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Spindle cell melanoma

MedGen UID:
83147
•Concept ID:
C0334444
•
Neoplastic Process
Synonyms: desmoplastic melanoma; Malignant Spindle Cell Melanoma; malignant spindle cell melanoma; Spindle cell malignant melanoma; Spindle Cell Malignant Melanoma; spindle cell malignant melanoma; Spindle Cell Melanoma; spindle cell melanoma; spitzoid malignant melanoma
SNOMED CT: Spindle cell melanoma (68827007); Spindle cell malignant melanoma (403923002)
 
Monarch Initiative: MONDO:0006427

Definition

A melanoma characterized by the presence of malignant spindle-shaped melanocytes. [from NCI]

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Ipilimumab and Nivolumab for Treatment of Eyelid Spindle Cell Melanoma.
Shoji MK, Rong AJ
Am J Ophthalmol 2023 Jun;250:e1-e2. Epub 2023 Feb 18 doi: 10.1016/j.ajo.2023.02.010. PMID: 36801380
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma.
Gleason BC, Calder KB, Cibull TL, Thomas AB, Billings SD, Morgan MB, Hiatt KM, Smoller BR
J Cutan Pathol 2009 May;36(5):543-7. Epub 2009 Mar 30 doi: 10.1111/j.1600-0560.2008.01099.x. PMID: 19476522

Recent clinical studies

Etiology

Prognostic nomograms for predicting long-term overall survival in spindle cell melanoma: a population-based study.
Lau WC, Huang L, Zheng X, Ming WK, Leong NC, Tak Wong Y, Yin Z, Yu H, Lyu J, Deng L
Front Endocrinol (Lausanne) 2024;15:1260966. Epub 2024 Mar 20 doi: 10.3389/fendo.2024.1260966. PMID: 38572477Free PMC Article
Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.
Boyraz B, Hung YP
APMIS 2022 Mar;130(3):140-154. Epub 2022 Jan 11 doi: 10.1111/apm.13203. PMID: 34942046
Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Spindle Cell Melanoma and Interdigitating Dendritic Cell Sarcoma: Do They Represent the Same Process?
Stowman AM, Mills SE, Wick MR
Am J Surg Pathol 2016 Sep;40(9):1270-9. doi: 10.1097/PAS.0000000000000678. PMID: 27299798
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

Diagnosis

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.
Boyraz B, Hung YP
APMIS 2022 Mar;130(3):140-154. Epub 2022 Jan 11 doi: 10.1111/apm.13203. PMID: 34942046
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245
Cutaneous desmoplastic melanoma.
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Therapy

Prognostic nomograms for predicting long-term overall survival in spindle cell melanoma: a population-based study.
Lau WC, Huang L, Zheng X, Ming WK, Leong NC, Tak Wong Y, Yin Z, Yu H, Lyu J, Deng L
Front Endocrinol (Lausanne) 2024;15:1260966. Epub 2024 Mar 20 doi: 10.3389/fendo.2024.1260966. PMID: 38572477Free PMC Article
Ipilimumab and Nivolumab for Treatment of Eyelid Spindle Cell Melanoma.
Shoji MK, Rong AJ
Am J Ophthalmol 2023 Jun;250:e1-e2. Epub 2023 Feb 18 doi: 10.1016/j.ajo.2023.02.010. PMID: 36801380
Clinical challenge - scratching the surface of the sheath.
Sheng J, Dermarkarian C, Foroozan R, Falardeau J
Surv Ophthalmol 2022 May-Jun;67(3):875-878. Epub 2021 Feb 19 doi: 10.1016/j.survophthal.2021.02.004. PMID: 33610587
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P, Kim KB
J Cutan Pathol 2012 Sep;39(9):821-5. Epub 2012 Jul 19 doi: 10.1111/j.1600-0560.2012.01950.x. PMID: 22809251Free PMC Article
Cutaneous desmoplastic melanoma.
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Prognosis

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.
Boyraz B, Hung YP
APMIS 2022 Mar;130(3):140-154. Epub 2022 Jan 11 doi: 10.1111/apm.13203. PMID: 34942046
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245
Cutaneous desmoplastic melanoma.
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Clinical prediction guides

Prognostic nomograms for predicting long-term overall survival in spindle cell melanoma: a population-based study.
Lau WC, Huang L, Zheng X, Ming WK, Leong NC, Tak Wong Y, Yin Z, Yu H, Lyu J, Deng L
Front Endocrinol (Lausanne) 2024;15:1260966. Epub 2024 Mar 20 doi: 10.3389/fendo.2024.1260966. PMID: 38572477Free PMC Article
PRAME expression in spindle cell melanoma, malignant peripheral nerve sheath tumour, and other cutaneous sarcomatoid neoplasms: a comparative analysis.
Hrycaj SM, Szczepanski JM, Zhao L, Siddiqui J, Thomas DG, Lucas DR, Patel RM, Harms PW, Bresler SC, Chan MP
Histopathology 2022 Dec;81(6):818-825. Epub 2022 Sep 28 doi: 10.1111/his.14797. PMID: 36102613Free PMC Article
Desmoplastic melanoma: a challenge for the oncologist.
Manfredini M, Pellacani G, Losi L, Maccaferri M, Tomasi A, Ponti G
Future Oncol 2017 Feb;13(4):337-345. Epub 2016 Oct 12 doi: 10.2217/fon-2016-0334. PMID: 27728982
A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma.
Weissinger SE, Keil P, Silvers DN, Klaus BM, Möller P, Horst BA, Lennerz JK
Mod Pathol 2014 Apr;27(4):524-34. Epub 2013 Sep 20 doi: 10.1038/modpathol.2013.162. PMID: 24051699
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

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