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Localized Malignant Gallbladder Neoplasm

MedGen UID:
82987
•Concept ID:
C0278806
•
Neoplastic Process
Synonym: Malignant Neoplasm of Gallbladder Localized

Definition

A malignant neoplasm that arises from the gallbladder and it has not spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Malignant Gallbladder Neoplasm

Professional guidelines

PubMed

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Gallbladder Cancer: Diagnosis, Surgical Management, and Adjuvant Therapies.
Hickman L, Contreras C
Surg Clin North Am 2019 Apr;99(2):337-355. doi: 10.1016/j.suc.2018.12.008. PMID: 30846038

Recent clinical studies

Etiology

Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Current update on gallbladder carcinoma.
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Multimodality Management of Localized Biliary Cancer.
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
How Should Gallbladder Cancer Be Managed?
Sachs TE, Akintorin O, Tseng J
Adv Surg 2018 Sep;52(1):89-100. Epub 2018 Jun 25 doi: 10.1016/j.yasu.2018.04.003. PMID: 30098623
Immunotherapeutic Approaches to Biliary Cancer.
Shah UA, Nandikolla AG, Rajdev L
Curr Treat Options Oncol 2017 Jul;18(7):44. doi: 10.1007/s11864-017-0486-9. PMID: 28660602

Diagnosis

Past, Present, and Future Management of Localized Biliary Tract Malignancies.
Li J, Rocha FG, Mayo SC
Surg Oncol Clin N Am 2023 Jan;32(1):83-99. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.07.007. PMID: 36410923
How I treat biliary tract cancer.
Lamarca A, Edeline J, Goyal L
ESMO Open 2022 Feb;7(1):100378. Epub 2022 Jan 13 doi: 10.1016/j.esmoop.2021.100378. PMID: 35032765Free PMC Article
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Current update on gallbladder carcinoma.
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up.
Madadi-Sanjani O, Wirth TC, Kuebler JF, Petersen C, Ure BM
Eur J Pediatr Surg 2019 Apr;29(2):143-149. Epub 2017 Dec 19 doi: 10.1055/s-0037-1615275. PMID: 29258149

Therapy

Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial.
Kelley RK, Ueno M, Yoo C, Finn RS, Furuse J, Ren Z, Yau T, Klümpen HJ, Chan SL, Ozaka M, Verslype C, Bouattour M, Park JO, Barajas O, Pelzer U, Valle JW, Yu L, Malhotra U, Siegel AB, Edeline J, Vogel A; KEYNOTE-966 Investigators
Lancet 2023 Jun 3;401(10391):1853-1865. Epub 2023 Apr 16 doi: 10.1016/S0140-6736(23)00727-4. PMID: 37075781
Multimodality Management of Localized Biliary Cancer.
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.
Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group
Lancet Oncol 2019 May;20(5):663-673. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(18)30915-X. PMID: 30922733
Radiation therapy in cholangiocellular carcinomas.
Brunner TB, Seufferlein T
Best Pract Res Clin Gastroenterol 2016 Aug;30(4):593-602. Epub 2016 Aug 24 doi: 10.1016/j.bpg.2016.08.003. PMID: 27644907
Surgical treatment of gall-bladder cancer.
Masior Ł, Krasnodębski M, Kobryń K, Grąt M, Krawczyk M
Pol Przegl Chir 2015 Jun;87(6):324-30. doi: 10.1515/pjs-2015-0063. PMID: 26247506

Prognosis

Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Current update on gallbladder carcinoma.
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up.
Madadi-Sanjani O, Wirth TC, Kuebler JF, Petersen C, Ure BM
Eur J Pediatr Surg 2019 Apr;29(2):143-149. Epub 2017 Dec 19 doi: 10.1055/s-0037-1615275. PMID: 29258149
How Should Gallbladder Cancer Be Managed?
Sachs TE, Akintorin O, Tseng J
Adv Surg 2018 Sep;52(1):89-100. Epub 2018 Jun 25 doi: 10.1016/j.yasu.2018.04.003. PMID: 30098623
Surgical treatment of gall-bladder cancer.
Masior Ł, Krasnodębski M, Kobryń K, Grąt M, Krawczyk M
Pol Przegl Chir 2015 Jun;87(6):324-30. doi: 10.1515/pjs-2015-0063. PMID: 26247506

Clinical prediction guides

Current progress in systemic therapy for biliary tract cancers.
Sutherland M, Ahmed O, Zaidi A, Ahmed S
J Hepatobiliary Pancreat Sci 2022 Oct;29(10):1094-1107. Epub 2021 Apr 5 doi: 10.1002/jhbp.939. PMID: 33735541
Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.
Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group
Lancet Oncol 2019 May;20(5):663-673. Epub 2019 Mar 25 doi: 10.1016/S1470-2045(18)30915-X. PMID: 30922733
Biliary tract cancers: understudied and poorly understood.
Chan E, Berlin J
J Clin Oncol 2015 Jun 1;33(16):1845-8. Epub 2015 Apr 27 doi: 10.1200/JCO.2014.59.7591. PMID: 25918294
Image-guided interstitial high-dose-rate brachytherapy in hepatocellular carcinoma.
Mohnike K, Wieners G, Pech M, Seidensticker M, Rühl R, Lopez-Haenninen E, Ricke J
Dig Dis 2009;27(2):170-4. Epub 2009 Jun 22 doi: 10.1159/000218350. PMID: 19546556

Recent systematic reviews

Unraveling early recurrence of risk factors in Gallbladder cancer: A systematic review and meta-analysis.
Yang SQ, Feng H, Tian Y, Zou RQ, Dai YS, Hu HJ, Li FY
Eur J Surg Oncol 2024 Jul;50(7):108372. Epub 2024 Apr 26 doi: 10.1016/j.ejso.2024.108372. PMID: 38718620
Benefit of adjuvant radiotherapy for gallbladder cancer: a comparability-based meta-analysis.
Choi SH, Rim CH, Shin IS, Yoon WS, Koom WS, Seong J
Hepatol Int 2022 Jun;16(3):712-727. Epub 2022 May 9 doi: 10.1007/s12072-022-10343-6. PMID: 35532861
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
Tumor location and concurrent liver resection, impact survival in T2 gallbladder cancer: a meta-analysis of the literature.
Khan SM, Emile SH, Choudhry MS, Sumbal R
Updates Surg 2021 Oct;73(5):1717-1726. Epub 2021 Aug 23 doi: 10.1007/s13304-021-01150-z. PMID: 34426958
Survival of surgery for recurrent biliary tract cancer: a single-center experience and systematic review of literature.
Miyazaki Y, Kokudo T, Amikura K, Kageyama Y, Takahashi A, Ohkohchi N, Sakamoto H
Jpn J Clin Oncol 2017 Mar 1;47(3):206-212. doi: 10.1093/jjco/hyw182. PMID: 27940488

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