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Abnormality of the vitamin B3 metabolism

MedGen UID:
867651
•Concept ID:
C4022040
•
Finding
HPO: HP:0100496

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the vitamin B3 metabolism

Professional guidelines

PubMed

Pathophysiology and clinical management of pellagra - a review.
Hołubiec P, Leończyk M, Staszewski F, Łazarczyk A, Jaworek AK, Wojas-Pelc A
Folia Med Cracov 2021 Sep 29;61(3):125-137. doi: 10.24425/fmc.2021.138956. PMID: 34882669
Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management.
Shanbhogue AK, Prasad SR, Takahashi N, Vikram R, Sahani DV
Radiology 2011 Mar;258(3):673-93. doi: 10.1148/radiol.10100376. PMID: 21339346
Autism, an extreme challenge to integrative medicine. Part 2: medical management.
Kidd PM
Altern Med Rev 2002 Dec;7(6):472-99. PMID: 12495373

Recent clinical studies

Therapy

NAD(+) repletion with niacin counteracts cancer cachexia.
Beltrà M, Pöllänen N, Fornelli C, Tonttila K, Hsu MY, Zampieri S, Moletta L, Corrà S, Porporato PE, Kivelä R, Viscomi C, Sandri M, Hulmi JJ, Sartori R, Pirinen E, Penna F
Nat Commun 2023 Apr 3;14(1):1849. doi: 10.1038/s41467-023-37595-6. PMID: 37012289Free PMC Article
Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential.
Nowak KL, Hopp K
Clin J Am Soc Nephrol 2020 Apr 7;15(4):577-584. Epub 2020 Feb 21 doi: 10.2215/CJN.13291019. PMID: 32086281Free PMC Article
Novel therapeutic approaches to xeroderma pigmentosum.
Weon JL, Glass DA 2nd
Br J Dermatol 2019 Aug;181(2):249-255. Epub 2018 Nov 25 doi: 10.1111/bjd.17253. PMID: 30265743
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J
Cell Metab 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. PMID: 22682224Free PMC Article
Polymorphic light eruption.
Tutrone WD, Spann CT, Scheinfeld N, Deleo VA
Dermatol Ther 2003;16(1):28-39. doi: 10.1046/j.1529-8019.2003.01605.x. PMID: 12919124

Prognosis

HBV Enhances Sorafenib Resistance in Hepatocellular Carcinoma by Reducing Ferroptosis via SRSF2-Mediated Abnormal PCLAF Splicing.
Liu L, Lv Z, Wang M, Zhang D, Liu D, Zhu F
Int J Mol Sci 2023 Feb 7;24(4) doi: 10.3390/ijms24043263. PMID: 36834680Free PMC Article
Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma.
Zhang W, Jing Y, Wang S, Wu Y, Sun Y, Zhuang J, Huang X, Chen S, Zhang X, Song Y, Hu Q, Ni Y
Biomolecules 2022 Oct 15;12(10) doi: 10.3390/biom12101487. PMID: 36291696Free PMC Article
Water Soluble Vitamins and their Role in Diabetes and its Complications.
Deshmukh SV, Prabhakar B, Kulkarni YA
Curr Diabetes Rev 2020;16(7):649-656. doi: 10.2174/1573399815666190916114040. PMID: 31526351
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management.
Shanbhogue AK, Prasad SR, Takahashi N, Vikram R, Sahani DV
Radiology 2011 Mar;258(3):673-93. doi: 10.1148/radiol.10100376. PMID: 21339346

Clinical prediction guides

Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1α to inhibit apoptosis.
Gao Z, Wang D, Yang J, Li M, Ling C, Lv D, Cao Y, Chen Z, Shi C, Shen H, Tang Y
Biomed Pharmacother 2023 Jul;163:114750. Epub 2023 Apr 21 doi: 10.1016/j.biopha.2023.114750. PMID: 37087978
Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma.
Zhang W, Jing Y, Wang S, Wu Y, Sun Y, Zhuang J, Huang X, Chen S, Zhang X, Song Y, Hu Q, Ni Y
Biomolecules 2022 Oct 15;12(10) doi: 10.3390/biom12101487. PMID: 36291696Free PMC Article
BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy.
Cao W, Liu X, Zhang Y, Li A, Xie Y, Zhou S, Song L, Xu R, Ma Y, Cai S, Tang X
Biomed Res Int 2021;2021:5556306. Epub 2021 Apr 16 doi: 10.1155/2021/5556306. PMID: 33987439Free PMC Article
Water Soluble Vitamins and their Role in Diabetes and its Complications.
Deshmukh SV, Prabhakar B, Kulkarni YA
Curr Diabetes Rev 2020;16(7):649-656. doi: 10.2174/1573399815666190916114040. PMID: 31526351
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

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