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Localized Unresectable Adult Liver Carcinoma

MedGen UID:
82979
Concept ID:
C0278773
Neoplastic Process
Synonyms: Localized Non-Resectable Adult Liver Cancer; Localized Non-Resectable Adult Liver Carcinoma; Localized Unresectable Adult Primary Cancer of Liver; Localized Unresectable Adult Primary Cancer of the Liver; Localized Unresectable Adult Primary Liver Cancer

Definition

A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Unresectable Adult Liver Carcinoma

Professional guidelines

PubMed

Liu QQ, Wang XX, Ji H, Dou QY, Zhang HM
Med Oncol 2024 Mar 25;41(5):91. doi: 10.1007/s12032-024-02309-5. PMID: 38526607
Salem R, Johnson GE, Kim E, Riaz A, Bishay V, Boucher E, Fowers K, Lewandowski R, Padia SA
Hepatology 2021 Nov;74(5):2342-2352. Epub 2021 Jun 11 doi: 10.1002/hep.31819. PMID: 33739462Free PMC Article
Haberal M, Akdur A, Moray G, Arslan G, Özçay F, Selçuk H, Özdemir H
Exp Clin Transplant 2017 Mar;15(Suppl 2):55-58. doi: 10.6002/ect.TOND16.L14. PMID: 28302000

Recent clinical studies

Etiology

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Salem R, Johnson GE, Kim E, Riaz A, Bishay V, Boucher E, Fowers K, Lewandowski R, Padia SA
Hepatology 2021 Nov;74(5):2342-2352. Epub 2021 Jun 11 doi: 10.1002/hep.31819. PMID: 33739462Free PMC Article
Powles T, van der Heijden MS, Castellano D, Galsky MD, Loriot Y, Petrylak DP, Ogawa O, Park SH, Lee JL, De Giorgi U, Bögemann M, Bamias A, Eigl BJ, Gurney H, Mukherjee SD, Fradet Y, Skoneczna I, Tsiatas M, Novikov A, Suárez C, Fay AP, Duran I, Necchi A, Wildsmith S, He P, Angra N, Gupta AK, Levin W, Bellmunt J; DANUBE study investigators
Lancet Oncol 2020 Dec;21(12):1574-1588. Epub 2020 Sep 21 doi: 10.1016/S1470-2045(20)30541-6. PMID: 32971005
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article

Diagnosis

Haruki K, Harimoto N, Furukawa K, Taniai T, Yanagaki M, Igarashi Y, Tsunematsu M, Shirai Y, Shirabe K, Ikegami T
J Am Coll Surg 2024 Jun 1;238(6):1137-1147. Epub 2024 Feb 7 doi: 10.1097/XCS.0000000000001032. PMID: 38323632
Fraquelli M, Nadarevic T, Colli A, Manzotti C, Giljaca V, Miletic D, Štimac D, Casazza G
Cochrane Database Syst Rev 2022 Sep 2;9(9):CD013483. doi: 10.1002/14651858.CD013483.pub2. PMID: 36053210Free PMC Article
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Haberal M, Akdur A, Moray G, Arslan G, Özçay F, Selçuk H, Özdemir H
Exp Clin Transplant 2017 Mar;15(Suppl 2):55-58. doi: 10.6002/ect.TOND16.L14. PMID: 28302000
Roman S
Curr Opin Oncol 2006 Jan;18(1):36-42. doi: 10.1097/01.cco.0000198976.43992.14. PMID: 16357562

Therapy

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Salem R, Johnson GE, Kim E, Riaz A, Bishay V, Boucher E, Fowers K, Lewandowski R, Padia SA
Hepatology 2021 Nov;74(5):2342-2352. Epub 2021 Jun 11 doi: 10.1002/hep.31819. PMID: 33739462Free PMC Article
Powles T, van der Heijden MS, Castellano D, Galsky MD, Loriot Y, Petrylak DP, Ogawa O, Park SH, Lee JL, De Giorgi U, Bögemann M, Bamias A, Eigl BJ, Gurney H, Mukherjee SD, Fradet Y, Skoneczna I, Tsiatas M, Novikov A, Suárez C, Fay AP, Duran I, Necchi A, Wildsmith S, He P, Angra N, Gupta AK, Levin W, Bellmunt J; DANUBE study investigators
Lancet Oncol 2020 Dec;21(12):1574-1588. Epub 2020 Sep 21 doi: 10.1016/S1470-2045(20)30541-6. PMID: 32971005
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article

Prognosis

Liu W, Wei R, Chen J, Li Y, Pang H, Zhang W, An C, Li C
Eur Radiol 2024 Aug;34(8):5094-5107. Epub 2024 Jan 30 doi: 10.1007/s00330-024-10581-2. PMID: 38291256Free PMC Article
Yang X, Chen B, Wang Y, Wang Y, Long J, Zhang N, Xue J, Xun Z, Zhang L, Cheng J, Lei J, Sun H, Li Y, Lin J, Xie F, Wang D, Pan J, Hu K, Guan M, Huo L, Shi J, Yu L, Zhou L, Zhou J, Lu Z, Yang X, Mao Y, Sang X, Lu Y, Zhao H
Hepatol Int 2023 Jun;17(3):709-719. Epub 2023 Feb 8 doi: 10.1007/s12072-022-10480-y. PMID: 36753026Free PMC Article
Salem R, Johnson GE, Kim E, Riaz A, Bishay V, Boucher E, Fowers K, Lewandowski R, Padia SA
Hepatology 2021 Nov;74(5):2342-2352. Epub 2021 Jun 11 doi: 10.1002/hep.31819. PMID: 33739462Free PMC Article
Chadha AS, Gunther JR, Hsieh CE, Aliru M, Mahadevan LS, Venkatesulu BP, Crane CH, Das P, Herman JM, Koay EJ, Taniguchi C, Holliday EB, Minsky BD, Suh Y, Park P, Sawakuchi G, Beddar S, Odisio BC, Gupta S, Loyer E, Kaur H, Raghav K, Javle MM, Kaseb AO, Krishnan S
Radiother Oncol 2019 Apr;133:54-61. Epub 2019 Jan 16 doi: 10.1016/j.radonc.2018.10.041. PMID: 30935582Free PMC Article
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article

Clinical prediction guides

Jiang H, Zuo M, Li W, Zhuo S, Wu P, An C
Int J Surg 2024 Sep 1;110(9):5672-5684. doi: 10.1097/JS9.0000000000001752. PMID: 38833331Free PMC Article
Yang X, Chen B, Wang Y, Wang Y, Long J, Zhang N, Xue J, Xun Z, Zhang L, Cheng J, Lei J, Sun H, Li Y, Lin J, Xie F, Wang D, Pan J, Hu K, Guan M, Huo L, Shi J, Yu L, Zhou L, Zhou J, Lu Z, Yang X, Mao Y, Sang X, Lu Y, Zhao H
Hepatol Int 2023 Jun;17(3):709-719. Epub 2023 Feb 8 doi: 10.1007/s12072-022-10480-y. PMID: 36753026Free PMC Article
Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Salem R, Johnson GE, Kim E, Riaz A, Bishay V, Boucher E, Fowers K, Lewandowski R, Padia SA
Hepatology 2021 Nov;74(5):2342-2352. Epub 2021 Jun 11 doi: 10.1002/hep.31819. PMID: 33739462Free PMC Article
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article

Recent systematic reviews

Barrow B, Martin Ii RCG
Surg Endosc 2023 Feb;37(2):817-834. Epub 2022 Sep 8 doi: 10.1007/s00464-022-09567-2. PMID: 36076101
Fraquelli M, Nadarevic T, Colli A, Manzotti C, Giljaca V, Miletic D, Štimac D, Casazza G
Cochrane Database Syst Rev 2022 Sep 2;9(9):CD013483. doi: 10.1002/14651858.CD013483.pub2. PMID: 36053210Free PMC Article
Walton M, Wade R, Claxton L, Sharif-Hurst S, Harden M, Patel J, Rowe I, Hodgson R, Eastwood A
Health Technol Assess 2020 Sep;24(48):1-264. doi: 10.3310/hta24480. PMID: 33001024Free PMC Article
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2017 Mar 7;3(3):CD011314. doi: 10.1002/14651858.CD011314.pub2. PMID: 28267205Free PMC Article

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