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Single lineage myelodysplasia

MedGen UID:
868620
•Concept ID:
C4023019
•
Disease or Syndrome
HPO: HP:0012150

Definition

Abnormality/dysplasia of a single myeloid cell (erythroid, granulocytic, or megakaryocytic). [from HPO]

Professional guidelines

PubMed

Recombinant human hematopoietic growth factors in the treatment of cytopenias.
Grosh WW, Quesenberry PJ
Clin Immunol Immunopathol 1992 Jan;62(1 Pt 2):S25-38. doi: 10.1016/0090-1229(92)90038-p. PMID: 1728985

Recent clinical studies

Etiology

Clonal dynamics of donor-derived myelodysplastic syndrome after unrelated hematopoietic cell transplantation for high-risk pediatric B-lymphoblastic leukemia.
Schwartz JR, Walsh MP, Ma J, Lamprecht T, Wang S, Wu G, Raimondi S, Triplett BM, Klco JM
Cold Spring Harb Mol Case Stud 2018 Oct;4(5) Epub 2018 Oct 1 doi: 10.1101/mcs.a002980. PMID: 29891567Free PMC Article
Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).
Della Porta MG, Tuechler H, Malcovati L, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres MA, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D, Greenberg PL, Cazzola M
Leukemia 2015 Jul;29(7):1502-13. Epub 2015 Feb 27 doi: 10.1038/leu.2015.55. PMID: 25721895
Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes.
Teo JT, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Athale U, Jardine L, Hand JP, Tsangaris E, Odame I, Beyene J, Dror Y
Pediatrics 2008 Jul;122(1):e139-48. doi: 10.1542/peds.2007-3415. PMID: 18595958
Disease progression in recently diagnosed patients with inherited marrow failure syndromes: a Canadian Inherited Marrow Failure Registry (CIMFR) report.
Steele JM, Sung L, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Odame I, Silva M, Champagne J, Ali K, Brossard J, Samson Y, Abish S, Le D, Jardine L, Hand JP, Lipton JH, Charpentier K, Stephens D, Freedman M, Dror Y; Canadian Inherited Marrow Failure Registry
Pediatr Blood Cancer 2006 Dec;47(7):918-25. doi: 10.1002/pbc.20876. PMID: 16676307
Optimizing therapy for myeloid disorders of Down syndrome.
Webb DK
Br J Haematol 2005 Oct;131(1):3-7. doi: 10.1111/j.1365-2141.2005.05700.x. PMID: 16173956

Diagnosis

Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report.
Sheng XF, Hong LL, Huang FY, Zhuang HF
J Int Med Res 2022 Sep;50(9):3000605221122741. doi: 10.1177/03000605221122741. PMID: 36134564Free PMC Article
Clonal dynamics of donor-derived myelodysplastic syndrome after unrelated hematopoietic cell transplantation for high-risk pediatric B-lymphoblastic leukemia.
Schwartz JR, Walsh MP, Ma J, Lamprecht T, Wang S, Wu G, Raimondi S, Triplett BM, Klco JM
Cold Spring Harb Mol Case Stud 2018 Oct;4(5) Epub 2018 Oct 1 doi: 10.1101/mcs.a002980. PMID: 29891567Free PMC Article
Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes.
Teo JT, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Athale U, Jardine L, Hand JP, Tsangaris E, Odame I, Beyene J, Dror Y
Pediatrics 2008 Jul;122(1):e139-48. doi: 10.1542/peds.2007-3415. PMID: 18595958
Optimizing therapy for myeloid disorders of Down syndrome.
Webb DK
Br J Haematol 2005 Oct;131(1):3-7. doi: 10.1111/j.1365-2141.2005.05700.x. PMID: 16173956
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Felix CA, Hosler MR, Provisor D, Salhany K, Sexsmith EA, Slater DJ, Cheung NK, Winick NJ, Strauss EA, Heyn R, Lange BJ, Malkin D
Blood 1996 May 15;87(10):4376-81. PMID: 8639798

Therapy

Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency.
Wu Z, Gao S, Diamond C, Kajigaya S, Chen J, Shi R, Palmer C, Hsu AP, Calvo KR, Hickstein DD, Holland SM, Young NS
Blood Adv 2020 Jun 23;4(12):2656-2670. doi: 10.1182/bloodadvances.2019001352. PMID: 32556286Free PMC Article
Optimizing therapy for myeloid disorders of Down syndrome.
Webb DK
Br J Haematol 2005 Oct;131(1):3-7. doi: 10.1111/j.1365-2141.2005.05700.x. PMID: 16173956
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Felix CA, Hosler MR, Provisor D, Salhany K, Sexsmith EA, Slater DJ, Cheung NK, Winick NJ, Strauss EA, Heyn R, Lange BJ, Malkin D
Blood 1996 May 15;87(10):4376-81. PMID: 8639798
Recombinant human hematopoietic growth factors in the treatment of cytopenias.
Grosh WW, Quesenberry PJ
Clin Immunol Immunopathol 1992 Jan;62(1 Pt 2):S25-38. doi: 10.1016/0090-1229(92)90038-p. PMID: 1728985
Differentiation induction in myelodysplasia and acute myeloid leukaemia: use of synergistic drug combinations.
Francis GE, Mufti GJ, Knowles SM, Berney JJ, Guimaraes JE, Secker-Walker LM, Hamblin TJ
Leuk Res 1987;11(11):971-7. doi: 10.1016/0145-2126(87)90115-9. PMID: 3480401

Prognosis

Acute myeloid leukemia with myelodysplasia-related changes and blasts of the mixed T/myeloid phenotype: a case report.
Sheng XF, Hong LL, Huang FY, Zhuang HF
J Int Med Res 2022 Sep;50(9):3000605221122741. doi: 10.1177/03000605221122741. PMID: 36134564Free PMC Article
Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).
Della Porta MG, Tuechler H, Malcovati L, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres MA, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D, Greenberg PL, Cazzola M
Leukemia 2015 Jul;29(7):1502-13. Epub 2015 Feb 27 doi: 10.1038/leu.2015.55. PMID: 25721895
Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes.
Teo JT, Klaassen R, Fernandez CV, Yanofsky R, Wu J, Champagne J, Silva M, Lipton JH, Brossard J, Samson Y, Abish S, Steele M, Ali K, Athale U, Jardine L, Hand JP, Tsangaris E, Odame I, Beyene J, Dror Y
Pediatrics 2008 Jul;122(1):e139-48. doi: 10.1542/peds.2007-3415. PMID: 18595958
Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.
Gibson S, Leung B, Squire JA, Hill M, Arima N, Goss P, Hogg D, Mills GB
Blood 1993 Sep 1;82(5):1561-72. PMID: 8364206
Differentiation induction in myelodysplasia and acute myeloid leukaemia: use of synergistic drug combinations.
Francis GE, Mufti GJ, Knowles SM, Berney JJ, Guimaraes JE, Secker-Walker LM, Hamblin TJ
Leuk Res 1987;11(11):971-7. doi: 10.1016/0145-2126(87)90115-9. PMID: 3480401

Clinical prediction guides

Mesenchymal stem/stromal cells from a transplanted, asymptomatic patient with Fanconi anemia exhibit an aging-like phenotype and dysregulated expression of genes implicated in hematopoiesis and myelodysplasia.
Haga CL, Boregowda SV, Booker CN, Krishnappa V, Strivelli J, Cappelli E, Phinney DG
Cytotherapy 2023 Apr;25(4):362-368. Epub 2022 Dec 5 doi: 10.1016/j.jcyt.2022.11.003. PMID: 36481320Free PMC Article
Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency.
Wu Z, Gao S, Diamond C, Kajigaya S, Chen J, Shi R, Palmer C, Hsu AP, Calvo KR, Hickstein DD, Holland SM, Young NS
Blood Adv 2020 Jun 23;4(12):2656-2670. doi: 10.1182/bloodadvances.2019001352. PMID: 32556286Free PMC Article
Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).
Della Porta MG, Tuechler H, Malcovati L, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres MA, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D, Greenberg PL, Cazzola M
Leukemia 2015 Jul;29(7):1502-13. Epub 2015 Feb 27 doi: 10.1038/leu.2015.55. PMID: 25721895
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Felix CA, Hosler MR, Provisor D, Salhany K, Sexsmith EA, Slater DJ, Cheung NK, Winick NJ, Strauss EA, Heyn R, Lange BJ, Malkin D
Blood 1996 May 15;87(10):4376-81. PMID: 8639798
Correlations between cytogenetics and morphology in myelodysplastic syndromes.
Vila L, Charrin C, Archimbaud E, Treille-Ritouet D, Fraisse J, Felman P, Fiere D, Germain D
Blut 1990 Apr;60(4):223-7. doi: 10.1007/BF01728788. PMID: 2337681

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