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Tonsillar squamous cell carcinoma

MedGen UID:
79101
Concept ID:
C0280317
Neoplastic Process
Synonym: Tonsil squamous cell carcinoma
 
Monarch Initiative: MONDO:0006470

Definition

A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTonsillar squamous cell carcinoma

Professional guidelines

PubMed

McMillan RA, Van Abel KM, Yin LX, Routman DM, Ma DJ, Neben Wittich MA, Price DL, Kasperbauer JL, Price KR, Chintakuntlawar AV, Moore EJ
Laryngoscope 2022 Feb;132(2):332-338. Epub 2021 Jul 8 doi: 10.1002/lary.29741. PMID: 34236086
Nami Saber C, Grønhøj C, Jensen DH, Nørregaard C, Carlander A, Garnæs E, Kiss K, Specht L, von Buchwald C
Oral Oncol 2017 Nov;74:105-110. Epub 2017 Oct 3 doi: 10.1016/j.oraloncology.2017.09.019. PMID: 29103737
Kuo YY, Chu PY, Chang SY, Wang YF, Tsai TL, Yang MH, Wang LW, Tai SK
J Chin Med Assoc 2013 Apr;76(4):211-7. Epub 2013 Mar 13 doi: 10.1016/j.jcma.2012.12.007. PMID: 23557888

Recent clinical studies

Etiology

Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Gama-Cuellar AG, Francisco ALN, Scarini JF, Mariano FV, Kowalski LP, Gondak R
J Appl Oral Sci 2022;30:e20210702. Epub 2022 May 16 doi: 10.1590/1678-7757-2020-0702. PMID: 35584505Free PMC Article
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Piña AR, Jimenez LS, Mariano FV, de Andrade BA, Carlos R, Altemani A, de Almeida OP
Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Apr;121(4):412-8. Epub 2015 Dec 19 doi: 10.1016/j.oooo.2015.12.002. PMID: 26972540
Kuo YY, Chu PY, Chang SY, Wang YF, Tsai TL, Yang MH, Wang LW, Tai SK
J Chin Med Assoc 2013 Apr;76(4):211-7. Epub 2013 Mar 13 doi: 10.1016/j.jcma.2012.12.007. PMID: 23557888

Diagnosis

Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Li Y, Hu C
Eur Arch Otorhinolaryngol 2023 Oct;280(10):4619-4625. Epub 2023 Jun 23 doi: 10.1007/s00405-023-08059-w. PMID: 37353591
McMillan RA, Van Abel KM, Yin LX, Routman DM, Ma DJ, Neben Wittich MA, Price DL, Kasperbauer JL, Price KR, Chintakuntlawar AV, Moore EJ
Laryngoscope 2022 Feb;132(2):332-338. Epub 2021 Jul 8 doi: 10.1002/lary.29741. PMID: 34236086
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article

Therapy

Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article
Li C, Yang J, Zheng S, Xu F, Han D, Bai L, Wei YL, Wang S, Lyu J
Cancer Control 2020 Jan-Dec;27(1):1073274820960481. doi: 10.1177/1073274820960481. PMID: 32951460Free PMC Article
Bhinder P, Chahin M, Zuberi L
J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619842904. doi: 10.1177/2324709619842904. PMID: 31010317Free PMC Article
Kennedy WR, Herman MP, Deraniyagala RL, Amdur RJ, Werning JW, Dziegielewski P, Kirwan J, Morris CG, Mendenhall WM
Eur Arch Otorhinolaryngol 2016 Aug;273(8):2117-25. Epub 2016 Apr 8 doi: 10.1007/s00405-016-4027-0. PMID: 27059836
Mourad WF, Hu KS, Puckett L, Hauerstock D, Shourbaji RA, Li Z, Manolidis S, Schantz S, Tran T, Jacobson A, Urken M, Culliney B, Persky M, Harrison LB
Am J Clin Oncol 2014 Feb;37(1):57-62. doi: 10.1097/COC.0b013e31826b9920. PMID: 23357967

Prognosis

Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Shinada M, Kato D, Tsuboi M, Ikeda N, Aoki S, Iguchi T, Li T, Kodera Y, Ota R, Koseki S, Shibahara H, Takahashi Y, Hashimoto Y, Chambers JK, Uchida K, Noguchi S, Kato Y, Nishimura R, Nakagawa T
J Vet Med Sci 2023 Oct 18;85(10):1068-1073. Epub 2023 Aug 4 doi: 10.1292/jvms.23-0062. PMID: 37544715Free PMC Article
Gama-Cuellar AG, Francisco ALN, Scarini JF, Mariano FV, Kowalski LP, Gondak R
J Appl Oral Sci 2022;30:e20210702. Epub 2022 May 16 doi: 10.1590/1678-7757-2020-0702. PMID: 35584505Free PMC Article
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article

Clinical prediction guides

Wang J, Li X, Niu D, Huang J, Ye E, Zhao Y, Yue S, Hou X, Wu J
Front Endocrinol (Lausanne) 2023;14:1158593. Epub 2023 Dec 7 doi: 10.3389/fendo.2023.1158593. PMID: 38130394Free PMC Article
Shinada M, Kato D, Tsuboi M, Ikeda N, Aoki S, Iguchi T, Li T, Kodera Y, Ota R, Koseki S, Shibahara H, Takahashi Y, Hashimoto Y, Chambers JK, Uchida K, Noguchi S, Kato Y, Nishimura R, Nakagawa T
J Vet Med Sci 2023 Oct 18;85(10):1068-1073. Epub 2023 Aug 4 doi: 10.1292/jvms.23-0062. PMID: 37544715Free PMC Article
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie MA, Geuking MB, Jochum W, McCoy KD, Stoeckli SJ, Ludewig B
Oncoimmunology 2021;10(1):1945202. Epub 2021 Jul 25 doi: 10.1080/2162402X.2021.1945202. PMID: 34367729Free PMC Article
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article
Kuo YY, Chu PY, Chang SY, Wang YF, Tsai TL, Yang MH, Wang LW, Tai SK
J Chin Med Assoc 2013 Apr;76(4):211-7. Epub 2013 Mar 13 doi: 10.1016/j.jcma.2012.12.007. PMID: 23557888

Recent systematic reviews

Ahmadi N, Chan M, Huo YR, Sritharan N, Chin RY
Surgeon 2019 Feb;17(1):6-14. Epub 2018 May 26 doi: 10.1016/j.surge.2018.04.009. PMID: 29843958

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