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Tonsillar squamous cell carcinoma

MedGen UID:
79101
•Concept ID:
C0280317
•
Neoplastic Process
Synonym: Tonsil squamous cell carcinoma
 
Monarch Initiative: MONDO:0006470

Definition

A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTonsillar squamous cell carcinoma

Professional guidelines

PubMed

Second Primary Tumors in Patients Presenting With Unilateral HPV-Associated Tonsillar Squamous Cell Carcinoma.
McMillan RA, Van Abel KM, Yin LX, Routman DM, Ma DJ, Neben Wittich MA, Price DL, Kasperbauer JL, Price KR, Chintakuntlawar AV, Moore EJ
Laryngoscope 2022 Feb;132(2):332-338. Epub 2021 Jul 8 doi: 10.1002/lary.29741. PMID: 34236086
Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes.
Nami Saber C, Grønhøj C, Jensen DH, Nørregaard C, Carlander A, Garnæs E, Kiss K, Specht L, von Buchwald C
Oral Oncol 2017 Nov;74:105-110. Epub 2017 Oct 3 doi: 10.1016/j.oraloncology.2017.09.019. PMID: 29103737
Treatment selection for tonsillar squamous cell carcinoma.
Kuo YY, Chu PY, Chang SY, Wang YF, Tsai TL, Yang MH, Wang LW, Tai SK
J Chin Med Assoc 2013 Apr;76(4):211-7. Epub 2013 Mar 13 doi: 10.1016/j.jcma.2012.12.007. PMID: 23557888

Recent clinical studies

Etiology

Mortality patterns of patients with tonsillar squamous cell carcinoma: a population-based study.
Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status.
Gama-Cuellar AG, Francisco ALN, Scarini JF, Mariano FV, Kowalski LP, Gondak R
J Appl Oral Sci 2022;30:e20210702. Epub 2022 May 16 doi: 10.1590/1678-7757-2020-0702. PMID: 35584505Free PMC Article
Second Primary Tumors in Patients Presenting With Unilateral HPV-Associated Tonsillar Squamous Cell Carcinoma.
McMillan RA, Van Abel KM, Yin LX, Routman DM, Ma DJ, Neben Wittich MA, Price DL, Kasperbauer JL, Price KR, Chintakuntlawar AV, Moore EJ
Laryngoscope 2022 Feb;132(2):332-338. Epub 2021 Jul 8 doi: 10.1002/lary.29741. PMID: 34236086
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil.
Piña AR, Jimenez LS, Mariano FV, de Andrade BA, Carlos R, Altemani A, de Almeida OP
Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Apr;121(4):412-8. Epub 2015 Dec 19 doi: 10.1016/j.oooo.2015.12.002. PMID: 26972540

Diagnosis

Mortality patterns of patients with tonsillar squamous cell carcinoma: a population-based study.
Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Second Primary Tumors in Patients Presenting With Unilateral HPV-Associated Tonsillar Squamous Cell Carcinoma.
McMillan RA, Van Abel KM, Yin LX, Routman DM, Ma DJ, Neben Wittich MA, Price DL, Kasperbauer JL, Price KR, Chintakuntlawar AV, Moore EJ
Laryngoscope 2022 Feb;132(2):332-338. Epub 2021 Jul 8 doi: 10.1002/lary.29741. PMID: 34236086
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma.
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma.
Haeggblom L, Attoff T, Hammarstedt-Nordenvall L, Näsman A
Cancer Med 2018 May;7(5):1717-1722. Epub 2018 Mar 23 doi: 10.1002/cam4.1400. PMID: 29573210Free PMC Article

Therapy

Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report.
Liska J, Liskova V, Trcka O, Ondic O, Hauer L, Baxa J, Kacerovska D
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2022 Dec;166(4):447-450. Epub 2021 Jun 28 doi: 10.5507/bp.2021.039. PMID: 34188253
Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma.
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article
Establishment and Validation of a Nomogram for Tonsil Squamous Cell Carcinoma: A Retrospective Study Based on the SEER Database.
Li C, Yang J, Zheng S, Xu F, Han D, Bai L, Wei YL, Wang S, Lyu J
Cancer Control 2020 Jan-Dec;27(1):1073274820960481. doi: 10.1177/1073274820960481. PMID: 32951460Free PMC Article
Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass.
Bhinder P, Chahin M, Zuberi L
J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619842904. doi: 10.1177/2324709619842904. PMID: 31010317Free PMC Article
Five-year outcomes of squamous cell carcinoma of the tonsil treated with radiotherapy.
Mourad WF, Hu KS, Puckett L, Hauerstock D, Shourbaji RA, Li Z, Manolidis S, Schantz S, Tran T, Jacobson A, Urken M, Culliney B, Persky M, Harrison LB
Am J Clin Oncol 2014 Feb;37(1):57-62. doi: 10.1097/COC.0b013e31826b9920. PMID: 23357967

Prognosis

Mortality patterns of patients with tonsillar squamous cell carcinoma: a population-based study.
Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Podoplanin promotes cell proliferation, survival, and migration of canine non-tonsillar squamous cell carcinoma.
Shinada M, Kato D, Tsuboi M, Ikeda N, Aoki S, Iguchi T, Li T, Kodera Y, Ota R, Koseki S, Shibahara H, Takahashi Y, Hashimoto Y, Chambers JK, Uchida K, Noguchi S, Kato Y, Nishimura R, Nakagawa T
J Vet Med Sci 2023 Oct 18;85(10):1068-1073. Epub 2023 Aug 4 doi: 10.1292/jvms.23-0062. PMID: 37544715Free PMC Article
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status.
Gama-Cuellar AG, Francisco ALN, Scarini JF, Mariano FV, Kowalski LP, Gondak R
J Appl Oral Sci 2022;30:e20210702. Epub 2022 May 16 doi: 10.1590/1678-7757-2020-0702. PMID: 35584505Free PMC Article
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma.
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article

Clinical prediction guides

Mortality patterns of patients with tonsillar squamous cell carcinoma: a population-based study.
Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Podoplanin promotes cell proliferation, survival, and migration of canine non-tonsillar squamous cell carcinoma.
Shinada M, Kato D, Tsuboi M, Ikeda N, Aoki S, Iguchi T, Li T, Kodera Y, Ota R, Koseki S, Shibahara H, Takahashi Y, Hashimoto Y, Chambers JK, Uchida K, Noguchi S, Kato Y, Nishimura R, Nakagawa T
J Vet Med Sci 2023 Oct 18;85(10):1068-1073. Epub 2023 Aug 4 doi: 10.1292/jvms.23-0062. PMID: 37544715Free PMC Article
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma.
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article
Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma.
Haeggblom L, Attoff T, Hammarstedt-Nordenvall L, Näsman A
Cancer Med 2018 May;7(5):1717-1722. Epub 2018 Mar 23 doi: 10.1002/cam4.1400. PMID: 29573210Free PMC Article

Recent systematic reviews

Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis.
Ahmadi N, Chan M, Huo YR, Sritharan N, Chin RY
Surgeon 2019 Feb;17(1):6-14. Epub 2018 May 26 doi: 10.1016/j.surge.2018.04.009. PMID: 29843958

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