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Adult Diffuse Large Cell Lymphoma

MedGen UID:
78882
Concept ID:
C0278762
Neoplastic Process

Definition

A B-or T-cell non-Hodgkin lymphoma composed of a diffuse large cell lymphocytic infiltrate occurring in adults. [from NCI]

Professional guidelines

PubMed

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Di M, Huntington SF, Olszewski AJ
Oncologist 2021 Feb;26(2):120-132. Epub 2020 Dec 9 doi: 10.1002/onco.13610. PMID: 33230948Free PMC Article

Recent clinical studies

Etiology

El Hussein S, Medeiros LJ, Lyapichev KA, Fang H, Jelloul FZ, Fiskus W, Chen J, Wei P, Schlette E, Xu J, Li S, Kanagal-Shamanna R, Yang H, Tang Z, Thakral B, Loghavi S, Jain N, Thompson PA, Ferrajoli A, Wierda WG, Jabbour E, Patel KP, Dabaja BS, Bhalla KN, Khoury JD
Pathology 2023 Jun;55(4):514-524. Epub 2023 Feb 25 doi: 10.1016/j.pathol.2022.12.354. PMID: 36933995
Lacy SE, Barrans SL, Beer PA, Painter D, Smith AG, Roman E, Cooke SL, Ruiz C, Glover P, Van Hoppe SJL, Webster N, Campbell PJ, Tooze RM, Patmore R, Burton C, Crouch S, Hodson DJ
Blood 2020 May 14;135(20):1759-1771. doi: 10.1182/blood.2019003535. PMID: 32187361Free PMC Article
Ramis-Zaldivar JE, Gonzalez-Farré B, Balagué O, Celis V, Nadeu F, Salmerón-Villalobos J, Andrés M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Bárcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdú-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera P, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I
Blood 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699. PMID: 31738823Free PMC Article
Chiappella A, Castellino A, Nicolosi M, Santambrogio E, Vitolo U
Expert Rev Hematol 2017 Apr;10(4):289-297. Epub 2017 Mar 27 doi: 10.1080/17474086.2017.1305264. PMID: 28290728
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551

Diagnosis

Goldman S, Cairo MS
Best Pract Res Clin Haematol 2023 Jun;36(2):101463. Epub 2023 Apr 2 doi: 10.1016/j.beha.2023.101463. PMID: 37353299
El Hussein S, Medeiros LJ, Lyapichev KA, Fang H, Jelloul FZ, Fiskus W, Chen J, Wei P, Schlette E, Xu J, Li S, Kanagal-Shamanna R, Yang H, Tang Z, Thakral B, Loghavi S, Jain N, Thompson PA, Ferrajoli A, Wierda WG, Jabbour E, Patel KP, Dabaja BS, Bhalla KN, Khoury JD
Pathology 2023 Jun;55(4):514-524. Epub 2023 Feb 25 doi: 10.1016/j.pathol.2022.12.354. PMID: 36933995
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Chiappella A, Castellino A, Nicolosi M, Santambrogio E, Vitolo U
Expert Rev Hematol 2017 Apr;10(4):289-297. Epub 2017 Mar 27 doi: 10.1080/17474086.2017.1305264. PMID: 28290728
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551

Therapy

Izutsu K, Kumode T, Yuda J, Nagai H, Mishima Y, Suehiro Y, Yamamoto K, Fujisaki T, Ishitsuka K, Ishizawa K, Ikezoe T, Nishikori M, Akahane D, Fujita J, Dinh M, Soong D, Noguchi H, Buchbjerg JK, Favaro E, Fukuhara N
Cancer Sci 2023 Dec;114(12):4643-4653. Epub 2023 Nov 3 doi: 10.1111/cas.15996. PMID: 37921363Free PMC Article
Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators
N Engl J Med 2019 Jan 3;380(1):45-56. Epub 2018 Dec 1 doi: 10.1056/NEJMoa1804980. PMID: 30501490
Crump M, Neelapu SS, Farooq U, Van Den Neste E, Kuruvilla J, Westin J, Link BK, Hay A, Cerhan JR, Zhu L, Boussetta S, Feng L, Maurer MJ, Navale L, Wiezorek J, Go WY, Gisselbrecht C
Blood 2017 Oct 19;130(16):1800-1808. Epub 2017 Aug 3 doi: 10.1182/blood-2017-03-769620. PMID: 28774879Free PMC Article
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551
Gisselbrecht C, Glass B, Mounier N, Singh Gill D, Linch DC, Trneny M, Bosly A, Ketterer N, Shpilberg O, Hagberg H, Ma D, Brière J, Moskowitz CH, Schmitz N
J Clin Oncol 2010 Sep 20;28(27):4184-90. Epub 2010 Jul 26 doi: 10.1200/JCO.2010.28.1618. PMID: 20660832Free PMC Article

Prognosis

Wang F, Du Z
Medicine (Baltimore) 2023 Dec 15;102(50):e36464. doi: 10.1097/MD.0000000000036464. PMID: 38115350Free PMC Article
Rossi A, Orecchioni S, Falvo P, Tabanelli V, Baiardi E, Agostinelli C, Melle F, Motta G, Calleri A, Fiori S, Corsini C, Casadei B, Mazzara S, Vitolo U, Bertolini F, Zinzani PL, Alcalay M, Pelicci PG, Pileri S, Tarella C, Derenzini E
Leukemia 2022 Jan;36(1):197-209. Epub 2021 Jul 24 doi: 10.1038/s41375-021-01347-6. PMID: 34304248Free PMC Article
Ying Z, Yang H, Guo Y, Li W, Zou D, Zhou D, Wang Z, Zhang M, Wu J, Liu H, Zhang P, Yang S, Zhou Z, Zheng H, Song Y, Zhu J
Cancer Med 2021 Feb;10(3):999-1011. Epub 2020 Dec 31 doi: 10.1002/cam4.3686. PMID: 33382529Free PMC Article
Mounier N, El Gnaoui T, Tilly H, Canioni D, Sebban C, Casasnovas RO, Delarue R, Sonet A, Beaussart P, Petrella T, Castaigne S, Bologna S, Salles G, Rahmouni A, Gaulard P, Haioun C
Haematologica 2013 Nov;98(11):1726-31. Epub 2013 Jun 10 doi: 10.3324/haematol.2013.090597. PMID: 23753028Free PMC Article
Coiffier B
Curr Opin Oncol 2001 Sep;13(5):325-34. doi: 10.1097/00001622-200109000-00003. PMID: 11555708

Clinical prediction guides

Shouse G, Danilov AV, Artz A
Curr Oncol Rep 2022 Sep;24(9):1189-1199. Epub 2022 Apr 14 doi: 10.1007/s11912-022-01272-6. PMID: 35420395
Kondo E
J Clin Exp Hematop 2016;56(2):100-108. doi: 10.3960/jslrt.56.100. PMID: 27980299Free PMC Article
Bhatt VR, Mourya R, Shrestha R, Armitage JO
Cancer Treat Rev 2015 Jun;41(6):476-85. Epub 2015 Apr 21 doi: 10.1016/j.ctrv.2015.04.006. PMID: 25913715
Testoni M, Zucca E, Young KH, Bertoni F
Ann Oncol 2015 Jun;26(6):1069-1080. Epub 2015 Jan 20 doi: 10.1093/annonc/mdv019. PMID: 25605746Free PMC Article
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551

Recent systematic reviews

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Khanmohammadi S, Fallahtafti P
J Cell Mol Med 2023 Jul;27(14):1928-1946. Epub 2023 May 29 doi: 10.1111/jcmm.17795. PMID: 37246627Free PMC Article
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Tavares A, Moreira I
Crit Rev Oncol Hematol 2021 Apr;160:103294. Epub 2021 Mar 3 doi: 10.1016/j.critrevonc.2021.103294. PMID: 33675907
Li J, Zhao S, Wang J, Chen J, Wen W, Zhang Q
Tumour Biol 2016 Mar;37(3):3619-37. Epub 2015 Oct 12 doi: 10.1007/s13277-015-4205-5. PMID: 26459310

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