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Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MedGen UID:
859699
•Concept ID:
C3900105
•
Neoplastic Process

Definition

A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Professional guidelines

PubMed

A new biomarker panel for differential diagnosis of cholangiocarcinoma: Results from an exploratory analysis.
Köhler B, Bes M, Chan HL, Esteban JI, Piratvisuth T, Sukeepaisarnjaroen W, Tanwandee T, Thongsawat S, Mang A, Morgenstern D, Swiatek-de Lange M, Dayyani F
Int J Biol Markers 2024 Jun;39(2):107-117. Epub 2024 Mar 28 doi: 10.1177/03936155241235185. PMID: 38549363
Intrahepatic cholangiocarcinoma and its differential diagnosis at MRI: how radiologist should assess MR features.
Granata V, Grassi R, Fusco R, Setola SV, Belli A, Ottaiano A, Nasti G, La Porta M, Danti G, Cappabianca S, Cutolo C, Petrillo A, Izzo F
Radiol Med 2021 Dec;126(12):1584-1600. Epub 2021 Nov 29 doi: 10.1007/s11547-021-01428-7. PMID: 34843029
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331

Recent clinical studies

Etiology

Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
State-of-the-art MR Imaging of Uncommon Hepatocellular Tumours: Fibrolamellar Hepatocellular Carcinoma and Combined Hepatocellularcholangiocarcinoma.
Anysz-Grodzicka A, Podgorska J, Cieszanowski A
Curr Med Imaging Rev 2019;15(3):269-280. doi: 10.2174/1573405614666180927113622. PMID: 31989878
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma after resection.
Song P, Midorikawa Y, Nakayama H, Higaki T, Moriguchi M, Aramaki O, Yamazaki S, Aoki M, Teramoto K, Takayama T
Cancer Med 2019 Oct;8(13):5862-5871. Epub 2019 Aug 13 doi: 10.1002/cam4.2495. PMID: 31407490Free PMC Article
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Diagnosis

Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
State-of-the-art MR Imaging of Uncommon Hepatocellular Tumours: Fibrolamellar Hepatocellular Carcinoma and Combined Hepatocellularcholangiocarcinoma.
Anysz-Grodzicka A, Podgorska J, Cieszanowski A
Curr Med Imaging Rev 2019;15(3):269-280. doi: 10.2174/1573405614666180927113622. PMID: 31989878
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Therapy

Atezolizumab and bevacizumab for non-resectable or metastatic combined hepatocellular-cholangiocarcinoma: A multicentric retrospective study.
Gigante E, Bouattour M, Bedoya JU, Regnault H, Ziol M, Assenat E, Paradis V, Calderaro J, Ganne-Carrié N, Bouhier-Leporrier K, Amaddeo G, Nault JC
United European Gastroenterol J 2024 May;12(4):429-439. Epub 2023 Dec 7 doi: 10.1002/ueg2.12503. PMID: 38059651Free PMC Article
Locoregional Therapy of Hepatocellular-Cholangiocarcinoma versus Hepatocellular Carcinoma: A Propensity Score-Matched Study.
Huang YH, Park BV, Chen YF, Gaba RC, Guzman G, Lokken RP
J Vasc Interv Radiol 2019 Sep;30(9):1317-1324. Epub 2019 Jul 30 doi: 10.1016/j.jvir.2019.03.024. PMID: 31375450
Combined hepatocellular-cholangiocarcinoma successfully treated with sorafenib: case report and review of the literature.
Futsukaichi Y, Tajiri K, Kobayashi S, Nagata K, Yasumura S, Takahara T, Minemura M, Yasuda I
Clin J Gastroenterol 2019 Apr;12(2):128-134. Epub 2018 Oct 29 doi: 10.1007/s12328-018-0918-5. PMID: 30374884
Systemic Therapy for Combined Hepatocellular-Cholangiocarcinoma: A Single-Institution Experience.
Trikalinos NA, Zhou A, Doyle MBM, Fowler KJ, Morton A, Vachharajani N, Amin M, Keller JW, Chapman WC, Brunt EM, Tan BR
J Natl Compr Canc Netw 2018 Oct;16(10):1193-1199. doi: 10.6004/jnccn.2018.7053. PMID: 30323089
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Prognosis

Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma after resection.
Song P, Midorikawa Y, Nakayama H, Higaki T, Moriguchi M, Aramaki O, Yamazaki S, Aoki M, Teramoto K, Takayama T
Cancer Med 2019 Oct;8(13):5862-5871. Epub 2019 Aug 13 doi: 10.1002/cam4.2495. PMID: 31407490Free PMC Article
Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma.
Kim MJ, Lee S, An C
Eur Radiol 2019 Sep;29(9):5101-5110. Epub 2019 Feb 20 doi: 10.1007/s00330-019-06030-0. PMID: 30788586
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387
Combined Hepatocellular Carcinoma and Cholangiocarcinoma: Diagnosis and Prognosis After Resection or Transplantation.
Wu CH, Yong CC, Liew EH, Tsang LL, Lazo M, Hsu HW, Ou HY, Yu CY, Chen TY, Huang TL, Concejero AM, Chen CL, Cheng YF
Transplant Proc 2016 May;48(4):1100-4. doi: 10.1016/j.transproceed.2015.11.029. PMID: 27320566

Clinical prediction guides

Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Clinical and pathological features of combined hepatocellular-cholangiocarcinoma compared with other liver cancers.
Wakizaka K, Yokoo H, Kamiyama T, Ohira M, Kato K, Fujii Y, Sugiyama K, Okada N, Ohata T, Nagatsu A, Shimada S, Orimo T, Kamachi H, Taketomi A
J Gastroenterol Hepatol 2019 Jun;34(6):1074-1080. Epub 2018 Dec 16 doi: 10.1111/jgh.14547. PMID: 30462849
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387
Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance.
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2017 Feb;70(3):423-434. Epub 2016 Nov 15 doi: 10.1111/his.13084. PMID: 27634656
Postresection Outcomes of Combined Hepatocellular Carcinoma-Cholangiocarcinoma, Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Yoon YI, Hwang S, Lee YJ, Kim KH, Ahn CS, Moon DB, Ha TY, Song GW, Jung DH, Lee JW, Hong SM, Yu ES, Lee SG
J Gastrointest Surg 2016 Feb;20(2):411-20. Epub 2015 Dec 1 doi: 10.1007/s11605-015-3045-3. PMID: 26628072

Recent systematic reviews

Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Long-term outcomes of combined hepatocellular-cholangiocarcinoma after hepatectomy or liver transplantation: A systematic review and meta-analysis.
Li DB, Si XY, Wang SJ, Zhou YM
Hepatobiliary Pancreat Dis Int 2019 Feb;18(1):12-18. Epub 2018 Oct 25 doi: 10.1016/j.hbpd.2018.10.001. PMID: 30442549
A pooled analysis of combined liver and inferior vena cava resection for hepatic malignancy.
Zhou Y, Wu L, Xu D, Wan T, Si X
HPB (Oxford) 2017 Sep;19(9):768-774. Epub 2017 Jun 20 doi: 10.1016/j.hpb.2017.05.008. PMID: 28645571

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