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Childhood acute megakaryoblastic leukemia

MedGen UID:
79023
•Concept ID:
C0279650
•
Neoplastic Process
Synonyms: Childhood Acute M7 Leukemia; Childhood Acute Megakaryoblastic Leukemia; childhood acute megakaryoblastic leukemia; Childhood Acute Megakaryocytic Leukemia; Childhood Acute Megakaryocytic Leukemia (M7); M7 Childhood Acute Megakaryocytic Leukemia; M7 Pediatric Acute Megakaryocytic Leukemia; Pediatric Acute M7 Leukemia; Pediatric Acute Megakaryoblastic Leukemia; Pediatric Acute Megakaryocytic Leukemia
 
Monarch Initiative: MONDO:0850267

Definition

An acute megakaryoblastic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood acute megakaryoblastic leukemia

Professional guidelines

PubMed

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.
Wiggers CRM, Govers AMAP, Lelieveld D, Egan DA, Zwaan CM, Sonneveld E, Coffer PJ, Bartels M
Pediatr Blood Cancer 2019 Aug;66(8):e27785. Epub 2019 May 1 doi: 10.1002/pbc.27785. PMID: 31044544

Recent clinical studies

Etiology

Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience.
Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome.
Savaşan S, Buck S, Raimondi SC, Becton DL, Weinstein H, Chang M, Ravindranath Y
Leuk Lymphoma 2006 Oct;47(10):2076-83. doi: 10.1080/10428190600773180. PMID: 17071479
Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience.
Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC
Blood 2001 Jun 15;97(12):3727-32. doi: 10.1182/blood.v97.12.3727. PMID: 11389009
Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases.
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Diagnosis

Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia.
Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience.
Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience.
Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC
Blood 2001 Jun 15;97(12):3727-32. doi: 10.1182/blood.v97.12.3727. PMID: 11389009
Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases.
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Therapy

Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia.
Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia.
Kandi R, Gutti U, Saladi RG, Gutti RK
Hematol Oncol Stem Cell Ther 2015 Jun;8(2):95-7. Epub 2014 Dec 27 doi: 10.1016/j.hemonc.2014.11.008. PMID: 25571789
Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases.
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Prognosis

Clinical Characteristics and Prognosis of 27 Patients with Childhood Acute Megakaryoblastic Leukemia.
Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience.
Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience.
Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC
Blood 2001 Jun 15;97(12):3727-32. doi: 10.1182/blood.v97.12.3727. PMID: 11389009
Expression of MDR-1/P-glycoprotein in childhood acute megakaryoblastic leukemia cells.
Ota S, Sato T, Kakuda H, Hirano K, Okimoto Y, Mori T, Nakazawa S, Kojima S, Matsuyama T, Tsuruo T
Leuk Lymphoma 1995 Nov;19(5-6):431-6. doi: 10.3109/10428199509112201. PMID: 8590843

Clinical prediction guides

Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study.
Miyauchi J, Sugita K, Okui M, Taguchi N, Clark SC, Shimizu K
J Cell Physiol 1991 Sep;148(3):404-13. doi: 10.1002/jcp.1041480311. PMID: 1655816
Childhood acute megakaryoblastic leukemia with internalization of hemic cells.
Shimizu H, Ui T, Sasaki K, Kawai S, Kaneko Y, Fujimoto T
Am J Pediatr Hematol Oncol 1990 Winter;12(4):477-9. doi: 10.1097/00043426-199024000-00013. PMID: 2285130

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