U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of T cell physiology

MedGen UID:
868761
•Concept ID:
C4023166
•
Pathologic Function
HPO: HP:0011840

Definition

A functional anomaly of T cells. [from HPO]

Conditions with this feature

Immunodeficiency, X-linked, with deficiency of 115,000 Dalton surface glycoprotein
MedGen UID:
326624
•Concept ID:
C1839982
•
Disease or Syndrome
See: Condition Record
Sarcoidosis, susceptibility to, 1
MedGen UID:
394568
•Concept ID:
C2697310
•
Finding
Any sarcoidosis in which the cause of the disease is a mutation in the HLA-DRB1 gene.
See: Condition Record
Immunodeficiency, X-linked, with deficiency of 115,000 Dalton surface glycoprotein
Sarcoidosis, susceptibility to, 1

Professional guidelines

PubMed

Comparative pathophysiology and management of protein-losing enteropathy.
Craven MD, Washabau RJ
J Vet Intern Med 2019 Mar;33(2):383-402. Epub 2019 Feb 14 doi: 10.1111/jvim.15406. PMID: 30762910Free PMC Article
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article
Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

Recent clinical studies

Etiology

T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease.
Zeng J, Liao Z, Yang H, Wang Q, Wu Z, Hua F, Zhou Z
Neurobiol Dis 2024 Apr;193:106461. Epub 2024 Mar 2 doi: 10.1016/j.nbd.2024.106461. PMID: 38437992
Spectrum of Genetic T-Cell Disorders from 22q11.2DS to CHARGE.
Urschel D, Hernandez-Trujillo VP
Clin Rev Allergy Immunol 2022 Aug;63(1):99-105. Epub 2022 Feb 8 doi: 10.1007/s12016-022-08927-z. PMID: 35133619
Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis.
Qiu J, Wu B, Goodman SB, Berry GJ, Goronzy JJ, Weyand CM
Front Immunol 2021;12:652771. Epub 2021 Apr 2 doi: 10.3389/fimmu.2021.652771. PMID: 33868292Free PMC Article
HBV-Induced Immune Imbalance in the Development of HCC.
Chen Y, Tian Z
Front Immunol 2019;10:2048. Epub 2019 Aug 27 doi: 10.3389/fimmu.2019.02048. PMID: 31507621Free PMC Article
T cell immunodeficiency.
Edgar JD
J Clin Pathol 2008 Sep;61(9):988-93. doi: 10.1136/jcp.2007.051144. PMID: 18755723

Diagnosis

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.
Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Cytotoxic CD161(-)CD8(+) T(EMRA) cells contribute to the pathogenesis of systemic lupus erythematosus.
Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K
EBioMedicine 2023 Apr;90:104507. Epub 2023 Mar 7 doi: 10.1016/j.ebiom.2023.104507. PMID: 36893588Free PMC Article
Approach to primary immunodeficiency.
Devonshire AL, Makhija M
Allergy Asthma Proc 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. PMID: 31690396Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Myelodysplastic syndromes.
Adès L, Itzykson R, Fenaux P
Lancet 2014 Jun 28;383(9936):2239-52. Epub 2014 Mar 21 doi: 10.1016/S0140-6736(13)61901-7. PMID: 24656536

Therapy

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS
Nat Commun 2022 Jan 21;13(1):440. doi: 10.1038/s41467-021-27716-4. PMID: 35064122Free PMC Article
PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations.
Jiang Y, Chen M, Nie H, Yuan Y
Hum Vaccin Immunother 2019;15(5):1111-1122. Epub 2019 Mar 19 doi: 10.1080/21645515.2019.1571892. PMID: 30888929Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Myelodysplastic syndromes.
Adès L, Itzykson R, Fenaux P
Lancet 2014 Jun 28;383(9936):2239-52. Epub 2014 Mar 21 doi: 10.1016/S0140-6736(13)61901-7. PMID: 24656536
Thymus transplantation.
Markert ML, Devlin BH, McCarthy EA
Clin Immunol 2010 May;135(2):236-46. Epub 2010 Mar 16 doi: 10.1016/j.clim.2010.02.007. PMID: 20236866Free PMC Article

Prognosis

Cytotoxic CD161(-)CD8(+) T(EMRA) cells contribute to the pathogenesis of systemic lupus erythematosus.
Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K
EBioMedicine 2023 Apr;90:104507. Epub 2023 Mar 7 doi: 10.1016/j.ebiom.2023.104507. PMID: 36893588Free PMC Article
CD38: An important regulator of T cell function.
Li W, Liang L, Liao Q, Li Y, Zhou Y
Biomed Pharmacother 2022 Sep;153:113395. Epub 2022 Jul 11 doi: 10.1016/j.biopha.2022.113395. PMID: 35834988
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS
Nat Commun 2022 Jan 21;13(1):440. doi: 10.1038/s41467-021-27716-4. PMID: 35064122Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Myelodysplastic syndromes.
Adès L, Itzykson R, Fenaux P
Lancet 2014 Jun 28;383(9936):2239-52. Epub 2014 Mar 21 doi: 10.1016/S0140-6736(13)61901-7. PMID: 24656536

Clinical prediction guides

Cytotoxic CD161(-)CD8(+) T(EMRA) cells contribute to the pathogenesis of systemic lupus erythematosus.
Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K
EBioMedicine 2023 Apr;90:104507. Epub 2023 Mar 7 doi: 10.1016/j.ebiom.2023.104507. PMID: 36893588Free PMC Article
The Role of Immunometabolism in the Pathogenesis of Systemic Lupus Erythematosus.
Robinson GA, Wilkinson MGL, Wincup C
Front Immunol 2021;12:806560. Epub 2022 Jan 26 doi: 10.3389/fimmu.2021.806560. PMID: 35154082Free PMC Article
Abnormality of regulatory T cells in common variable immunodeficiency.
Azizi G, Hafezi N, Mohammadi H, Yazdani R, Alinia T, Tavakol M, Aghamohammadi A, Mirshafiey A
Cell Immunol 2017 May;315:11-17. Epub 2016 Dec 29 doi: 10.1016/j.cellimm.2016.12.007. PMID: 28284485
Arginine and immunity.
Popovic PJ, Zeh HJ 3rd, Ochoa JB
J Nutr 2007 Jun;137(6 Suppl 2):1681S-1686S. doi: 10.1093/jn/137.6.1681S. PMID: 17513447
Immunopathogenesis of psoriasis.
Ozawa M, Aiba S
Curr Drug Targets Inflamm Allergy 2004 Jun;3(2):137-44. doi: 10.2174/1568010043343868. PMID: 15180466

Recent systematic reviews

γδ T cells in oral diseases.
Wei XY, Tan YQ, Zhou G
Inflamm Res 2024 May;73(5):867-876. Epub 2024 Apr 2 doi: 10.1007/s00011-024-01870-z. PMID: 38563967
Systematic Review: Safety and Efficacy of mRNA COVID-19 Vaccines in Pregnant Women.
Lam JN, Nehira J, Phung O, Deng B
J Pharm Pract 2024 Aug;37(4):967-976. Epub 2023 Aug 22 doi: 10.1177/08971900231196065. PMID: 37605626
Activation of the Monocyte/Macrophage System and Abnormal Blood Levels of Lymphocyte Subpopulations in Individuals with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
Arteaga-Henríquez G, Lugo-Marín J, Gisbert L, Setién-Ramos I, Martínez-Gallo M, Pujol-Borrell R, Ramos-Quiroga JA
Int J Mol Sci 2022 Nov 18;23(22) doi: 10.3390/ijms232214329. PMID: 36430805Free PMC Article
Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells-Peritoneal Stroma Interactions.
Terri M, Trionfetti F, Montaldo C, Cordani M, Tripodi M, Lopez-Cabrera M, Strippoli R
Front Immunol 2021;12:607204. Epub 2021 Mar 29 doi: 10.3389/fimmu.2021.607204. PMID: 33854496Free PMC Article
Early initiation of antiretroviral therapy in HIV-infected adults and adolescents: a systematic review.
Anglemyer A, Rutherford GW, Easterbrook PJ, Horvath T, Vitória M, Jan M, Doherty MC
AIDS 2014 Mar;28 Suppl 2:S105-18. doi: 10.1097/QAD.0000000000000232. PMID: 24849469

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...