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Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation

MedGen UID:
76025
•Concept ID:
C0279763
•
Neoplastic Process
Synonyms: Adenocanthoma of Endometrium; Endometrial Endometrioid Adenocarcinoma with Squamous Differentiation

Definition

An endometrioid adenocarcinoma of the endometrium showing squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation

Professional guidelines

PubMed

Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Recent clinical studies

Etiology

A large multicenter propensity match study of sentinel lymph node biopsy feasibility in endometrioid variants of endometrial cancer.
Capozzi VA, Rosati A, Vargiu V, Sozzi G, Cosentino F, Chiantera V, Scambia G, Berretta R, Fanfani F
Eur J Surg Oncol 2022 Jun;48(6):1390-1394. Epub 2022 Jan 31 doi: 10.1016/j.ejso.2022.01.025. PMID: 35120817
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
A Combined Morphologic and Molecular Approach to Retrospectively Identify KRAS-Mutated Mesonephric-like Adenocarcinomas of the Endometrium.
Kolin DL, Costigan DC, Dong F, Nucci MR, Howitt BE
Am J Surg Pathol 2019 Mar;43(3):389-398. doi: 10.1097/PAS.0000000000001193. PMID: 30489318
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Malignant lesions of the female genital tract and peritoneum that may be underdiagnosed.
Young RH, Clement PB
Semin Diagn Pathol 1995 Feb;12(1):14-29. PMID: 7770671

Diagnosis

Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.
Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Prognosis

How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.
Katoh T, Yasuda M, Hasegawa K, Kozawa E, Maniwa J, Sasano H
Diagn Pathol 2012 Nov 28;7:164. doi: 10.1186/1746-1596-7-164. PMID: 23190574Free PMC Article
CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker.
Hoshimoto K, Yamauchi N, Takazawa Y, Onda T, Taketani Y, Fukayama M
Pathol Res Pract 2003;199(2):71-7. doi: 10.1078/0344-0338-00357. PMID: 12747468
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341
Sertoliform endometrial adenocarcinoma: a study of four cases.
Eichhorn JH, Young RH, Clement PB
Int J Gynecol Pathol 1996 Apr;15(2):119-26. doi: 10.1097/00004347-199604000-00005. PMID: 8786200

Clinical prediction guides

Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.
Katoh T, Yasuda M, Hasegawa K, Kozawa E, Maniwa J, Sasano H
Diagn Pathol 2012 Nov 28;7:164. doi: 10.1186/1746-1596-7-164. PMID: 23190574Free PMC Article
CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker.
Hoshimoto K, Yamauchi N, Takazawa Y, Onda T, Taketani Y, Fukayama M
Pathol Res Pract 2003;199(2):71-7. doi: 10.1078/0344-0338-00357. PMID: 12747468
Sertoliform endometrial adenocarcinoma: a study of four cases.
Eichhorn JH, Young RH, Clement PB
Int J Gynecol Pathol 1996 Apr;15(2):119-26. doi: 10.1097/00004347-199604000-00005. PMID: 8786200
A clinicopathologic study of endometrial carcinoma with special reference to new histological variants.
Sato Y, Ozaki M, Ueda G, Tanizawa O
Nihon Sanka Fujinka Gakkai Zasshi 1985 Jun;37(6):1015-9. PMID: 2991395

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