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Bilineage myelodysplasia

MedGen UID:
868621
•Concept ID:
C4023020
•
Disease or Syndrome
HPO: HP:0012149

Definition

Myelodysplasia with dysplastic changes in two of the myeloid lineages [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBilineage myelodysplasia

Recent clinical studies

Etiology

Morphologic and Molecular Characteristics of De Novo AML With JAK2 V617F Mutation.
Hidalgo-López JE, Kanagal-Shamanna R, Medeiros LJ, Estrov Z, Yin CC, Verstovsek S, Konoplev S, Jorgensen JL, Mohammad MM, Miranda RN, Zhao C, Lee J, Zuo Z, Bueso-Ramos CE
J Natl Compr Canc Netw 2017 Jun;15(6):790-796. doi: 10.6004/jnccn.2017.0106. PMID: 28596259
Bone marrow trephine findings in acute myeloid leukaemia with multilineage dysplasia.
Ngo N, Lampert IA, Naresh KN
Br J Haematol 2008 Feb;140(3):279-86. Epub 2007 Oct 31 doi: 10.1111/j.1365-2141.2007.06882.x. PMID: 17973948

Diagnosis

Morphologic and Molecular Characteristics of De Novo AML With JAK2 V617F Mutation.
Hidalgo-López JE, Kanagal-Shamanna R, Medeiros LJ, Estrov Z, Yin CC, Verstovsek S, Konoplev S, Jorgensen JL, Mohammad MM, Miranda RN, Zhao C, Lee J, Zuo Z, Bueso-Ramos CE
J Natl Compr Canc Netw 2017 Jun;15(6):790-796. doi: 10.6004/jnccn.2017.0106. PMID: 28596259
Bone marrow trephine findings in acute myeloid leukaemia with multilineage dysplasia.
Ngo N, Lampert IA, Naresh KN
Br J Haematol 2008 Feb;140(3):279-86. Epub 2007 Oct 31 doi: 10.1111/j.1365-2141.2007.06882.x. PMID: 17973948

Prognosis

iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation and dismal outcome.
Xie W, Xu J, Hu S, Li S, Wang W, Cameron Yin C, Toruner G, Tang Z, Medeiros LJ, Tang G
Mod Pathol 2020 Jul;33(7):1389-1397. Epub 2020 Feb 7 doi: 10.1038/s41379-020-0494-3. PMID: 32034282

Clinical prediction guides

Mesenchymal stem/stromal cells from a transplanted, asymptomatic patient with Fanconi anemia exhibit an aging-like phenotype and dysregulated expression of genes implicated in hematopoiesis and myelodysplasia.
Haga CL, Boregowda SV, Booker CN, Krishnappa V, Strivelli J, Cappelli E, Phinney DG
Cytotherapy 2023 Apr;25(4):362-368. Epub 2022 Dec 5 doi: 10.1016/j.jcyt.2022.11.003. PMID: 36481320Free PMC Article
iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation and dismal outcome.
Xie W, Xu J, Hu S, Li S, Wang W, Cameron Yin C, Toruner G, Tang Z, Medeiros LJ, Tang G
Mod Pathol 2020 Jul;33(7):1389-1397. Epub 2020 Feb 7 doi: 10.1038/s41379-020-0494-3. PMID: 32034282

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