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Malignant Gastrinoma

MedGen UID:
83121
•Concept ID:
C0334283
•
Neoplastic Process
Synonyms: G cell tumor, malignant; Gastrin cell tumor, malignant; Gastrinoma, malignant; Malignant G cell tumor; Malignant gastrinoma
SNOMED CT: Malignant G cell tumor (19756007); Malignant gastrinoma (19756007); Gastrin cell tumor, malignant (19756007); Gastrinoma, malignant (19756007); G cell tumor, malignant (19756007)

Definition

A gastrin-producing neuroendocrine tumor. It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome. It displays vascular invasion and metastasizes to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma.
Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT
Cancer 2002 Jan 15;94(2):331-43. doi: 10.1002/cncr.10195. PMID: 11900219

Recent clinical studies

Etiology

Parathyroid carcinoma in multiple endocrine neoplasia type 1. Case report and review of the literature.
del Pozo C, García-Pascual L, Balsells M, Barahona MJ, Veloso E, González C, Anglada-Barceló J
Hormones (Athens) 2011 Oct-Dec;10(4):326-31. doi: 10.14310/horm.2002.1325. PMID: 22281890
Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma.
Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT
Cancer 2002 Jan 15;94(2):331-43. doi: 10.1002/cncr.10195. PMID: 11900219
Benign and malignant gastrinoma.
Stabile BE, Passaro E Jr
Am J Surg 1985 Jan;149(1):144-50. doi: 10.1016/s0002-9610(85)80024-6. PMID: 2857072
The Zollinger-Ellison syndrome--23 years later.
Deveney CW, Deveney KS, Way LW
Ann Surg 1978 Sep;188(3):384-93. doi: 10.1097/00000658-197809000-00014. PMID: 686901Free PMC Article
Proceedings: Malignant gastrinoma following total gastrectomy.
Passaro E Jr, Gordon HE
Arch Surg 1974 Apr;108(4):444-8. doi: 10.1001/archsurg.1974.01350280050009. PMID: 4273862

Diagnosis

Parathyroid carcinoma in multiple endocrine neoplasia type 1. Case report and review of the literature.
del Pozo C, García-Pascual L, Balsells M, Barahona MJ, Veloso E, González C, Anglada-Barceló J
Hormones (Athens) 2011 Oct-Dec;10(4):326-31. doi: 10.14310/horm.2002.1325. PMID: 22281890
Primary lymph node malignant gastrinoma with metastasis to Virchow's node: a case report.
Westreich R, Brower S, Lawson W
Otolaryngol Head Neck Surg 2004 Dec;131(6):1027-8. doi: 10.1016/j.otohns.2004.03.017. PMID: 15577814
Diagnostic accuracy of ultrasound-guided fine-needle pancreatic biopsy.
Tikkakoski T, Siniluoto T, Päivänsalo M, Typpö T, Turunen J, Apaja-Sarkkinen M
Rofo 1992 Feb;156(2):178-81. doi: 10.1055/s-2008-1032860. PMID: 1739779
Gastric gastrinoma.
Liu TH, Zhong SX, Chen YF, Lin Y, Chen J, Li DC, Wang DT, Gu CF, Yie SF
Chin Med J (Engl) 1989 Oct;102(10):774-82. PMID: 2517058
Proceedings: Malignant gastrinoma following total gastrectomy.
Passaro E Jr, Gordon HE
Arch Surg 1974 Apr;108(4):444-8. doi: 10.1001/archsurg.1974.01350280050009. PMID: 4273862

Therapy

Diagnostic accuracy of ultrasound-guided fine-needle pancreatic biopsy.
Tikkakoski T, Siniluoto T, Päivänsalo M, Typpö T, Turunen J, Apaja-Sarkkinen M
Rofo 1992 Feb;156(2):178-81. doi: 10.1055/s-2008-1032860. PMID: 1739779
The Zollinger-Ellison syndrome. A case report.
du Toit DF, Louwrens H, Esterhuizen N, Falck VC, du Toit LB
S Afr Med J 1985 Oct 12;68(8):607-8. PMID: 3876607
Successful treatment of a malignant gastrinoma with streptozotocin.
Hayes JR, O'Connell N, O'Neill T, Fennelly JJ, Weir DG
Gut 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285. PMID: 178577Free PMC Article
Chemotherapy for malignant Zollinger-Ellison tumors: successful treatment with streptozocin and fluorouracil.
Ruffner BW Jr
Arch Intern Med 1976 Sep;136(9):1032-4. PMID: 134679
Proceedings: Malignant gastrinoma following total gastrectomy.
Passaro E Jr, Gordon HE
Arch Surg 1974 Apr;108(4):444-8. doi: 10.1001/archsurg.1974.01350280050009. PMID: 4273862

Prognosis

Bone metastases in malignant gastrinoma.
Barton JC, Hirschowitz BI, Maton PN, Jensen RT
Gastroenterology 1986 Nov;91(5):1179-85. doi: 10.1016/s0016-5085(86)80014-2. PMID: 3758610
Pylorus preserving pancreatoduodenectomy for gastrinoma. A case report.
Cavina E, Pagliai EF, Goletti O, Chiarugi M, Chirico A
Ital J Surg Sci 1986;16(4):291-5. PMID: 3557935
Benign and malignant gastrinoma.
Stabile BE, Passaro E Jr
Am J Surg 1985 Jan;149(1):144-50. doi: 10.1016/s0002-9610(85)80024-6. PMID: 2857072
Successful treatment of a malignant gastrinoma with streptozotocin.
Hayes JR, O'Connell N, O'Neill T, Fennelly JJ, Weir DG
Gut 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285. PMID: 178577Free PMC Article
Proceedings: Malignant gastrinoma following total gastrectomy.
Passaro E Jr, Gordon HE
Arch Surg 1974 Apr;108(4):444-8. doi: 10.1001/archsurg.1974.01350280050009. PMID: 4273862

Clinical prediction guides

MEN1 clinical background.
Igaz P
Adv Exp Med Biol 2009;668:1-15. doi: 10.1007/978-1-4419-1664-8_1. PMID: 20175448
Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma.
Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT
Cancer 2002 Jan 15;94(2):331-43. doi: 10.1002/cncr.10195. PMID: 11900219
Pancreatic endocrine tumour: a 22-year clinico-pathological experience with morphological, immunohistochemical observation and a review of the literature.
Lam KY, Lo CY
Eur J Surg Oncol 1997 Feb;23(1):36-42. doi: 10.1016/s0748-7983(97)80140-0. PMID: 9066745
Bone metastases in malignant gastrinoma.
Barton JC, Hirschowitz BI, Maton PN, Jensen RT
Gastroenterology 1986 Nov;91(5):1179-85. doi: 10.1016/s0016-5085(86)80014-2. PMID: 3758610
Pylorus preserving pancreatoduodenectomy for gastrinoma. A case report.
Cavina E, Pagliai EF, Goletti O, Chiarugi M, Chirico A
Ital J Surg Sci 1986;16(4):291-5. PMID: 3557935

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