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Microcystic adnexal carcinoma

MedGen UID:
83399
•Concept ID:
C0346027
•
Neoplastic Process
Synonym: Malignant syringoma
SNOMED CT: Eccrine epithelioma (400135003); Syringomatous carcinoma (128896007); Microcystic adnexal carcinoma (128896007); Sclerosing sweat duct carcinoma (128896007); Eccrine epithelioma of skin (254722001); Microcystic adnexal carcinoma of skin (254712007); Malignant syringoma (254712007); Syringoid eccrine carcinoma (254712007); Syringomatous sweat duct carcinoma (254712007); Sclerosing sweat duct carcinoma (254712007); Microcystic adnexal carcinoma (254712007); Eccrine epithelioma (254722001)
 
Monarch Initiative: MONDO:0003519

Definition

A low grade adenocarcinoma with ductal differentiation, arising from the sweat glands. It presents as a scar usually in the face. It is characterized by the formation of small ducts and it frequently involves nerves and perineural spaces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrocystic adnexal carcinoma

Professional guidelines

PubMed

Microcystic adnexal carcinoma of the head and neck: Characteristics, treatment, and survival statistics.
Behbahani S, Yeh CJ, Pinto JO, Wassef D, Povolotskiy R, Joseph N, Lambert WC, Schwartz RA
Dermatol Ther 2021 Jan;34(1):e14559. Epub 2020 Dec 3 doi: 10.1111/dth.14559. PMID: 33210380
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Determinants of Microcystic Adnexal Carcinoma Management and Outcomes in British Columbia.
Burleigh A, Zloty D, Crawford RI
J Cutan Med Surg 2020 Sep/Oct;24(5):536-537. Epub 2020 Jun 25 doi: 10.1177/1203475420936646. PMID: 32584171

Recent clinical studies

Etiology

Approaches to Perineural, Lymphovascular, and Single-Cell Disease.
Collins MK, Behshad R, Maloney M, Pugliano-Mauro M
Dermatol Surg 2019 Dec;45 Suppl 2:S118-S128. doi: 10.1097/DSS.0000000000002259. PMID: 31764297
Demographics and outcomes of microcystic adnexal carcinoma.
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, Otley CC, Roenigk RK
J Am Acad Dermatol 2018 Oct;79(4):756-758. Epub 2018 Mar 17 doi: 10.1016/j.jaad.2018.03.010. PMID: 29559397
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
Connolly KL, Nehal KS, Disa JJ
Plast Reconstr Surg 2017 Jan;139(1):181e-190e. doi: 10.1097/PRS.0000000000002853. PMID: 28027254
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588

Diagnosis

Microcystic adnexal carcinoma.
Kura MM, Aliporewala VM, Bolde S, Bijwe S
Indian J Dermatol Venereol Leprol 2020 Sep-Oct;86(5):595-596. doi: 10.4103/ijdvl.IJDVL_677_18. PMID: 31347515
Malignant Sweat Gland Tumors.
Ahn CS, Sangüeza OP
Hematol Oncol Clin North Am 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002. PMID: 30497677
Microcystic Adnexal Carcinoma: A Review of the Literature.
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
Treatments for microcystic adnexal carcinoma--A review.
Chaudhari SP, Mortazie MB, Blattner CM, Garelik J, Wolff M, Daulat J, Chaudhari PJ
J Dermatolog Treat 2016;27(3):278-84. Epub 2015 Nov 11 doi: 10.3109/09546634.2015.1089351. PMID: 26331917
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588

Therapy

A review of Mohs micrographic surgery for skin cancer. Part 1: Melanoma and rare skin cancers.
Charalambides M, Yannoulias B, Malik N, Mann JK, Celebi P, Veitch D, Wernham A
Clin Exp Dermatol 2022 May;47(5):833-849. Epub 2022 Feb 22 doi: 10.1111/ced.15081. PMID: 34939669
Emerging therapies for rare cutaneous cancers: A systematic review.
Garcia A, Nelson K, Patel V
Cancer Treat Rev 2021 Nov;100:102266. Epub 2021 Aug 16 doi: 10.1016/j.ctrv.2021.102266. PMID: 34418780
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Treatments for microcystic adnexal carcinoma--A review.
Chaudhari SP, Mortazie MB, Blattner CM, Garelik J, Wolff M, Daulat J, Chaudhari PJ
J Dermatolog Treat 2016;27(3):278-84. Epub 2015 Nov 11 doi: 10.3109/09546634.2015.1089351. PMID: 26331917
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300

Prognosis

Microcystic adnexal carcinoma of the head and neck: Characteristics, treatment, and survival statistics.
Behbahani S, Yeh CJ, Pinto JO, Wassef D, Povolotskiy R, Joseph N, Lambert WC, Schwartz RA
Dermatol Ther 2021 Jan;34(1):e14559. Epub 2020 Dec 3 doi: 10.1111/dth.14559. PMID: 33210380
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Demographics and outcomes of microcystic adnexal carcinoma.
King BJ, Tolkachjov SN, Winchester DS, Baum CL, Brewer JD, Arpey CJ, Otley CC, Roenigk RK
J Am Acad Dermatol 2018 Oct;79(4):756-758. Epub 2018 Mar 17 doi: 10.1016/j.jaad.2018.03.010. PMID: 29559397
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Microcystic Adnexal Carcinoma: A Review of the Literature.
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578

Clinical prediction guides

Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma.
Gambichler T, Hartenstein I, Dreißigacker M, Stockfleth E, Stücker M, Schaller J, Schulze HJ, Becker JC, Käfferlein HU, Brüning T, Lang K
Clin Exp Dermatol 2021 Aug;46(6):1052-1057. Epub 2021 May 1 doi: 10.1111/ced.14634. PMID: 33714217
Microcystic Adnexal Carcinoma of the Nipple.
Wong LK, Kereke AR, Wright AE, Vyas KS
Wounds 2018 Jun;30(6):E65-E67. PMID: 30059333
Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
Wetter R, Goldstein GD
Dermatol Ther 2008 Nov-Dec;21(6):452-8. doi: 10.1111/j.1529-8019.2008.00246.x. PMID: 19076623
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446
Microcystic adnexal carcinoma.
Cooper PH, Mills SE
J Am Acad Dermatol 1984 May;10(5 Pt 2):908-14. doi: 10.1016/s0190-9622(84)80445-4. PMID: 6725679

Recent systematic reviews

A Systematic Review of the Epidemiology, Clinical Characteristics, Treatment, and Outcomes for Desmoplastic Trichoepithelioma: Underscoring Mohs Micrographic Surgery in Management.
Nanda R, Srivastava D, Nijhawan RI
Dermatol Surg 2024 Aug 1;50(8):695-698. Epub 2024 Apr 9 doi: 10.1097/DSS.0000000000004194. PMID: 38595132
Emerging therapies for rare cutaneous cancers: A systematic review.
Garcia A, Nelson K, Patel V
Cancer Treat Rev 2021 Nov;100:102266. Epub 2021 Aug 16 doi: 10.1016/j.ctrv.2021.102266. PMID: 34418780

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