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Anticonvulsant Hypersensitivity Syndrome

MedGen UID:
817116
•Concept ID:
C3810813
•
Disease or Syndrome

Definition

A form of drug hypersensitivity syndrome caused by anti-convulsants. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnticonvulsant Hypersensitivity Syndrome

Professional guidelines

PubMed

Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients.
Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY
Clin Neurol Neurosurg 2015 Nov;138:1-7. Epub 2015 Jul 8 doi: 10.1016/j.clineuro.2015.07.008. PMID: 26209753
Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management.
Verrotti A, Trotta D, Salladini C, Chiarelli F
CNS Drugs 2002;16(3):197-205. doi: 10.2165/00023210-200216030-00006. PMID: 11888340
Anticonvulsant hypersensitivity syndrome: incidence, prevention and management.
Knowles SR, Shapiro LE, Shear NH
Drug Saf 1999 Dec;21(6):489-501. doi: 10.2165/00002018-199921060-00005. PMID: 10612272

Recent clinical studies

Etiology

Pathogenesis and clinical approaches to anticonvulsant hypersensitivity syndrome: current state of knowledge.
Scaparrotta A, Verrotti A, Consilvio NP, Cingolani A, Di Pillo S, Di Gioacchino M, Verini M, Chiarelli F
Int J Immunopathol Pharmacol 2011 Apr-Jun;24(2):277-84. doi: 10.1177/039463201102400201. PMID: 21658302
The anticonvulsant hypersensitivity syndrome.
Baba M, Karakaş M, Aksungur VL, Homan S, Yücel A, Acar MA, Memişoglu HR
J Eur Acad Dermatol Venereol 2003 Jul;17(4):399-401. doi: 10.1046/j.1468-3083.2003.00750.x. PMID: 12834448
Anticonvulsant drug hypersensitivity.
Galindo PA, Borja J, Gómez E, Mur P, Gudín M, García R, Encinas C, Romero G, Garrido JA, Cortina P, Feo F
J Investig Allergol Clin Immunol 2002;12(4):299-304. PMID: 12926190
Anticonvulsant hypersensitivity syndrome in children: incidence, prevention and management.
Verrotti A, Trotta D, Salladini C, Chiarelli F
CNS Drugs 2002;16(3):197-205. doi: 10.2165/00023210-200216030-00006. PMID: 11888340
Anticonvulsant hypersensitivity syndrome.
Vittorio CC, Muglia JJ
Arch Intern Med 1995 Nov 27;155(21):2285-90. PMID: 7487252

Diagnosis

Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): A literature review.
de Groot AC
Contact Dermatitis 2022 Jun;86(6):443-479. Epub 2022 Mar 29 doi: 10.1111/cod.14090. PMID: 35233782
Anticonvulsant hypersensitivity syndrome: clinic case and literature review.
Leonangeli S, Fraire JA, Loza JL
Rev Fac Cien Med Univ Nac Cordoba 2020 Aug 21;77(3):211-213. doi: 10.31053/1853.0605.v77.n3.27857. PMID: 32991111
Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome.
Fernando SL
Australas J Dermatol 2014 Feb;55(1):15-23. Epub 2013 Jul 19 doi: 10.1111/ajd.12085. PMID: 23866082
Pathogenesis and clinical approaches to anticonvulsant hypersensitivity syndrome: current state of knowledge.
Scaparrotta A, Verrotti A, Consilvio NP, Cingolani A, Di Pillo S, Di Gioacchino M, Verini M, Chiarelli F
Int J Immunopathol Pharmacol 2011 Apr-Jun;24(2):277-84. doi: 10.1177/039463201102400201. PMID: 21658302
Anticonvulsant hypersensitivity syndrome.
Morkunas AR, Miller MB
Crit Care Clin 1997 Oct;13(4):727-39. doi: 10.1016/s0749-0704(05)70366-3. PMID: 9330838

Therapy

Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): A literature review.
de Groot AC
Contact Dermatitis 2022 Jun;86(6):443-479. Epub 2022 Mar 29 doi: 10.1111/cod.14090. PMID: 35233782
Anticonvulsant hypersensitivity syndrome: clinic case and literature review.
Leonangeli S, Fraire JA, Loza JL
Rev Fac Cien Med Univ Nac Cordoba 2020 Aug 21;77(3):211-213. doi: 10.31053/1853.0605.v77.n3.27857. PMID: 32991111
Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome.
Fernando SL
Australas J Dermatol 2014 Feb;55(1):15-23. Epub 2013 Jul 19 doi: 10.1111/ajd.12085. PMID: 23866082
Pathogenesis and clinical approaches to anticonvulsant hypersensitivity syndrome: current state of knowledge.
Scaparrotta A, Verrotti A, Consilvio NP, Cingolani A, Di Pillo S, Di Gioacchino M, Verini M, Chiarelli F
Int J Immunopathol Pharmacol 2011 Apr-Jun;24(2):277-84. doi: 10.1177/039463201102400201. PMID: 21658302
Anticonvulsant hypersensitivity syndrome.
Morkunas AR, Miller MB
Crit Care Clin 1997 Oct;13(4):727-39. doi: 10.1016/s0749-0704(05)70366-3. PMID: 9330838

Prognosis

Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome.
Fernando SL
Australas J Dermatol 2014 Feb;55(1):15-23. Epub 2013 Jul 19 doi: 10.1111/ajd.12085. PMID: 23866082
Anticonvulsant hypersensitivity syndrome: an update.
Knowles SR, Dewhurst N, Shear NH
Expert Opin Drug Saf 2012 Sep;11(5):767-78. Epub 2012 Jul 14 doi: 10.1517/14740338.2012.705828. PMID: 22794330
Anticonvulsant drug hypersensitivity.
Galindo PA, Borja J, Gómez E, Mur P, Gudín M, García R, Encinas C, Romero G, Garrido JA, Cortina P, Feo F
J Investig Allergol Clin Immunol 2002;12(4):299-304. PMID: 12926190
Anticonvulsant hypersensitivity syndrome: incidence, prevention and management.
Knowles SR, Shapiro LE, Shear NH
Drug Saf 1999 Dec;21(6):489-501. doi: 10.2165/00002018-199921060-00005. PMID: 10612272
Anticonvulsant hypersensitivity syndrome.
Vittorio CC, Muglia JJ
Arch Intern Med 1995 Nov 27;155(21):2285-90. PMID: 7487252

Clinical prediction guides

Anticonvulsant hypersensitivity syndrome: an update.
Knowles SR, Dewhurst N, Shear NH
Expert Opin Drug Saf 2012 Sep;11(5):767-78. Epub 2012 Jul 14 doi: 10.1517/14740338.2012.705828. PMID: 22794330
In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review.
Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH, Koren G
Mol Diagn Ther 2009;13(5):313-30. doi: 10.1007/BF03256336. PMID: 19791835
Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review.
Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH, Koren G
Drug Saf 2009;32(5):391-408. doi: 10.2165/00002018-200932050-00003. PMID: 19419234
Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents.
Seitz CS, Pfeuffer P, Raith P, Bröcker EB, Trautmann A
Ann Allergy Asthma Immunol 2006 Nov;97(5):698-702. doi: 10.1016/S1081-1206(10)61103-9. PMID: 17165282
The anticonvulsant hypersensitivity syndrome.
Baba M, Karakaş M, Aksungur VL, Homan S, Yücel A, Acar MA, Memişoglu HR
J Eur Acad Dermatol Venereol 2003 Jul;17(4):399-401. doi: 10.1046/j.1468-3083.2003.00750.x. PMID: 12834448

Recent systematic reviews

In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review.
Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH, Koren G
Mol Diagn Ther 2009;13(5):313-30. doi: 10.1007/BF03256336. PMID: 19791835
Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review.
Elzagallaai AA, Knowles SR, Rieder MJ, Bend JR, Shear NH, Koren G
Drug Saf 2009;32(5):391-408. doi: 10.2165/00002018-200932050-00003. PMID: 19419234

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