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Grade III meningioma

MedGen UID:
79186
•Concept ID:
C0280801
•
Neoplastic Process
Synonyms: Grade 3 Meningioma; grade 3 meningioma; Grade III Meningioma; grade III meningioma; meningioma, malignant; WHO Grade 3 Meningioma; WHO Grade III Meningioma; WHO grade III meningioma
 
Monarch Initiative: MONDO:0020634

Definition

A malignant meningioma with aggressive clinical course. It recurs in approximately 50-78% of the cases. This category includes the anaplastic (malignant) meningioma, papillary meningioma, and rhabdoid meningioma. [from NCI]

Professional guidelines

PubMed

Review of controversies in management of non-benign meningioma.
Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Recent clinical studies

Etiology

TERT promoter mutations in primary and secondary WHO grade III meningioma.
Maier AD, Stenman A, Svahn F, Mirian C, Bartek J Jr, Juhler M, Zedenius J, Broholm H, Mathiesen T
Brain Pathol 2021 Jan;31(1):61-69. Epub 2020 Sep 15 doi: 10.1111/bpa.12892. PMID: 32805769Free PMC Article
High-risk Meningioma: Initial Outcomes From NRG Oncology/RTOG 0539.
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article
Radiation-Induced Meningiomas: An Exhaustive Review of the Literature.
Yamanaka R, Hayano A, Kanayama T
World Neurosurg 2017 Jan;97:635-644.e8. Epub 2016 Oct 3 doi: 10.1016/j.wneu.2016.09.094. PMID: 27713063
Review of controversies in management of non-benign meningioma.
Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Diagnosis

Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy.
Rana R, Sharma S, Ganguly NK
Mol Biol Rep 2021 Dec;48(12):8061-8074. Epub 2021 Oct 23 doi: 10.1007/s11033-021-06740-z. PMID: 34687392Free PMC Article
Survival Benefit of Adjuvant Radiotherapy in Elderly Patients with WHO Grade III Meningioma.
Zhou H, Bai HX, Chan L, Zhang PJ, Karakousis G, Huang R, Xiao B, Yang L
World Neurosurg 2019 Nov;131:e303-e311. Epub 2019 Jul 26 doi: 10.1016/j.wneu.2019.07.140. PMID: 31356979
Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature.
Bender L, Lhermitte B, Carinato H, Baloglu S, Helali M, Cebula H, Antoni D, Noel G
World J Surg Oncol 2019 Apr 16;17(1):70. doi: 10.1186/s12957-019-1596-6. PMID: 30992070Free PMC Article
Radiation-Induced Meningiomas: An Exhaustive Review of the Literature.
Yamanaka R, Hayano A, Kanayama T
World Neurosurg 2017 Jan;97:635-644.e8. Epub 2016 Oct 3 doi: 10.1016/j.wneu.2016.09.094. PMID: 27713063
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Therapy

High-risk Meningioma: Initial Outcomes From NRG Oncology/RTOG 0539.
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article
Efficacy and toxicity of particle radiotherapy in WHO grade II and grade III meningiomas: a systematic review.
Wu A, Jin MC, Meola A, Wong HN, Chang SD
Neurosurg Focus 2019 Jun 1;46(6):E12. doi: 10.3171/2019.3.FOCUS1967. PMID: 31153145
Radiation-Induced Meningiomas: An Exhaustive Review of the Literature.
Yamanaka R, Hayano A, Kanayama T
World Neurosurg 2017 Jan;97:635-644.e8. Epub 2016 Oct 3 doi: 10.1016/j.wneu.2016.09.094. PMID: 27713063
Review of controversies in management of non-benign meningioma.
Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209
World Health Organization grade III meningiomas. A retrospective study for outcome and prognostic factors assessment.
Champeaux C, Wilson E, Brandner S, Shieff C, Thorne L
Br J Neurosurg 2015;29(5):693-8. Epub 2015 Jun 22 doi: 10.3109/02688697.2015.1054350. PMID: 26098606

Prognosis

Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy.
Rana R, Sharma S, Ganguly NK
Mol Biol Rep 2021 Dec;48(12):8061-8074. Epub 2021 Oct 23 doi: 10.1007/s11033-021-06740-z. PMID: 34687392Free PMC Article
Neurosurgical follow-up and treatment of a series of 26 WHO grade III meningiomas.
Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:219-225. Epub 2021 Jul 16 doi: 10.1016/j.jocn.2021.06.047. PMID: 34373031
Primary intracranial papillary meningioma: Analysis of factors of prognosis and systematic review.
Zhang GS, Zhang YY, He F, Ou ML, Wang LK, Liao L, Ran RJ, Xiang HH, Chen JH, Wang SJ
J Clin Neurosci 2021 Sep;91:118-124. Epub 2021 Jul 5 doi: 10.1016/j.jocn.2021.06.025. PMID: 34373015
TERT promoter mutations in primary and secondary WHO grade III meningioma.
Maier AD, Stenman A, Svahn F, Mirian C, Bartek J Jr, Juhler M, Zedenius J, Broholm H, Mathiesen T
Brain Pathol 2021 Jan;31(1):61-69. Epub 2020 Sep 15 doi: 10.1111/bpa.12892. PMID: 32805769Free PMC Article
Grade III meningioma with gastro-intestinal tract and brain metastases: case report and review of the literature.
Bender L, Lhermitte B, Carinato H, Baloglu S, Helali M, Cebula H, Antoni D, Noel G
World J Surg Oncol 2019 Apr 16;17(1):70. doi: 10.1186/s12957-019-1596-6. PMID: 30992070Free PMC Article

Clinical prediction guides

Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth.
Das A, Alshareef M, Henderson F Jr, Martinez Santos JL, Vandergrift WA 3rd, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D
Clin Transl Oncol 2020 Jul;22(7):1138-1145. Epub 2019 Nov 15 doi: 10.1007/s12094-019-02240-6. PMID: 31732915
Clinical and histopathological predictors of outcome in malignant meningioma.
Maier AD, Bartek J Jr, Eriksson F, Ugleholdt H, Juhler M, Broholm H, Mathiesen TI
Neurosurg Rev 2020 Apr;43(2):643-653. Epub 2019 Mar 13 doi: 10.1007/s10143-019-01093-5. PMID: 30868425
Survival Benefit of Adjuvant Radiotherapy in Elderly Patients with WHO Grade III Meningioma.
Zhou H, Bai HX, Chan L, Zhang PJ, Karakousis G, Huang R, Xiao B, Yang L
World Neurosurg 2019 Nov;131:e303-e311. Epub 2019 Jul 26 doi: 10.1016/j.wneu.2019.07.140. PMID: 31356979
Meningioma grading using conventional MRI histogram analysis based on 3D tumor measurement.
Li X, Miao Y, Han L, Dong J, Guo Y, Shang Y, Xie L, Song Q, Liu A
Eur J Radiol 2019 Jan;110:45-53. Epub 2018 Nov 22 doi: 10.1016/j.ejrad.2018.11.016. PMID: 30599872
Prognostic value of estrogen receptor in WHO Grade III meningioma: a long-term follow-up study from a single institution.
Hua L, Zhu H, Li J, Tang H, Kuang D, Wang Y, Tang F, Chen X, Zhou L, Xie Q, Gong Y
J Neurosurg 2018 Jun;128(6):1698-1706. Epub 2017 Aug 18 doi: 10.3171/2017.2.JNS162566. PMID: 28820306

Recent systematic reviews

Metastasis of Intracranial Meningioma to the Osseous Spine: Systematic Literature Review and Case Report.
Zhou JJ, Farber SH, de Andrada Pereira B, DiDomenico JD, Williams GP, Almefty KK, Kakarla UK, Uribe JS, Turner JD
World Neurosurg 2024 Mar;183:192-203. Epub 2023 Nov 22 doi: 10.1016/j.wneu.2023.11.056. PMID: 37995989
Primary intracranial papillary meningioma: Analysis of factors of prognosis and systematic review.
Zhang GS, Zhang YY, He F, Ou ML, Wang LK, Liao L, Ran RJ, Xiang HH, Chen JH, Wang SJ
J Clin Neurosci 2021 Sep;91:118-124. Epub 2021 Jul 5 doi: 10.1016/j.jocn.2021.06.025. PMID: 34373015
Prognostic factors and long-term outcomes of primary intracranial rhabdoid meningioma: A systematic review.
Zhang YY, Zhang L, Liu YZ, Zhang R, Zhang GH
Clin Neurol Neurosurg 2020 Sep;196:105971. Epub 2020 Jun 1 doi: 10.1016/j.clineuro.2020.105971. PMID: 32516684
Efficacy and toxicity of particle radiotherapy in WHO grade II and grade III meningiomas: a systematic review.
Wu A, Jin MC, Meola A, Wong HN, Chang SD
Neurosurg Focus 2019 Jun 1;46(6):E12. doi: 10.3171/2019.3.FOCUS1967. PMID: 31153145

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