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Abnormal dental enamel morphology

MedGen UID:: 867426
•Concept ID:: C4021800
•: Anatomical Abnormality

Synonym:	Abnormality of dental enamel

HPO:	HP:0000682

Definition

An abnormality of the dental enamel. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal dental enamel morphology

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of connective tissue
    - Abnormal odontoid tissue morphology
      - Abnormal dental enamel morphology
        Amelogenesis imperfecta
        Amelogenesis imperfecta type 1
        Amelogenesis imperfecta - hypoplastic autosomal dominant - local
        Amelogenesis imperfecta type 1A
        Amelogenesis imperfecta type 1C
        Amelogenesis imperfecta type 1F
        Amelogenesis imperfecta type 1H
        Amelogenesis imperfecta, type 1J
        Amelogenesis imperfecta type 2
        Amelogenesis imperfecta hypomaturation type 2A2
        Amelogenesis imperfecta hypomaturation type 2A3
        Amelogenesis imperfecta hypomaturation type 2A4
        Amelogenesis imperfecta hypomaturation type 2A5
        Amelogenesis imperfecta type 2A1
        Amelogenesis imperfecta, hypomaturation type, IIa6
        Amelogenesis imperfecta type 1E
        Amelogenesis imperfecta type 1G
        Amelogenesis imperfecta, hypocalcification type
        Amelogenesis imperfecta type 3B
        Amelogenesis imperfecta, type 3A
        Amelogenesis imperfecta, type 3C
        Hypomaturation-hypoplastic amelogenesis imperfecta with taurodontism
        X-linked amelogenesis imperfecta hypoplastic/hypomaturation 2
        Dental enamel pits
        Enamel agenesis
        Enamel hypomineralization
        Hypocalcification of dental enamel
        Hypomature dental enamel
        Enamel pearls
        Hypomature enamel

Conditions with this feature

Tricho-oculo-dermo-vertebral syndrome

MedGen UID:: 355714
•Concept ID:: C1866427
•: Disease or Syndrome

See: Condition Record

Tricho-oculo-dermo-vertebral syndrome

Professional guidelines

PubMed

Developmental defects of enamel and dentine: challenges for basic science research and clinical management.

Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

Developmental enamel defects in the primary dentition: aetiology and clinical management.

Salanitri S, Seow WK
Aust Dent J 2013 Jun;58(2):133-40; quiz 266. Epub 2013 May 5 doi: 10.1111/adj.12039. PMID: 23713631

Molar incisor hypomineralization: review and recommendations for clinical management.

William V, Messer LB, Burrow MF
Pediatr Dent 2006 May-Jun;28(3):224-32. PMID: 16805354

See all (77)

Recent clinical studies

Etiology

Hereditary Disorders of Cardiovascular Calcification.

Rutsch F, Buers I, Nitschke Y
Arterioscler Thromb Vasc Biol 2021 Jan;41(1):35-47. Epub 2020 Nov 12 doi: 10.1161/ATVBAHA.120.315577. PMID: 33176451

RNA Editing in Interferonopathies.

Frassinelli L, Galardi S, Ciafrè SA, Michienzi A
Methods Mol Biol 2021;2181:269-286. doi: 10.1007/978-1-0716-0787-9_16. PMID: 32729086

Developmental defects of enamel and dentine: challenges for basic science research and clinical management.

Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

A literature review of dental erosion in children.

Taji S, Seow WK
Aust Dent J 2010 Dec;55(4):358-67; quiz 475. doi: 10.1111/j.1834-7819.2010.01255.x. PMID: 21133936

Amelogenesis imperfecta.

Crawford PJ, Aldred M, Bloch-Zupan A
Orphanet J Rare Dis 2007 Apr 4;2:17. doi: 10.1186/1750-1172-2-17. PMID: 17408482 Free PMC Article

See all (652)

Diagnosis

Hereditary Disorders of Cardiovascular Calcification.

Rutsch F, Buers I, Nitschke Y
Arterioscler Thromb Vasc Biol 2021 Jan;41(1):35-47. Epub 2020 Nov 12 doi: 10.1161/ATVBAHA.120.315577. PMID: 33176451

Developmental defects of enamel and dentine: challenges for basic science research and clinical management.

Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

A literature review of dental erosion in children.

Taji S, Seow WK
Aust Dent J 2010 Dec;55(4):358-67; quiz 475. doi: 10.1111/j.1834-7819.2010.01255.x. PMID: 21133936

Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia.

Barron MJ, McDonnell ST, Mackie I, Dixon MJ
Orphanet J Rare Dis 2008 Nov 20;3:31. doi: 10.1186/1750-1172-3-31. PMID: 19021896 Free PMC Article

Amelogenesis imperfecta.

Crawford PJ, Aldred M, Bloch-Zupan A
Orphanet J Rare Dis 2007 Apr 4;2:17. doi: 10.1186/1750-1172-2-17. PMID: 17408482 Free PMC Article

See all (581)

Therapy

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.

Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J
Sci Rep 2021 Nov 17;11(1):22405. doi: 10.1038/s41598-021-01541-7. PMID: 34789780 Free PMC Article

Gene-environment interaction in molar-incisor hypomineralization.

Bezamat M, Souza JF, Silva FMF, Corrêa EG, Fatturi AL, Brancher JA, Carvalho FM, Cavallari T, Bertolazo L, Machado-Souza C, Koruyucu M, Bayram M, Racic A, Harrison BM, Sweat YY, Letra A, Studen-Pavlovich D, Seymen F, Amendt B, Werneck RI, Costa MC, Modesto A, Vieira AR
PLoS One 2021;16(1):e0241898. Epub 2021 Jan 6 doi: 10.1371/journal.pone.0241898. PMID: 33406080 Free PMC Article

Treatment of developmental defects of enamel.

Ndokaj A, Jedlinski M, Pasqualotto D, Stamegna C, Capocci M, Rinaldo F
Clin Ter 2021 Jan-Feb;171(1):e55-e56. doi: 10.7417/CT.2021.2282. PMID: 33346328

JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis.

Fragoulis GE, McInnes IB, Siebert S
Rheumatology (Oxford) 2019 Feb 1;58(Suppl 1):i43-i54. doi: 10.1093/rheumatology/key276. PMID: 30806709 Free PMC Article

A literature review of dental erosion in children.

Taji S, Seow WK
Aust Dent J 2010 Dec;55(4):358-67; quiz 475. doi: 10.1111/j.1834-7819.2010.01255.x. PMID: 21133936

See all (343)

Prognosis

Orthodontic Analysis behind the Extraction of Hypomineralised First Molars.

Garib D, Rios D, Ciantelli TL, Miranda F
Monogr Oral Sci 2024;32:261-273. Epub 2024 Jul 1 doi: 10.1159/000538892. PMID: 39321766

"Pitted" lesions in dermatology.

Adya KA, Inamadar AC, Palit A
Int J Dermatol 2017 Jan;56(1):3-17. Epub 2016 Sep 9 doi: 10.1111/ijd.13358. PMID: 27613605

Molar Incisor Hypomineralization.

Rao MH, Aluru SC, Jayam C, Bandlapalli A, Patel N
J Contemp Dent Pract 2016 Jul 1;17(7):609-13. PMID: 27595731

Dens invaginatus: review, relevance, and report of 3 cases.

Khan SA, Khan SY, Bains VK, Bains R, Loomba K
J Dent Child (Chic) 2012 Sep-Dec;79(3):143-53. PMID: 23433617

Kohlschutter syndrome in siblings.

Donnai D, Tomlin PI, Winter RM
Clin Dysmorphol 2005 Jul;14(3):123-126. PMID: 15930900

See all (257)

Clinical prediction guides

Developmental Defects of Enamel.

Martins DDS, Ionta FQ, Pompermaier Garlet G, Lima RR, Neves AA, Rios D, Lussi A
Monogr Oral Sci 2024;32:10-34. Epub 2024 Jul 1 doi: 10.1159/000538850. PMID: 39321764

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.

Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J
Sci Rep 2021 Nov 17;11(1):22405. doi: 10.1038/s41598-021-01541-7. PMID: 34789780 Free PMC Article

Type I interferonopathies in pediatric rheumatology.

Volpi S, Picco P, Caorsi R, Candotti F, Gattorno M
Pediatr Rheumatol Online J 2016 Jun 4;14(1):35. doi: 10.1186/s12969-016-0094-4. PMID: 27260006 Free PMC Article

The oral manifestations of celiac disease: information for the pediatric dentist.

Ferraz EG, Campos Ede J, Sarmento VA, Silva LR
Pediatr Dent 2012 Nov-Dec;34(7):485-8. PMID: 23265166

Amelogenesis imperfecta.

Crawford PJ, Aldred M, Bloch-Zupan A
Orphanet J Rare Dis 2007 Apr 4;2:17. doi: 10.1186/1750-1172-2-17. PMID: 17408482 Free PMC Article

See all (495)

Recent systematic reviews

Dental caries and developmental defects of enamel in cerebral palsy: A meta-analysis.

de Oliveira TN, Drumond VZ, de Arruda JAA, Pani SC, Vargas-Ferreira F, Eustachio RR, Mesquita RA, Abreu LG
Oral Dis 2024 Sep;30(6):3828-3837. Epub 2024 Apr 16 doi: 10.1111/odi.14957. PMID: 38623066

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.

Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J
Sci Rep 2021 Nov 17;11(1):22405. doi: 10.1038/s41598-021-01541-7. PMID: 34789780 Free PMC Article

Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies.

Kirthiga M, Murugan M, Saikia A, Kirubakaran R
Pediatr Dent 2019 Mar 15;41(2):95-112. PMID: 30992106 Free PMC Article

Structural, mechanical and chemical evaluation of molar-incisor hypomineralization-affected enamel: A systematic review.

Elhennawy K, Manton DJ, Crombie F, Zaslansky P, Radlanski RJ, Jost-Brinkmann PG, Schwendicke F
Arch Oral Biol 2017 Nov;83:272-281. Epub 2017 Aug 19 doi: 10.1016/j.archoralbio.2017.08.008. PMID: 28843745

Association between developmental defects of enamel and dental caries: A systematic review and meta-analysis.

Vargas-Ferreira F, Salas MM, Nascimento GG, Tarquinio SB, Faggion CM Jr, Peres MA, Thomson WM, Demarco FF
J Dent 2015 Jun;43(6):619-28. Epub 2015 Apr 8 doi: 10.1016/j.jdent.2015.03.011. PMID: 25862273

See all (21)

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Abnormal dental enamel morphology

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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