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Dysgerminoma of ovary

MedGen UID:
83414
•Concept ID:
C0346185
•
Neoplastic Process
Synonyms: dysgerminoma; Dysgerminoma of Ovary; dysgerminoma of ovary; Dysgerminoma of the Ovary; dysgerminoma of the ovary; Germ Cell Dysgerminoma of Ovary; germ cell dysgerminoma of ovary; Germ Cell Dysgerminoma of the Ovary; germ cell dysgerminoma of the ovary; Malignant dysgerminoma of ovary; Malignant dysgerminomatous germ cell tumor of ovary; Ovarian Dysgerminoma; ovarian dysgerminoma; Ovarian Germ Cell Dysgerminoma; ovarian germ cell dysgerminoma; ovary dysgerminoma (disease)
SNOMED CT: Malignant dysgerminomatous germ cell tumor of ovary (254874008); Malignant dysgerminoma of ovary (254874008)
 
Monarch Initiative: MONDO:0003481

Definition

A malignant germ cell tumor arising from the ovary. Morphologically, it is identical to seminoma and consists of a monotonous population of germ cells with abundant pale cytoplasm and uniform nuclei. The stroma invariably contains chronic inflammatory cells, mostly T-lymphocytes. It responds to chemotherapy or radiotherapy and the prognosis relates to the tumor stage. [from NCI]

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Current Strategy for the Treatment of Ovarian Germ Cell Tumors: Role of Extensive Surgery.
Li J, Wu X
Curr Treat Options Oncol 2016 Aug;17(8):44. doi: 10.1007/s11864-016-0416-2. PMID: 27357180
Controversies in the management of germ cell tumours of the ovary.
Patterson DM, Rustin GJ
Curr Opin Oncol 2006 Sep;18(5):500-6. doi: 10.1097/01.cco.0000239891.44031.38. PMID: 16894300

Recent clinical studies

Etiology

Effect of estrogen and progesterone on the growth of human ovarian dysgerminoma heterotransplanted to athymic nude mice.
Ochiai K, Isonishi S, Hirama Y, Yasuda M, Terashima Y
Asia Oceania J Obstet Gynaecol 1991 Jun;17(2):147-58. doi: 10.1111/j.1447-0756.1991.tb00039.x. PMID: 1867584

Diagnosis

Diagnostic dilemma of an unusual pelvic mass in a young girl.
Rajbhandari S, Shrestha B, Karki A
JNMA J Nepal Med Assoc 2007 Oct-Dec;46(168):199-202. PMID: 18340374

Prognosis

Diagnostic dilemma of an unusual pelvic mass in a young girl.
Rajbhandari S, Shrestha B, Karki A
JNMA J Nepal Med Assoc 2007 Oct-Dec;46(168):199-202. PMID: 18340374

Clinical prediction guides

Effect of estrogen and progesterone on the growth of human ovarian dysgerminoma heterotransplanted to athymic nude mice.
Ochiai K, Isonishi S, Hirama Y, Yasuda M, Terashima Y
Asia Oceania J Obstet Gynaecol 1991 Jun;17(2):147-58. doi: 10.1111/j.1447-0756.1991.tb00039.x. PMID: 1867584

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