3699. Epub 2013 Sep 12 doi: 10.1182/blood-2013-08-518886. PMID: 24030381Free PMC Article
Kröger N, Damon L, Zander AR, Wandt H, Derigs G, Ferrante P, Demirer T, Rosti G; Solid Tumor Working Party of the European Group for Blood and Marrow Transplantation; German Adjuvant Breast Cancer Study Group; University of California, San Francisco
Bone Marrow Transplant 2003 Dec;32(12):1153-7. doi: 10.1038/sj.bmt.1704291. PMID: 14647269
Storniolo AM, Moloney WC, Rosenthal DS, Cox C, Bennett JM
Leukemia 1990 Nov;4(11):766-70. PMID: 2232890

Diagnosis

McGrath R, Fay M, McAnena L
BMJ Case Rep 2024 Oct 30;17(10) doi: 10.1136/bcr-2023-258203. PMID: 39477459
Radia DH, Green A, Oni C, Moonim M
Br J Haematol 2020 Mar;188(5):623-640. Epub 2020 Jan 27 doi: 10.1111/bjh.16288. PMID: 31985050
Gundabolu K, Kong G, Verma A
CMAJ 2009 Feb 17;180(4):471. doi: 10.1503/cmaj.080424. PMID: 19221364Free PMC Article
Bölke E, Gerber PA, Peiper M, Engers R, Pape H
Wien Klin Wochenschr 2008;120(7-8):209. doi: 10.1007/s00508-008-0952-2. PMID: 18500594
Kröger N, Damon L, Zander AR, Wandt H, Derigs G, Ferrante P, Demirer T, Rosti G; Solid Tumor Working Party of the European Group for Blood and Marrow Transplantation; German Adjuvant Breast Cancer Study Group; University of California, San Francisco
Bone Marrow Transplant 2003 Dec;32(12):1153-7. doi: 10.1038/sj.bmt.1704291. PMID: 14647269

Therapy

McGrath R, Fay M, McAnena L
BMJ Case Rep 2024 Oct 30;17(10) doi: 10.1136/bcr-2023-258203. PMID: 39477459
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Madhusoodhan PP, Carroll WL, Bhatla T
Curr Probl Pediatr Adolesc Health Care 2016 Jul;46(7):229-241. Epub 2016 Jun 6 doi: 10.1016/j.cppeds.2016.04.003. PMID: 27283082
Rowe JM
Leukemia 2000 Mar;14(3):480-7. doi: 10.1038/sj.leu.2401539. PMID: 10720146
Korinek JK, Guarda LA, Bolivar R, Stroehlein JR
Gastroenterology 1983 Sep;85(3):732-4. PMID: 6575926

Prognosis

Lee H
Camb Q Healthc Ethics 2014 Jan;23(1):109-11. Epub 2013 Nov 11 doi: 10.1017/S0963180113000558. PMID: 24229502
Pantanowitz L, Steingart R, Miller KB, Kruskal JB, Pihan G
Arch Pathol Lab Med 2005 Feb;129(2):262-3. doi: 10.5858/2005-129-262-LA. PMID: 15679438
Kröger N, Damon L, Zander AR, Wandt H, Derigs G, Ferrante P, Demirer T, Rosti G; Solid Tumor Working Party of the European Group for Blood and Marrow Transplantation; German Adjuvant Breast Cancer Study Group; University of California, San Francisco
Bone Marrow Transplant 2003 Dec;32(12):1153-7. doi: 10.1038/sj.bmt.1704291. PMID: 14647269
Rowe JM
Leukemia 2000 Mar;14(3):480-7. doi: 10.1038/sj.leu.2401539. PMID: 10720146
Storniolo AM, Moloney WC, Rosenthal DS, Cox C, Bennett JM
Leukemia 1990 Nov;4(11):766-70. PMID: 2232890

Clinical prediction guides

Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal RK, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL
Blood 2021 Mar 11;137(10):1377-1391. doi: 10.1182/blood.2020007897. PMID: 32871587Free PMC Article
Keating GM
Drugs 2009;69(17):2501-18. doi: 10.2165/11202840-000000000-00000. PMID: 19911860
Kröger N, Damon L, Zander AR, Wandt H, Derigs G, Ferrante P, Demirer T, Rosti G; Solid Tumor Working Party of the European Group for Blood and Marrow Transplantation; German Adjuvant Breast Cancer Study Group; University of California, San Francisco
Bone Marrow Transplant 2003 Dec;32(12):1153-7. doi: 10.1038/sj.bmt.1704291. PMID: 14647269
Giles F, Estey E, O'Brien S
Cancer 2003 Nov 15;98(10):2095-104. doi: 10.1002/cncr.11791. PMID: 14601078

Recent systematic reviews

Kunacheewa C, Thongthang P, Ungprasert P, Utchariyaprasit E, Owattanapanich W
Hematology 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425. PMID: 31221030
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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