U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clear cell acanthoma

MedGen UID:
83098
•Concept ID:
C0333992
•
Neoplastic Process
Synonyms: Acanthoma, Clear Cell; Acanthoma, Degos; Acanthomas, Clear Cell; Clear Cell Acanthoma; Clear Cell Acanthomas; Degos Acanthoma
SNOMED CT: Clear cell acanthoma (65540008); Clear cell acanthoma (254670002); Clear cell acanthoma of Degos (254670002); Degos' acanthoma (254670002)
 
Monarch Initiative: MONDO:0002086

Definition

An acanthoma characterized by the presence of psoriasiform epidermal acanthosis and basal cells with pale cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell acanthoma

Professional guidelines

PubMed

Comparative study of treatment methods for benign lichenoid keratosis of the face.
Yoon JH, Baek EJ, Park EJ, Kim KH
Dermatol Ther 2022 May;35(5):e15419. Epub 2022 Mar 12 doi: 10.1111/dth.15419. PMID: 35246904
Lesions With an Epidermal Hyperplastic Pattern: Morphologic Clues in the Differential Diagnosis.
Fernandez-Flores A
Am J Dermatopathol 2016 Jan;38(1):1-16; quiz 17-9. doi: 10.1097/DAD.0000000000000324. PMID: 26730692
Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.
Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908

Recent clinical studies

Etiology

Clear Cell Acanthoma: A Series of 70 Cases.
Marcoval J, Moreno-Vílchez C, Torrecilla-Vall-Llossera C, Muntaner-Virgili C, Penín RM
Actas Dermosifiliogr 2023 Sep;114(8):668-673. Epub 2023 Apr 29 doi: 10.1016/j.ad.2023.04.028. PMID: 37127205
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease.
Kuo KL, Lo CS, Lee LY, Yang CH, Kuo TT
J Am Acad Dermatol 2019 Mar;80(3):749-755. Epub 2018 Dec 14 doi: 10.1016/j.jaad.2016.07.032. PMID: 30558902
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.
Morrison LK, Duffey M, Janik M, Shamma HN
Int J Dermatol 2010 Sep;49(9):1008-11. doi: 10.1111/j.1365-4632.2010.04521.x. PMID: 20931670
How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors.
Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G
J Am Acad Dermatol 2010 Sep;63(3):377-86; quiz 387-8. doi: 10.1016/j.jaad.2009.11.697. PMID: 20708470

Diagnosis

Clear Cell Acanthoma: A Series of 70 Cases.
Marcoval J, Moreno-Vílchez C, Torrecilla-Vall-Llossera C, Muntaner-Virgili C, Penín RM
Actas Dermosifiliogr 2023 Sep;114(8):668-673. Epub 2023 Apr 29 doi: 10.1016/j.ad.2023.04.028. PMID: 37127205
Clear cell acanthoma.
Wagner G, Back W, Sachse MM
J Dtsch Dermatol Ges 2021 Jan;19(1):31-36. Epub 2020 Sep 28 doi: 10.1111/ddg.14270. PMID: 32989899
Clear Cell Acanthoma of the Areola and Nipple.
Hidalgo-García Y, Gonzálvo P, Mallo-García S, Fernández-Sánchez C
Actas Dermosifiliogr 2016 Nov;107(9):793-795. Epub 2016 May 17 doi: 10.1016/j.ad.2016.04.008. PMID: 27206609
Clear cell acanthoma.
Portal C, Fang F, Kanner W, Wilson B
Cutis 2013 Aug;92(2):62,77-9. PMID: 24087787
Clear cell acanthoma.
Tempark T, Shwayder T
Clin Exp Dermatol 2012 Dec;37(8):831-7. doi: 10.1111/j.1365-2230.2012.04428.x. PMID: 23171155

Therapy

Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation.
Drumm C, Ngan K, Crema J, Khirwadkar N, Defty C, Eustace K
J Dermatolog Treat 2022 Aug;33(5):2687-2688. Epub 2022 Apr 21 doi: 10.1080/09546634.2022.2049587. PMID: 35238268
Clear Cell Acanthoma: Sural Nerve Entrapment and Neuropathy After Excision.
Bennett M, Sinclair R
Dermatol Surg 2021 Nov 1;47(11):1534-1535. doi: 10.1097/DSS.0000000000003234. PMID: 34608085
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids.
González-Guerra E, Rodriguez JR, Casado AF, Taboada AC, Toro JAC, Bran EL
An Bras Dermatol 2017;92(5 Suppl 1):27-29. doi: 10.1590/abd1806-4841.20175683. PMID: 29267438Free PMC Article
Clear Cell Acanthoma of the Areola and Nipple.
Hidalgo-García Y, Gonzálvo P, Mallo-García S, Fernández-Sánchez C
Actas Dermosifiliogr 2016 Nov;107(9):793-795. Epub 2016 May 17 doi: 10.1016/j.ad.2016.04.008. PMID: 27206609
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902

Prognosis

Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation.
Drumm C, Ngan K, Crema J, Khirwadkar N, Defty C, Eustace K
J Dermatolog Treat 2022 Aug;33(5):2687-2688. Epub 2022 Apr 21 doi: 10.1080/09546634.2022.2049587. PMID: 35238268
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases.
Veiga RR, Barros RS, Santos JE, Abreu Junior JM, Bittencourt Mde J, Miranda MF
An Bras Dermatol 2013 Jan-Feb;88(1):84-9. doi: 10.1590/s0365-05962013000100010. PMID: 23539008Free PMC Article
A case of polypoid clear cell acanthoma on the scrotum.
Kawaguchi H, Tatewaki S, Takeuchi M
J Dermatol 2004 Mar;31(3):236-8. doi: 10.1111/j.1346-8138.2004.tb00662.x. PMID: 15187345
Psoriasis-like dermoscopic pattern of clear cell acanthoma.
Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460
Polypoid clear cell acanthoma: case report.
Inalöz HS, Patel G, Knight AG
J Eur Acad Dermatol Venereol 2000 Nov;14(6):511-2. doi: 10.1046/j.1468-3083.2000.00141.x. PMID: 11444278

Clinical prediction guides

Clear Cell Acanthoma on the Areola.
Borda LJ, Mervis JS, Romanelli P, Lev-Tov H
Dermatol Online J 2018 Jul 15;24(7) PMID: 30261576
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma.
Scanni G, Pellacani G
An Bras Dermatol 2014 Sep-Oct;89(5):803-5. doi: 10.1590/abd1806-4841.20143079. PMID: 25184922Free PMC Article
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Psoriasis-like dermoscopic pattern of clear cell acanthoma.
Bugatti L, Filosa G, Broganelli P, Tomasini C
J Eur Acad Dermatol Venereol 2003 Jul;17(4):452-5. doi: 10.1046/j.1468-3083.2003.00754.x. PMID: 12834460
Lectin-binding sites in clear cell acanthoma.
Akiyama M, Hayakawa K, Watanabe Y, Nishikawa T
J Cutan Pathol 1990 Aug;17(4):197-201. doi: 10.1111/j.1600-0560.1990.tb00084.x. PMID: 2394862

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...