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Uveal Class 1 Melanoma

MedGen UID:: 823836
•Concept ID:: C3831088
•: Neoplastic Process

Synonym:

Class 1 Uveal Melanoma

Definition

Gene expression profiling that classifies uveal melanomas into a low-grade group. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVUveal Class 1 Melanoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Uveal melanoma
        Uveal Melanoma by Gene Expression Profile
        Uveal Class 1 Melanoma
        Uveal Class 1a Melanoma
        Uveal Class 1b Melanoma

Professional guidelines

PubMed

Practical guidelines for the management of adverse events of the T cell engager bispecific tebentafusp.

Hassel JC, Berking C, Forschner A, Gebhardt C, Heinzerling L, Meier F, Ochsenreither S, Siveke J, Hauschild A, Schadendorf D
Eur J Cancer 2023 Sep;191:112986. Epub 2023 Jul 11 doi: 10.1016/j.ejca.2023.112986. PMID: 37595494

Uveal Melanoma Treatment and Prognostication.

Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342

HLA Class I and II genotype in uveal melanoma: relation to occurrence and prognosis.

Maat W, Haasnoot GW, Claas FH, Schalij-Delfos NE, Schreuder GM, Jager MJ
Invest Ophthalmol Vis Sci 2006 Jan;47(1):3-6. doi: 10.1167/iovs.05-1122. PMID: 16384937

See all (3)

Recent clinical studies

Etiology

Intrinsic disorder in PRAME and its role in uveal melanoma.

Antonietti M, Gonzalez DJT, Djulbegovic M, Dayhoff GW 2nd, Uversky VN, Shields CL, Karp CL
Cell Commun Signal 2023 Aug 25;21(1):222. doi: 10.1186/s12964-023-01197-y. PMID: 37626310 Free PMC Article

Iris melanoma: Prognostication for metastasis.

Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703

Single-cell analysis reveals new evolutionary complexity in uveal melanoma.

Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW
Nat Commun 2020 Jan 24;11(1):496. doi: 10.1038/s41467-019-14256-1. PMID: 31980621 Free PMC Article

Variability of Bad Prognosis in Uveal Melanoma.

Shao YF, Echegaray JJ, Singh N, Singh AD
Ophthalmol Retina 2019 Feb;3(2):186-193. Epub 2018 Sep 21 doi: 10.1016/j.oret.2018.09.007. PMID: 31014770

Genetic determinants of uveal melanoma.

Couturier J, Saule S
Dev Ophthalmol 2012;49:150-165. Epub 2011 Oct 21 doi: 10.1159/000328270. PMID: 22042019

See all (69)

Diagnosis

Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.

Hamid O, Hassel JC, Shoushtari AN, Meier F, Bauer TM, Salama AKS, Kirkwood JM, Ascierto PA, Lorigan PC, Mauch C, Orloff M, Evans TRJ, Holland C, Edukulla R, Abedin SE, Middleton MR
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006747. PMID: 37286303 Free PMC Article

Iris melanoma: Prognostication for metastasis.

Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703

The "ART" of Epigenetics in Melanoma: From histone "Alterations, to Resistance and Therapies".

Strub T, Ballotti R, Bertolotto C
Theranostics 2020;10(4):1777-1797. Epub 2020 Jan 1 doi: 10.7150/thno.36218. PMID: 32042336 Free PMC Article

Uveal Melanoma Treatment and Prognostication.

Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342

Uveal melanoma: estimating prognosis.

Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538 Free PMC Article

See all (48)

Therapy

15-Gene Expression Profile and PRAME as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1).

Harbour JW, Correa ZM, Schefler AC, Mruthyunjaya P, Materin MA, Aaberg TA Jr, Skalet AH, Reichstein DA, Weis E, Kim IK, Fuller TS, Demirci H, Piggott KD, Williams BK, Shildkrot E, Capone A Jr, Oliver SC, Walter SD, Mason J 3rd, Char DH, Altaweel M, Wells JR, Duker JS, Hovland PG, Gombos DS, Tsai T, Javid C, Marr BP, Gao A, Decatur CL, Dollar JJ, Kurtenbach S, Zhang S
J Clin Oncol 2024 Oct;42(28):3319-3329. Epub 2024 Jul 25 doi: 10.1200/JCO.24.00447. PMID: 39052972 Free PMC Article

Intrinsic disorder in PRAME and its role in uveal melanoma.

Antonietti M, Gonzalez DJT, Djulbegovic M, Dayhoff GW 2nd, Uversky VN, Shields CL, Karp CL
Cell Commun Signal 2023 Aug 25;21(1):222. doi: 10.1186/s12964-023-01197-y. PMID: 37626310 Free PMC Article

Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.

Phase I Study of Safety, Tolerability, and Efficacy of Tebentafusp Using a Step-Up Dosing Regimen and Expansion in Patients With Metastatic Uveal Melanoma.

Carvajal RD, Nathan P, Sacco JJ, Orloff M, Hernandez-Aya LF, Yang J, Luke JJ, Butler MO, Stanhope S, Collins L, McAlpine C, Holland C, Abdullah SE, Sato T
J Clin Oncol 2022 Jun 10;40(17):1939-1948. Epub 2022 Mar 7 doi: 10.1200/JCO.21.01805. PMID: 35254876 Free PMC Article

Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma.

Middleton MR, McAlpine C, Woodcock VK, Corrie P, Infante JR, Steven NM, Evans TRJ, Anthoney A, Shoushtari AN, Hamid O, Gupta A, Vardeu A, Leach E, Naidoo R, Stanhope S, Lewis S, Hurst J, O'Kelly I, Sznol M
Clin Cancer Res 2020 Nov 15;26(22):5869-5878. Epub 2020 Aug 18 doi: 10.1158/1078-0432.CCR-20-1247. PMID: 32816891 Free PMC Article

See all (29)

Prognosis

Intrinsic disorder in PRAME and its role in uveal melanoma.

Antonietti M, Gonzalez DJT, Djulbegovic M, Dayhoff GW 2nd, Uversky VN, Shields CL, Karp CL
Cell Commun Signal 2023 Aug 25;21(1):222. doi: 10.1186/s12964-023-01197-y. PMID: 37626310 Free PMC Article

Iris melanoma: Prognostication for metastasis.

Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703

Variability of Bad Prognosis in Uveal Melanoma.

Shao YF, Echegaray JJ, Singh N, Singh AD
Ophthalmol Retina 2019 Feb;3(2):186-193. Epub 2018 Sep 21 doi: 10.1016/j.oret.2018.09.007. PMID: 31014770

Uveal Melanoma Treatment and Prognostication.

Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342

Uveal melanoma: estimating prognosis.

Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538 Free PMC Article

See all (74)

Clinical prediction guides

Iris melanoma: Prognostication for metastasis.

Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703

Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma.

Variability of Bad Prognosis in Uveal Melanoma.

Shao YF, Echegaray JJ, Singh N, Singh AD
Ophthalmol Retina 2019 Feb;3(2):186-193. Epub 2018 Sep 21 doi: 10.1016/j.oret.2018.09.007. PMID: 31014770

Uveal Melanoma Treatment and Prognostication.

Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342

Uveal melanoma: estimating prognosis.

Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538 Free PMC Article

See all (61)