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Posterior pituitary hypoplasia

MedGen UID:
868797
•Concept ID:
C4023202
•
Anatomical Abnormality
Synonym: Neurohypophysis hypoplasia
 
HPO: HP:0011757

Definition

Underdevelopment of the neurohypophysis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosterior pituitary hypoplasia

Conditions with this feature

Pituitary hormone deficiency, combined, 6
MedGen UID:
462790
•Concept ID:
C3151440
•
Disease or Syndrome
Any combined pituitary hormone deficiencies, genetic form in which the cause of the disease is a mutation in the OTX2 gene.
See: Condition Record
Pituitary hormone deficiency, combined, 6

Professional guidelines

PubMed

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Differential diagnosis of familial diabetes insipidus.
Robertson GL
Handb Clin Neurol 2021;181:239-248. doi: 10.1016/B978-0-12-820683-6.00017-8. PMID: 34238460
Diagnosis and management of central diabetes insipidus in adults.
Garrahy A, Moran C, Thompson CJ
Clin Endocrinol (Oxf) 2019 Jan;90(1):23-30. Epub 2018 Oct 23 doi: 10.1111/cen.13866. PMID: 30269342

Recent clinical studies

Etiology

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Age-associated abnormalities of water homeostasis.
Cowen LE, Hodak SP, Verbalis JG
Endocrinol Metab Clin North Am 2013 Jun;42(2):349-70. Epub 2013 Apr 17 doi: 10.1016/j.ecl.2013.02.005. PMID: 23702406Free PMC Article
Clinico-radiological correlation in childhood hypopituitarism.
Dutta P, Bhansali A, Singh P, Rajput R, Bhadada S
Indian Pediatr 2010 Jul;47(7):615-8. Epub 2009 Oct 14 doi: 10.1007/s13312-010-0135-x. PMID: 20019395
Endocrine disorders in pediatric - onset Langerhans Cell Histiocytosis.
Amato MC, Elias LL, Elias J, Santos AC, Bellucci AD, Moreira AC, De Castro M
Horm Metab Res 2006 Nov;38(11):746-51. doi: 10.1055/s-2006-955086. PMID: 17111302
Posterior pituitary dysfunction after traumatic brain injury.
Agha A, Thornton E, O'Kelly P, Tormey W, Phillips J, Thompson CJ
J Clin Endocrinol Metab 2004 Dec;89(12):5987-92. doi: 10.1210/jc.2004-1058. PMID: 15579748

Diagnosis

Syndrome of inappropriate antidiuretic hormone secretion as an adverse reaction of ciprofloxacin: a case report and literature review.
Švitek L, Grubišić B, Schonberger E, Zlosa M, Sabadi D, Lišnjić D, Canecki-Varžić S, Bilić-Ćurčić I, Mandić S
Biochem Med (Zagreb) 2024 Feb 15;34(1):010803. Epub 2023 Dec 15 doi: 10.11613/BM.2024.010803. PMID: 38125612Free PMC Article
Diabetes insipidus.
Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS
Nat Rev Dis Primers 2019 Aug 8;5(1):54. doi: 10.1038/s41572-019-0103-2. PMID: 31395885
Is it micropenis? Does size matter?
Wood K, Nanduri V, Merchant N
Arch Dis Child Fetal Neonatal Ed 2017 Jul;102(4):F345. Epub 2016 Dec 5 doi: 10.1136/archdischild-2016-311874. PMID: 27920045
MRI of Wolfram syndrome (DIDMOAD).
Galluzzi P, Filosomi G, Vallone IM, Bardelli AM, Venturi C
Neuroradiology 1999 Oct;41(10):729-31. doi: 10.1007/s002340050832. PMID: 10552021
Current approaches to imaging of the sellar region and pituitary.
Naidich MJ, Russell EJ
Endocrinol Metab Clin North Am 1999 Mar;28(1):45-79, vi. doi: 10.1016/s0889-8529(05)70057-8. PMID: 10207685

Therapy

Syndrome of inappropriate antidiuretic hormone secretion as an adverse reaction of ciprofloxacin: a case report and literature review.
Švitek L, Grubišić B, Schonberger E, Zlosa M, Sabadi D, Lišnjić D, Canecki-Varžić S, Bilić-Ćurčić I, Mandić S
Biochem Med (Zagreb) 2024 Feb 15;34(1):010803. Epub 2023 Dec 15 doi: 10.11613/BM.2024.010803. PMID: 38125612Free PMC Article
Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Endocrine abnormalities in cardiofaciocutaneous syndrome: a case of precocious puberty, hyperprolactinemia and diabetes insipidus.
Lenet S, Polychronakos C
BMJ Case Rep 2019 Jun 18;12(6) doi: 10.1136/bcr-2018-229032. PMID: 31217210Free PMC Article
Remission of congenital diabetes insipidus after eight years.
Chiu HK, Kletter GB
J Pediatr Endocrinol Metab 2007 Jun;20(6):733-7. doi: 10.1515/jpem.2007.20.6.733. PMID: 17663299
Diabetes insipidus, acute myelogenous leukemia, and monosomy 7.
Mozersky RP, Bahl VK, Meisner D, Patel H
J Am Osteopath Assoc 1996 Feb;96(2):116-8. doi: 10.7556/jaoa.1996.96.2.116. PMID: 8838908

Prognosis

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
A case of PHACE syndrome with growth hormone deficiency and abnormal thyroid functions.
Bongsebandhu-Phubhakdi C, Tempark T, Jakchairoongruang K, Supornsilpchai V
J Pediatr Endocrinol Metab 2019 Nov 26;32(11):1283-1286. doi: 10.1515/jpem-2019-0078. PMID: 31473685
Utility of AVP gene testing in familial neurohypophyseal diabetes insipidus.
Chitturi S, Harris M, Thomsett MJ, Bowling F, McGown I, Cowley D, Leong GM, Batch J, Cotterill AM
Clin Endocrinol (Oxf) 2008 Dec;69(6):926-30. Epub 2008 May 20 doi: 10.1111/j.1365-2265.2008.03303.x. PMID: 18494865
Endocrine disorders in pediatric - onset Langerhans Cell Histiocytosis.
Amato MC, Elias LL, Elias J, Santos AC, Bellucci AD, Moreira AC, De Castro M
Horm Metab Res 2006 Nov;38(11):746-51. doi: 10.1055/s-2006-955086. PMID: 17111302
Persistent trigeminal artery: an anatomical study.
Tulsi RS, Locket NA
Aust N Z J Surg 1985 Aug;55(4):397-402. doi: 10.1111/j.1445-2197.1985.tb00908.x. PMID: 3870171

Clinical prediction guides

Syndrome of inappropriate antidiuretic hormone secretion as an adverse reaction of ciprofloxacin: a case report and literature review.
Švitek L, Grubišić B, Schonberger E, Zlosa M, Sabadi D, Lišnjić D, Canecki-Varžić S, Bilić-Ćurčić I, Mandić S
Biochem Med (Zagreb) 2024 Feb 15;34(1):010803. Epub 2023 Dec 15 doi: 10.11613/BM.2024.010803. PMID: 38125612Free PMC Article
Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Endocrine abnormalities in cardiofaciocutaneous syndrome: a case of precocious puberty, hyperprolactinemia and diabetes insipidus.
Lenet S, Polychronakos C
BMJ Case Rep 2019 Jun 18;12(6) doi: 10.1136/bcr-2018-229032. PMID: 31217210Free PMC Article
Utility of AVP gene testing in familial neurohypophyseal diabetes insipidus.
Chitturi S, Harris M, Thomsett MJ, Bowling F, McGown I, Cowley D, Leong GM, Batch J, Cotterill AM
Clin Endocrinol (Oxf) 2008 Dec;69(6):926-30. Epub 2008 May 20 doi: 10.1111/j.1365-2265.2008.03303.x. PMID: 18494865
Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma.
Heikens J, Michiels EM, Behrendt H, Endert E, Bakker PJ, Fliers E
Eur J Cancer 1998 Sep;34(10):1592-7. doi: 10.1016/s0959-8049(98)00212-3. PMID: 9893634

Recent systematic reviews

A Comprehensive Study of Spindle Cell Oncocytoma of the Pituitary Gland: Series of 6 Cases and Meta-Analysis of 85 Cases.
Hasegawa H, Van Gompel JJ, Oushy SH, Pollock BE, Link MJ, Meyer FB, Bancos I, Erickson D, Davidge-Pitts CJ, Little JT, Uhm JH, Swanson AA, Giannini C, Mahajan A, Atkinson JL
World Neurosurg 2021 May;149:e197-e216. Epub 2021 Feb 18 doi: 10.1016/j.wneu.2021.02.051. PMID: 33610869
Primary Tumors of the Posterior Pituitary Gland: A Systematic Review of the Literature in Light of the New 2017 World Health Organization Classification of Pituitary Tumors.
Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty JA
World Neurosurg 2021 Jan;145:148-158. Epub 2020 Sep 8 doi: 10.1016/j.wneu.2020.09.023. PMID: 32916355

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