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Posterior pituitary hypoplasia

MedGen UID:
868797
Concept ID:
C4023202
Anatomical Abnormality
Synonym: Neurohypophysis hypoplasia
 
HPO: HP:0011757

Definition

Underdevelopment of the neurohypophysis. [from HPO]

Term Hierarchy

Conditions with this feature

Pituitary hormone deficiency, combined, 6
MedGen UID:
462790
Concept ID:
C3151440
Disease or Syndrome
Any combined pituitary hormone deficiencies, genetic form in which the cause of the disease is a mutation in the OTX2 gene.

Professional guidelines

PubMed

Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Robertson GL
Handb Clin Neurol 2021;181:239-248. doi: 10.1016/B978-0-12-820683-6.00017-8. PMID: 34238460
Garrahy A, Moran C, Thompson CJ
Clin Endocrinol (Oxf) 2019 Jan;90(1):23-30. Epub 2018 Oct 23 doi: 10.1111/cen.13866. PMID: 30269342

Recent clinical studies

Etiology

Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Nannette G, Bar C, Diene G, Pienkowski C, Oliver-Petit I, Jouret B, Cartault A, Porquet-Bordes V, Salles JP, Grunenwald S, Edouard T, Molinas C, Tauber M
J Clin Endocrinol Metab 2023 Jan 17;108(2):323-330. doi: 10.1210/clinem/dgac583. PMID: 36201475
Guryildirim M, Kontzialis M, Ozen M, Kocak M
Radiographics 2019 Oct;39(6):1739-1759. doi: 10.1148/rg.2019190017. PMID: 31589569
Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J
Rheumatol Int 2019 Aug;39(8):1467-1476. Epub 2019 Jun 15 doi: 10.1007/s00296-019-04338-0. PMID: 31203400
Cowen LE, Hodak SP, Verbalis JG
Endocrinol Metab Clin North Am 2013 Jun;42(2):349-70. Epub 2013 Apr 17 doi: 10.1016/j.ecl.2013.02.005. PMID: 23702406Free PMC Article

Diagnosis

Robertson GL
Handb Clin Neurol 2021;181:239-248. doi: 10.1016/B978-0-12-820683-6.00017-8. PMID: 34238460
Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS
Nat Rev Dis Primers 2019 Aug 8;5(1):54. doi: 10.1038/s41572-019-0103-2. PMID: 31395885
Leroy C, Karrouz W, Douillard C, Do Cao C, Cortet C, Wémeau JL, Vantyghem MC
Ann Endocrinol (Paris) 2013 Dec;74(5-6):496-507. Epub 2013 Nov 25 doi: 10.1016/j.ando.2013.10.002. PMID: 24286605
Ferran Kd, Paiva IA, Gilban DL, Resende M, Souza MA, Beserra IC, Guimarães MM
Arq Neuropsiquiatr 2010 Jun;68(3):400-5. doi: 10.1590/s0004-282x2010000300014. PMID: 20602044
Maghnie M
Horm Res 2003;59 Suppl 1:42-54. doi: 10.1159/000067844. PMID: 12566720

Therapy

Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J
Rheumatol Int 2019 Aug;39(8):1467-1476. Epub 2019 Jun 15 doi: 10.1007/s00296-019-04338-0. PMID: 31203400
Rachdaoui N, Sarkar DK
Alcohol Res 2017;38(2):255-276. PMID: 28988577Free PMC Article
Karaca Z, Tanriverdi F, Atmaca H, Unluhizarci K, Kelestimur F
Growth Horm IGF Res 2012 Jun-Aug;22(3-4):146-9. Epub 2012 May 22 doi: 10.1016/j.ghir.2012.04.008. PMID: 22627149
Gutenberg A, Hans V, Puchner MJ, Kreutzer J, Brück W, Caturegli P, Buchfelder M
Eur J Endocrinol 2006 Jul;155(1):101-7. doi: 10.1530/eje.1.02183. PMID: 16793955

Prognosis

Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Sharma H, Purwar N, Kumar A, Sahlot R, Garg U, Sharma B, Mathur SK
J Pediatr Endocrinol Metab 2021 Jul 27;34(7):851-858. Epub 2021 Apr 7 doi: 10.1515/jpem-2021-0049. PMID: 33823100
Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J
Rheumatol Int 2019 Aug;39(8):1467-1476. Epub 2019 Jun 15 doi: 10.1007/s00296-019-04338-0. PMID: 31203400
Di Iorgi N, Morana G, Allegri AE, Napoli F, Gastaldi R, Calcagno A, Patti G, Loche S, Maghnie M
Best Pract Res Clin Endocrinol Metab 2016 Dec;30(6):705-736. Epub 2016 Nov 24 doi: 10.1016/j.beem.2016.11.008. PMID: 27974186
Kelberman D, Dattani MT
Horm Res 2007;68 Suppl 5:138-44. Epub 2007 Dec 10 doi: 10.1159/000110610. PMID: 18174732

Clinical prediction guides

Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Brauner R, Bignon-Topalovic J, Bashamboo A, McElreavey K
PLoS One 2023;18(12):e0292664. Epub 2023 Dec 14 doi: 10.1371/journal.pone.0292664. PMID: 38096238Free PMC Article
Voutetakis A
Handb Clin Neurol 2021;181:9-27. doi: 10.1016/B978-0-12-820683-6.00002-6. PMID: 34238482
Lodge EJ, Xekouki P, Silva TS, Kochi C, Longui CA, Faucz FR, Santambrogio A, Mills JL, Pankratz N, Lane J, Sosnowska D, Hodgson T, Patist AL, Francis-West P, Helmbacher F, Stratakis C, Andoniadou CL
JCI Insight 2020 Oct 27;5(23) doi: 10.1172/jci.insight.134310. PMID: 33108146Free PMC Article
Kelberman D, Dattani MT
Horm Res 2007;68 Suppl 5:138-44. Epub 2007 Dec 10 doi: 10.1159/000110610. PMID: 18174732

Recent systematic reviews

Hasegawa H, Van Gompel JJ, Oushy SH, Pollock BE, Link MJ, Meyer FB, Bancos I, Erickson D, Davidge-Pitts CJ, Little JT, Uhm JH, Swanson AA, Giannini C, Mahajan A, Atkinson JL
World Neurosurg 2021 May;149:e197-e216. Epub 2021 Feb 18 doi: 10.1016/j.wneu.2021.02.051. PMID: 33610869
Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty JA
World Neurosurg 2021 Jan;145:148-158. Epub 2020 Sep 8 doi: 10.1016/j.wneu.2020.09.023. PMID: 32916355

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