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Melanoma Arising from Blue Nevus

MedGen UID:
83150
•Concept ID:
C0334447
•
Neoplastic Process
Synonyms: Blue nevus, malignant; Blue Nevus-Like Melanoma; Malignant blue nevus; Malignant Blue Nevus; Malignant blue nevus of skin; Malignant Blue Nevus of Skin; Malignant Blue Nevus of the Skin; Malignant Cutaneous Blue Nevus; Malignant melanoma in blue nevus; Malignant Skin Blue Nevus
SNOMED CT: Blue nevus, malignant (67159000); Malignant blue nevus (67159000); Malignant melanoma in blue nevus (307603002); Malignant blue nevus of skin (307603002)

Definition

A rare melanoma which develops in a pre-existing blue nevus. It occurs more frequently on the scalp, face, orbit, back, buttocks, extremities, hands, and feet. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanoma Arising from Blue Nevus

Recent clinical studies

Etiology

Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study.
Caccavale S, Calabrese G, Mattiello E, Broganelli P, Ramondetta A, Pieretti G, Alfano R, Argenziano G
Dermatology 2021;237(3):473-478. Epub 2020 Oct 14 doi: 10.1159/000510221. PMID: 33053549
Melanoma Ex Blue Nevus With GNA11 Mutation and BAP1 Loss: Case Report and Review of the Literature.
Chang LW, Kazlouskaya V, Kazi R, Davar D, Ferris RL, Ho J, Karunamurthy A, Jedrych JJ, Bunimovich YL
Am J Dermatopathol 2020 Nov;42(11):854-857. doi: 10.1097/DAD.0000000000001652. PMID: 32310862Free PMC Article
Atypical cellular blue nevus or malignant blue nevus?
Daltro LR, Yaegashi LB, Freitas RA, Fantini BC, Souza CD
An Bras Dermatol 2017 Jan-Feb;92(1):110-112. doi: 10.1590/abd1806-4841.20174502. PMID: 28225968Free PMC Article
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221
Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls.
Murali R, McCarthy SW, Scolyer RA
Adv Anat Pathol 2009 Nov;16(6):365-82. doi: 10.1097/PAP.0b013e3181bb6b53. PMID: 19851128

Diagnosis

SF3B1 and BAP1 mutations in blue nevus-like melanoma.
Griewank KG, Müller H, Jackett LA, Emberger M, Möller I, van de Nes JA, Zimmer L, Livingstone E, Wiesner T, Scholz SL, Cosgarea I, Sucker A, Schimming T, Hillen U, Schilling B, Paschen A, Reis H, Mentzel T, Kutzner H, Rütten A, Murali R, Scolyer RA, Schadendorf D
Mod Pathol 2017 Jul;30(7):928-939. Epub 2017 Apr 14 doi: 10.1038/modpathol.2017.23. PMID: 28409567Free PMC Article
Blue nevus-like and blue nevus-associated melanoma: a comprehensive review of the literature.
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Blue nevus of the prostate.
Dailey VL, Hameed O
Arch Pathol Lab Med 2011 Jun;135(6):799-802. doi: 10.5858/2010-0022-RS.1. PMID: 21631277
Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls.
Murali R, McCarthy SW, Scolyer RA
Adv Anat Pathol 2009 Nov;16(6):365-82. doi: 10.1097/PAP.0b013e3181bb6b53. PMID: 19851128
Variants of melanoma.
Reed RJ, Martin P
Semin Cutan Med Surg 1997 Jun;16(2):137-58. doi: 10.1016/s1085-5629(97)80008-9. PMID: 9220553

Therapy

Concurrent Ki-67 and p53 immunolabeling in cutaneous melanocytic neoplasms: an adjunct for recognition of the vertical growth phase in malignant melanomas?
Kaleem Z, Lind AC, Humphrey PA, Sueper RH, Swanson PE, Ritter JH, Wick MR
Mod Pathol 2000 Mar;13(3):217-22. doi: 10.1038/modpathol.3880040. PMID: 10757331

Prognosis

Melanoma arising in plaque-type blue nevus and dermal melanocytosis: Diagnostic and prognostic value of BAP1.
Requena C, Traves V, Ferrandis E, Antón Almero M, García-Casado Z, Manrique-Silva E, Santos Briz Á, Escalonilla P, Nagore E
Actas Dermosifiliogr 2023 Jul-Aug;114(7):636-641. Epub 2023 Apr 23 doi: 10.1016/j.ad.2023.04.016. PMID: 37088284
Melanoma Ex Blue Nevus With GNA11 Mutation and BAP1 Loss: Case Report and Review of the Literature.
Chang LW, Kazlouskaya V, Kazi R, Davar D, Ferris RL, Ho J, Karunamurthy A, Jedrych JJ, Bunimovich YL
Am J Dermatopathol 2020 Nov;42(11):854-857. doi: 10.1097/DAD.0000000000001652. PMID: 32310862Free PMC Article
SF3B1 and BAP1 mutations in blue nevus-like melanoma.
Griewank KG, Müller H, Jackett LA, Emberger M, Möller I, van de Nes JA, Zimmer L, Livingstone E, Wiesner T, Scholz SL, Cosgarea I, Sucker A, Schimming T, Hillen U, Schilling B, Paschen A, Reis H, Mentzel T, Kutzner H, Rütten A, Murali R, Scolyer RA, Schadendorf D
Mod Pathol 2017 Jul;30(7):928-939. Epub 2017 Apr 14 doi: 10.1038/modpathol.2017.23. PMID: 28409567Free PMC Article
Blue nevus-like and blue nevus-associated melanoma: a comprehensive review of the literature.
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221

Clinical prediction guides

Melanoma Developing from an Intradermal Nevus: Report on Two Patients.
Ledić Drvar D, Radoš J, Manola I, Mataić A, Dotlić S, Krušlin B
Acta Dermatovenerol Croat 2023 Aug;31(1):40-42. PMID: 37843090
Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study.
Caccavale S, Calabrese G, Mattiello E, Broganelli P, Ramondetta A, Pieretti G, Alfano R, Argenziano G
Dermatology 2021;237(3):473-478. Epub 2020 Oct 14 doi: 10.1159/000510221. PMID: 33053549
A successfully treated malignant melanoma arising in a large congenital vulvar blue nevus.
Lin W, Song P, Ran X, Li R, Jiang X
Dermatol Ther 2020 Nov;33(6):e13821. Epub 2020 Jul 13 doi: 10.1111/dth.13821. PMID: 32531081
Blue nevus-like and blue nevus-associated melanoma: a comprehensive review of the literature.
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221

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