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Prostatic Neoplasms, Castration-Resistant

MedGen UID:
772466
Concept ID:
C3658267
Neoplastic Process
Synonyms: Androgen Independent Prostatic Neoplasms; Androgen Insensitive Prostatic Neoplasms; Androgen Resistant Prostatic Neoplasms; Androgen-Independent Prostatic Neoplasm; Androgen-Independent Prostatic Neoplasms; Androgen-Insensitive Prostatic Neoplasm; Androgen-Insensitive Prostatic Neoplasms; Androgen-Resistant Prostatic Neoplasm; Androgen-Resistant Prostatic Neoplasms; Castration Resistant Prostatic Neoplasms; Castration-Resistant Prostatic Neoplasm; Castration-Resistant Prostatic Neoplasms; Hormone Refractory Prostatic Neoplasms; Neoplasm, Androgen-Independent Prostatic; Neoplasm, Androgen-Insensitive Prostatic; Neoplasm, Androgen-Resistant Prostatic; Neoplasm, Castration-Resistant Prostatic; Neoplasms, Androgen-Independent Prostatic; Neoplasms, Androgen-Insensitive Prostatic; Neoplasms, Androgen-Resistant Prostatic; Neoplasms, Castration-Resistant Prostatic; Prostatic Neoplasm, Androgen-Independent; Prostatic Neoplasm, Androgen-Insensitive; Prostatic Neoplasm, Androgen-Resistant; Prostatic Neoplasm, Castration-Resistant; Prostatic Neoplasms, Androgen Independent; Prostatic Neoplasms, Androgen Insensitive; Prostatic Neoplasms, Androgen Resistant; Prostatic Neoplasms, Androgen-Independent; Prostatic Neoplasms, Androgen-Insensitive; Prostatic Neoplasms, Androgen-Resistant; Prostatic Neoplasms, Castration Resistant; Prostatic Neoplasms, Hormone Refractory

Definition

Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstatic Neoplasms, Castration-Resistant

Professional guidelines

PubMed

Demus T, Getzenberg RH, Nieder AM
Urol Pract 2023 Jan;10(1):90-97. Epub 2022 Dec 19 doi: 10.1097/UPJ.0000000000000362. PMID: 37103443
Maluf F, Soares A, Avanço G, Hada AL, Cardoso APG, Carneiro A, Herchenhorn D, Jardim DLF, Schutz FA, Kater FR, Pereira FMT, Monteiro FSM, Morbeck IAP, Reolon JFN, da Trindade KM, Andrade LMQDS, Nogueira LM, Furoni R, Natel RA, Dos Reis RB, Fogace RN, Souza VC
Int Braz J Urol 2021 Mar-Apr;47(2):359-373. doi: 10.1590/S1677-5538.IBJU.2020.0249. PMID: 33284538Free PMC Article
Srinivas S, Mohamed AF, Appukkuttan S, Botteman M, Ng X, Joshi N, Tsai JH, Fang J, Waldeck AR, Simmons SJ
Cancer Med 2020 Sep;9(18):6586-6596. Epub 2020 Jul 29 doi: 10.1002/cam4.3321. PMID: 32725755Free PMC Article

Recent clinical studies

Etiology

Chandran E, Figg WD, Madan R
Cancer Biol Ther 2022 Dec 31;23(1):186-190. doi: 10.1080/15384047.2022.2037985. PMID: 35220877Free PMC Article
Ge R, Wang Z, Montironi R, Jiang Z, Cheng M, Santoni M, Huang K, Massari F, Lu X, Cimadamore A, Lopez-Beltran A, Cheng L
Ann Oncol 2020 Apr;31(4):470-479. Epub 2020 Feb 13 doi: 10.1016/j.annonc.2020.02.002. PMID: 32139297
Teo MY, Rathkopf DE, Kantoff P
Annu Rev Med 2019 Jan 27;70:479-499. doi: 10.1146/annurev-med-051517-011947. PMID: 30691365Free PMC Article
Mansinho A, Macedo D, Fernandes I, Costa L
Adv Exp Med Biol 2018;1096:117-133. doi: 10.1007/978-3-319-99286-0_7. PMID: 30324351
Chang AJ, Autio KA, Roach M 3rd, Scher HI
Nat Rev Clin Oncol 2014 Jun;11(6):308-23. Epub 2014 May 20 doi: 10.1038/nrclinonc.2014.68. PMID: 24840073Free PMC Article

Diagnosis

Achard V, Putora PM, Omlin A, Zilli T, Fischer S
Oncology 2022;100(1):48-59. Epub 2021 Nov 15 doi: 10.1159/000519861. PMID: 34781285
Haffner MC, Zwart W, Roudier MP, True LD, Nelson WG, Epstein JI, De Marzo AM, Nelson PS, Yegnasubramanian S
Nat Rev Urol 2021 Feb;18(2):79-92. Epub 2020 Dec 16 doi: 10.1038/s41585-020-00400-w. PMID: 33328650Free PMC Article
Teo MY, Rathkopf DE, Kantoff P
Annu Rev Med 2019 Jan 27;70:479-499. doi: 10.1146/annurev-med-051517-011947. PMID: 30691365Free PMC Article
Mansinho A, Macedo D, Fernandes I, Costa L
Adv Exp Med Biol 2018;1096:117-133. doi: 10.1007/978-3-319-99286-0_7. PMID: 30324351
Chang AJ, Autio KA, Roach M 3rd, Scher HI
Nat Rev Clin Oncol 2014 Jun;11(6):308-23. Epub 2014 May 20 doi: 10.1038/nrclinonc.2014.68. PMID: 24840073Free PMC Article

Therapy

Armstrong AJ, Azad AA, Iguchi T, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Alcaraz A, Alekseev B, Shore ND, Gomez-Veiga F, Rosbrook B, Zohren F, Yamada S, Haas GP, Stenzl A
J Clin Oncol 2022 May 20;40(15):1616-1622. Epub 2022 Apr 14 doi: 10.1200/JCO.22.00193. PMID: 35420921Free PMC Article
Achard V, Putora PM, Omlin A, Zilli T, Fischer S
Oncology 2022;100(1):48-59. Epub 2021 Nov 15 doi: 10.1159/000519861. PMID: 34781285
Rosellini M, Santoni M, Mollica V, Rizzo A, Cimadamore A, Scarpelli M, Storti N, Battelli N, Montironi R, Massari F
Int J Mol Sci 2021 Feb 4;22(4) doi: 10.3390/ijms22041551. PMID: 33557050Free PMC Article
Fizazi K, Shore N, Tammela TL, Ulys A, Vjaters E, Polyakov S, Jievaltas M, Luz M, Alekseev B, Kuss I, Kappeler C, Snapir A, Sarapohja T, Smith MR; ARAMIS Investigators
N Engl J Med 2019 Mar 28;380(13):1235-1246. Epub 2019 Feb 14 doi: 10.1056/NEJMoa1815671. PMID: 30763142
Scher HI, Morris MJ, Stadler WM, Higano C, Basch E, Fizazi K, Antonarakis ES, Beer TM, Carducci MA, Chi KN, Corn PG, de Bono JS, Dreicer R, George DJ, Heath EI, Hussain M, Kelly WK, Liu G, Logothetis C, Nanus D, Stein MN, Rathkopf DE, Slovin SF, Ryan CJ, Sartor O, Small EJ, Smith MR, Sternberg CN, Taplin ME, Wilding G, Nelson PS, Schwartz LH, Halabi S, Kantoff PW, Armstrong AJ; Prostate Cancer Clinical Trials Working Group 3
J Clin Oncol 2016 Apr 20;34(12):1402-18. Epub 2016 Feb 22 doi: 10.1200/JCO.2015.64.2702. PMID: 26903579Free PMC Article

Prognosis

Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, Olmos D, Mainwaring PN, Lee JY, Uemura H, De Porre P, Smith AA, Brookman-May SD, Li S, Zhang K, Rooney B, Lopez-Gitlitz A, Small EJ
Eur Urol 2021 Jan;79(1):150-158. Epub 2020 Sep 6 doi: 10.1016/j.eururo.2020.08.011. PMID: 32907777
Mateo J, Seed G, Bertan C, Rescigno P, Dolling D, Figueiredo I, Miranda S, Nava Rodrigues D, Gurel B, Clarke M, Atkin M, Chandler R, Messina C, Sumanasuriya S, Bianchini D, Barrero M, Petermolo A, Zafeiriou Z, Fontes M, Perez-Lopez R, Tunariu N, Fulton B, Jones R, McGovern U, Ralph C, Varughese M, Parikh O, Jain S, Elliott T, Sandhu S, Porta N, Hall E, Yuan W, Carreira S, de Bono JS
J Clin Invest 2020 Apr 1;130(4):1743-1751. doi: 10.1172/JCI132031. PMID: 31874108Free PMC Article
Khalaf DJ, Annala M, Taavitsainen S, Finch DL, Oja C, Vergidis J, Zulfiqar M, Sunderland K, Azad AA, Kollmannsberger CK, Eigl BJ, Noonan K, Wadhwa D, Attwell A, Keith B, Ellard SL, Le L, Gleave ME, Wyatt AW, Chi KN
Lancet Oncol 2019 Dec;20(12):1730-1739. Epub 2019 Nov 11 doi: 10.1016/S1470-2045(19)30688-6. PMID: 31727538
Teo MY, Rathkopf DE, Kantoff P
Annu Rev Med 2019 Jan 27;70:479-499. doi: 10.1146/annurev-med-051517-011947. PMID: 30691365Free PMC Article
Ryan CJ, Smith MR, Fizazi K, Saad F, Mulders PF, Sternberg CN, Miller K, Logothetis CJ, Shore ND, Small EJ, Carles J, Flaig TW, Taplin ME, Higano CS, de Souza P, de Bono JS, Griffin TW, De Porre P, Yu MK, Park YC, Li J, Kheoh T, Naini V, Molina A, Rathkopf DE; COU-AA-302 Investigators
Lancet Oncol 2015 Feb;16(2):152-60. Epub 2015 Jan 16 doi: 10.1016/S1470-2045(14)71205-7. PMID: 25601341

Clinical prediction guides

Jackson P, Hofman M, McIntosh L, Buteau JP, Ravi Kumar A
Semin Nucl Med 2022 Mar;52(2):243-254. Epub 2021 Dec 8 doi: 10.1053/j.semnuclmed.2021.11.003. PMID: 34893320
Fendler WP, Weber M, Iravani A, Hofman MS, Calais J, Czernin J, Ilhan H, Saad F, Small EJ, Smith MR, Perez PM, Hope TA, Rauscher I, Londhe A, Lopez-Gitlitz A, Cheng S, Maurer T, Herrmann K, Eiber M, Hadaschik B
Clin Cancer Res 2019 Dec 15;25(24):7448-7454. Epub 2019 Sep 11 doi: 10.1158/1078-0432.CCR-19-1050. PMID: 31511295
Mateo J, Fizazi K, Gillessen S, Heidenreich A, Perez-Lopez R, Oyen WJG, Shore N, Smith M, Sweeney C, Tombal B, Tomlins SA, de Bono JS
Eur Urol 2019 Feb;75(2):285-293. Epub 2018 Aug 14 doi: 10.1016/j.eururo.2018.07.035. PMID: 30119985
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S
Lancet Oncol 2018 Jun;19(6):825-833. Epub 2018 May 8 doi: 10.1016/S1470-2045(18)30198-0. PMID: 29752180
Scher HI, Morris MJ, Stadler WM, Higano C, Basch E, Fizazi K, Antonarakis ES, Beer TM, Carducci MA, Chi KN, Corn PG, de Bono JS, Dreicer R, George DJ, Heath EI, Hussain M, Kelly WK, Liu G, Logothetis C, Nanus D, Stein MN, Rathkopf DE, Slovin SF, Ryan CJ, Sartor O, Small EJ, Smith MR, Sternberg CN, Taplin ME, Wilding G, Nelson PS, Schwartz LH, Halabi S, Kantoff PW, Armstrong AJ; Prostate Cancer Clinical Trials Working Group 3
J Clin Oncol 2016 Apr 20;34(12):1402-18. Epub 2016 Feb 22 doi: 10.1200/JCO.2015.64.2702. PMID: 26903579Free PMC Article

Recent systematic reviews

Patell K, Kurian M, Garcia JA, Mendiratta P, Barata PC, Jia AY, Spratt DE, Brown JR
Expert Rev Anticancer Ther 2023 Jul;23(7):731-744. Epub 2023 May 24 doi: 10.1080/14737140.2023.2213892. PMID: 37194261
Cao B, Kim M, Reizine NM, Moreira DM
Eur Urol Oncol 2023 Jun;6(3):237-250. Epub 2023 Jan 20 doi: 10.1016/j.euo.2023.01.001. PMID: 36682938
Alcaraz Asensio A, Alvarez Ossorio JL, Cozar Olmo JM, Chantada Abal V, Juarez Soto A, Linares Espinos E, Moreno Jimenez J, Muñoz Rodriguez J, Perez Fentes D, Plata Bello A, Rodrigo Aliaga M, Unda Urzaiz M, Vilaseca A
Actas Urol Esp (Engl Ed) 2022 May;46(4):193-213. Epub 2022 Mar 16 doi: 10.1016/j.acuroe.2021.11.001. PMID: 35305957
Wenzel M, Nocera L, Collà Ruvolo C, Würnschimmel C, Tian Z, Shariat SF, Saad F, Tilki D, Graefen M, Kluth LA, Briganti A, Mandel P, Montorsi F, Chun FKH, Karakiewicz PI
Prostate Cancer Prostatic Dis 2022 Feb;25(2):139-148. Epub 2021 May 30 doi: 10.1038/s41391-021-00395-4. PMID: 34054128Free PMC Article
Wang L, Paller CJ, Hong H, De Felice A, Alexander GC, Brawley O
JAMA Oncol 2021 Mar 1;7(3):412-420. doi: 10.1001/jamaoncol.2020.6973. PMID: 33443584Free PMC Article

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