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Gallbladder Adenocarcinoma with Squamous Metaplasia

MedGen UID:
83538
•Concept ID:
C0279655
•
Neoplastic Process
Synonyms: Adenocarcinoma of Gallbladder with Squamous Metaplasia; Adenocarcinoma of the Gallbladder with Squamous Metaplasia

Definition

An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Adenocarcinoma with Squamous Metaplasia

Recent clinical studies

Etiology

Expression of Human Epidermal Growth Factor Receptor (Her 2/neu) and Proliferative Marker Ki-67: Association with Clinicopathological Parameters in Gallbladder Carcinoma.
Pujani M, Makker I, Makker A, Jetley S, Goel MM, Jetley S
Asian Pac J Cancer Prev 2016;17(8):3903-9. PMID: 27644637
Female sex hormone receptors in gallbladder cancer.
Saranga Bharathi R, Singh R, Gupta R, Verma GR, Kalra N, Kiran K, Joshi K
J Gastrointest Cancer 2015 Jun;46(2):143-8. doi: 10.1007/s12029-015-9698-z. PMID: 25772307
Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas.
Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D, Saka B, Losada H, Bagci P, Adsay NV
Mod Pathol 2011 Aug;24(8):1069-78. Epub 2011 Apr 29 doi: 10.1038/modpathol.2011.68. PMID: 21532545
Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm.
Stranahan PL, LaRoe J, McCombs R, Rahim I, Kuhn CW, Pettijohn DE
Oncol Rep 1998 Jan-Feb;5(1):235-9. doi: 10.3892/or.5.1.235. PMID: 9458328
Carcinoma of extrahepatic bile ducts. A histopathologic study.
Laitio M
Pathol Res Pract 1983 Aug;178(1):67-72. doi: 10.1016/S0344-0338(83)80087-9. PMID: 6647153

Diagnosis

Sperm protein antigen 17 and Sperm flagellar 1 cancer testis antigens are expressed in a rare case of ciliated foregut cyst of the common hepatic duct.
Grizzi F, Chiriva-Internati M, Miranda E, Zaharie R, Hajjar NA, Zaharie F, Del Arco CD, Fernández-Aceñero MJ, Bresalier RS, Moiş E
Pathol Res Pract 2023 Jul;247:154546. Epub 2023 May 18 doi: 10.1016/j.prp.2023.154546. PMID: 37224658
A pseudoepidermoid cyst arising from exuberant squamous metaplasia of the gallbladder.
Teo CH, Leow CK, Chang SA
Arch Pathol Lab Med 2005 Jun;129(6):e138-40. doi: 10.5858/2005-129-e138-APCAFE. PMID: 15913441

Prognosis

Sperm protein antigen 17 and Sperm flagellar 1 cancer testis antigens are expressed in a rare case of ciliated foregut cyst of the common hepatic duct.
Grizzi F, Chiriva-Internati M, Miranda E, Zaharie R, Hajjar NA, Zaharie F, Del Arco CD, Fernández-Aceñero MJ, Bresalier RS, Moiş E
Pathol Res Pract 2023 Jul;247:154546. Epub 2023 May 18 doi: 10.1016/j.prp.2023.154546. PMID: 37224658
Female sex hormone receptors in gallbladder cancer.
Saranga Bharathi R, Singh R, Gupta R, Verma GR, Kalra N, Kiran K, Joshi K
J Gastrointest Cancer 2015 Jun;46(2):143-8. doi: 10.1007/s12029-015-9698-z. PMID: 25772307
Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas.
Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D, Saka B, Losada H, Bagci P, Adsay NV
Mod Pathol 2011 Aug;24(8):1069-78. Epub 2011 Apr 29 doi: 10.1038/modpathol.2011.68. PMID: 21532545
Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm.
Stranahan PL, LaRoe J, McCombs R, Rahim I, Kuhn CW, Pettijohn DE
Oncol Rep 1998 Jan-Feb;5(1):235-9. doi: 10.3892/or.5.1.235. PMID: 9458328

Clinical prediction guides

Sperm protein antigen 17 and Sperm flagellar 1 cancer testis antigens are expressed in a rare case of ciliated foregut cyst of the common hepatic duct.
Grizzi F, Chiriva-Internati M, Miranda E, Zaharie R, Hajjar NA, Zaharie F, Del Arco CD, Fernández-Aceñero MJ, Bresalier RS, Moiş E
Pathol Res Pract 2023 Jul;247:154546. Epub 2023 May 18 doi: 10.1016/j.prp.2023.154546. PMID: 37224658
Expression of Human Epidermal Growth Factor Receptor (Her 2/neu) and Proliferative Marker Ki-67: Association with Clinicopathological Parameters in Gallbladder Carcinoma.
Pujani M, Makker I, Makker A, Jetley S, Goel MM, Jetley S
Asian Pac J Cancer Prev 2016;17(8):3903-9. PMID: 27644637
Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas.
Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D, Saka B, Losada H, Bagci P, Adsay NV
Mod Pathol 2011 Aug;24(8):1069-78. Epub 2011 Apr 29 doi: 10.1038/modpathol.2011.68. PMID: 21532545
Gastric phenotypic expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry.
Tatematsu M, Ichinose M, Miki K, Tatematsu K, Kishikawa H, Ito N
Virchows Arch A Pathol Anat Histopathol 1988;413(1):25-32. doi: 10.1007/BF00844278. PMID: 3131954
Inappropriate mucin production in gall bladder metaplasia and neoplasia--an immunohistological study.
De Boer WG, Ma J, Rees JW, Nayman J
Histopathology 1981 May;5(3):295-303. doi: 10.1111/j.1365-2559.1981.tb01788.x. PMID: 7239450

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