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Abnormality of T cell physiology

MedGen UID:
868761
Concept ID:
C4023166
Pathologic Function
HPO: HP:0011840

Definition

A functional anomaly of T cells. [from HPO]

Conditions with this feature

Immunodeficiency, X-linked, with deficiency of 115,000 Dalton surface glycoprotein
MedGen UID:
326624
Concept ID:
C1839982
Disease or Syndrome
Sarcoidosis, susceptibility to, 1
MedGen UID:
394568
Concept ID:
C2697310
Finding
Any sarcoidosis in which the cause of the disease is a mutation in the HLA-DRB1 gene.

Professional guidelines

PubMed

Craven MD, Washabau RJ
J Vet Intern Med 2019 Mar;33(2):383-402. Epub 2019 Feb 14 doi: 10.1111/jvim.15406. PMID: 30762910Free PMC Article
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

Recent clinical studies

Etiology

Kouli A, Williams-Gray CH
J Parkinsons Dis 2022;12(s1):S93-S104. doi: 10.3233/JPD-223228. PMID: 35661020Free PMC Article
Qiu J, Wu B, Goodman SB, Berry GJ, Goronzy JJ, Weyand CM
Front Immunol 2021;12:652771. Epub 2021 Apr 2 doi: 10.3389/fimmu.2021.652771. PMID: 33868292Free PMC Article
Chen Y, Tian Z
Front Immunol 2019;10:2048. Epub 2019 Aug 27 doi: 10.3389/fimmu.2019.02048. PMID: 31507621Free PMC Article
Sullivan KE
Immunol Rev 2019 Jan;287(1):186-201. doi: 10.1111/imr.12701. PMID: 30565249
Fischer A
Immunodefic Rev 1992;3(2):83-100. PMID: 1554500

Diagnosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K
EBioMedicine 2023 Apr;90:104507. Epub 2023 Mar 7 doi: 10.1016/j.ebiom.2023.104507. PMID: 36893588Free PMC Article
Devonshire AL, Makhija M
Allergy Asthma Proc 2019 Nov 1;40(6):465-469. doi: 10.2500/aap.2019.40.4273. PMID: 31690396
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Adès L, Itzykson R, Fenaux P
Lancet 2014 Jun 28;383(9936):2239-52. Epub 2014 Mar 21 doi: 10.1016/S0140-6736(13)61901-7. PMID: 24656536

Therapy

Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS
Nat Commun 2022 Jan 21;13(1):440. doi: 10.1038/s41467-021-27716-4. PMID: 35064122Free PMC Article
Jiang Y, Chen M, Nie H, Yuan Y
Hum Vaccin Immunother 2019;15(5):1111-1122. Epub 2019 Mar 19 doi: 10.1080/21645515.2019.1571892. PMID: 30888929Free PMC Article
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Adès L, Itzykson R, Fenaux P
Lancet 2014 Jun 28;383(9936):2239-52. Epub 2014 Mar 21 doi: 10.1016/S0140-6736(13)61901-7. PMID: 24656536
Markert ML, Devlin BH, McCarthy EA
Clin Immunol 2010 May;135(2):236-46. Epub 2010 Mar 16 doi: 10.1016/j.clim.2010.02.007. PMID: 20236866Free PMC Article

Prognosis

Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K
EBioMedicine 2023 Apr;90:104507. Epub 2023 Mar 7 doi: 10.1016/j.ebiom.2023.104507. PMID: 36893588Free PMC Article
Li W, Liang L, Liao Q, Li Y, Zhou Y
Biomed Pharmacother 2022 Sep;153:113395. Epub 2022 Jul 11 doi: 10.1016/j.biopha.2022.113395. PMID: 35834988
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS
Nat Commun 2022 Jan 21;13(1):440. doi: 10.1038/s41467-021-27716-4. PMID: 35064122Free PMC Article
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Adès L, Itzykson R, Fenaux P
Lancet 2014 Jun 28;383(9936):2239-52. Epub 2014 Mar 21 doi: 10.1016/S0140-6736(13)61901-7. PMID: 24656536

Clinical prediction guides

Xiong H, Cui M, Kong N, Jing J, Xu Y, Liu X, Yang F, Xu Z, Yan Y, Zhao D, Zou Z, Xia M, Cen J, Tan G, Huai C, Fu Q, Guo Q, Chen K
EBioMedicine 2023 Apr;90:104507. Epub 2023 Mar 7 doi: 10.1016/j.ebiom.2023.104507. PMID: 36893588Free PMC Article
Robinson GA, Wilkinson MGL, Wincup C
Front Immunol 2021;12:806560. Epub 2022 Jan 26 doi: 10.3389/fimmu.2021.806560. PMID: 35154082Free PMC Article
Cassioli C, Baldari CT
Cells 2019 Jul 29;8(8) doi: 10.3390/cells8080789. PMID: 31362462Free PMC Article
Popovic PJ, Zeh HJ 3rd, Ochoa JB
J Nutr 2007 Jun;137(6 Suppl 2):1681S-1686S. doi: 10.1093/jn/137.6.1681S. PMID: 17513447
Ozawa M, Aiba S
Curr Drug Targets Inflamm Allergy 2004 Jun;3(2):137-44. doi: 10.2174/1568010043343868. PMID: 15180466

Recent systematic reviews

Wei XY, Tan YQ, Zhou G
Inflamm Res 2024 May;73(5):867-876. Epub 2024 Apr 2 doi: 10.1007/s00011-024-01870-z. PMID: 38563967
Terri M, Trionfetti F, Montaldo C, Cordani M, Tripodi M, Lopez-Cabrera M, Strippoli R
Front Immunol 2021;12:607204. Epub 2021 Mar 29 doi: 10.3389/fimmu.2021.607204. PMID: 33854496Free PMC Article
Yu X, Wang M, Li L, Zhang L, Chan MTV, Wu WKK
J Cell Mol Med 2020 Jun;24(11):5966-5972. Epub 2020 Apr 30 doi: 10.1111/jcmm.15208. PMID: 32351034Free PMC Article
Anglemyer A, Rutherford GW, Easterbrook PJ, Horvath T, Vitória M, Jan M, Doherty MC
AIDS 2014 Mar;28 Suppl 2:S105-18. doi: 10.1097/QAD.0000000000000232. PMID: 24849469
Mao X, Lillington DM, Czepulkowski B, Russell-Jones R, Young BD, Whittaker S
Genes Chromosomes Cancer 2003 Mar;36(3):250-60. doi: 10.1002/gcc.10152. PMID: 12557225

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