U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Posterior pituitary hypoplasia

MedGen UID:
868797
•Concept ID:
C4023202
•
Anatomical Abnormality
Synonym: Neurohypophysis hypoplasia
 
HPO: HP:0011757

Definition

Underdevelopment of the neurohypophysis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosterior pituitary hypoplasia

Conditions with this feature

Pituitary hormone deficiency, combined, 6
MedGen UID:
462790
•Concept ID:
C3151440
•
Disease or Syndrome
Any combined pituitary hormone deficiencies, genetic form in which the cause of the disease is a mutation in the OTX2 gene.
See: Condition Record
Pituitary hormone deficiency, combined, 6

Professional guidelines

PubMed

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Differential diagnosis of familial diabetes insipidus.
Robertson GL
Handb Clin Neurol 2021;181:239-248. doi: 10.1016/B978-0-12-820683-6.00017-8. PMID: 34238460
Diagnosis and management of central diabetes insipidus in adults.
Garrahy A, Moran C, Thompson CJ
Clin Endocrinol (Oxf) 2019 Jan;90(1):23-30. Epub 2018 Oct 23 doi: 10.1111/cen.13866. PMID: 30269342

Recent clinical studies

Etiology

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults.
Nannette G, Bar C, Diene G, Pienkowski C, Oliver-Petit I, Jouret B, Cartault A, Porquet-Bordes V, Salles JP, Grunenwald S, Edouard T, Molinas C, Tauber M
J Clin Endocrinol Metab 2023 Jan 17;108(2):323-330. doi: 10.1210/clinem/dgac583. PMID: 36201475
Acute Headache in the Emergency Setting.
Guryildirim M, Kontzialis M, Ozen M, Kocak M
Radiographics 2019 Oct;39(6):1739-1759. doi: 10.1148/rg.2019190017. PMID: 31589569
Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review.
Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J
Rheumatol Int 2019 Aug;39(8):1467-1476. Epub 2019 Jun 15 doi: 10.1007/s00296-019-04338-0. PMID: 31203400
Age-associated abnormalities of water homeostasis.
Cowen LE, Hodak SP, Verbalis JG
Endocrinol Metab Clin North Am 2013 Jun;42(2):349-70. Epub 2013 Apr 17 doi: 10.1016/j.ecl.2013.02.005. PMID: 23702406Free PMC Article

Diagnosis

Differential diagnosis of familial diabetes insipidus.
Robertson GL
Handb Clin Neurol 2021;181:239-248. doi: 10.1016/B978-0-12-820683-6.00017-8. PMID: 34238460
Diabetes insipidus.
Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS
Nat Rev Dis Primers 2019 Aug 8;5(1):54. doi: 10.1038/s41572-019-0103-2. PMID: 31395885
Diabetes insipidus.
Leroy C, Karrouz W, Douillard C, Do Cao C, Cortet C, Wémeau JL, Vantyghem MC
Ann Endocrinol (Paris) 2013 Dec;74(5-6):496-507. Epub 2013 Nov 25 doi: 10.1016/j.ando.2013.10.002. PMID: 24286605
Septo-optic dysplasia.
Ferran Kd, Paiva IA, Gilban DL, Resende M, Souza MA, Beserra IC, Guimarães MM
Arq Neuropsiquiatr 2010 Jun;68(3):400-5. doi: 10.1590/s0004-282x2010000300014. PMID: 20602044
Diabetes insipidus.
Maghnie M
Horm Res 2003;59 Suppl 1:42-54. doi: 10.1159/000067844. PMID: 12566720

Therapy

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review.
Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J
Rheumatol Int 2019 Aug;39(8):1467-1476. Epub 2019 Jun 15 doi: 10.1007/s00296-019-04338-0. PMID: 31203400
Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System.
Rachdaoui N, Sarkar DK
Alcohol Res 2017;38(2):255-276. PMID: 28988577Free PMC Article
Posterior pituitary functions are not altered after growth hormone replacement therapy in hypopituitarism due to Sheehan's syndrome.
Karaca Z, Tanriverdi F, Atmaca H, Unluhizarci K, Kelestimur F
Growth Horm IGF Res 2012 Jun-Aug;22(3-4):146-9. Epub 2012 May 22 doi: 10.1016/j.ghir.2012.04.008. PMID: 22627149
Primary hypophysitis: clinical-pathological correlations.
Gutenberg A, Hans V, Puchner MJ, Kreutzer J, Brück W, Caturegli P, Buchfelder M
Eur J Endocrinol 2006 Jul;155(1):101-7. doi: 10.1530/eje.1.02183. PMID: 16793955

Prognosis

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Pituitary hypoplasia is the best MRI predictor of the severity and type of growth hormone deficiency in children with congenital growth hormone deficiency.
Sharma H, Purwar N, Kumar A, Sahlot R, Garg U, Sharma B, Mathur SK
J Pediatr Endocrinol Metab 2021 Jul 27;34(7):851-858. Epub 2021 Apr 7 doi: 10.1515/jpem-2021-0049. PMID: 33823100
Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review.
Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J
Rheumatol Int 2019 Aug;39(8):1467-1476. Epub 2019 Jun 15 doi: 10.1007/s00296-019-04338-0. PMID: 31203400
Classical and non-classical causes of GH deficiency in the paediatric age.
Di Iorgi N, Morana G, Allegri AE, Napoli F, Gastaldi R, Calcagno A, Patti G, Loche S, Maghnie M
Best Pract Res Clin Endocrinol Metab 2016 Dec;30(6):705-736. Epub 2016 Nov 24 doi: 10.1016/j.beem.2016.11.008. PMID: 27974186
Hypopituitarism oddities: congenital causes.
Kelberman D, Dattani MT
Horm Res 2007;68 Suppl 5:138-44. Epub 2007 Dec 10 doi: 10.1159/000110610. PMID: 18174732

Clinical prediction guides

Oxytocin: physiology, pharmacology, and clinical application for labor management.
Hermesch AC, Kernberg AS, Layoun VR, Caughey AB
Am J Obstet Gynecol 2024 Mar;230(3S):S729-S739. Epub 2023 Jul 16 doi: 10.1016/j.ajog.2023.06.041. PMID: 37460365
Exome sequencing in 16 patients with pituitary stalk interruption syndrome: A monocentric study.
Brauner R, Bignon-Topalovic J, Bashamboo A, McElreavey K
PLoS One 2023;18(12):e0292664. Epub 2023 Dec 14 doi: 10.1371/journal.pone.0292664. PMID: 38096238Free PMC Article
Pituitary stalk interruption syndrome.
Voutetakis A
Handb Clin Neurol 2021;181:9-27. doi: 10.1016/B978-0-12-820683-6.00002-6. PMID: 34238482
Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.
Lodge EJ, Xekouki P, Silva TS, Kochi C, Longui CA, Faucz FR, Santambrogio A, Mills JL, Pankratz N, Lane J, Sosnowska D, Hodgson T, Patist AL, Francis-West P, Helmbacher F, Stratakis C, Andoniadou CL
JCI Insight 2020 Oct 27;5(23) doi: 10.1172/jci.insight.134310. PMID: 33108146Free PMC Article
Hypopituitarism oddities: congenital causes.
Kelberman D, Dattani MT
Horm Res 2007;68 Suppl 5:138-44. Epub 2007 Dec 10 doi: 10.1159/000110610. PMID: 18174732

Recent systematic reviews

A Comprehensive Study of Spindle Cell Oncocytoma of the Pituitary Gland: Series of 6 Cases and Meta-Analysis of 85 Cases.
Hasegawa H, Van Gompel JJ, Oushy SH, Pollock BE, Link MJ, Meyer FB, Bancos I, Erickson D, Davidge-Pitts CJ, Little JT, Uhm JH, Swanson AA, Giannini C, Mahajan A, Atkinson JL
World Neurosurg 2021 May;149:e197-e216. Epub 2021 Feb 18 doi: 10.1016/j.wneu.2021.02.051. PMID: 33610869
Primary Tumors of the Posterior Pituitary Gland: A Systematic Review of the Literature in Light of the New 2017 World Health Organization Classification of Pituitary Tumors.
Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty JA
World Neurosurg 2021 Jan;145:148-158. Epub 2020 Sep 8 doi: 10.1016/j.wneu.2020.09.023. PMID: 32916355

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...