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Dyssynergia

MedGen UID:
13945
Concept ID:
C0004134
Sign or Symptom
Synonym: Ataxia
SNOMED CT: Ataxia (loss of muscle coordination) (20262006); Ataxia (20262006); Dyssynergia (39384006)
 
HPO: HP:0010867

Definition

A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDyssynergia

Professional guidelines

PubMed

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Bunni J, Laugharne MJ
Langenbecks Arch Surg 2023 Feb 2;408(1):75. doi: 10.1007/s00423-023-02755-1. PMID: 36729157
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group
Neurogastroenterol Motil 2020 Jan;32(1):e13679. Epub 2019 Aug 12 doi: 10.1111/nmo.13679. PMID: 31407463Free PMC Article

Recent clinical studies

Etiology

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group
Neurogastroenterol Motil 2020 Jan;32(1):e13679. Epub 2019 Aug 12 doi: 10.1111/nmo.13679. PMID: 31407463Free PMC Article
Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G
World J Urol 2018 Oct;36(10):1517-1527. Epub 2018 May 11 doi: 10.1007/s00345-018-2301-z. PMID: 29752515
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584

Diagnosis

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Damianos JA, Tomar SK, Azpiroz F, Barba E
Am J Gastroenterol 2023 Jan 1;118(1):41-45. Epub 2022 Sep 30 doi: 10.14309/ajg.0000000000002044. PMID: 36191283Free PMC Article
Felt-Bersma RJF
Curr Opin Gastroenterol 2021 Jan;37(1):59-65. doi: 10.1097/MOG.0000000000000689. PMID: 33060396
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584

Therapy

Santucci NR, Chogle A, Leiby A, Mascarenhas M, Borlack RE, Lee A, Perez M, Russell A, Yeh AM
Complement Ther Med 2021 Jun;59:102711. Epub 2021 Mar 15 doi: 10.1016/j.ctim.2021.102711. PMID: 33737146
Cariati M, Chiarello MM, Cannistra' M, Lerose MA, Brisinda G
Handb Exp Pharmacol 2021;263:185-226. doi: 10.1007/164_2019_326. PMID: 32072269
Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584
Lacy BE, Loew B, Crowell MD
Drugs Today (Barc) 2009 Dec;45(12):843-53. doi: 10.1358/dot.2009.45.12.1423115. PMID: 20135019
McGuire EJ, Brady S
J Urol 1979 Jun;121(6):774-7. doi: 10.1016/s0022-5347(17)56987-6. PMID: 458950

Prognosis

Quigley EMM
Semin Neurol 2023 Aug;43(4):562-571. Epub 2023 Aug 14 doi: 10.1055/s-0043-1771457. PMID: 37579786
Blackett JW, Gautam M, Mishra R, Oblizajek NR, Kathavarayan Ramu S, Bailey KR, Bharucha AE
Gastroenterology 2022 Dec;163(6):1582-1592.e2. Epub 2022 Aug 19 doi: 10.1053/j.gastro.2022.08.034. PMID: 35995074Free PMC Article
Neshatian L, Williams MOU, Quigley EM
Dig Dis Sci 2021 Jul;66(7):2345-2352. Epub 2020 Aug 5 doi: 10.1007/s10620-020-06519-5. PMID: 32761289
Maison POM, Lazarus J
Paediatr Int Child Health 2017 Nov;37(4):280-285. Epub 2017 Jul 17 doi: 10.1080/20469047.2017.1351745. PMID: 28714784
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859

Clinical prediction guides

Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Srinivasan SG, Muthyala A, Sharma M, Feuerhak K, Boon A, Bailey KR, Bharucha AE
Clin Gastroenterol Hepatol 2022 Sep;20(9):2091-2101.e5. Epub 2021 Dec 8 doi: 10.1016/j.cgh.2021.11.040. PMID: 34896282Free PMC Article
Kour S, Rajan DS, Fortuna TR, Anderson EN, Ward C, Lee Y, Lee S, Shin YB, Chae JH, Choi M, Siquier K, Cantagrel V, Amiel J, Stolerman ES, Barnett SS, Cousin MA, Castro D, McDonald K, Kirmse B, Nemeth AH, Rajasundaram D, Innes AM, Lynch D, Frosk P, Collins A, Gibbons M, Yang M, Desguerre I, Boddaert N, Gitiaux C, Rydning SL, Selmer KK, Urreizti R, Garcia-Oguiza A, Osorio AN, Verdura E, Pujol A, McCurry HR, Landers JE, Agnihotri S, Andriescu EC, Moody SB, Phornphutkul C, Sacoto MJG, Begtrup A, Houlden H, Kirschner J, Schorling D, Rudnik-Schöneborn S, Strom TM, Leiz S, Juliette K, Richardson R, Yang Y, Zhang Y, Wang M, Wang J, Wang X, Platzer K, Donkervoort S, Bönnemann CG, Wagner M, Issa MY, Elbendary HM, Stanley V, Maroofian R, Gleeson JG, Zaki MS, Senderek J, Pandey UB
Nat Commun 2021 May 7;12(1):2558. doi: 10.1038/s41467-021-22627-w. PMID: 33963192Free PMC Article
Cariati M, Chiarello MM, Cannistra' M, Lerose MA, Brisinda G
Handb Exp Pharmacol 2021;263:185-226. doi: 10.1007/164_2019_326. PMID: 32072269
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775

Recent systematic reviews

Chaichanavichkij P, Vollebregt PF, Scott SM, Knowles CH
Colorectal Dis 2020 Dec;22(12):1832-1841. Epub 2020 Jun 11 doi: 10.1111/codi.15120. PMID: 32403161
Whitehead WE, Palsson OS, Simrén M
Neurogastroenterol Motil 2016 Jun;28(6):783-92. doi: 10.1111/nmo.12852. PMID: 27214096
Liu N, Zhou M, Biering-Sørensen F, Krassioukov AV
Spinal Cord 2015 Jul;53(7):500-9. Epub 2015 Mar 24 doi: 10.1038/sc.2015.39. PMID: 25800696
Mangera A, Apostolidis A, Andersson KE, Dasgupta P, Giannantoni A, Roehrborn C, Novara G, Chapple C
Eur Urol 2014 May;65(5):981-90. Epub 2013 Nov 1 doi: 10.1016/j.eururo.2013.10.033. PMID: 24239446
Rao SS, Ozturk R, Laine L
Am J Gastroenterol 2005 Jul;100(7):1605-15. doi: 10.1111/j.1572-0241.2005.41845.x. PMID: 15984989

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