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Non-Metastatic Gestational Trophoblastic Tumor

MedGen UID:
83654
•Concept ID:
C0280478
•
Neoplastic Process
Synonyms: Non-Metastatic Gestational Trophoblastic Neoplasm; Non-Metastatic GTT; Nonmetastatic Gestational Trophoblastic Tumor

Definition

Gestational trophoblastic tumor that is confined to the site in which it initially manifested. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Metastatic Gestational Trophoblastic Tumor

Professional guidelines

PubMed

Optimal management of low-risk gestational trophoblastic neoplasia.
Goldstein DP, Berkowitz RS, Horowitz NS
Expert Rev Anticancer Ther 2015;15(11):1293-304. Epub 2015 Oct 30 doi: 10.1586/14737140.2015.1088786. PMID: 26517533
Current management of gestational trophoblastic diseases.
Berkowitz RS, Goldstein DP
Gynecol Oncol 2009 Mar;112(3):654-62. Epub 2008 Oct 12 doi: 10.1016/j.ygyno.2008.09.005. PMID: 18851873
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865

Recent clinical studies

Etiology

Fertility-sparing surgical interventions for low-risk, non-metastatic gestational trophoblastic neoplasia.
Boonyapipat S, Nanthamongkolkul K, Saeaib N, Liabsuetrakul T
Cochrane Database Syst Rev 2024 Sep 23;9(9):CD014755. doi: 10.1002/14651858.CD014755.pub2. PMID: 39312299Free PMC Article
Cost-effectiveness of second curettage for treatment of low-risk non-metastatic gestational trophoblastic neoplasia.
Batman S, Skeith A, Allen A, Munro E, Caughey A, Bruegl A
Gynecol Oncol 2020 Jun;157(3):711-715. Epub 2020 Apr 8 doi: 10.1016/j.ygyno.2020.03.029. PMID: 32276791Free PMC Article
Optimal management of low-risk gestational trophoblastic neoplasia.
Goldstein DP, Berkowitz RS, Horowitz NS
Expert Rev Anticancer Ther 2015;15(11):1293-304. Epub 2015 Oct 30 doi: 10.1586/14737140.2015.1088786. PMID: 26517533
Current management of gestational trophoblastic diseases.
Berkowitz RS, Goldstein DP
Gynecol Oncol 2009 Mar;112(3):654-62. Epub 2008 Oct 12 doi: 10.1016/j.ygyno.2008.09.005. PMID: 18851873
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865

Diagnosis

Hysterectomy versus chemotherapy for low-risk non-metastatic gestational trophoblastic neoplasia (GTN): A cost-effectiveness analysis.
Mitric C, Sayyid RK, Fleshner NE, Look Hong NJ, Bouchard-Fortier G
Gynecol Oncol 2024 Aug;187:30-36. Epub 2024 May 4 doi: 10.1016/j.ygyno.2024.04.014. PMID: 38705127
Cost-effectiveness of second curettage for treatment of low-risk non-metastatic gestational trophoblastic neoplasia.
Batman S, Skeith A, Allen A, Munro E, Caughey A, Bruegl A
Gynecol Oncol 2020 Jun;157(3):711-715. Epub 2020 Apr 8 doi: 10.1016/j.ygyno.2020.03.029. PMID: 32276791Free PMC Article
Optimal management of low-risk gestational trophoblastic neoplasia.
Goldstein DP, Berkowitz RS, Horowitz NS
Expert Rev Anticancer Ther 2015;15(11):1293-304. Epub 2015 Oct 30 doi: 10.1586/14737140.2015.1088786. PMID: 26517533
Current management of gestational trophoblastic diseases.
Berkowitz RS, Goldstein DP
Gynecol Oncol 2009 Mar;112(3):654-62. Epub 2008 Oct 12 doi: 10.1016/j.ygyno.2008.09.005. PMID: 18851873
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865

Therapy

Fertility-sparing surgical interventions for low-risk, non-metastatic gestational trophoblastic neoplasia.
Boonyapipat S, Nanthamongkolkul K, Saeaib N, Liabsuetrakul T
Cochrane Database Syst Rev 2024 Sep 23;9(9):CD014755. doi: 10.1002/14651858.CD014755.pub2. PMID: 39312299Free PMC Article
Hysterectomy versus chemotherapy for low-risk non-metastatic gestational trophoblastic neoplasia (GTN): A cost-effectiveness analysis.
Mitric C, Sayyid RK, Fleshner NE, Look Hong NJ, Bouchard-Fortier G
Gynecol Oncol 2024 Aug;187:30-36. Epub 2024 May 4 doi: 10.1016/j.ygyno.2024.04.014. PMID: 38705127
Optimal management of low-risk gestational trophoblastic neoplasia.
Goldstein DP, Berkowitz RS, Horowitz NS
Expert Rev Anticancer Ther 2015;15(11):1293-304. Epub 2015 Oct 30 doi: 10.1586/14737140.2015.1088786. PMID: 26517533
Outcomes of Non-Metastatic Gestational Trophoblastic Neoplasia: Twelve Year Experience from a Northern Thailand Tertiary Care Center.
Suprasert P, Manopunya M
Asian Pac J Cancer Prev 2015;16(14):5913-6. doi: 10.7314/apjcp.2015.16.14.5913. PMID: 26320472
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865

Prognosis

Intraplacental choriocarcinoma: Systematic review and management guidance.
Jiao L, Ghorani E, Sebire NJ, Seckl MJ
Gynecol Oncol 2016 Jun;141(3):624-631. Epub 2016 Apr 6 doi: 10.1016/j.ygyno.2016.03.026. PMID: 27020699
Optimal management of low-risk gestational trophoblastic neoplasia.
Goldstein DP, Berkowitz RS, Horowitz NS
Expert Rev Anticancer Ther 2015;15(11):1293-304. Epub 2015 Oct 30 doi: 10.1586/14737140.2015.1088786. PMID: 26517533
Outcomes of Non-Metastatic Gestational Trophoblastic Neoplasia: Twelve Year Experience from a Northern Thailand Tertiary Care Center.
Suprasert P, Manopunya M
Asian Pac J Cancer Prev 2015;16(14):5913-6. doi: 10.7314/apjcp.2015.16.14.5913. PMID: 26320472
Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center.
Davis MR, Howitt BE, Quade BJ, Crum CP, Horowitz NS, Goldstein DP, Berkowitz RS
Gynecol Oncol 2015 Jun;137(3):456-61. Epub 2015 Mar 12 doi: 10.1016/j.ygyno.2015.03.006. PMID: 25773203
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865

Clinical prediction guides

First-line hysterectomy for women with low-risk non-metastatic gestational trophoblastic neoplasia no longer wishing to conceive.
Bolze PA, Mathe M, Hajri T, You B, Dabi Y, Schott AM, Patrier S, Massardier J, Golfier F
Gynecol Oncol 2018 Aug;150(2):282-287. Epub 2018 Jun 8 doi: 10.1016/j.ygyno.2018.05.030. PMID: 29887485
Optimal management of low-risk gestational trophoblastic neoplasia.
Goldstein DP, Berkowitz RS, Horowitz NS
Expert Rev Anticancer Ther 2015;15(11):1293-304. Epub 2015 Oct 30 doi: 10.1586/14737140.2015.1088786. PMID: 26517533
Comparison of methotrexate, actinomycin D, and etoposide for treating low-risk gestational trophoblastic neoplasia.
Baptista AM, Belfort P
Int J Gynaecol Obstet 2012 Oct;119(1):35-8. Epub 2012 Aug 9 doi: 10.1016/j.ijgo.2012.04.027. PMID: 22877838
Does chest CT matter in the staging of GTN?
Darby S, Jolley I, Pennington S, Hancock BW
Gynecol Oncol 2009 Jan;112(1):155-60. Epub 2008 Nov 18 doi: 10.1016/j.ygyno.2008.10.003. PMID: 19019416
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654

Recent systematic reviews

Fertility-sparing surgical interventions for low-risk, non-metastatic gestational trophoblastic neoplasia.
Boonyapipat S, Nanthamongkolkul K, Saeaib N, Liabsuetrakul T
Cochrane Database Syst Rev 2024 Sep 23;9(9):CD014755. doi: 10.1002/14651858.CD014755.pub2. PMID: 39312299Free PMC Article
Intraplacental choriocarcinoma: Systematic review and management guidance.
Jiao L, Ghorani E, Sebire NJ, Seckl MJ
Gynecol Oncol 2016 Jun;141(3):624-631. Epub 2016 Apr 6 doi: 10.1016/j.ygyno.2016.03.026. PMID: 27020699

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