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Malignant neoplasm of acoustic nerve

MedGen UID:
83418
•Concept ID:
C0346331
•
Neoplastic Process
Synonyms: Cancer of the Vestibulocochlear Nerve; cancer of the vestibulocochlear nerve; Cancer of Vestibulocochlear Nerve; cancer of vestibulocochlear nerve; Malignant Acoustic Nerve Neoplasm; malignant acoustic nerve neoplasm; Malignant Acoustic Nerve Tumor; malignant acoustic nerve tumor; malignant acoustic nerve tumour; Malignant Eighth Cranial Nerve Neoplasm; malignant eighth cranial nerve neoplasm; Malignant Eighth Cranial Nerve Tumor; malignant eighth cranial nerve tumor; malignant eighth cranial nerve tumour; Malignant Neoplasm of Acoustic Nerve; malignant neoplasm of acoustic nerve; Malignant Neoplasm of Eighth Cranial Nerve; malignant neoplasm of eighth cranial nerve; Malignant Neoplasm of the Acoustic Nerve; malignant neoplasm of the acoustic nerve; Malignant Neoplasm of the Eighth Cranial Nerve; malignant neoplasm of the eighth cranial nerve; Malignant Neoplasm of the Vestibulocochlear Nerve; malignant neoplasm of the vestibulocochlear nerve; Malignant Neoplasm of Vestibulocochlear Nerve; malignant neoplasm of vestibulocochlear nerve; Malignant Tumor of Acoustic Nerve; malignant tumor of acoustic nerve; Malignant tumor of acoustic vestibular nerve; malignant tumor of acoustic vestibular nerve; Malignant Tumor of Eighth Cranial Nerve; malignant tumor of eighth cranial nerve; Malignant Tumor of the Acoustic Nerve; malignant tumor of the acoustic nerve; Malignant Tumor of the Eighth Cranial Nerve; malignant tumor of the eighth cranial nerve; Malignant Tumor of the Vestibulocochlear Nerve; malignant tumor of the vestibulocochlear nerve; Malignant Tumor of Vestibulocochlear Nerve; malignant tumor of vestibulocochlear nerve; malignant tumour of acoustic nerve; malignant tumour of acoustic vestibular nerve; malignant tumour of eighth cranial nerve; malignant tumour of the acoustic nerve; malignant tumour of the eighth cranial nerve; malignant tumour of the vestibulocochlear nerve; malignant tumour of vestibulocochlear nerve; Malignant Vestibulocochlear Nerve Neoplasm; malignant vestibulocochlear nerve neoplasm; Malignant Vestibulocochlear Nerve Tumor; malignant vestibulocochlear nerve tumor; malignant vestibulocochlear nerve tumour; vestibulocochlear nerve cancer
SNOMED CT: Malignant tumor of acoustic vestibular nerve (254980001)
 
Monarch Initiative: MONDO:0002432

Definition

A primary or metastatic malignant neoplasm affecting the eighth cranial nerve, also referred to as the vestibulocochlear nerve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant neoplasm of acoustic nerve

Professional guidelines

PubMed

Targeted Therapies in the Treatment of Vestibular Schwannomas: Current State and New Horizons.
Welling DB
Otolaryngol Clin North Am 2023 Jun;56(3):543-556. Epub 2023 Apr 4 doi: 10.1016/j.otc.2023.02.013. PMID: 37024334
Surgical management of skull base meningiomas and vestibular schwannomas.
Gambacciani C, Grimod G, Sameshima T, Santonocito OS
Curr Opin Oncol 2022 Nov 1;34(6):713-722. Epub 2022 Sep 7 doi: 10.1097/CCO.0000000000000904. PMID: 36093884
Management of Vestibular Schwannoma (Including NF2): Facial Nerve Considerations.
Kaul V, Cosetti MK
Otolaryngol Clin North Am 2018 Dec;51(6):1193-1212. doi: 10.1016/j.otc.2018.07.015. PMID: 30390772

Recent clinical studies

Etiology

Surgical management of skull base meningiomas and vestibular schwannomas.
Gambacciani C, Grimod G, Sameshima T, Santonocito OS
Curr Opin Oncol 2022 Nov 1;34(6):713-722. Epub 2022 Sep 7 doi: 10.1097/CCO.0000000000000904. PMID: 36093884
Safety and Efficacy of Hypofractionated Stereotactic Radiosurgery in Facial Nerve Schwannoma.
Fatima N, La Dine AK, Barnard ZR, Ko K, Peng K, Slattery WH, Lekovic GP
Otol Neurotol 2022 Sep 1;43(8):e841-e845. Epub 2022 Jul 28 doi: 10.1097/MAO.0000000000003594. PMID: 35900912
Auditory brainstem implant program development.
Schwartz MS, Wilkinson EP
Laryngoscope 2017 Aug;127(8):1909-1915. Epub 2016 Sep 26 doi: 10.1002/lary.26312. PMID: 27716925
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819
Bilateral acoustic neuromas.
Anand VT, Byrnes DP, Walby AP, Kerr AG
Clin Otolaryngol Allied Sci 1993 Oct;18(5):365-71. doi: 10.1111/j.1365-2273.1993.tb00594.x. PMID: 8877201

Diagnosis

Hearing loss and vestibular schwannoma: new insights into Schwann cells implication.
Mohamed T, Melfi V, Colciago A, Magnaghi V
Cell Death Dis 2023 Sep 23;14(9):629. doi: 10.1038/s41419-023-06141-z. PMID: 37741837Free PMC Article
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819
Neurofibromatosis type 2.
Evans GR, Lloyd SKW, Ramsden RT
Adv Otorhinolaryngol 2011;70:91-98. Epub 2011 Feb 24 doi: 10.1159/000322482. PMID: 21358190
The vestibulocochlear nerve.
Spickler EM, Govila L
Semin Ultrasound CT MR 2002 Jun;23(3):218-37. doi: 10.1016/s0887-2171(02)90048-x. PMID: 12168998
Hearing loss.
Weissman JL
Radiology 1996 Jun;199(3):593-611. doi: 10.1148/radiology.199.3.8637972. PMID: 8637972

Therapy

Open surgery vs. stereotactic radiosurgery for tumour-related trigeminal neuralgia: A systematic review.
Nugroho SW, Anindya Y, Hafif M, Wicaksana BA, Desbassari F, Sadewo W, Perkasa SAH
Clin Neurol Neurosurg 2023 May;228:107683. Epub 2023 Mar 21 doi: 10.1016/j.clineuro.2023.107683. PMID: 37001475
Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis.
Balossier A, Tuleasca C, Delsanti C, Troude L, Thomassin JM, Roche PH, Régis J
Neurosurgery 2023 Jun 1;92(6):1130-1141. Epub 2023 Feb 3 doi: 10.1227/neu.0000000000002354. PMID: 36735500Free PMC Article
Safety and Efficacy of Hypofractionated Stereotactic Radiosurgery in Facial Nerve Schwannoma.
Fatima N, La Dine AK, Barnard ZR, Ko K, Peng K, Slattery WH, Lekovic GP
Otol Neurotol 2022 Sep 1;43(8):e841-e845. Epub 2022 Jul 28 doi: 10.1097/MAO.0000000000003594. PMID: 35900912
Neurofibromatosis Clinical Trial Consortium.
Packer RJ, Fisher MJ, Cutter G, Cole-Plourde K, Korf BR
J Child Neurol 2018 Jan;33(1):82-91. doi: 10.1177/0883073817739196. PMID: 29246097
Chemotherapy: present and future.
Terry AR, Plotkin SR
Otolaryngol Clin North Am 2012 Apr;45(2):471-86, x. doi: 10.1016/j.otc.2011.12.013. PMID: 22483828

Prognosis

Hearing loss and vestibular schwannoma: new insights into Schwann cells implication.
Mohamed T, Melfi V, Colciago A, Magnaghi V
Cell Death Dis 2023 Sep 23;14(9):629. doi: 10.1038/s41419-023-06141-z. PMID: 37741837Free PMC Article
Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis.
Balossier A, Tuleasca C, Delsanti C, Troude L, Thomassin JM, Roche PH, Régis J
Neurosurgery 2023 Jun 1;92(6):1130-1141. Epub 2023 Feb 3 doi: 10.1227/neu.0000000000002354. PMID: 36735500Free PMC Article
Safety and Efficacy of Hypofractionated Stereotactic Radiosurgery in Facial Nerve Schwannoma.
Fatima N, La Dine AK, Barnard ZR, Ko K, Peng K, Slattery WH, Lekovic GP
Otol Neurotol 2022 Sep 1;43(8):e841-e845. Epub 2022 Jul 28 doi: 10.1097/MAO.0000000000003594. PMID: 35900912
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113
Neurofibromatosis 2.
Hoa M, Slattery WH 3rd
Otolaryngol Clin North Am 2012 Apr;45(2):315-32, viii. doi: 10.1016/j.otc.2011.12.005. PMID: 22483819

Clinical prediction guides

Hearing loss and vestibular schwannoma: new insights into Schwann cells implication.
Mohamed T, Melfi V, Colciago A, Magnaghi V
Cell Death Dis 2023 Sep 23;14(9):629. doi: 10.1038/s41419-023-06141-z. PMID: 37741837Free PMC Article
Neuromonitoring of the cochlear nerve during vestibular schwannoma resection and simultaneous cochlear implantation.
Weiss NM, Großmann W, Schraven SP, Oberhoffner T, Mlynski R
HNO 2021 Aug;69(Suppl 2):82-87. Epub 2021 May 21 doi: 10.1007/s00106-021-00997-3. PMID: 34019139
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113
Intralabyrinthine schwannomas.
Neff BA, Willcox TO Jr, Sataloff RT
Otol Neurotol 2003 Mar;24(2):299-307. doi: 10.1097/00129492-200303000-00028. PMID: 12621348
Bilateral acoustic neuromas.
Anand VT, Byrnes DP, Walby AP, Kerr AG
Clin Otolaryngol Allied Sci 1993 Oct;18(5):365-71. doi: 10.1111/j.1365-2273.1993.tb00594.x. PMID: 8877201

Recent systematic reviews

Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis.
Balossier A, Tuleasca C, Delsanti C, Troude L, Thomassin JM, Roche PH, Régis J
Neurosurgery 2023 Jun 1;92(6):1130-1141. Epub 2023 Feb 3 doi: 10.1227/neu.0000000000002354. PMID: 36735500Free PMC Article
Systematic Review and Meta-analysis for Surgery Versus Stereotactic Radiosurgery for Jugular Paragangliomas.
Campbell JC, Lee JW, Ledbetter L, Wick CC, Riska KM, Cunningham CD, Russomando AC, Truong T, Hong H, Kuchibhatla M, Kaylie DM
Otol Neurotol 2023 Mar 1;44(3):195-200. Epub 2022 Dec 31 doi: 10.1097/MAO.0000000000003781. PMID: 36728610
Treatment for vestibular schwannoma: Systematic review and single arm meta-analysis.
Thai NLB, Mai NY, Vuong NL, Tin NM, Karam D, Refaey MA, Shahin KM, Soliman AL, Al Khudari R, Thuan TM, Sabbah GM, El-Qushayri AE, Karimzadeh S, Hirayama K, Huy NT
Am J Otolaryngol 2022 Mar-Apr;43(2):103337. Epub 2021 Dec 20 doi: 10.1016/j.amjoto.2021.103337. PMID: 34973662
Indications and contraindications of auditory brainstem implants: systematic review and illustrative cases.
Merkus P, Di Lella F, Di Trapani G, Pasanisi E, Beltrame MA, Zanetti D, Negri M, Sanna M
Eur Arch Otorhinolaryngol 2014 Jan;271(1):3-13. Epub 2013 Feb 13 doi: 10.1007/s00405-013-2378-3. PMID: 23404468
Systematic review of quality of life in the management of vestibular schwannoma.
Gauden A, Weir P, Hawthorne G, Kaye A
J Clin Neurosci 2011 Dec;18(12):1573-84. Epub 2011 Oct 19 doi: 10.1016/j.jocn.2011.05.009. PMID: 22014598

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