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Adult medulloblastoma

MedGen UID:
78898
•Concept ID:
C0278876
•
Neoplastic Process
Synonyms: Adult Medulloblastoma; Adult Medulloblastomas; Medulloblastoma, Adult; Medulloblastomas, Adult
 
Monarch Initiative: MONDO:0002794

Definition

A medulloblastoma occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult medulloblastoma

Professional guidelines

PubMed

Medulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol.
Bleeker L, Kouwenhoven MCM, de Heer I, Lissenberg-Witte BI, Gijsbers AH, Dubbink HJ, Kros JM, Gijtenbeek JMM, Kurt E, van der Rijt CCD, Swaak-Kragten AT, de Vos FY, van der Weide HL, French PJ, van den Bent MJ, Wesseling P, Bromberg JEC
J Neurooncol 2023 Mar;162(1):225-235. Epub 2023 Mar 15 doi: 10.1007/s11060-023-04285-8. PMID: 36920679Free PMC Article
The Role of Chemotherapy in the Treatment of Adult Medulloblastoma.
Chen B, Chen C, Zhao Y, Cui W, Xu J
World Neurosurg 2022 Jul;163:e435-e449. Epub 2022 Apr 6 doi: 10.1016/j.wneu.2022.04.004. PMID: 35398321
Updates on Management of Adult Medulloblastoma.
Majd N, Penas-Prado M
Curr Treat Options Oncol 2019 Jun 24;20(8):64. doi: 10.1007/s11864-019-0663-0. PMID: 31236711

Recent clinical studies

Etiology

Differentiating between adult intracranial medulloblastoma and ependymoma using MRI.
Deng J, Xue C, Liu X, Li S, Zhou J
Clin Radiol 2023 Mar;78(3):e288-e293. Epub 2023 Jan 2 doi: 10.1016/j.crad.2022.11.016. PMID: 36646528
Adult medulloblastoma in an Australian population.
Parakh S, Davies A, Westcott K, Roos D, Abou-Hamden A, Ahern E, Lau PKH, Cheruvu S, Pranavan G, Pullar A, Lynam J, Gzell C, Whittle JR, Cain S, Inglis PL, Harrup R, Anazodo A, Hovey E, Cher L, Gan HK
J Clin Neurosci 2022 Aug;102:65-70. Epub 2022 Jun 18 doi: 10.1016/j.jocn.2022.06.008. PMID: 35728397
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, Stichel D, von Deimling A, Giannini C, Raskin S, Van Meir EG, Chan JA, Fults D, Chambless LB, Kim SK, Vasiljevic A, Faure-Conter C, Vibhakar R, Jung S, Leary S, Mora J, McLendon RE, Pollack IF, Hauser P, Grajkowska WA, Rubin JB, van Veelen MC, French PJ, Kros JM, Liau LM, Pfister SM, Kool M, Kijima N, Taylor MD, Packer RJ, Northcott PA, Korshunov A, Ramaswamy V
Acta Neuropathol 2021 Nov;142(5):859-871. Epub 2021 Aug 18 doi: 10.1007/s00401-021-02358-4. PMID: 34409497Free PMC Article
Clinical and mutational profiles of adult medulloblastoma groups.
Wong GC, Li KK, Wang WW, Liu AP, Huang QJ, Chan AK, Poon MF, Chung NY, Wong QH, Chen H, Chan DTM, Liu XZ, Mao Y, Zhang ZY, Shi ZF, Ng HK
Acta Neuropathol Commun 2020 Nov 10;8(1):191. doi: 10.1186/s40478-020-01066-6. PMID: 33172502Free PMC Article
Updates on Management of Adult Medulloblastoma.
Majd N, Penas-Prado M
Curr Treat Options Oncol 2019 Jun 24;20(8):64. doi: 10.1007/s11864-019-0663-0. PMID: 31236711

Diagnosis

Medulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol.
Bleeker L, Kouwenhoven MCM, de Heer I, Lissenberg-Witte BI, Gijsbers AH, Dubbink HJ, Kros JM, Gijtenbeek JMM, Kurt E, van der Rijt CCD, Swaak-Kragten AT, de Vos FY, van der Weide HL, French PJ, van den Bent MJ, Wesseling P, Bromberg JEC
J Neurooncol 2023 Mar;162(1):225-235. Epub 2023 Mar 15 doi: 10.1007/s11060-023-04285-8. PMID: 36920679Free PMC Article
Differentiating between adult intracranial medulloblastoma and ependymoma using MRI.
Deng J, Xue C, Liu X, Li S, Zhou J
Clin Radiol 2023 Mar;78(3):e288-e293. Epub 2023 Jan 2 doi: 10.1016/j.crad.2022.11.016. PMID: 36646528
Adult medulloblastoma in an Australian population.
Parakh S, Davies A, Westcott K, Roos D, Abou-Hamden A, Ahern E, Lau PKH, Cheruvu S, Pranavan G, Pullar A, Lynam J, Gzell C, Whittle JR, Cain S, Inglis PL, Harrup R, Anazodo A, Hovey E, Cher L, Gan HK
J Clin Neurosci 2022 Aug;102:65-70. Epub 2022 Jun 18 doi: 10.1016/j.jocn.2022.06.008. PMID: 35728397
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, Stichel D, von Deimling A, Giannini C, Raskin S, Van Meir EG, Chan JA, Fults D, Chambless LB, Kim SK, Vasiljevic A, Faure-Conter C, Vibhakar R, Jung S, Leary S, Mora J, McLendon RE, Pollack IF, Hauser P, Grajkowska WA, Rubin JB, van Veelen MC, French PJ, Kros JM, Liau LM, Pfister SM, Kool M, Kijima N, Taylor MD, Packer RJ, Northcott PA, Korshunov A, Ramaswamy V
Acta Neuropathol 2021 Nov;142(5):859-871. Epub 2021 Aug 18 doi: 10.1007/s00401-021-02358-4. PMID: 34409497Free PMC Article
Updates on Management of Adult Medulloblastoma.
Majd N, Penas-Prado M
Curr Treat Options Oncol 2019 Jun 24;20(8):64. doi: 10.1007/s11864-019-0663-0. PMID: 31236711

Therapy

Medulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol.
Bleeker L, Kouwenhoven MCM, de Heer I, Lissenberg-Witte BI, Gijsbers AH, Dubbink HJ, Kros JM, Gijtenbeek JMM, Kurt E, van der Rijt CCD, Swaak-Kragten AT, de Vos FY, van der Weide HL, French PJ, van den Bent MJ, Wesseling P, Bromberg JEC
J Neurooncol 2023 Mar;162(1):225-235. Epub 2023 Mar 15 doi: 10.1007/s11060-023-04285-8. PMID: 36920679Free PMC Article
Adult Medulloblastoma Demographic, Tumor and Treatment Impact since 2006: A Canadian University Experience.
Quinones MC, Bélanger K, Lemieux Blanchard É, Lemieux B, Bahary JP, Masucci LG, Roberge D, Menard C, Lambert C, Berthelet F, Moumdjian R, Florescu M
Curr Oncol 2021 Aug 14;28(4):3104-3114. doi: 10.3390/curroncol28040271. PMID: 34436037Free PMC Article
Proton therapy for adult medulloblastoma: Acute toxicity and disease control outcomes.
Liu IC, Holtzman AL, Rotondo RL, Indelicato DJ, Gururangan S, Cavaliere R, Carter B, Morris CG, Tavanaiepour D, Rutenberg MS
J Neurooncol 2021 Jul;153(3):467-476. Epub 2021 Jun 8 doi: 10.1007/s11060-021-03783-x. PMID: 34105033
Updates on Management of Adult Medulloblastoma.
Majd N, Penas-Prado M
Curr Treat Options Oncol 2019 Jun 24;20(8):64. doi: 10.1007/s11864-019-0663-0. PMID: 31236711
The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature.
Balducci M, Chiesa S, Chieffo D, Manfrida S, Dinapoli N, Fiorentino A, Miccichè F, Frascino V, Anile C, Valentini V, De Bari B
J Neurooncol 2012 Jan;106(2):315-23. Epub 2011 Jul 31 doi: 10.1007/s11060-011-0665-7. PMID: 21805324

Prognosis

Medulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol.
Bleeker L, Kouwenhoven MCM, de Heer I, Lissenberg-Witte BI, Gijsbers AH, Dubbink HJ, Kros JM, Gijtenbeek JMM, Kurt E, van der Rijt CCD, Swaak-Kragten AT, de Vos FY, van der Weide HL, French PJ, van den Bent MJ, Wesseling P, Bromberg JEC
J Neurooncol 2023 Mar;162(1):225-235. Epub 2023 Mar 15 doi: 10.1007/s11060-023-04285-8. PMID: 36920679Free PMC Article
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, Stichel D, von Deimling A, Giannini C, Raskin S, Van Meir EG, Chan JA, Fults D, Chambless LB, Kim SK, Vasiljevic A, Faure-Conter C, Vibhakar R, Jung S, Leary S, Mora J, McLendon RE, Pollack IF, Hauser P, Grajkowska WA, Rubin JB, van Veelen MC, French PJ, Kros JM, Liau LM, Pfister SM, Kool M, Kijima N, Taylor MD, Packer RJ, Northcott PA, Korshunov A, Ramaswamy V
Acta Neuropathol 2021 Nov;142(5):859-871. Epub 2021 Aug 18 doi: 10.1007/s00401-021-02358-4. PMID: 34409497Free PMC Article
Clinical and mutational profiles of adult medulloblastoma groups.
Wong GC, Li KK, Wang WW, Liu AP, Huang QJ, Chan AK, Poon MF, Chung NY, Wong QH, Chen H, Chan DTM, Liu XZ, Mao Y, Zhang ZY, Shi ZF, Ng HK
Acta Neuropathol Commun 2020 Nov 10;8(1):191. doi: 10.1186/s40478-020-01066-6. PMID: 33172502Free PMC Article
Updates on Management of Adult Medulloblastoma.
Majd N, Penas-Prado M
Curr Treat Options Oncol 2019 Jun 24;20(8):64. doi: 10.1007/s11864-019-0663-0. PMID: 31236711
Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers.
Shonka N, Brandes A, De Groot JF
Oncology (Williston Park) 2012 Nov;26(11):1083-91. PMID: 23330353

Clinical prediction guides

The Role of Chemotherapy in the Treatment of Adult Medulloblastoma.
Chen B, Chen C, Zhao Y, Cui W, Xu J
World Neurosurg 2022 Jul;163:e435-e449. Epub 2022 Apr 6 doi: 10.1016/j.wneu.2022.04.004. PMID: 35398321
Clinical Audit of Survival Outcomes and Prognostic Factors in Adolescents and Adults with Medulloblastoma.
Patil R, Gupta T, Maitre M, Dasgupta A, Sahay A, Epari S, Shirsat N, Chatterjee A, Krishnatry R, Goda JS, Moiyadi A, Patil V, Chinnaswamy G, Bano N, Jalali R
J Adolesc Young Adult Oncol 2022 Feb;11(1):68-77. Epub 2021 Apr 23 doi: 10.1089/jayao.2021.0034. PMID: 33891492Free PMC Article
Neurocognitive dysfunction in adult cerebellar medulloblastoma.
Harrison RA, Kesler SR, Johnson JM, Penas-Prado M, Sullaway CM, Wefel JS
Psychooncology 2019 Jan;28(1):131-138. Epub 2018 Nov 5 doi: 10.1002/pon.4920. PMID: 30315720
The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature.
Balducci M, Chiesa S, Chieffo D, Manfrida S, Dinapoli N, Fiorentino A, Miccichè F, Frascino V, Anile C, Valentini V, De Bari B
J Neurooncol 2012 Jan;106(2):315-23. Epub 2011 Jul 31 doi: 10.1007/s11060-011-0665-7. PMID: 21805324
FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma.
Ramaswamy V, Northcott PA, Taylor MD
Cancer Genet 2011 Nov;204(11):577-88. doi: 10.1016/j.cancergen.2011.11.001. PMID: 22200083

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