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Abasia

MedGen UID:
776653
•Concept ID:
C0877217
•
Finding
HPO: HP:0012651

Definition

A severe form of gait ataxia such that an affected person cannot walk at all. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbasia

Conditions with this feature

Atonic-astatic syndrome of Foerster
MedGen UID:
395300
•Concept ID:
C1859594
•
Disease or Syndrome
See: Condition Record
Atonic-astatic syndrome of Foerster

Recent clinical studies

Etiology

Functional gait disorders, clinical phenomenology, and classification.
Baizabal-Carvallo JF, Alonso-Juarez M, Jankovic J
Neurol Sci 2020 Apr;41(4):911-915. Epub 2019 Dec 12 doi: 10.1007/s10072-019-04185-8. PMID: 31832998
The "chair test" to aid in the diagnosis of psychogenic gait disorders.
Okun MS, Rodriguez RL, Foote KD, Fernandez HH
Neurologist 2007 Mar;13(2):87-91. doi: 10.1097/01.nrl.0000256358.52613.cc. PMID: 17351529
Gait abnormalities in psychogenic movement disorders.
Baik JS, Lang AE
Mov Disord 2007 Feb 15;22(3):395-9. doi: 10.1002/mds.21283. PMID: 17216648
The role of weakness of triceps surae muscles in astasia without abasia.
Hachisuka K, Ohnishi A, Yamaga M, Dozono K, Ueta M, Ogata H
J Neurol Neurosurg Psychiatry 1997 May;62(5):496-500. doi: 10.1136/jnnp.62.5.496. PMID: 9153609Free PMC Article
Pharmacokinetics and toxicity of bismuth compounds.
Slikkerveer A, de Wolff FA
Med Toxicol Adverse Drug Exp 1989 Sep-Oct;4(5):303-23. doi: 10.1007/BF03259915. PMID: 2682129

Diagnosis

From hysteria to gait dementia: History of the concept of astasia-abasia.
Walusinski O
Rev Neurol (Paris) 2023 Jun;179(6):523-532. Epub 2023 Apr 6 doi: 10.1016/j.neurol.2022.12.012. PMID: 37030986
Functional gait disorders, clinical phenomenology, and classification.
Baizabal-Carvallo JF, Alonso-Juarez M, Jankovic J
Neurol Sci 2020 Apr;41(4):911-915. Epub 2019 Dec 12 doi: 10.1007/s10072-019-04185-8. PMID: 31832998
The "chair test" to aid in the diagnosis of psychogenic gait disorders.
Okun MS, Rodriguez RL, Foote KD, Fernandez HH
Neurologist 2007 Mar;13(2):87-91. doi: 10.1097/01.nrl.0000256358.52613.cc. PMID: 17351529
Metaiodobenzylguanidine total-body scintigraphy required for revealing occult neuroblastoma in opsoclonus-myoclonus syndrome.
Swart JF, de Kraker J, van der Lely N
Eur J Pediatr 2002 May;161(5):255-8. Epub 2002 Mar 13 doi: 10.1007/s00431-002-0934-8. PMID: 12012219
Bizarre posture and movement disorder with third ventricle astrocytoma.
Hanson PA, Peck F
Dev Med Child Neurol 1977 Feb;19(1):54-7. doi: 10.1111/j.1469-8749.1977.tb08020.x. PMID: 844666

Therapy

Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models.
Ibrahim KM, Darwish SF, Mantawy EM, El-Demerdash E
Mol Cell Biochem 2024 Aug;479(8):1873-1893. Epub 2023 Jul 31 doi: 10.1007/s11010-023-04805-0. PMID: 37522975Free PMC Article
Astasia-abasia and psychogenic tremor post-temporal lobectomy.
Arabi MR, Wazne J, Nasreddine W, Najjar M, Beydoun A
Epilepsy Behav 2012 Apr;23(4):503-4. Epub 2012 Mar 3 doi: 10.1016/j.yebeh.2011.12.013. PMID: 22386590
The role of weakness of triceps surae muscles in astasia without abasia.
Hachisuka K, Ohnishi A, Yamaga M, Dozono K, Ueta M, Ogata H
J Neurol Neurosurg Psychiatry 1997 May;62(5):496-500. doi: 10.1136/jnnp.62.5.496. PMID: 9153609Free PMC Article
Astasia-abasia revealing a primary Sjögren's syndrome.
Lafforgue P, Toussirot E, Billé F, Acquaviva PC
Clin Rheumatol 1993 Jun;12(2):261-4. doi: 10.1007/BF02231539. PMID: 8358991
Pharmacokinetics and toxicity of bismuth compounds.
Slikkerveer A, de Wolff FA
Med Toxicol Adverse Drug Exp 1989 Sep-Oct;4(5):303-23. doi: 10.1007/BF03259915. PMID: 2682129

Prognosis

Elevated red blood cell distribution width is associated with poor outcome in osteoporotic vertebral fracture.
Sakai Y, Wakao N, Matsui H, Watanabe T, Iida H, Katsumi A
J Bone Miner Metab 2021 Nov;39(6):1048-1057. Epub 2021 Jul 1 doi: 10.1007/s00774-021-01242-1. PMID: 34196844
Paul Blocq and (psychogenic) astasia abasia.
Okun MS, Koehler PJ
Mov Disord 2007 Jul 30;22(10):1373-1378. doi: 10.1002/mds.21474. PMID: 17516452
The "chair test" to aid in the diagnosis of psychogenic gait disorders.
Okun MS, Rodriguez RL, Foote KD, Fernandez HH
Neurologist 2007 Mar;13(2):87-91. doi: 10.1097/01.nrl.0000256358.52613.cc. PMID: 17351529
From trepidant abasia to motor network failure--gait disorders as a consequence of subcortical vascular encephalopathy (SVE): review of historical and contemporary concepts.
Baezner H, Hennerici M
J Neurol Sci 2005 Mar 15;229-230:81-8. Epub 2004 Dec 19 doi: 10.1016/j.jns.2004.11.008. PMID: 15760624
Metaiodobenzylguanidine total-body scintigraphy required for revealing occult neuroblastoma in opsoclonus-myoclonus syndrome.
Swart JF, de Kraker J, van der Lely N
Eur J Pediatr 2002 May;161(5):255-8. Epub 2002 Mar 13 doi: 10.1007/s00431-002-0934-8. PMID: 12012219

Clinical prediction guides

Functional gait disorders: Demographic and clinical correlations.
Tinazzi M, Pilotto A, Morgante F, Marcuzzo E, Cuoco S, Ceravolo R, Mazzucchi S, Padovani A, Romito LM, Eleopra R, Nicoletti A, Dallocchio C, Arbasino C, Bono F, Magro G, Demartini B, Gambini O, Modugno N, Olivola E, Bonanni L, Zanolin E, Albanese A, Ferrazzano G, Tessitore A, Lopiano L, Calandra-Buonaura G, Petracca M, Esposito M, Pisani A, Manganotti P, Tesolin L, Teatini F, Defazio G, Ercoli T, Stocchi F, Erro R, Zappia M, Geroin C
Parkinsonism Relat Disord 2021 Oct;91:32-36. Epub 2021 Aug 25 doi: 10.1016/j.parkreldis.2021.08.012. PMID: 34479056
Elevated red blood cell distribution width is associated with poor outcome in osteoporotic vertebral fracture.
Sakai Y, Wakao N, Matsui H, Watanabe T, Iida H, Katsumi A
J Bone Miner Metab 2021 Nov;39(6):1048-1057. Epub 2021 Jul 1 doi: 10.1007/s00774-021-01242-1. PMID: 34196844
Functional gait disorders, clinical phenomenology, and classification.
Baizabal-Carvallo JF, Alonso-Juarez M, Jankovic J
Neurol Sci 2020 Apr;41(4):911-915. Epub 2019 Dec 12 doi: 10.1007/s10072-019-04185-8. PMID: 31832998
Paul Blocq and (psychogenic) astasia abasia.
Okun MS, Koehler PJ
Mov Disord 2007 Jul 30;22(10):1373-1378. doi: 10.1002/mds.21474. PMID: 17516452
The "chair test" to aid in the diagnosis of psychogenic gait disorders.
Okun MS, Rodriguez RL, Foote KD, Fernandez HH
Neurologist 2007 Mar;13(2):87-91. doi: 10.1097/01.nrl.0000256358.52613.cc. PMID: 17351529

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