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Orbit Capillary Hemangioma

MedGen UID:
83421
•Concept ID:
C0346351
•
Neoplastic Process
Synonyms: Capillary Angioma of Orbit; Capillary Angioma of the Orbit; Capillary hemangioma of orbit; Capillary Hemangioma of Orbit; Capillary Hemangioma of the Orbit; Orbit Capillary Angioma
SNOMED CT: Capillary hemangioma of orbit (254997007)

Definition

A capillary hemangioma arising from the orbit. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbit Capillary Hemangioma

Professional guidelines

PubMed

Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Management.
Alvarez R, Mastorakos P, Hogan E, Scott G, Lonser RR, Wiley HE, Chew EY, Chittiboina P
Neurosurgery 2021 Apr 15;88(5):1012-1020. doi: 10.1093/neuros/nyaa565. PMID: 33442737Free PMC Article
β-blockers in the treatment of periocular infantile hemangioma.
Al-Haddad C, El Salloukh NA, El Moussawi Z
Curr Opin Ophthalmol 2019 Sep;30(5):319-325. doi: 10.1097/ICU.0000000000000591. PMID: 31394556
New developments in the management of periocular capillary hemangioma in children.
Ni N, Wagner RS, Langer P, Guo S
J Pediatr Ophthalmol Strabismus 2011 Sep-Oct;48(5):269-76; quiz 268, 277. Epub 2010 Oct 21 doi: 10.3928/01913913-20101018-02. PMID: 20964274

Recent clinical studies

Etiology

Ocular and Periocular Tumors in Asian Indian Children and Adolescents.
Kaliki S, Das AV
Indian Pediatr 2020 Jun 15;57(6):512-514. Epub 2020 Mar 12 PMID: 32221055
To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.
Mehta A, Bajaj MS, Pushker N, Chawla B, Pujari A, Grewal SS, Grewal SPS, Singh SR, Kishore A, Yadav NS
Indian J Ophthalmol 2019 Dec;67(12):1974-1980. doi: 10.4103/ijo.IJO_59_19. PMID: 31755431Free PMC Article
Leksell Radiosurgery for the 3 H Tumors: Hemangiomas, Hemangioblastomas, and Hemangiopericytomas.
Johnson S, Niranjan A, Kano H, Lunsford LD
Prog Neurol Surg 2019;34:223-231. Epub 2019 May 16 doi: 10.1159/000493068. PMID: 31096251
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Periorbital lesions misdiagnosed as dermoid cysts.
Al-Muhaylib A, Alkatan HM, Al-Faky YH, Alsuhaibani AH
J AAPOS 2017 Dec;21(6):509-511. Epub 2017 Oct 28 doi: 10.1016/j.jaapos.2017.07.215. PMID: 29107796

Diagnosis

Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Tufted angiomas of the head and neck.
Häußler SM, Uecker FC, Knopke S, Roßner F, Olze H, Böttcher A
HNO 2018 Jan;66(Suppl 1):1-6. doi: 10.1007/s00106-017-0375-3. PMID: 28667388
Recent Advances in Orbital Tumors--A Review of Publications from 2014-2016.
Honavar SG, Manjandavida FP
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):153-158. doi: 10.22608/APO.201736. PMID: 28399335
Congenital Eyelid Rhabdomyosarcoma.
Lee YC, Hsu YH, Yang SH, Huang TL
Ophthalmic Plast Reconstr Surg 2016 Sep-Oct;32(5):e104-6. doi: 10.1097/IOP.0000000000000290. PMID: 25216197
Capillary hemangioma (infantile periocular hemangioma).
Haik BG, Karcioglu ZA, Gordon RA, Pechous BP
Surv Ophthalmol 1994 Mar-Apr;38(5):399-426. doi: 10.1016/0039-6257(94)90172-4. PMID: 8009426

Therapy

β-blockers in the treatment of periocular infantile hemangioma.
Al-Haddad C, El Salloukh NA, El Moussawi Z
Curr Opin Ophthalmol 2019 Sep;30(5):319-325. doi: 10.1097/ICU.0000000000000591. PMID: 31394556
The Use of β-Blockers for the Treatment of Periocular Hemangiomas in Infants: A Report by the American Academy of Ophthalmology.
Hutchinson AK, Kraker RT, Pineles SL, VanderVeen DK, Wilson LB, Galvin JA, Lambert SR
Ophthalmology 2019 Jan;126(1):146-155. Epub 2018 Aug 1 doi: 10.1016/j.ophtha.2018.07.023. PMID: 30075202
Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids.
Xu S, Jia R, Ge S, Lin M, Fan X
J Paediatr Child Health 2014 Apr;50(4):271-9. Epub 2013 Dec 23 doi: 10.1111/jpc.12464. PMID: 24754793
Propranolol therapy for infantile hemangioma.
Gunturi N, Ramgopal S, Balagopal S, Scott JX
Indian Pediatr 2013 Mar;50(3):307-13. doi: 10.1007/s13312-013-0098-9. PMID: 23680605
New developments in the management of periocular capillary hemangioma in children.
Ni N, Wagner RS, Langer P, Guo S
J Pediatr Ophthalmol Strabismus 2011 Sep-Oct;48(5):269-76; quiz 268, 277. Epub 2010 Oct 21 doi: 10.3928/01913913-20101018-02. PMID: 20964274

Prognosis

Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Management.
Alvarez R, Mastorakos P, Hogan E, Scott G, Lonser RR, Wiley HE, Chew EY, Chittiboina P
Neurosurgery 2021 Apr 15;88(5):1012-1020. doi: 10.1093/neuros/nyaa565. PMID: 33442737Free PMC Article
Optic Nerve Hemangioblastoma: Review.
Darbari S, Meena RK, Sawarkar D, Doddamani RS
World Neurosurg 2019 Aug;128:211-215. Epub 2019 May 1 doi: 10.1016/j.wneu.2019.04.224. PMID: 31054346
Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit.
Schwartz SR, Blei F, Ceisler E, Steele M, Furlan L, Kodsi S
J AAPOS 2006 Jun;10(3):262-8. doi: 10.1016/j.jaapos.2006.01.210. PMID: 16814181
Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications.
Kreusel KM
Fam Cancer 2005;4(1):43-7. doi: 10.1007/s10689-004-1327-0. PMID: 15883709
Capillary hemangioma of the lids and orbit: an analysis of the clinical features and therapeutic results in 101 cases.
Haik BG, Jakobiec FA, Ellsworth RM, Jones IS
Ophthalmology 1979 May;86(5):760-92. doi: 10.1016/s0161-6420(79)35452-5. PMID: 545208

Clinical prediction guides

Ophthalmic involvement in PHACES syndrome: prevalence, spectrum of anomalies, and outcomes.
Soliman SE, Wan MJ, Pennal A, Pope E, Mireskandari K
J AAPOS 2022 Jun;26(3):129.e1-129.e7. Epub 2022 May 10 doi: 10.1016/j.jaapos.2022.01.011. PMID: 35550864
The Experience Of Intralesional Bleomycin For Orbital Vascular Anomalies.
Kamil Z, Qurban Q, Hassan Khan MT
J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):240-243. PMID: 34137537
Clinical and Radiological Evaluation of Periocular Infantile Hemangioma Treated With Oral Propranolol: A Case Series.
Ginguerra MA, Saito O, Fernandes JBVD, Castro DS, Matayoshi S
Am J Ophthalmol 2018 Jan;185:48-55. Epub 2017 Nov 15 doi: 10.1016/j.ajo.2017.10.021. PMID: 29103963
Intralesional and sub-Tenon's infusion of corticosteroids for treatment of refractory periorbital and orbital capillary haemangioma.
Friling R, Axer-Siegel R, Ben-Amitai D, Goldenberg-Cohen N, Weinberger D, Snir M
Eye (Lond) 2009 Jun;23(6):1302-7. Epub 2008 Nov 7 doi: 10.1038/eye.2008.300. PMID: 18989344
Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit.
Schwartz SR, Blei F, Ceisler E, Steele M, Furlan L, Kodsi S
J AAPOS 2006 Jun;10(3):262-8. doi: 10.1016/j.jaapos.2006.01.210. PMID: 16814181

Recent systematic reviews

Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids.
Xu S, Jia R, Ge S, Lin M, Fan X
J Paediatr Child Health 2014 Apr;50(4):271-9. Epub 2013 Dec 23 doi: 10.1111/jpc.12464. PMID: 24754793
The use of propranolol in the management of periocular capillary haemangioma--a systematic review.
Spiteri Cornish K, Reddy AR
Eye (Lond) 2011 Oct;25(10):1277-83. Epub 2011 Jul 8 doi: 10.1038/eye.2011.164. PMID: 21738233Free PMC Article

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