Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Hypercortisolism

MedGen UID:: 7899
•Concept ID:: C0001622
•: Disease or Syndrome

Synonyms:	Adrenocortical hyperfunction; Hyperadrenalism; Overproduction of cortisol
SNOMED CT:	Disorder of corticoadrenal overactivity (275437005); Adrenocortical hyperfunction (275437005); Hypercortisolism (47270006); Overproduction of cortisol (47270006); Hypercorticism (47270006)

Monarch Initiative:	MONDO:0006640

Definition

Abnormally high level of cortisol in the blood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHypercortisolism

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of endocrine system
        Disorder of adrenal gland
        Hypercortisolism
        Cushing syndrome
        ACTH-dependent Cushing syndrome
        Ectopic Cushing syndrome
        Pituitary dependent hypercortisolism
        ACTH-independent Cushing syndrome
        ACTH-independent Cushing syndrome due to rare cortisol-producing adrenal tumor
        Cushing syndrome due to macronodular adrenal hyperplasia
        Primary pigmented nodular adrenocortical disease
        Endogenous Cushing syndrome
        Recurrent Endogenous Cushing Syndrome
        Iatrogenic Cushing disease
        Hyperaldosteronism
        Bartter syndrome
        Antenatal Bartter syndrome
        Bartter disease type 1
        Bartter disease type 2
        Bartter disease type 3
        Bartter disease type 5
        Bartter disease type 4A
        Bartter disease type 4B
        Bartter syndrome type 4
        Bartter syndrome with hypocalcemia
        Familial hyperaldosteronism
        Familial hyperaldosteronism type II
        Familial hyperaldosteronism type III
        Glucocorticoid-remediable aldosteronism
        Primary aldosteronism
        Dexamethasone-suppressible primary hyperaldosteronism
        Glucocortocoid-insensitive primary hyperaldosteronism
        Secondary hyperaldosteronism

Professional guidelines

PubMed

Cushing's syndrome: Treatment and new therapeutic approaches.

Ferriere A, Tabarin A
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101381. Epub 2020 Jan 30 doi: 10.1016/j.beem.2020.101381. PMID: 32035797

Diagnosis and Treatment of Pituitary Adenomas: A Review.

Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Cushing's Syndrome: Screening and Diagnosis.

Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

See all (213)

Recent clinical studies

Etiology

Possible, probable, and certain hypercortisolism: A continuum in the risk of comorbidity.

Araujo-Castro M, Pascual-Corrales E, Lamas C
Ann Endocrinol (Paris) 2023 Apr;84(2):272-284. Epub 2023 Feb 1 doi: 10.1016/j.ando.2023.01.005. PMID: 36736771

Efficacy and Safety of Osilodrostat in Paraneoplastic Cushing Syndrome: A Real-World Multicenter Study in France.

Dormoy A, Haissaguerre M, Vitellius G, Do Cao C, Geslot A, Drui D, Lasolle H, Vieira-Pinto O, Salenave S, François M, Puerto M, Boullay HD, Mayer A, Rod A, Laurent C, Chanson P, Reznik Y, Castinetti F, Chabre O, Baudin E, Raverot G, Tabarin A, Young J
J Clin Endocrinol Metab 2023 May 17;108(6):1475-1487. doi: 10.1210/clinem/dgac691. PMID: 36470583 Free PMC Article

Cushing's Syndrome: Screening and Diagnosis.

Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

Adrenal incidentaloma.

Arnaldi G, Boscaro M
Best Pract Res Clin Endocrinol Metab 2012 Aug;26(4):405-19. Epub 2012 May 22 doi: 10.1016/j.beem.2011.12.006. PMID: 22863384

Side effects of corticosteroid therapy.

Buchman AL
J Clin Gastroenterol 2001 Oct;33(4):289-94. doi: 10.1097/00004836-200110000-00006. PMID: 11588541

See all (1031)

Diagnosis

Cushing Syndrome: A Review.

Reincke M, Fleseriu M
JAMA 2023 Jul 11;330(2):170-181. doi: 10.1001/jama.2023.11305. PMID: 37432427

Cushing's disease.

Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112

Cushing's syndrome: Treatment and new therapeutic approaches.

Ferriere A, Tabarin A
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101381. Epub 2020 Jan 30 doi: 10.1016/j.beem.2020.101381. PMID: 32035797

Diagnosis of Cushing's Syndrome in the Modern Era.

Nieman LK
Endocrinol Metab Clin North Am 2018 Jun;47(2):259-273. doi: 10.1016/j.ecl.2018.02.001. PMID: 29754631

Diagnosis and Treatment of Pituitary Adenomas: A Review.

Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

See all (1222)

Therapy

Cushing's disease: adrenal steroidogenesis inhibitors.

Pivonello R, Simeoli C, Di Paola N, Colao A
Pituitary 2022 Oct;25(5):726-732. Epub 2022 Aug 29 doi: 10.1007/s11102-022-01262-8. PMID: 36036308 Free PMC Article

Cushing's disease.

Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112

Cushing's syndrome: Treatment and new therapeutic approaches.

Ferriere A, Tabarin A
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101381. Epub 2020 Jan 30 doi: 10.1016/j.beem.2020.101381. PMID: 32035797

Diagnosis and Treatment of Pituitary Adenomas: A Review.

Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Cushing's Syndrome: Screening and Diagnosis.

Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

See all (664)

Prognosis

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.

Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301

Cushing's disease.

Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112

Cushing's Syndrome: Screening and Diagnosis.

Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

Cushing's syndrome.

Lacroix A, Feelders RA, Stratakis CA, Nieman LK
Lancet 2015 Aug 29;386(9996):913-27. Epub 2015 May 21 doi: 10.1016/S0140-6736(14)61375-1. PMID: 26004339

Side effects of corticosteroid therapy.

Buchman AL
J Clin Gastroenterol 2001 Oct;33(4):289-94. doi: 10.1097/00004836-200110000-00006. PMID: 11588541

See all (507)

Clinical prediction guides

Cushing Syndrome: A Review.

Reincke M, Fleseriu M
JAMA 2023 Jul 11;330(2):170-181. doi: 10.1001/jama.2023.11305. PMID: 37432427

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.

Approach to the Patient: Diagnosis of Cushing Syndrome.

Savas M, Mehta S, Agrawal N, van Rossum EFC, Feelders RA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3162-3174. doi: 10.1210/clinem/dgac492. PMID: 36036941 Free PMC Article

Diagnosis and Treatment of Pituitary Adenomas: A Review.

Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Cushing's Syndrome: Screening and Diagnosis.

Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

See all (664)

Recent systematic reviews

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.

Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis.

Mondin A, Barbot M, Voltan G, Tizianel I, Vedolin CK, Mazzeo P, Lazzara M, Boscaro M, Scaroni C, Ceccato F
J Endocrinol Invest 2023 Oct;46(10):1947-1959. Epub 2023 Apr 20 doi: 10.1007/s40618-023-02099-z. PMID: 37079177 Free PMC Article

Time to Diagnosis in Cushing's Syndrome: A Meta-Analysis Based on 5367 Patients.

Rubinstein G, Osswald A, Hoster E, Losa M, Elenkova A, Zacharieva S, Machado MC, Hanzu FA, Zopp S, Ritzel K, Riester A, Braun LT, Kreitschmann-Andermahr I, Storr HL, Bansal P, Barahona MJ, Cosaro E, Dogansen SC, Johnston PC, Santos de Oliveira R, Raftopoulos C, Scaroni C, Valassi E, van der Werff SJA, Schopohl J, Beuschlein F, Reincke M
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgz136. PMID: 31665382

Cushing's syndrome and pregnancy outcomes: a systematic review of published cases.

Caimari F, Valassi E, Garbayo P, Steffensen C, Santos A, Corcoy R, Webb SM
Endocrine 2017 Feb;55(2):555-563. Epub 2016 Oct 4 doi: 10.1007/s12020-016-1117-0. PMID: 27704478

Silent corticotroph adenomas.

Cooper O
Pituitary 2015 Apr;18(2):225-31. doi: 10.1007/s11102-014-0624-3. PMID: 25534889 Free PMC Article

See all (38)

MedGen

National Center for Biotechnology Information

Send to:

Hypercortisolism

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity