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Metastatic malignant neoplasm in the colon

MedGen UID:
83432
•Concept ID:
C0346974
•
Neoplastic Process
Synonyms: Metastatic Malignant Neoplasm in the Colon; metastatic malignant neoplasm in the colon; Metastatic malignant neoplasm of colon; Metastatic malignant neoplasm to colon; Metastatic Malignant Neoplasm to the Colon; metastatic malignant neoplasm to the colon; Metastatic Neoplasm to the Colon; metastatic neoplasm to the colon; Metastatic Tumor to the Colon; metastatic tumor to the colon; metastatic tumour to the colon; Secondary malignant neoplasm of colon
SNOMED CT: Secondary malignant neoplasm of colon (94260004); Metastatic malignant neoplasm to colon (94260004); Metastatic malignant neoplasm of colon (94260004)
 
Monarch Initiative: MONDO:0041447

Definition

The spread of a malignant neoplasm to the colon. This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic malignant neoplasm in the colon

Professional guidelines

PubMed

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Farkas L, Garrido-Laguna I, Grem JL, Gunn A, Hecht JR, Hoffe S, Hubbard J, Hunt S, Johung KL, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2021 Mar 2;19(3):329-359. doi: 10.6004/jnccn.2021.0012. PMID: 33724754

Recent clinical studies

Etiology

Controversies in the treatment of RAS wild-type metastatic colorectal cancer.
Vera R, Salgado M, Safont MJ, Gallego J, González E, Élez E, Aranda E
Clin Transl Oncol 2021 Apr;23(4):827-839. Epub 2020 Aug 13 doi: 10.1007/s12094-020-02475-8. PMID: 32789773Free PMC Article
Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial.
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis.
Kim EK, Song MJ, Jung Y, Lee WS, Jang HH
Cancer Genomics Proteomics 2019 Nov-Dec;16(6):583-592. doi: 10.21873/cgp.20161. PMID: 31659112Free PMC Article
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer.
Zeng H, Umar S, Rust B, Lazarova D, Bordonaro M
Int J Mol Sci 2019 Mar 11;20(5) doi: 10.3390/ijms20051214. PMID: 30862015Free PMC Article
The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer.
Wang S, Miao Z, Yang Q, Wang Y, Zhang J
Can J Gastroenterol Hepatol 2018;2018:7628763. Epub 2018 Nov 7 doi: 10.1155/2018/7628763. PMID: 30533404Free PMC Article

Diagnosis

Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial.
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma.
Grech P, Schofield JB
Histopathology 2020 Feb;76(3):342-353. Epub 2020 Jan 28 doi: 10.1111/his.14011. PMID: 31587346
Role of TGF-β in metastatic colon cancer: it is finally time for targeted therapy.
Villalba M, Evans SR, Vidal-Vanaclocha F, Calvo A
Cell Tissue Res 2017 Oct;370(1):29-39. Epub 2017 May 30 doi: 10.1007/s00441-017-2633-9. PMID: 28560691
Determinants of metastatic competency in colorectal cancer.
Tauriello DV, Calon A, Lonardo E, Batlle E
Mol Oncol 2017 Jan;11(1):97-119. Epub 2017 Jan 3 doi: 10.1002/1878-0261.12018. PMID: 28085225Free PMC Article
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article

Therapy

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer.
Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A
Nat Commun 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. PMID: 37741832Free PMC Article
FRESCO-2: a global Phase III study investigating the efficacy and safety of fruquintinib in metastatic colorectal cancer.
Dasari A, Sobrero A, Yao J, Yoshino T, Schelman W, Yang Z, Chien C, Kania M, Tabernero J, Eng C
Future Oncol 2021 Aug;17(24):3151-3162. Epub 2021 May 17 doi: 10.2217/fon-2021-0202. PMID: 33993740
Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial.
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis.
Kim EK, Song MJ, Jung Y, Lee WS, Jang HH
Cancer Genomics Proteomics 2019 Nov-Dec;16(6):583-592. doi: 10.21873/cgp.20161. PMID: 31659112Free PMC Article
Modifiable risk factors for colon cancer.
Giovannucci E
Gastroenterol Clin North Am 2002 Dec;31(4):925-43. doi: 10.1016/s0889-8553(02)00057-2. PMID: 12489270

Prognosis

Right colon cancer: The influence of specific location on recurrence and survival.
Cavadas AS, Gonçalves E, Pereira CC, Rodrigues J, Pereira JC
Cancer Treat Res Commun 2023;36:100724. Epub 2023 May 25 doi: 10.1016/j.ctarc.2023.100724. PMID: 37267659
Survival trends in solid cancers in the Nordic countries through 50 years.
Hemminki J, Försti A, Hemminki A, Hemminki K
Eur J Cancer 2022 Nov;175:77-85. Epub 2022 Sep 9 doi: 10.1016/j.ejca.2022.08.015. PMID: 36096040
Sex, racial/ethnic and socioeconomic disparities in patients with metastatic bone disease.
Jawad MU, Pollock BH, Wise BL, Zeitlinger LN, O' Donnell EF, Carr-Ascher JR, Cizik A, Ferrell B, Thorpe SW, Randall RL
J Surg Oncol 2022 Mar;125(4):766-774. Epub 2021 Dec 10 doi: 10.1002/jso.26765. PMID: 34889456Free PMC Article
Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer.
Kim K, Kim YW, Shim H, Kim BR, Kwon HY
J BUON 2018 Dec;23(7):11-18. PMID: 30722106
Determinants of metastatic competency in colorectal cancer.
Tauriello DV, Calon A, Lonardo E, Batlle E
Mol Oncol 2017 Jan;11(1):97-119. Epub 2017 Jan 3 doi: 10.1002/1878-0261.12018. PMID: 28085225Free PMC Article

Clinical prediction guides

Right colon cancer: The influence of specific location on recurrence and survival.
Cavadas AS, Gonçalves E, Pereira CC, Rodrigues J, Pereira JC
Cancer Treat Res Commun 2023;36:100724. Epub 2023 May 25 doi: 10.1016/j.ctarc.2023.100724. PMID: 37267659
Clinical significance of 206 station lymph node in transverse colon cancer.
Xu YX, Huang Y, Wang XJ, Ye DX, Chi P
Cancer Med 2022 Jun;11(12):2366-2376. Epub 2022 Apr 18 doi: 10.1002/cam4.4626. PMID: 35437894Free PMC Article
Clinical Significance and Prognostic Relevance of Microsatellite Instability in Sporadic Colorectal Cancer Patients.
Copija A, Waniczek D, Witkoś A, Walkiewicz K, Nowakowska-Zajdel E
Int J Mol Sci 2017 Jan 6;18(1) doi: 10.3390/ijms18010107. PMID: 28067827Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO
Mol Cell Proteomics 2012 Apr;11(4):M111.014647. Epub 2011 Dec 9 doi: 10.1074/mcp.M111.014647. PMID: 22159717Free PMC Article

Recent systematic reviews

Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Short-term outcomes in robot-assisted compared to laparoscopic colon cancer resections: a systematic review and meta-analysis.
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis.
O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598
Performance of artificial intelligence in colonoscopy for adenoma and polyp detection: a systematic review and meta-analysis.
Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A
Gastrointest Endosc 2021 Jan;93(1):77-85.e6. Epub 2020 Jun 26 doi: 10.1016/j.gie.2020.06.059. PMID: 32598963

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