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Type B Spindle Cell Melanoma

MedGen UID:
83149
•Concept ID:
C0334446
•
Neoplastic Process
Synonyms: Malignant Spindle Cell Type B Melanoma; Spindle cell melanoma - type B; Spindle cell melanoma, type B; Spindle Cell Type B Malignant Melanoma
SNOMED CT: Spindle cell melanoma - type B (40244008); Spindle cell melanoma, type B (40244008)

Definition

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType B Spindle Cell Melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
The Spitzoid lesion: rethinking Spitz tumors, atypical variants, 'Spitzoid melanoma' and risk assessment.
Barnhill RL
Mod Pathol 2006 Feb;19 Suppl 2:S21-33. doi: 10.1038/modpathol.3800519. PMID: 16446713
Management of small elevated pigmented choroidal lesions.
Char DH, Hogan MJ
Br J Ophthalmol 1977 Jan;61(1):54-8. doi: 10.1136/bjo.61.1.54. PMID: 836778Free PMC Article

Recent clinical studies

Etiology

Cytologic Findings in Serous Effusion Specimens from Melanoma Patients.
Shield PW, Ribu DL
Acta Cytol 2023;67(5):557-563. Epub 2023 Mar 30 doi: 10.1159/000530427. PMID: 36996775
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus.
Sherrill AM, Crespo G, Prakash AV, Messina JL
Am J Dermatopathol 2011 Feb;33(1):35-9. doi: 10.1097/DAD.0b013e3181e5dfa0. PMID: 21124206
Inverse correlation between expression of HLA-B and c-myc in uveal melanoma.
Blom DJ, Mooy CM, Luyten GP, Kerkvliet S, Ouwerkerk I, Zwinderman AH, Schrier PI, Jager MJ
J Pathol 1997 Jan;181(1):75-9. doi: 10.1002/(SICI)1096-9896(199701)181:1<75::AID-PATH724>3.0.CO;2-V. PMID: 9072006
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

Diagnosis

Cytologic Findings in Serous Effusion Specimens from Melanoma Patients.
Shield PW, Ribu DL
Acta Cytol 2023;67(5):557-563. Epub 2023 Mar 30 doi: 10.1159/000530427. PMID: 36996775
The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.
Roncati L, Piscioli F
Acta Dermatovenerol Croat 2020 Dec;28(7):236-237. PMID: 33834997
Extranodal B Cell Lymphoma with Prominent Spindle Cell Features Arising in Uterus and in Maxillary Sinus: Report of Two Cases and Literature Review.
Li Y, Cui W, Woodroof JM, Zhang D
Ann Clin Lab Sci 2016 Spring;46(2):213-8. PMID: 27098631
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P, Kim KB
J Cutan Pathol 2012 Sep;39(9):821-5. Epub 2012 Jul 19 doi: 10.1111/j.1600-0560.2012.01950.x. PMID: 22809251Free PMC Article
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628

Therapy

Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
BRAF V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens.
Lee PJ, Dennis K, Madan R, Fan F
Acta Cytol 2019;63(1):10-16. Epub 2018 Nov 5 doi: 10.1159/000491814. PMID: 30396186
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.
Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, Spijkers-Hagelstein JA, de Vetter JR, de Man J, Buijsman RC, Zaman GJ
PLoS One 2015;10(5):e0125021. Epub 2015 May 27 doi: 10.1371/journal.pone.0125021. PMID: 26018524Free PMC Article
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P, Kim KB
J Cutan Pathol 2012 Sep;39(9):821-5. Epub 2012 Jul 19 doi: 10.1111/j.1600-0560.2012.01950.x. PMID: 22809251Free PMC Article
Uveal melanomas: correlation of cytologic features with prognosis.
Gamel JW, McLean IW, Foster WD, Zimmerman LE
Cancer 1978 May;41(5):1897-901. doi: 10.1002/1097-0142(197805)41:5<1897::aid-cncr2820410534>3.0.co;2-2. PMID: 647633

Prognosis

The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.
Roncati L, Piscioli F
Acta Dermatovenerol Croat 2020 Dec;28(7):236-237. PMID: 33834997
BRAF V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens.
Lee PJ, Dennis K, Madan R, Fan F
Acta Cytol 2019;63(1):10-16. Epub 2018 Nov 5 doi: 10.1159/000491814. PMID: 30396186
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker.
Agaimy A, Specht K, Stoehr R, Lorey T, Märkl B, Niedobitek G, Straub M, Hager T, Reis AC, Schilling B, Schneider-Stock R, Hartmann A, Mentzel T
Am J Surg Pathol 2016 Feb;40(2):181-91. doi: 10.1097/PAS.0000000000000527. PMID: 26448190
Amelanotic acral melanomas: clinicopathological, BRAF mutation, and KIT aberration analyses.
Choi YD, Chun SM, Jin SA, Lee JB, Yun SJ
J Am Acad Dermatol 2013 Nov;69(5):700-707. Epub 2013 Aug 21 doi: 10.1016/j.jaad.2013.06.035. PMID: 23972510

Clinical prediction guides

Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
BRAF V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens.
Lee PJ, Dennis K, Madan R, Fan F
Acta Cytol 2019;63(1):10-16. Epub 2018 Nov 5 doi: 10.1159/000491814. PMID: 30396186
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker.
Agaimy A, Specht K, Stoehr R, Lorey T, Märkl B, Niedobitek G, Straub M, Hager T, Reis AC, Schilling B, Schneider-Stock R, Hartmann A, Mentzel T
Am J Surg Pathol 2016 Feb;40(2):181-91. doi: 10.1097/PAS.0000000000000527. PMID: 26448190
Expression and distribution of MMPs and TIMPs in human uveal melanoma.
Lai K, Conway RM, Crouch R, Jager MJ, Madigan MC
Exp Eye Res 2008 Jun;86(6):936-41. Epub 2008 Mar 16 doi: 10.1016/j.exer.2008.03.010. PMID: 18423620

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