U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uveal Class 1b Melanoma

MedGen UID:
823837
•Concept ID:
C3831089
•
Neoplastic Process
Synonym: Class 1b Uveal Melanoma

Definition

Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveal Class 1b Melanoma

Recent clinical studies

Etiology

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Single-cell analysis reveals new evolutionary complexity in uveal melanoma.
Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW
Nat Commun 2020 Jan 24;11(1):496. doi: 10.1038/s41467-019-14256-1. PMID: 31980621Free PMC Article
Relationship between clinical features, GEP class, and PRAME expression in uveal melanoma.
Schefler AC, Koca E, Bernicker EH, Correa ZM
Graefes Arch Clin Exp Ophthalmol 2019 Jul;257(7):1541-1545. Epub 2019 May 7 doi: 10.1007/s00417-019-04335-w. PMID: 31065847
Association between traditional clinical high-risk features and gene expression profile classification in uveal melanoma.
Nguyen BT, Kim RS, Bretana ME, Kegley E, Schefler AC
Graefes Arch Clin Exp Ophthalmol 2018 Feb;256(2):421-427. Epub 2017 Nov 28 doi: 10.1007/s00417-017-3856-x. PMID: 29185101
New concepts in the molecular understanding of uveal melanoma.
Reichstein D
Curr Opin Ophthalmol 2017 May;28(3):219-227. doi: 10.1097/ICU.0000000000000366. PMID: 28257297

Diagnosis

Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.
Hamid O, Hassel JC, Shoushtari AN, Meier F, Bauer TM, Salama AKS, Kirkwood JM, Ascierto PA, Lorigan PC, Mauch C, Orloff M, Evans TRJ, Holland C, Edukulla R, Abedin SE, Middleton MR
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006747. PMID: 37286303Free PMC Article
Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Relationship between clinical features, GEP class, and PRAME expression in uveal melanoma.
Schefler AC, Koca E, Bernicker EH, Correa ZM
Graefes Arch Clin Exp Ophthalmol 2019 Jul;257(7):1541-1545. Epub 2019 May 7 doi: 10.1007/s00417-019-04335-w. PMID: 31065847
Association between traditional clinical high-risk features and gene expression profile classification in uveal melanoma.
Nguyen BT, Kim RS, Bretana ME, Kegley E, Schefler AC
Graefes Arch Clin Exp Ophthalmol 2018 Feb;256(2):421-427. Epub 2017 Nov 28 doi: 10.1007/s00417-017-3856-x. PMID: 29185101
Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics.
Plasseraud KM, Wilkinson JK, Oelschlager KM, Poteet TM, Cook RW, Stone JF, Monzon FA
Diagn Pathol 2017 Aug 4;12(1):59. doi: 10.1186/s13000-017-0650-3. PMID: 28778171Free PMC Article

Therapy

Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.
Hamid O, Hassel JC, Shoushtari AN, Meier F, Bauer TM, Salama AKS, Kirkwood JM, Ascierto PA, Lorigan PC, Mauch C, Orloff M, Evans TRJ, Holland C, Edukulla R, Abedin SE, Middleton MR
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006747. PMID: 37286303Free PMC Article
Association between Tumor Regression Rate and Gene Expression Profile after Iodine 125 Plaque Radiotherapy for Uveal Melanoma.
Mruthyunjaya P, Seider MI, Stinnett S, Schefler A; Ocular Oncology Study Consortium
Ophthalmology 2017 Oct;124(10):1532-1539. Epub 2017 May 23 doi: 10.1016/j.ophtha.2017.04.013. PMID: 28549517

Prognosis

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Relationship between clinical features, GEP class, and PRAME expression in uveal melanoma.
Schefler AC, Koca E, Bernicker EH, Correa ZM
Graefes Arch Clin Exp Ophthalmol 2019 Jul;257(7):1541-1545. Epub 2019 May 7 doi: 10.1007/s00417-019-04335-w. PMID: 31065847
Association between traditional clinical high-risk features and gene expression profile classification in uveal melanoma.
Nguyen BT, Kim RS, Bretana ME, Kegley E, Schefler AC
Graefes Arch Clin Exp Ophthalmol 2018 Feb;256(2):421-427. Epub 2017 Nov 28 doi: 10.1007/s00417-017-3856-x. PMID: 29185101
Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics.
Plasseraud KM, Wilkinson JK, Oelschlager KM, Poteet TM, Cook RW, Stone JF, Monzon FA
Diagn Pathol 2017 Aug 4;12(1):59. doi: 10.1186/s13000-017-0650-3. PMID: 28778171Free PMC Article
New concepts in the molecular understanding of uveal melanoma.
Reichstein D
Curr Opin Ophthalmol 2017 May;28(3):219-227. doi: 10.1097/ICU.0000000000000366. PMID: 28257297

Clinical prediction guides

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA.
Berry DE, Schefler AC, Seider MI, Materin M, Stinnett S, Mruthyunjaya P; Ocular Oncology Study Consortium
Retina 2020 Feb;40(2):214-224. doi: 10.1097/IAE.0000000000002385. PMID: 31972790Free PMC Article
Association between traditional clinical high-risk features and gene expression profile classification in uveal melanoma.
Nguyen BT, Kim RS, Bretana ME, Kegley E, Schefler AC
Graefes Arch Clin Exp Ophthalmol 2018 Feb;256(2):421-427. Epub 2017 Nov 28 doi: 10.1007/s00417-017-3856-x. PMID: 29185101
Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics.
Plasseraud KM, Wilkinson JK, Oelschlager KM, Poteet TM, Cook RW, Stone JF, Monzon FA
Diagn Pathol 2017 Aug 4;12(1):59. doi: 10.1186/s13000-017-0650-3. PMID: 28778171Free PMC Article
New concepts in the molecular understanding of uveal melanoma.
Reichstein D
Curr Opin Ophthalmol 2017 May;28(3):219-227. doi: 10.1097/ICU.0000000000000366. PMID: 28257297

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...