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Cranial nerve neuropathy

MedGen UID:: 1160
•Concept ID:: C0010266
•: Disease or Syndrome

Synonyms:	Cranial Nerve Disease; Cranial Nerve Diseases; Cranial Nerve Disorder; Cranial Nerve Disorders; Cranial Neuropathies; Cranial Neuropathy; Nervus Cranialis Disorder; Nervus Cranialis Disorders; Neuropathies, Cranial; Neuropathy, Cranial
SNOMED CT:	Cranial nerve disorder (73013002); Cranial neuropathy (73013002); Disorder of cranial nerve (73013002)

Monarch Initiative:	MONDO:0003569

Definition

A neoplastic or non-neoplastic disorder that affects one of the cranial nerves. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCranial nerve neuropathy

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of nervous system
        Cranial nerve neuropathy
        Abducens nerve disorder
        Abducens nerve neoplasm
        Abducens nerve palsy
        Accessory nerve disorder
        Palsy of accessory nerve
        Spinal accessory nerve neoplasm
        Cranial nerve neoplasm
        Facial nerve neoplasm
        Glossopharyngeal nerve neoplasm
        Hypoglossal nerve neoplasm
        Schwannoma of twelfth cranial nerve
        Malignant cranial nerve neoplasm
        Malignant neoplasm of acoustic nerve
        Malignant olfactory nerve neoplasm
        Malignant Optic Nerve Neoplasm
        Oculomotor nerve cancer
        Oculomotor nerve neoplasm
        Olfactory nerve neoplasm
        Olfactory Neurogenic Tumor
        Optic nerve neoplasm
        Bilateral meningioma of optic nerve
        Optic nerve glioma
        Optic nerve sheath meningioma
        Optic Nerve Sheath Solitary Fibrous Tumor
        Trigeminal nerve neoplasm
        Trigeminal schwannoma
        Trochlear nerve neoplasm
        Vagus nerve neoplasm
        Vagal paraganglioma
        Vestibular schwannoma
        Bilateral vestibular schwannoma
        Neurofibromatosis, type 2
        Unilateral vestibular schwannoma
        Vestibulocochlear nerve neoplasm
        Cranial nerve paralysis
        Cranial Nerve II Palsy
        Facial paralysis
        Acquired Facial Nerve Palsy
        Congenital facial nerve palsy
        Facial Nerve Palsy Related to Birth
        Facial Nerve Palsy Related to Trauma
        Fourth cranial nerve palsy
        Glossopharyngeal nerve paralysis
        Hypoglossal nerve palsy
        Oculomotor nerve palsy
        Congenital oculomotor nerve palsy
        Holmes-Adie syndrome
        Palsy of vagus nerve
        Progressive bulbar palsy
        Brown-Vialetto-van Laere syndrome 1
        Trigeminal nerve palsy
        Vestibulocochlear nerve palsy
        Disorder of eye movements
        Duane anomaly
        Duane retraction syndrome 2
        Duane syndrome type 1
        Miller Fisher syndrome
        Nystagmus
        Congenital nystagmus
        Divergence nystagmus
        Horizontal nystagmus
        Nystagmus-induced head nodding
        Pendular nystagmus
        Rotary nystagmus
        Vertical nystagmus
        Ophthalmoplegia
        External ophthalmoplegia
        Internal ophthalmoplegia
        Internuclear ophthalmoplegia
        Ophthalmoplegic migraine
        Progressive external ophthalmoplegia
        Progressive ophthalmoplegia
        Progressive supranuclear palsy
        Supranuclear ophthalmoplegia
        Total ophthalmoplegia
        Opsoclonus-myoclonus syndrome
        Strabismus
        Concomitant strabismus
        Cyclodeviation
        Esodeviation
        Esotropia
        Exodeviation
        Exotropia
        Heterophoria
        Heterotropia
        Hyperdeviation
        Hypertropia
        Hypodeviation
        Hypotropia
        Incomitant strabismus
        Monocular strabismus
        Paralytic strabismus
        Tolosa-Hunt syndrome
        Disorder of optic nerve
        Ischemic optic neuropathy
        Low tension glaucoma
        Non-Neoplastic Optic Nerve Disorder
        Optic nerve hypoplasia
        Optic neuropathy
        Optic atrophy
        Hereditary optic atrophy
        Optic disc drusen
        Optic neuritis
        Neuromyelitis optica
        Retrobulbar optic neuritis
        Papilledema
        Facial nerve disorder
        Facial neuralgia
        Trigeminal nerve disorder
        Facial palsy
        Bilateral facial palsy
        Facial diplegia
        Unilateral facial palsy
        Geniculate herpes zoster
        Hemifacial atrophy
        Melkersson-Rosenthal syndrome
        Oromandibular-limb hypogenesis spectrum
        Glossopharyngeal nerve disorder
        Hypoglossal nerve disorder
        Infection of cranial nerve
        Olfactory nerve disorder
        Olfactory esthesioneuroblastoma
        Kadish Stage A Olfactory Neuroblastoma
        Kadish Stage B Olfactory Neuroblastoma
        Kadish Stage C Olfactory Neuroblastoma
        Nasal cavity olfactory neuroblastoma
        Recurrent Olfactory Neuroblastoma
        Sinonasal Olfactory Neuroblastoma
        Pseudobulbar paralysis
        Third cranial nerve disorder
        Trochlear nerve disorder
        Vagus nerve disorder
        Vocal cord paralysis
        Bilateral vocal cord paralysis
        Unilateral vocal cord paralysis
        Vocal cord paresis
        Vestibulocochlear nerve disorder
        Cogan syndrome
        Vestibular neuronitis

Professional guidelines

PubMed

Management and long-term comorbidities of patients with necrotizing otitis externa.

Arslan IB, Pekcevik Y, Cukurova I
Eur Arch Otorhinolaryngol 2023 Jun;280(6):2755-2761. Epub 2022 Dec 18 doi: 10.1007/s00405-022-07784-y. PMID: 36528642 Free PMC Article

Radiotherapy in the treatment of benign meningioma of the skull base.

Nutting C, Brada M, Brazil L, Sibtain A, Saran F, Westbury C, Moore A, Thomas DG, Traish D, Ashley S
J Neurosurg 1999 May;90(5):823-7. doi: 10.3171/jns.1999.90.5.0823. PMID: 10223446

See all (2)

Recent clinical studies

Etiology

Prevalence of and risk factors for cranial neuropathy in diabetic and non-diabetic patients.

AlZailaie AK, Aseeri AM, Algahtany AM, Algahtany MM, Algahtany MA
Eur Rev Med Pharmacol Sci 2023 Jun;27(11):4990-4997. doi: 10.26355/eurrev_202306_32616. PMID: 37318473

COVID-19 associated cranial nerve neuropathy: A systematic review.

Finsterer J, Scorza FA, Scorza C, Fiorini A
Bosn J Basic Med Sci 2022 Feb 1;22(1):39-45. doi: 10.17305/bjbms.2021.6341. PMID: 34392827 Free PMC Article

Neurological impact of eosinophilic granulomatosis with polyangiitis.

Gomes I, Girão A, Gomes J, Rebelo O, Jesus-Ribeiro J
Acta Neurol Belg 2022 Feb;122(1):123-128. Epub 2021 Apr 27 doi: 10.1007/s13760-021-01683-5. PMID: 33905106

Pembrolizumab Monotherapy for Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma: A Single-Arm Phase II Trial (KEYNOTE-629).

Grob JJ, Gonzalez R, Basset-Seguin N, Vornicova O, Schachter J, Joshi A, Meyer N, Grange F, Piulats JM, Bauman JR, Zhang P, Gumuscu B, Swaby RF, Hughes BGM
J Clin Oncol 2020 Sep 1;38(25):2916-2925. Epub 2020 Jul 16 doi: 10.1200/JCO.19.03054. PMID: 32673170 Free PMC Article

Recurrent Painful Ophthalmoplegic Neuropathy and Oculomotor Nerve Schwannoma: A Pediatric Case Report with Long-Term MRI Follow-Up and Literature Review.

Petruzzelli MG, Margari M, Furente F, Costanza MC, Legrottaglie AR, Dicuonzo F, Margari L
Pain Res Manag 2019;2019:5392945. Epub 2019 Sep 25 doi: 10.1155/2019/5392945. PMID: 31662812 Free PMC Article

See all (13)

Diagnosis

COVID-19 associated cranial nerve neuropathy: A systematic review.

Finsterer J, Scorza FA, Scorza C, Fiorini A
Bosn J Basic Med Sci 2022 Feb 1;22(1):39-45. doi: 10.17305/bjbms.2021.6341. PMID: 34392827 Free PMC Article

Neurological impact of eosinophilic granulomatosis with polyangiitis.

Gomes I, Girão A, Gomes J, Rebelo O, Jesus-Ribeiro J
Acta Neurol Belg 2022 Feb;122(1):123-128. Epub 2021 Apr 27 doi: 10.1007/s13760-021-01683-5. PMID: 33905106

Relapsing Painful Ophthalmoplegic Neuropathy: No longer a "Migraine," but Still a Headache.

Smith SV, Schuster NM
Curr Pain Headache Rep 2018 Jun 14;22(7):50. doi: 10.1007/s11916-018-0705-5. PMID: 29904898

Gustatory rhinitis.

Jovancevic L, Georgalas C, Savovic S, Janjevic D
Rhinology 2010 Mar 2;48(1):7-10. doi: 10.4193/Rhin07.153. PMID: 20502728

Parapharyngeal space neoplasms.

Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

See all (26)

Therapy

Prevalence of and risk factors for cranial neuropathy in diabetic and non-diabetic patients.

AlZailaie AK, Aseeri AM, Algahtany AM, Algahtany MM, Algahtany MA
Eur Rev Med Pharmacol Sci 2023 Jun;27(11):4990-4997. doi: 10.26355/eurrev_202306_32616. PMID: 37318473

Recurrent Painful Ophthalmoplegic Neuropathy with Unilateral Oculomotor and Trochlear Nerve Palsy in an 8-year-old Girl.

Akhondian J, Ashrafzadeh F, Seilanian Toosi F, Esmaeilzadeh M, Beiraghi Toosi M, Imannezhad S, Saeedi Zand N, Hashemi N
J Binocul Vis Ocul Motil 2022 Oct-Dec;72(4):199-204. Epub 2022 Jul 22 PMID: 35867412

Pembrolizumab Monotherapy for Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma: A Single-Arm Phase II Trial (KEYNOTE-629).

Single fraction versus fractionated linac-based stereotactic radiotherapy for vestibular schwannoma: a single-institution experience.

Collen C, Ampe B, Gevaert T, Moens M, Linthout N, De Ridder M, Verellen D, D'Haens J, Storme G
Int J Radiat Oncol Biol Phys 2011 Nov 15;81(4):e503-9. Epub 2011 Jun 12 doi: 10.1016/j.ijrobp.2011.04.066. PMID: 21665381

The usefulness of the blink reflex in the early diagnosis of cranial nerve neuropathy associated with diabetes mellitus.

Al-Azzawi LM, Mirza Kb, Kummoona R
Electromyogr Clin Neurophysiol 2004 Sep;44(6):323-7. PMID: 15473343

See all (11)

Prognosis

Recurrent Painful Ophthalmoplegic Neuropathy and Oculomotor Nerve Schwannoma: A Pediatric Case Report with Long-Term MRI Follow-Up and Literature Review.

Petruzzelli MG, Margari M, Furente F, Costanza MC, Legrottaglie AR, Dicuonzo F, Margari L
Pain Res Manag 2019;2019:5392945. Epub 2019 Sep 25 doi: 10.1155/2019/5392945. PMID: 31662812 Free PMC Article

Relapsing Painful Ophthalmoplegic Neuropathy: No longer a "Migraine," but Still a Headache.

Smith SV, Schuster NM
Curr Pain Headache Rep 2018 Jun 14;22(7):50. doi: 10.1007/s11916-018-0705-5. PMID: 29904898

Single fraction versus fractionated linac-based stereotactic radiotherapy for vestibular schwannoma: a single-institution experience.

Otogenic cranial base osteomyelitis: a proposed prognosis-based system for disease classification.

Lee S, Hooper R, Fuller A, Turlakow A, Cousins V, Nouraei R
Otol Neurotol 2008 Aug;29(5):666-72. doi: 10.1097/MAO.0b013e318179972f. PMID: 18520626

Parapharyngeal space neoplasms.

Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809

See all (11)

Clinical prediction guides

Management and long-term comorbidities of patients with necrotizing otitis externa.

Arslan IB, Pekcevik Y, Cukurova I
Eur Arch Otorhinolaryngol 2023 Jun;280(6):2755-2761. Epub 2022 Dec 18 doi: 10.1007/s00405-022-07784-y. PMID: 36528642 Free PMC Article

Neurological impact of eosinophilic granulomatosis with polyangiitis.

Gomes I, Girão A, Gomes J, Rebelo O, Jesus-Ribeiro J
Acta Neurol Belg 2022 Feb;122(1):123-128. Epub 2021 Apr 27 doi: 10.1007/s13760-021-01683-5. PMID: 33905106

Single fraction versus fractionated linac-based stereotactic radiotherapy for vestibular schwannoma: a single-institution experience.

Gustatory rhinitis.

Jovancevic L, Georgalas C, Savovic S, Janjevic D
Rhinology 2010 Mar 2;48(1):7-10. doi: 10.4193/Rhin07.153. PMID: 20502728

Otogenic cranial base osteomyelitis: a proposed prognosis-based system for disease classification.

Lee S, Hooper R, Fuller A, Turlakow A, Cousins V, Nouraei R
Otol Neurotol 2008 Aug;29(5):666-72. doi: 10.1097/MAO.0b013e318179972f. PMID: 18520626

See all (12)

Recent systematic reviews

COVID-19 associated cranial nerve neuropathy: A systematic review.

Finsterer J, Scorza FA, Scorza C, Fiorini A
Bosn J Basic Med Sci 2022 Feb 1;22(1):39-45. doi: 10.17305/bjbms.2021.6341. PMID: 34392827 Free PMC Article

Stereotactic Radiosurgery in Large Intracranial Meningiomas: A Systematic Review.

Fatima N, Meola A, Pollom E, Chaudhary N, Soltys S, Chang SD
World Neurosurg 2019 Sep;129:269-275. Epub 2019 Jun 19 doi: 10.1016/j.wneu.2019.06.064. PMID: 31226450

See all (2)

MedGen

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Cranial nerve neuropathy

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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